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1.
Health Expect ; 27(4): e14177, 2024 Aug.
Article in English | MEDLINE | ID: mdl-39129706

ABSTRACT

BACKGROUND: Experiencing gender-based violence (GBV) is common among refugees. Intersecting systems of oppression can increase the risk of GBV and of suffering detrimental consequences, while concurrently creating barriers to meaningful support. Despite this, refugees with lived experience of GBV are rarely involved in the development, planning and adaptation of services and policies. METHODS: This article reports on a formative research process that aimed to involve public contributors (refugee victim-survivors of GBV) and relevant stakeholders in co-designing a service model aimed at improving psychosocial support in Sweden. Led by a partnership of public contributors and academic researchers, the research process consisted of iterative cycles of co-design workshops, complemented by scoping of existing literature. RESULTS: The co-design process resulted in a characterisation of the psychosocial service system needs, as perceived by the survivor co-researchers and stakeholders, and a two-level empowerment and support service model. The model included (i) a community-based intervention to promote help-seeking and (ii) psychosocial group support delivered in specialist clinics. Outcomes of the project included perceived benefits for those involved, service-led direct changes and acquisition of funding for continued research on the co-designed model. CONCLUSION: Improving psychosocial support for refugees in Sweden affected by GBV requires safe spaces to connect with peers and familiarise with available services, laws and rights in the society. Further, strengthened collaborations across sectors are necessary to meet the variety of needs. Co-design workshops were an effective way to initiate changes in the service delivery model for psychosocial support for refugees in Sweden affected by GBV. PATIENT OR PUBLIC CONTRIBUTIONS: This is a participatory reflection on a participatory process. The survivor co-researchers contributed to designing and carrying out the PPI process and have co-authored this manuscript.


Subject(s)
Gender-Based Violence , Refugees , Humans , Refugees/psychology , Sweden , Psychosocial Support Systems , Female , Male , Survivors/psychology , Social Support
2.
Sci Rep ; 14(1): 18902, 2024 08 14.
Article in English | MEDLINE | ID: mdl-39143145

ABSTRACT

The COVID-19 pandemic has disrupted people's lives and caused significant economic damage around the world, but its impact on people's mental health has not been paid due attention by the research community. According to anecdotal data, the pandemic has raised serious concerns related to mental health among the masses. However, no systematic investigations have been conducted previously on mental health monitoring and, in particular, detection of post-traumatic stress disorder (PTSD). The goal of this study is to use classical machine learning approaches to classify tweets into COVID-PTSD positive or negative categories. To this end, we employed various Machine Learning (ML) classifiers, to segregate the psychotic difficulties with the user's PTSD in the context of COVID-19, including Random Forest Support Vector Machine, Naïve Bayes, and K-Nearest Neighbor. ML models are trained and tested using various combinations of feature selection strategies to get the best possible combination. Based on our experimentation on real-world dataset, we demonstrate our model's effectiveness to perform classification with an accuracy of 83.29% using Support Vector Machine as classifier and unigram as a feature pattern.


Subject(s)
COVID-19 , Machine Learning , Social Media , Stress Disorders, Post-Traumatic , Support Vector Machine , Survivors , Humans , Stress Disorders, Post-Traumatic/psychology , Stress Disorders, Post-Traumatic/diagnosis , Stress Disorders, Post-Traumatic/epidemiology , COVID-19/psychology , COVID-19/epidemiology , Survivors/psychology , SARS-CoV-2/isolation & purification , Bayes Theorem , Mental Health
3.
Clin Biomech (Bristol, Avon) ; 118: 106318, 2024 Aug.
Article in English | MEDLINE | ID: mdl-39116645

