RÉSUMÉ
Clinical trials of PDWHF are ongoing and the final results are not yet available; however early lessons learned have allowed us to modify these trials. It is anticipated that the patient accrual will be completed within the next six months, and the last patient will complete the trial within the next year. At that time, we hope to have new insight into the role of PDWHF in the treatment of lower extremity ulcers. At this time, we are encouraged by the early improvement seen in patients entering the PDWHF versus saline trial. Preliminary results suggest that PDWHF improves the healing of diabetic ulcers of the lower extremity.
Sujet(s)
Plaquettes , Substances de croissance/usage thérapeutique , Ulcère de la jambe/thérapie , Cicatrisation de plaie , Maladie chronique , Neuropathies diabétiques/complications , Méthode en double aveugle , Humains , Ulcère de la jambe/étiologie , Études prospectivesRÉSUMÉ
As the width of surgical margins declines, histologic evaluation of the margins is needed to assess the completeness of excision of a malignant melanoma. We studied 221 specimens in 59 patients and compared the interpretations of frozen and paraffin sections from the same block. Frozen sections had a sensitivity of 100% in detecting melanoma when present and a specificity of 90%.
Sujet(s)
Coupes minces congelées , Mélanome/chirurgie , Tumeurs cutanées/chirurgie , Faux positifs , Fibrose , Humains , Mélanome/diagnostic , Mélanome/anatomopathologie , Chirurgie de Mohs , Récidive tumorale locale/chirurgie , Sensibilité et spécificité , Peau/anatomopathologie , Tumeurs cutanées/diagnostic , Tumeurs cutanées/anatomopathologieRÉSUMÉ
Spindle cell tumors arising in the lymph nodes are very rare. We report the light microscopic, histochemical, immunohistochemical, and ultrastructural findings of an unusual solitary spindle cell tumor in a peripheral lymph node of a 45-year-old woman. Microscopically, the tumor was characterized by interlacing fascicles of uniform spindle cells with nuclear palisading and formation of Verocay bodies. Numerous erythrocytes were found interstitially. There were no mitotic figures or significant nuclear atypia. The ultrastructural findings of abundant myofilaments with dense bodies indicated myoid differentiation. The clinical and pathologic findings favored this being a benign tumor and could represent a unique example of "intranodal myofibroblastoma." The differential diagnosis includes neurilemoma, leiomyoma, and, more importantly, leiomyosarcoma, Kaposi's sarcoma, and other metastatic spindle cell tumors.