RÉSUMÉ
The lipid spectrum of erythrocyte membranes was studied by thin-layer and gas-liquid chromatography in patients with lung cancer in the process of antineoplastic cytostatic chemotherapy. The control group of examined subjects was formed of healthy volunteers. During a course of antineoplastic polychemotherapy according to the CAM scheme (cyclophosphan, adriamycin, methotrexate) disorders of the erythrocyte membrane lipid spectrum in patients with II-IV stage lung cancer remained or became still more manifest.
Sujet(s)
Protocoles de polychimiothérapie antinéoplasique/pharmacologie , Membrane érythrocytaire/effets des médicaments et des substances chimiques , Tumeurs du poumon/sang , Lipides membranaires/sang , Sujet âgé , Protocoles de polychimiothérapie antinéoplasique/usage thérapeutique , Chromatographie sur couche mince , Cyclophosphamide/administration et posologie , Cyclophosphamide/pharmacologie , Doxorubicine/administration et posologie , Doxorubicine/pharmacologie , Membrane érythrocytaire/métabolisme , Ionisation de flamme , Humains , Tumeurs du poumon/traitement médicamenteux , Tumeurs du poumon/anatomopathologie , Mâle , Méthotrexate/administration et posologie , Méthotrexate/pharmacologie , Adulte d'âge moyen , Stadification tumorale , Facteurs tempsRÉSUMÉ
Reversible aggregation of the peripheral blood erythrocytes was studied in patients with stages III-IV lung cancer and patients with stages II-III tumors of the head and neck (cancer of the tongue, larynx, and buccal mucosa). The parameters examined were as follows: U0 and Ud--minimal and maximal stability of aggregates, tau---red cell aggregation half-period, A--the amplitude of photometric signal (in mm) characterizing the count of erythrocytes, Ia--aggregation index, and K--integral coefficient. The findings indicate an appreciable intensification of reversible aggregation of red cells in cancer: a significant increase of U0, Ud, A, Ia, and K and decrease of tau.
Sujet(s)
Agrégation érythrocytaire , Tumeurs de la tête et du cou/sang , Tumeurs du poumon/sang , Adulte , Sujet âgé , Humains , Mâle , Adulte d'âge moyenRÉSUMÉ
Scanning electron microscopy of the relief of the surface of peripheral red blood cells in patients with tumors of the head and neck (cancer of the tongue, larynx, and fundal buccal mucosa) of stages II-III and with stages III-IV lung cancer revealed similar changes, characterized by a manifest drop in the count of discocytes and increased share of transitional, prehemolytic, and degenerative forms of cells.
Sujet(s)
Membrane érythrocytaire/anatomopathologie , Érythrocytes/anatomopathologie , Tumeurs de la tête et du cou/anatomopathologie , Tumeurs du poumon/anatomopathologie , Adulte , Taille de la cellule , Membrane érythrocytaire/ultrastructure , Érythrocytes/ultrastructure , Tumeurs de la tête et du cou/sang , Humains , Tumeurs du poumon/sang , Mâle , Microscopie électronique , Adulte d'âge moyenSujet(s)
Protocoles de polychimiothérapie antinéoplasique/usage thérapeutique , Calcium/métabolisme , Carcinome pulmonaire non à petites cellules/sang , Carcinome à petites cellules/sang , Membrane érythrocytaire/métabolisme , Tumeurs du poumon/sang , Carcinome pulmonaire non à petites cellules/traitement médicamenteux , Carcinome pulmonaire non à petites cellules/physiopathologie , Carcinome à petites cellules/traitement médicamenteux , Carcinome à petites cellules/physiopathologie , Cyclophosphamide/administration et posologie , Doxorubicine/administration et posologie , Membrane érythrocytaire/effets des médicaments et des substances chimiques , Membrane érythrocytaire/physiologie , Humains , Tumeurs du poumon/traitement médicamenteux , Tumeurs du poumon/physiopathologie , Mâle , Potentiels de membrane/effets des médicaments et des substances chimiques , Méthotrexate/administration et posologie , Canaux potassiques/métabolismeRÉSUMÉ
Cytophotometric (sulfhydryl groups and lipoproteins) and interferometric (dry mass) studies of the peripheral blood erythrocytes were carried out in 94 untreated patients with tumors of different localization (lung cancer, tumors of the head and neck, gastric cancer, and cancer of the large intestine). Control group consisted of healthy volunteers. The concentrations of sulfhydryl groups, lipoproteins, and mean values of dry mass of red cells of the patients with tumors were reliably lower than those in healthy controls. The degree of changes in the studied parameters depended on the tumor localization.