ABSTRACT

BACKGROUND: Covid-19 has dramatically increased the number of admissions in intensive care units due to respiratory complications. In some cases, the arousal of neurological impairments, such as peripheral neuropathies, have been revealed. The purpose of this research was to characterize the gait pattern and muscle activity changes in Covid-19 survivors compared to physiological gait. METHODS: Twelve post-Covid-19 participants admitted to intensive care units and twelve non-disabled controls were considered. Kinematics, kinetics and surface electromyographic data were collected for each participant during walking. Post Covid-19 participants were further divided into two sub-groups, according to the number of days spent in the intensive care units. Lower limb joint angles, moments and powers were extracted as well as the muscle activity of four muscles bilaterally, the spatial, temporal and spatiotemporal parameters of gait and the ground reaction forces. The extracted variables were compared through OneWay-ANOVA or Kruskal-Wallis tests where appropriate (p < 0.05). FINDINGS: Overall, the considered parameters revealed statistically significant reduction in gait speed, cadence, range of motion in the sagittal plane, anteroposterior and vertical ground reaction forces between pathological and control participants. Larger alterations of the gait patterns were highlighted in the post-Covid-19 group hospitalized in intensive care units longer than 35 days, where a reduced muscle activity was observed on all the analyzed muscles. INTERPRETATION: Results suggested that the severity of gait impairments in post-Covid-19 participants might be correlated with intensive care units-bedding period. Gait biomechanics assessment could be adopted in the clinical decision-making process to improve treatment protocols in post-Covid-19 survivors.


Subject(s)
COVID-19 , Gait , SARS-CoV-2 , Survivors , Walking , Humans , COVID-19/physiopathology , Male , Middle Aged , Female , Biomechanical Phenomena , Gait Analysis/methods , Electromyography , Range of Motion, Articular , Muscle, Skeletal/physiopathology , Aged , Intensive Care Units , Adult
4.
Adv Exp Med Biol ; 1458: 1-18, 2024.
Article in English | MEDLINE | ID: mdl-39102186

ABSTRACT

The COVID-19 pandemic has brought significant changes in daily life for humanity and has had a profound impact on mental health. As widely acknowledged, the pandemic has led to notable increases in rates of anxiety, depression, distress, and other mental health-related issues, affecting both infected patients and non-infected individuals. COVID-19 patients and survivors face heightened risks for various neurological and psychiatric disorders and complications. Vulnerable populations, including those with pre-existing mental health conditions and individuals living in poverty or frailty, may encounter additional challenges. Tragically, suicide rates have also risen, particularly among young people, due to factors such as unemployment, financial crises, domestic violence, substance abuse, and social isolation. Efforts are underway to address these mental health issues, with healthcare professionals urged to regularly screen both COVID-19 and post-COVID-19 patients and survivors for psychological distress, ensuring rapid and appropriate interventions. Ongoing periodic follow-up and multidimensional, interdisciplinary approaches are essential for individuals experiencing long-term psychiatric sequelae. Preventive strategies must be developed to mitigate mental health problems during both the acute and recovery phases of COVID-19 infection. Vaccination efforts continue to prioritize vulnerable populations, including those with mental health conditions, to prevent future complications. Given the profound implications of mental health problems, including shorter life expectancy, diminished quality of life, heightened distress among caregivers, and substantial economic burden, it is imperative that political and health authorities prioritize the mental well-being of all individuals affected by COVID-19, including infected individuals, non-infected individuals, survivors, and caregivers.


Subject(s)
COVID-19 , Mental Health , Pandemics , COVID-19/economics , COVID-19/epidemiology , COVID-19/psychology , Mental Health/economics , Mental Health/statistics & numerical data , Humans , Pandemics/economics , Pandemics/statistics & numerical data , Survivors/psychology , Post-Acute COVID-19 Syndrome/economics , Post-Acute COVID-19 Syndrome/epidemiology , Post-Acute COVID-19 Syndrome/psychology , Depression/epidemiology , Depression/psychology , Anxiety/epidemiology , Anxiety/psychology , Caregivers/psychology , Life Expectancy , Quality of Life , Health Policy/trends
6.
Sci Rep ; 14(1): 18968, 2024 08 16.
Article in English | MEDLINE | ID: mdl-39152162

