RÉSUMÉ
OBJECTIVE: To determine the frequency and effects of nosocomial respiratory viral infections (RVIs) in premature neonates, including those who may be asymptomatic. STUDY DESIGN: We performed a year-long surveillance for RVIs in infants <33 weeks gestational age admitted to 2 Syracuse neonatal intensive care units. Infants were enrolled within 3 days of neonatal intensive care unit admission and were sampled for RVIs until discharge using a multiplex polymerase chain reaction assay capable of detecting 17 different respiratory viruses or subtypes. RESULTS: Twenty-six of 50 prematurely born infants (52%) tested positive for a respiratory virus at least once during their birth hospitalization. Testing positive for a respiratory virus was significantly associated with longer length of stay (70 days vs 35 days, P = .002) and prolonged ventilatory support (51 vs 13 days, P = .002). Infants who tested positive for a respiratory virus during their birth hospitalization had more than twice the rate of developing bronchopulmonary dysplasia (P < .05). CONCLUSION: Nosocomial RVIs were frequent in our study population, despite the absence of clinical indicators of illness. Length of hospital stay was significantly longer and a diagnosis of bronchopulmonary dysplasia was more common in infants who had respiratory viruses detected.
Sujet(s)
Soins intensifs néonatals/méthodes , Infections de l'appareil respiratoire/diagnostic , Maladies virales/diagnostic , Femelle , Âge gestationnel , Hospitalisation , Humains , Nouveau-né , Prématuré , Unités de soins intensifs néonatals , Mâle , Staphylococcus aureus résistant à la méticilline/métabolisme , Réaction de polymérisation en chaîne/méthodes , Études prospectives , Ventilation artificielle , Virus respiratoires syncytiaux/métabolisme , Infections de l'appareil respiratoire/virologie , Respirovirus/métabolismeRÉSUMÉ
An infant had a subdural empyema caused by the rare Salmonella species enterica subspecies houtenae (IV) serotype 44:z4,z23:- after only indirect exposure to exotic reptiles in her foster home. Infants recovering from preexisting subdural hematoma are at risk for development of empyema.