ABSTRACT
Extinct from nature, captive young Alagoas curassows (Pauxi mitu) were found agonizing or dead with respiratory disease. Intranuclear inclusion bodies were found in the epithelia of the trachea, associated with marked necrotic tracheitis. An Aviadenovirus was isolated in chicken eggs and characterized genetically with 99% identity to the fowl Aviadenovirus A, as based on the hexon protein gene. This is the first report of respiratory disease caused by Aviadenovirus in any cracid species in Brazil, recommending for stricter biosecurity in the conservation premises. RESEARCH HIGHLIGHTS Fatal tracheitis in curassows extinct from nature was associated with Aviadenovirus A. Seven-month-old Alagoas curassows (Aves: Cracidae) died with haemorrhagic tracheitis. Aviadenovirus A with 99% identity to fowl adenovirus 1 was detected in dead curassows. Fatal tracheitis by Aviadenovirus was described in Pauxi mitu (Aves: Cracidae).
Subject(s)
Aviadenovirus/classification , Galliformes/virology , Poultry Diseases/diagnosis , Tracheitis/veterinary , Animals , Aviadenovirus/genetics , Aviadenovirus/isolation & purification , Brazil , Fatal Outcome , Fowl adenovirus A/genetics , Inclusion Bodies, Viral/virology , Intranuclear Inclusion Bodies/virology , Necrosis/veterinary , Poultry Diseases/pathology , Poultry Diseases/virology , Trachea/pathology , Trachea/virology , Tracheitis/diagnosis , Tracheitis/pathology , Tracheitis/virologyABSTRACT
Histopathologic features of New Mexico 2009 H1N1 fatalities have not been representative of those reported nationwide. We retrospectively reviewed medical records of all New Mexico 2009 pandemic influenza A (pH1N1) fatalities (n = 50). In cases in which autopsy was performed (n = 12), histologic sections and culture results were examined. In contrast to previously published studies, the majority of our fatalities did not have diffuse alveolar damage (DAD) (2/12; 16.7%). Common findings included pulmonary interstitial inflammation and edema, tracheobronchitis, and pneumonia. Two cases had significant extra-pulmonary manifestations: myocarditis and cerebral edema with herniation. The majority had a rapid disease course: range from 1 to 12 days (median, 2 days), and Native Americans were disproportionately represented among fatalities. These findings suggest that New Mexico H1N1 fatalities generally did not survive long enough to develop the classic picture of DAD. Pathologists should be aware that H1N1 may cause extra-pulmonary pathology and perform postmortem cultures and histologic sampling accordingly.
Subject(s)
Influenza A Virus, H1N1 Subtype , Influenza, Human/mortality , Adolescent , Adult , Age Distribution , Aged , Aged, 80 and over , Brain Edema/pathology , Brain Edema/virology , Bronchitis/pathology , Bronchitis/virology , Child , Child, Preschool , Comorbidity , Encephalocele/pathology , Encephalocele/virology , Female , Forensic Pathology , Humans , Infant , Male , Middle Aged , Myocarditis/pathology , Myocarditis/virology , New Mexico/epidemiology , Obesity/epidemiology , Pandemics , Pneumonia, Viral/pathology , Pulmonary Edema/pathology , Pulmonary Edema/virology , Racial Groups/statistics & numerical data , Retrospective Studies , Sex Distribution , Tracheitis/pathology , Tracheitis/virology , Young AdultABSTRACT
The presence of antibodies against human parainfluenza viruses type 2 and 3 was studied in 1 793 sera from an infantile population under 14 years old. The hemagglutination inhibition technique was used for screening the clinical samples. Of the total of analyzed sera, 1 382 (77.1%) were positive. The presence of antibodies against type 2 was confirmed in 320 of them (17.8%), and against type 3 in 334 (18.6%). The simultaneous seropositivity predominated in 805 (44.9%). The circulation of human parainfluenza viruses was corroborated during all the months of the year and in all the analyzed age groups. It was observed an increase in the positivity percentages with age.