ABSTRACT

COVID-19 is a highly contagious virus that uses Angiotensin-converting enzyme 2 (ACE2) as a receptor to enter human cells. The virus leads to an increase in inflammatory cytokines (i.e. IL-6) and an impaired coagulation system, which can cause serious complications during and after the disease. Physical exercise has been shown to improve COVID-19 complications through various mechanisms, such as modulation of the immune and coagulation systems. Therefore, this study investigated the effects of 8 weeks of training on inflammatory, coagulation, and physical factors in patients with COVID-19 during the recovery phase. Twenty-seven male and female volunteers (age 20-45 years) who recently recovered from COVID-19 were assigned to the control (n = 13) or the training group (n = 14). Blood samples, aerobic capacity and muscle endurance were collected 24 h before the start of the interventions and 24 h after the final training session in week 4 and 48 h after the final training session in week 8. IL-6, ACE2, fibrinogen, and D-dimer were measured using ELISA. The training group showed a significant increase in muscle endurance (p = 0.004) and aerobic capacity (p = 0.009) compared to the control group. Serum levels of IL-6 and fibrinogen decreased in the training group but this decrease was not statistically significant (p > 0.05). Despite a slight increase in the quality of life and sleep in the training group, no statistically significant difference was observed between the training and the control group. It appears that physical training has beneficial effects on the coagulation system, inflammatory factors, and sleep quality and can facilitate the recovery of COVID-19 patients.


Subject(s)
Angiotensin-Converting Enzyme 2 , Blood Coagulation , COVID-19 , Exercise , Interleukin-6 , SARS-CoV-2 , Humans , COVID-19/blood , Male , Female , Angiotensin-Converting Enzyme 2/metabolism , Adult , Interleukin-6/blood , Middle Aged , Exercise/physiology , Young Adult , Fibrin Fibrinogen Degradation Products/metabolism , Fibrin Fibrinogen Degradation Products/analysis , Survivors , Fibrinogen/metabolism , Exercise Therapy/methods
8.
Violence Vict ; 39(3): 263-276, 2024 Aug 06.
Article in English | MEDLINE | ID: mdl-39107067

ABSTRACT

The COVID-19 pandemic has had significant impacts on the economic well-being of women, particularly those experiencing intimate partner violence (IPV). While some scholars have included common economic risk factors in their studies on COVID-related IPV experiences, fewer have looked specifically at the nature of the financial issues experienced. As such, the purpose of this study was to better understand the types of financial issues that survivors experienced because of the COVID-19 pandemic and their association with different forms of IPV. In July 2022, a sample of 571 women-identifying IPV survivors living in the United States participated in an online survey via Qualtrics panel service. The mean age of participants was 42, and 69% identified as White, non-Hispanic. On average, participants experienced approximately three COVID-related financial issues. After controlling for sociodemographic characteristics, economic abuse and economic abuse-related financial debt were both significantly associated with COVID-related financial issues. Study findings have important implications for economically supporting IPV survivors through research, policy, and practice.


Subject(s)
COVID-19 , Intimate Partner Violence , Survivors , Humans , Female , Adult , Intimate Partner Violence/economics , United States , Middle Aged , Surveys and Questionnaires , SARS-CoV-2 , Young Adult
9.
Health Expect ; 27(1): e13946, 2024 Feb.
Article in English | MEDLINE | ID: mdl-39102707

ABSTRACT

OBJECTIVE: This study uses capital theory to investigate survivors' investments in their bodies and the resources they accumulate during their rehabilitation trajectory, and how these factors impact their perception of recovery from their impairments. METHODS: Qualitative interviews were conducted with 20 patients of working age and their relatives, with audio recordings transcribed verbatim. Data analysis utilized an abductive approach informed by Bourdieu's capital theory. FINDINGS: During the initial phases of rehabilitation (acute and subacute), survivors invest in their physical bodies and acquire physical capital. However, they encounter a range of complex barriers when attempting to convert this capital into the resources necessary for re-entering the workforce or pursuing education. These difficulties are linked to the lack of specialized community services in the later phases of their rehabilitation trajectory. DISCUSSION AND CONCLUSION: Present-day Danish healthcare rehabilitation focuses on restoring physical function and recovering physical capital. However, comprehensive rehabilitation to enhance mental and cognitive abilities and increase levels of emotional capital, which is crucial for working-age individuals, is inadequately addressed within community services. This results in unequal treatment and care, contradicting the stated goal of equality in the Danish healthcare system. PATIENT OR PUBLIC CONTRIBUTION: This study incorporated the perspectives of 20 individuals who have survived severe traumatic brain injury, as well as their relatives, to gain insights into their experiences throughout the rehabilitation process, the resources they have accumulated and how these factors contribute to their sense of recovery.


