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Arch Pharm Res ; 41(12): 1117-1130, 2018 Dec.
Article de Anglais | MEDLINE | ID: mdl-28895057

RÉSUMÉ

Four new ursane-type triterpenoid saponins, clinopoursaponins A-D (1-4), six new oleanane-type triterpenoid saponins, clinopodiside VII-XII (5-10), as well as eight known triterpene analogues (11-18), were isolated from the aerial parts of Clinopodium chinense (Benth.) O. Kuntze. The structures of the new compounds were determined based on extensive spectral analyses, including 1D (1H and 13C) and 2D NMR experiments (COSY, NOESY, HSQC, 2D TOCSY, HSQC-TOCSY and HMBC), HR-ESI-MS and chemical methods. Compounds 1-18 were evaluated for their protective effects against anoxia/reoxygenation-induced apoptosis in H9c2 cells and cytotoxicities against murine mammary carcinoma cell line 4T1. Compounds 8, 9 and 18 exhibited significant protective effects, while compound 1 exhibited cytotoxic activity with IC50 value of 7.4 µm compared to 7.6 µm for the positive control 10-hydroxycamptothecin.


Sujet(s)
Antinéoplasiques/pharmacologie , Lamiaceae/composition chimique , Saponines/pharmacologie , Triterpènes/pharmacologie , Animaux , Antinéoplasiques/composition chimique , Antinéoplasiques/isolement et purification , Apoptose/effets des médicaments et des substances chimiques , Lignée cellulaire , Prolifération cellulaire/effets des médicaments et des substances chimiques , Relation dose-effet des médicaments , Tests de criblage d'agents antitumoraux , Souris , Structure moléculaire , Saponines/composition chimique , Saponines/isolement et purification , Relation structure-activité , Triterpènes/composition chimique , Triterpènes/isolement et purification
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