RÉSUMÉ
Thirteen patients with thrombotic thrombocytopenic purpura were treated at our facility between 1985 and 1991. All patients were treated with plasma therapy (both plasma exchange and plasma infusions), prednisone, intravenous immunoglobulin, and antiplatelet agents. Twelve patients achieved remission (92.3%). One patient died from cerebral hemorrhage. Vincristine was administered to 5 patients who did not respond after the first two plasmaphereses. Splenectomy was performed in a patient who relapsed four times within a 2-year period. From the 12 patients achieving remission, 11 have been still in remission for a period of 3 to 69 months.
Sujet(s)
Immunisation passive , Échange plasmatique , Antiagrégants plaquettaires/usage thérapeutique , Prednisone/usage thérapeutique , Purpura thrombotique thrombocytopénique/thérapie , Splénectomie , Vincristine/usage thérapeutique , Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Acide acétylsalicylique/usage thérapeutique , Association thérapeutique , Dipyridamole/usage thérapeutique , Femelle , Hématocrite , Humains , L-Lactate dehydrogenase/sang , Mâle , Adulte d'âge moyen , Plasma sanguin , Numération des plaquettes/effets des médicaments et des substances chimiques , Purpura thrombotique thrombocytopénique/enzymologieRÉSUMÉ
Among 387 cases of non-Hodgkin's lymphoma (NHL) treated in our units between January 1977 and December 1990, 52 (13.4%) had primary extranodal (PE) NHL of the head and neck. The median age was 55 years with a M:F ratio of 1.9:1. The most frequent primary site was the tonsil (28 cases), followed by oral cavity, parotid gland, orbit and other sites. The aggressive histological subtypes predominate. 55.2% of the patients were in stage I and 44.8% in stage II of disease. The CR rate was high (94.2%). The 5 years' overall survival rate was 65% and it was influenced mainly by stage (stage I 82.5% vs. 48.7% in stage II). Sex, age and histology did not significantly affect survival rate. Patients with primary Waldeyer's ring involvement (WR group) did not differ significantly from the other primary sites analyzed as a group (non-WR group) in respect to median age, sex distribution, histology and CR rates. They differed, however, in: (1) stage distribution with stage II disease more frequent in the WR group; (2) overall survival and disease-free survival both of which were significantly better in the non-WR group; and (3) the high incidence of GI tract involvement as initial manifestation of relapse in the WR group. It is concluded that the behaviour of the Waldeyer's ring PE-NHL is rather distinctive and should be considered separately from the other PE-NHL of the head and neck.