Subject(s)
Brain Injuries, Traumatic , Interviews as Topic , Qualitative Research , Humans , Denmark , Male , Female , Adult , Middle Aged , Brain Injuries, Traumatic/rehabilitation , Brain Injuries, Traumatic/psychology , Survivors/psychology
11.
Occup Ther Int ; 2024: 8414358, 2024.
Article in English | MEDLINE | ID: mdl-39108662

ABSTRACT

Background: Statistics indicate a high prevalence of TBI in South Africa, with many individuals with TBI not returning to work. The lack of return to work among TBI survivors is particularly due to factors such as injury severity, preinjury educational and occupational status, and age at injury. However, in addition to the above factors, there was the COVID-19 pandemic, which resulted in the de-escalation of nonessential outpatient services in order to assist with curbing the spread of the virus. Objective: The aim of the article is to explore the experiences and perceptions of TBI survivors about accessing vocational rehabilitation during the COVID-19 pandemic and how this has affected their worker roles. Method: A descriptive, explorative qualitative research design was used, and semistructured interviews were conducted to collect data. The authors subsequently analysed the transcribed data using a thematic analysis approach. The COREQ (consolidated criteria for reporting qualitative research) checklist was used as a reporting guideline. Ten TBI survivors and two individuals working in the public health sector participated in this study. Two semistructured interviews were conducted with each research participant. Results: Three themes emanated from the study, namely, Theme 1: "The barriers to accessing rehabilitation during the COVID-19 pandemic" represents the participants' barriers to accessing rehabilitation programmes throughout the COVID-19 pandemic. Theme 2: "Lack of rehabilitation negatively influenced the individual with TBI occupational performance" describes how the lack of OT rehabilitation during the COVID-19 pandemic impacted the participants' quality of life. Theme 3: "Factors that facilitated access to rehabilitation during the COVID-19 pandemic" describes the factors that facilitated access to OT rehabilitation services during the COVID-19 pandemic. Conclusion: The study found that there were barriers and facilitators to accessing occupational therapy rehabilitation during the COVID-19 pandemic for TBI survivors. More research needs to be conducted to explore the efficacy of telehealth/telemedicine for occupational therapy rehabilitation and the role of the occupational therapist in global pandemics.


Subject(s)
Brain Injuries, Traumatic , COVID-19 , Qualitative Research , Rehabilitation, Vocational , Survivors , Humans , COVID-19/epidemiology , Male , Adult , Female , Survivors/psychology , Rehabilitation, Vocational/methods , Brain Injuries, Traumatic/rehabilitation , Brain Injuries, Traumatic/psychology , South Africa/epidemiology , Middle Aged , Health Services Accessibility , SARS-CoV-2 , Return to Work , Pandemics , Young Adult
12.
Medicine (Baltimore) ; 103(32): e39156, 2024 Aug 09.
Article in English | MEDLINE | ID: mdl-39121260

ABSTRACT

In critical care settings, ultrasound (US) of the quadriceps muscle and Bioelectrical Impedance Analysis (BIA) are noninvasive and widely available tools to evaluate muscle mass. We studied whether baseline muscle mass affects physical function in intensive care unit (ICU) survivors after discharge. This retrospective review of a prospective cohort enrolled 30 patients admitted to the medical ICU between April 2016 and June 2018. On ICU admission, quadriceps muscle thickness and skeletal muscle mass were measured using US and BIA, respectively. Muscle strength and physical function were measured using handgrip dynamometry, the 6-min walk test, and the Barthel index questionnaire survey during every clinic visit at 1, 3, 6, and 12 months after hospital discharge. Skeletal muscle mass at ICU admission was statistically correlated with the 6-min walk distance (6MWD) and Barthel index score. The segmental lean mass of the right arm was also positively correlated with handgrip muscle strength at 6 months after discharge. Likewise, the correlation between quadriceps muscle thickness at ICU admission and 6MWD at 6 months after discharge was positive and statistically significant. Multivariate regression analysis showed that skeletal muscle mass was associated with a reduced 6MWD, but the length of ICU stay was not. The segmental lean mass of the right arm also showed a significant association with handgrip strength after discharge. Low muscle mass on ICU admission is associated with reduced muscle strength, causing impaired physical function after hospital discharge in ICU survivors.


