RÉSUMÉ
In this work, the production of a novel methodology for the application of natural corrosion inhibitors on steel, using an autoclave is presented. Tests were carried out using Artemisia vulgaris. The inhibitor was produced with a simple soxhlet extraction process using 15 g of Artemisia vulgaris and 260 mL of Ether. Once the inhibitor was produced, the steel was immersed in it, to form a coating that protects the material against corrosion. Thermogravimetry analyzes (TGA) were performed on the inhibitor, to determine the degradation temperature; it was observed that, at 321 °C, the loss of organic mass begins. After applying the inhibitor to the steel, the Fourier Transform Infrared Spectroscopy (FTIR) technique was used to determine the vibrational bands and the difference between the spectra for the steels before and after the coating was applied. For the evaluation of the method efficiency, Electrochemical Impedance Spectroscopy (EIS) and polarization resistance tests were performed, where Nyquist diagrams and Tafel curves were obtained, for steels with and without treatment. In this case, an increase of 93% in the corrosion resistance, and an 88% decrease in the corrosion rate were observed, proving that this methodology can be used to protect steel against corrosion and extend the steel's useful life.
RÉSUMÉ
Una infusión controlada por concentración objetivo, es un sistema guiado por ordenador que permite administrar fármacos de tal manera que se alcance y mantenga una concentración definida en un compartimento tisular, generalmente el plasma o el cerebro, basado en un modelo farmacocinético y farmacodinámico. En este artículo se presenta el caso de una paciente a la que se le aplicó anestesia total intravenosa controlada por concentración objetivo en sitio efectivo, utilizando un programa desarrollado conjuntamente por el Departamento de Anestesiología y el programa de Bioingeniería de la Universidad de Antioquia. Luego de haber sido validado con otros programas similares como el Stanpump®, se procedió a realizar una prueba clínica. Los resultados fueron satisfactorios y se alcanzaron profundidades de anestesia adecuadas para el procedimiento quirúrgico, acordes con las concentraciones en sitio efectivo reportadas a nivel mundial. Además, el comportamiento hemodinámico del paciente fue estable y su recuperación fue satisfactoria.
An infusión controlled by a target concentratiuon is a system guided by a computer that allows the administration of pharmachologycal drugs in Duch way that a defined concentration is reached and maintained in a tissue compartment; generally, plasma or the brain, based on a pharmachodynamic and pharmacokinetic model. In this article, the case of a patient to whom total intravenous anesthesia was applied, controlled by target concentration in effective site, using a program developed together by the anesthesiology department and the bioengineering program of the Universidad de Antioquia is presented. After being validated with other similar programs like the Standpump, a clinical test was made. The results were satisfactory and the adequate anesthesia depths were reached for the surgical procedure, in accordance with the concentrations in the effective site reported worldwide. Additionally, the homodynamic behavior of the patient was stable and his recovery was satisfactory as well.