The Impact of Liquid Biopsies Positive for EGFR Mutations on Overall Survival in Non-Small Cell Lung Cancer Patients.

In recent years, non-small cell lung cancer treatment has been revolutionized. EGFR tyrosine kinase inhibitors and our improved understanding of its alterations have driven new diagnostic strategies. Liquid biopsies have emerged as a useful tool in these contexts, showing potential utility in early diagnosis combined with low-dose CT scans, as well as potential in monitoring treatment response and predicting the development of patients. We studied the circulating tumor DNA (ctDNA) of 38 EGFR-mutated non-small cell lung cancer patients at diagnosis in different moments of their disease by liquid biopsy techniques. Our results show that mean overall survival was significantly lower when a liquid biopsy was positive for the detection of EGFR mutations compared with wild-type patients in their liquid biopsy in both univariate (29 ± 4 vs. 104 ± 19 months; p = 0.004) and multivariate analysis (p = 0.008). Taking this into consideration, liquid biopsies could be key to improving the control of this disease.

[Peri-testicular fibromatosis (testicular fibrous pseudotumor)]. / Periorquitis fibromatosa (pseudotumor fibroso testicular).

OBJECTIVE: We report a case of fibromatous periorchitis, a rare entity that may have differential diagnosis problems with other lesions. METHODS: Our patient underwent a surgical procedure with resection of the tunica vaginalis testis after intraoperative histological evaluation. RESULTS: Findings observed in both intraoperative biopsy and specimen histopathological study were key for diagnosis. CONCLUSIONS: Although macroscopic appearance of the lesion can be of great value, fibromatous periorchitis diagnosis is based on the histologic features, being important to avoid erroneous therapeutic decisions.

Periorquitis fibromatosa (pseudotumor fibroso testicular) / Fifromatous periorchitis (testicular fibrous pseudotumour)

Objetivo: Presentamos un caso de periorquitis fibromatosa, rara entidad que puede plantear problemas de diagnóstico diferencial con otras lesiones. Métodos: Nuestro paciente fue intervenido quirúrgicamente, practicándose la resección de la vaginal testicular, tras estudio histológico intraoperatorio de la lesión. Resultados: Los hallazgos observados tanto en la biopsia intraoperatoria como en el estudio histopatológico de la pieza quirúrgica, fueron claves para el diagnóstico de la lesión. Conclusiones: El diagnóstico de la periorquitis fibromatosa se basa en el aspecto histológico de lesión, si bien su apariencia macroscópica parece ser de gran valor orientativo, lo que resulta muy importante a la hora de evitar conductas terapéuticas improcedentes (AU)