Subject(s)
Intensive Care Units , Quadriceps Muscle , Survivors , Humans , Male , Female , Retrospective Studies , Intensive Care Units/statistics & numerical data , Middle Aged , Republic of Korea/epidemiology , Aged , Quadriceps Muscle/diagnostic imaging , Quadriceps Muscle/physiopathology , Survivors/statistics & numerical data , Muscle Strength/physiology , Hand Strength/physiology , Electric Impedance , Muscle, Skeletal/diagnostic imaging , Muscle, Skeletal/physiopathology , Ultrasonography
13.
BMJ Open ; 14(8): e081663, 2024 Aug 06.
Article in English | MEDLINE | ID: mdl-39107025

ABSTRACT

INTRODUCTION: Sexual violence is a significant public health concern with severe physical, social and psychological consequences, which can be mitigated by health service utilisation. However, in Uganda and much of sub-Saharan Africa, these services are significantly underused, with 9 out of 10 survivors not seeking care due to a range of psychological, cultural, economic and logistical factors. Thus, there is a strong need for research to improve health service utilisation for survivors of sexual violence. METHODS AND ANALYSIS: The proposed study seeks to address the underutilization of health services for female survivors of sexual violence using a discrete choice experiment (DCE). The study will be conducted in the greater Masaka region of southwestern Uganda and target adult female survivors of sexual violence. We will first undertake qualitative interviews with 56 survivors of sexual violence to identify the key attributes and levels of the DCE. In order to ensure a sufficiently powered sample, 312 women who meet inclusion criteria will be interviewed. Our primary analysis will employ a mixed (random parameters) logit model. We will also model the role of individual-specific characteristics through latent class models. ETHICS AND DISSEMINATION: The study protocol was reviewed and approved by the following ethics review boards in Uganda and the USA: the Uganda Virus Research Institute (UVRI), the Uganda National Council for Science and Technology (HS2364ES), Washington University in St Louis and the University of Michigan. Our methods conform to established guidelines for the protection of human subjects involved in research. Our dissemination plan targets a broad audience, ranging from policymakers and government agencies to healthcare providers, academic communities and survivors themselves.


Subject(s)
Patient Acceptance of Health Care , Sex Offenses , Survivors , Humans , Uganda , Female , Survivors/psychology , Sex Offenses/psychology , Patient Acceptance of Health Care/psychology , Patient Acceptance of Health Care/statistics & numerical data , Adult , Choice Behavior , Patient Preference , Research Design , Qualitative Research
14.
BMC Public Health ; 24(1): 2143, 2024 Aug 07.
Article in English | MEDLINE | ID: mdl-39112982

ABSTRACT

INTRODUCTION: Stroke is the leading cause of death and disability among adults and elderly individuals worldwide. Although several primary studies have been conducted to determine the prevalence of poststroke cognitive impairment among stroke survivors in sub-Saharan Africa, these studies have presented inconsistent findings. Therefore, this study aimed to determine the pooled prevalence of poststroke cognitive impairment and identify its associated factors among stroke survivors in sub-Saharan Africa. METHODS: The studies were retrieved from the Google Scholar, Scopus, PubMed, and Web of Science databases. A manual search of the reference lists of the included studies was performed. A random-effects DerSimonian-Laird model was used to compute the pooled prevalence of poststroke cognitive impairment among stroke survivors in sub-Saharan Africa. RESULTS: A total of 10 primary studies with a sample size of 1,709 stroke survivors were included in the final meta-analysis. The pooled prevalence of PSCI was obtained from the 9 included studies with a sample size of 1,566. In contrast, the data regarding the associated factors were obtained from all the 10 included studies with a sample size of 1,709. The pooled prevalence of poststroke cognitive impairment among stroke survivors was 59.61% (95% CI: 46.87, 72.35); I2 = 96.47%; P < 0.001). Increased age (≥ 45 years) [AOR = 1.23, 95% CI: 1.09, 1.40], lower educational level [AOR = 4.35, 95% CI: 2.87, 6.61], poor functional recovery [AOR = 1.75, 95% CI: 1.42, 2.15], and left hemisphere stroke [AOR = 4.88, 95% CI: 2.98, 7.99] were significantly associated with poststroke cognitive impairment. CONCLUSIONS: The pooled prevalence of poststroke cognitive impairment was considerably high among stroke survivors in sub-Saharan Africa. Increased age, lower educational level, poor functional recovery, and left hemisphere stroke were the pooled independent predictors of poststroke cognitive impairment in sub-Saharan Africa. Stakeholders should focus on empowering education and lifestyle modifications, keeping their minds engaged, staying connected with social activities and introducing rehabilitative services for stroke survivors with these identified factors to reduce the risk of developing poststroke cognitive impairment.


