ABSTRACT
Chest imaging is often used as a complementary tool in the evaluation of coronavirus disease 2019 (COVID-19) patients, helping physicians to augment their clinical suspicion. Despite not being diagnostic for COVID-19, chest CT may help clinicians to isolate high suspicion patients with suggestive imaging findings. However, COVID-19 findings on CT are also common to other pulmonary infections and non-infectious diseases, and radiologists and point-of-care physicians should be aware of possible mimickers. This state-of-the-art review goal is to summarize and illustrate possible etiologies that may have a similar pattern on chest CT as COVID-19. The review encompasses both infectious etiologies, such as non-COVID viral pneumonia, Mycoplasma pneumoniae, Pneumocystis jiroveci, and pulmonary granulomatous infectious, and non-infectious disorders, such as pulmonary embolism, fat embolism, cryptogenic organizing pneumonia, non-specific interstitial pneumonia, desquamative interstitial pneumonia, and acute and chronic eosinophilic pneumonia.
Subject(s)
COVID-19/diagnostic imaging , Tomography, X-Ray Computed/methods , Adult , Aged , Community-Acquired Infections/diagnostic imaging , Diagnosis, Differential , Embolism, Fat/diagnostic imaging , Female , Granulomatous Disease, Chronic/diagnostic imaging , Humans , Lung Diseases/diagnostic imaging , Lung Diseases, Interstitial/diagnostic imaging , Male , Middle Aged , Pneumonia, Mycoplasma/diagnostic imaging , Pneumonia, Pneumocystis/diagnostic imaging , Pneumonia, Viral/diagnostic imaging , Pulmonary Embolism/diagnostic imaging , Pulmonary Eosinophilia/diagnostic imaging , Radiography, Thoracic/methods , Time FactorsSubject(s)
Cognitive Dysfunction , Granulomatous Disease, Chronic/diagnosis , Mastitis/diagnosis , Breast Neoplasms/diagnosis , Breast Neoplasms/diagnostic imaging , Diagnosis, Differential , Female , Granulomatous Disease, Chronic/diagnostic imaging , Granulomatous Disease, Chronic/surgery , Humans , Mastitis/diagnostic imaging , Mastitis/surgery , Middle AgedABSTRACT
Sarcoidosis is a multisystem granulomatous disease of unknown cause. The osteoarticular involvement in sarcoidosis is rare and is often associated with cutaneous and long-standing chronic multisystem disease. More common in black women, osseous sarcoidosis is difficult to diagnose, with an incidence of 3 to 13%. The most characteristic radiological clinical picture evidences rounded, well-defined cysts, with no periosteal reaction and without peripheral sclerosis. The small bones of hands and feet are the most frequently involved sites. This report aims to demonstrate a rare case of osteoarticular sarcoidosis with characteristic clinical presentation, and highlight the importance of detecting osteoarticular involvement in this pathology.
Subject(s)
Granulomatous Disease, Chronic/pathology , Musculoskeletal Diseases/pathology , Sarcoidosis/pathology , Skin Diseases/pathology , Aged, 80 and over , Female , Granulomatous Disease, Chronic/diagnostic imaging , Hand Bones/diagnostic imaging , Hand Bones/pathology , Humans , Musculoskeletal Diseases/diagnostic imaging , Radiography , Sarcoidosis/diagnostic imaging , Skin Diseases/diagnostic imaging , Telangiectasis/pathologyABSTRACT
Burkholderia species, notably Burkholderia cepacia and Burkholderia gladioli, are important pathogens in patients with chronic granulomatous disease (CGD). Burkholderia pseudomallei, the causative agent of melioidosis, is endemic in Southeast Asia and northern Australia but is a rare pathogen in other parts of the world. We describe the occurrence of B. pseudomallei infection in a Puerto Rican patient with CGD. This is one of only a small number of documented cases of melioidosis autochthonous to the Americas and is the first reported case of B. pseudomallei infection in a CGD patient from the Americas. We conclude that B. pseudomallei, like B. cepacia and B. gladioli, should be considered a potential pathogen in patients with CGD and that melioidosis should be considered in the differential diagnosis for ill residents of or travelers to Puerto Rico.