Subject(s)
Cognitive Dysfunction , Stroke , Survivors , Humans , Cognitive Dysfunction/epidemiology , Cognitive Dysfunction/etiology , Stroke/complications , Stroke/epidemiology , Stroke/psychology , Africa South of the Sahara/epidemiology , Survivors/psychology , Survivors/statistics & numerical data , Prevalence , Risk Factors
15.
Front Public Health ; 12: 1405697, 2024.
Article in English | MEDLINE | ID: mdl-39100955

ABSTRACT

Background: Road traffic injuries (RTI) pose a global public health threat, especially in low- and middle-income nations. These injuries typically cause orthopaedic problems that may negatively impair a person's physical and mental health and quality of life. Our study examined the quality of life of road traffic orthopaedic injuries (RTOI) survivors. Methods: A cross-sectional study at five Rwandan referral hospitals, included 369 adult RTOI victims. Two years post-injury, participants completed the European Quality of life 5 Dimension 5 (EQ-5D-5L) and Visual Analogue Scale (VAS) Questionnaire between June 2 and August 31, 2022, with informed consent. Three EQ-5D-5L-VAS scores were used: low (0-40%), fair (41-60%), and excellent (61-100%). We used logistic regression analysis with a significance threshold of p < 0.05 to determine odds ratios (OR) and 95% CI. Results: The RTOI victims had a mean age of 37.5 ± 11.26 years with sex ratio M:F:3:1. Usual activities (66.8%) and mobility (54.8%) were the most affected EQ-5D-5L dimensions. Residence, hospital stay, rehabilitation, and return to work affected mobility, usual activities, pain/discomfort, and anxiety/depression. The EQ-5D-5L/VAS score showed 34.95% poor QoL (0-40%) and 35.50% good QoL. Factors affecting QoL include level of education (OR = 1.66, p < <0.01), type of intervention (OR = 1.22, p = 0.003), rehabilitation (OR = 2.41, p < 0.01) and level of disability (OR = 196.41, p < 0.01). Mobility, self-care, usual activities, pain, comfort, anxiety, and depression vary moderately on Shannon's index. Conclusion: The study highlights the significant impact of road traffic orthopaedic injuries (RTOI) on survivors' quality of life in Rwanda, revealing challenges in mobility and daily activities. Factors influencing quality of life include education level, medical intervention type, rehabilitation, and disability degree. The findings emphasize the need for tailored rehabilitation strategies and policy interventions to improve long-term outcomes for RTOI survivors.


Subject(s)
Accidents, Traffic , Quality of Life , Survivors , Humans , Quality of Life/psychology , Male , Female , Rwanda , Adult , Cross-Sectional Studies , Accidents, Traffic/statistics & numerical data , Survivors/psychology , Survivors/statistics & numerical data , Middle Aged , Surveys and Questionnaires , Wounds and Injuries/psychology
16.
Crit Care ; 28(1): 260, 2024 Aug 02.
Article in English | MEDLINE | ID: mdl-39095884

ABSTRACT

BACKGROUND: This study aimed to explore the characteristics of abnormal regional resting-state functional magnetic resonance imaging (rs-fMRI) activity in comatose patients in the early period after cardiac arrest (CA), and to investigate their relationships with neurological outcomes. We also explored the correlations between jugular venous oxygen saturation (SjvO2) and rs-fMRI activity in resuscitated comatose patients. We also examined the relationship between the amplitude of the N20-baseline and the rs-fMRI activity within the intracranial conduction pathway of somatosensory evoked potentials (SSEPs). METHODS: Between January 2021 and January 2024, eligible post-resuscitated patients were screened to undergo fMRI examination. The amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) of rs-fMRI blood oxygenation level-dependent (BOLD) signals were used to characterize regional neural activity. Neurological outcomes were evaluated using the Glasgow-Pittsburgh cerebral performance category (CPC) scale at 3 months after CA. RESULTS: In total, 20 healthy controls and 31 post-resuscitated patients were enrolled in this study. The rs-fMRI activity of resuscitated patients revealed complex changes, characterized by increased activity in some local brain regions and reduced activity in others compared to healthy controls (P < 0.05). However, the mean ALFF values of the whole brain were significantly greater in CA patients (P = 0.011). Among the clusters of abnormal rs-fMRI activity, the cluster values of ALFF in the left middle temporal gyrus and inferior temporal gyrus and the cluster values of ReHo in the right precentral gyrus, superior frontal gyrus and middle frontal gyrus were strongly correlated with the CPC score (P < 0.001). There was a strong correlation between the mean ALFF and SjvO2 in CA patients (r = 0.910, P < 0.001). The SSEP N20-baseline amplitudes in CA patients were negatively correlated with thalamic rs-fMRI activity (all P < 0.001). CONCLUSIONS: This study revealed that abnormal rs-fMRI BOLD signals in resuscitated patients showed complex changes, characterized by increased activity in some local brain regions and reduced activity in others. Abnormal BOLD signals were associated with neurological outcomes in resuscitated patients. The mean ALFF values of the whole brain were closely related to SjvO2 levels, and changes in the thalamic BOLD signals correlated with the N20-baseline amplitudes of SSEP responses. TRIAL REGISTRATION: NCT05966389 (Registered July 27, 2023).


Subject(s)
Coma , Heart Arrest , Magnetic Resonance Imaging , Survivors , Humans , Male , Female , Magnetic Resonance Imaging/methods , Prospective Studies , Middle Aged , Coma/physiopathology , Coma/diagnostic imaging , Heart Arrest/complications , Heart Arrest/physiopathology , Aged , Survivors/statistics & numerical data , Cohort Studies , Rest/physiology , Adult
17.
BMC Res Notes ; 17(1): 215, 2024 Aug 01.
Article in English | MEDLINE | ID: mdl-39090677

ABSTRACT

OBJECTIVE: Post-ICU survivors face higher mortality and often require costly rehabilitation or palliative care, such as occupational therapy, physiotherapy and hospice. However, there is a lack of data quantifying the demand for these services, particularly in developing countries like Uganda. Therefore, this prospective cohort study aimed to investigate the 90-day mortality rate, functional status, and mortality risk factors among 121 ICU patients discharged from three tertiary hospital ICUs in Uganda by tracking their vital and physical functional status for three months with follow-ups on days 30, 60, and 90, and identifying risk factors through Cox regression. RESULTS: The study revealed that 18 out of 121 ICU patients (14.88%, 95% CI: 9.52-22.51%) died within 90 days post-discharge, while 36.36% achieved normal physical functional status. Factors associated with higher 90-day mortality included raised intracranial pressure (HR 1.92, 95% CI: 1.76-2.79, p = 0.04), acute kidney injury (HR 4.13, 95% CI: 2.16-7.89, p < 0.01), and renal replacement therapy (HR 3.34, 95% CI: 2.21-5.06, p < 0.01). The high mortality rate and the fact that nearly two-thirds of patients did not attain normal functional status 90 days post discharge underscores the need for enhanced post-ICU rehabilitation services.


Subject(s)
Intensive Care Units , Survivors , Humans , Intensive Care Units/statistics & numerical data , Male , Female , Prospective Studies , Uganda/epidemiology , Middle Aged , Adult , Survivors/statistics & numerical data , Risk Factors , Developing Countries/statistics & numerical data , Poverty , Aged
18.
Eur J Psychotraumatol ; 15(1): 2364443, 2024.
Article in English | MEDLINE | ID: mdl-38949539

ABSTRACT

Background: Despite its popularity, evidence of the effectiveness of Psychological First Aid (PFA) is scarce.Objective: To assess whether PFA, compared to psychoeducation (PsyEd), an attention placebo control, reduces PTSD and depressive symptoms three months post-intervention.Methods: In two emergency departments, 166 recent-trauma adult survivors were randomised to a single session of PFA (n = 78) (active listening, breathing retraining, categorisation of needs, assisted referral to social networks, and PsyEd) or stand-alone PsyEd (n = 88). PTSD and depressive symptoms were assessed at baseline (T0), one (T1), and three months post-intervention (T2) with the PTSD Checklist (PCL-C at T0 and PCL-S at T1/T2) and the Beck Depression Inventory-II (BDI-II). Self-reported side effects, post-trauma increased alcohol/substance consumption and interpersonal conflicts, and use of psychotropics, psychotherapy, sick leave, and complementary/alternative medicine were also explored.Results: 86 participants (51.81% of those randomised) dropped out at T2. A significant proportion of participants in the PsyEd group also received PFA components (i.e. contamination). From T0 to T2, we did not find a significant advantage of PFA in reducing PTSD (p = .148) or depressive symptoms (p = .201). However, we found a significant dose-response effect between the number of delivered components, session duration, and PTSD symptom reduction. No significant difference in self-reported adverse effects was found. At T2, a smaller proportion of participants assigned to PFA reported increased consumption of alcohol/substances (OR = 0.09, p = .003), interpersonal conflicts (OR = 0.27, p = .014), and having used psychotropics (OR = 0.23, p = .013) or sick leave (OR = 0.11, p = .047).Conclusions: Three months post-intervention, we did not find evidence that PFA outperforms PsyEd in reducing PTSD or depressive symptoms. Contamination may have affected our results. PFA, nonetheless, appears to be promising in modifying some post-trauma behaviours. Further research is needed.


Psychological First Aid (PFA) is widely recommended early after trauma.We assessed PFA's effectiveness for decreasing PTSD symptoms and other problems 3 months post-trauma.We didn't find definitive evidence of PFA's effectiveness. Still, it seems to be a safe intervention.


Subject(s)
Depression , Emergency Service, Hospital , Stress Disorders, Post-Traumatic , Humans , Stress Disorders, Post-Traumatic/therapy , Male , Female , Adult , Depression/therapy , Emergency Service, Hospital/statistics & numerical data , First Aid , Survivors/psychology , Psychotherapy , Middle Aged , Treatment Outcome , Psychiatric Status Rating Scales
20.
Torture ; 34(1): 71-82, 2024.
Article in English | MEDLINE | ID: mdl-38975916

ABSTRACT

INTRODUCTION: In October 2019 in Chile, massive protests broke out in the so-called social uprising. The repressive response of the armed forces and Carabineros (Police) resulted in serious and mas-sive violations of human rights, with between 400 and 500 victims of ocular trauma caused mainly by shots from anti-riot shotguns, constituting the largest number of cases in the world linked to a single event. It is proposed to evaluate the different dimensions of the impact of ocular trauma due to state violence, using the concept of psychosocial trauma and a support model that integrates the medical-psychological and social dimensions. METHODS: Human rights violations of the period are described, focusing on cases of ocular trauma, and state and civil society responses. The requests of a survivors' organisations regarding truth, justice and reparation is presented. A clinical case of ocular trauma treated in our centre is analyzed. RESULTS: Survivors of ocular trauma manifest post-traumatic reactions regardless of the severity of their ocular injuries. The impact on the mental health of survi-vors of ocular trauma due to state violence is a phenomenon where the psychic and psychosocial im-pact of trauma due to socio-political violence intersects with the short- and long-term mental health effects. DISCUSSION: The impact of sociopolitical trauma must be understood considering both the in-dividual and social subject, considering their cultural, socioeconomic and political reality. Recovery from traumatic psychological injury must be addressed in its medical, sensory rehabilitation, psycho-logical and psychosocial dimensions, including processes of social recognition, search for justice and comprehensive reparation of damage. In contexts of impunity, a model is proposed that integrates rehabilitation with psycho-legal support, promotion of agency and organisation, within the frame-work of commitment to the movement and principles of human rights.


Subject(s)
Eye Injuries , Human Rights , Psychological Trauma , Humans , Chile , Eye Injuries/psychology , Psychological Trauma/psychology , Male , Adult , Survivors/psychology , Violence/psychology
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