RÉSUMÉ
BACKGROUND: Our aim was to investigate the clinical and prognostic features of the patients with prosthetic valve endocarditis (PVE) in a multicenter nation-wide study. METHODS: The present nation-wide study consisted of 75 consecutive patients with PVE treated at 13 major hospitals in Turkey from 2005 to 2012. RESULTS: The patients who died during follow-up were significantly older than the survivors and had higher C-reactive protein (CRP), creatinine, poor NYHA functional class and large vegetations. High creatinine level (odds ratio [OR] 2.6, 95% confidence interval [CI] 1.14-6.13), poor functional status (OR 24.5; 95% CI 3.1-196.5) and high CRP (OR 1.02; 95% CI1.00-1.03) measured on admission were independent risk associates for in-hospital mortality. CONCLUSIONS: High creatinine level, poor functional status and high CRP measured on admission were independent risk associates for in-hospital mortality, whereas a NYHA class ofIII/IV and high CRP reflected independent risk for stroke/mortality end point.
Sujet(s)
Endocardite/mortalité , Implantation de valve prothétique cardiaque/effets indésirables , Prothèse valvulaire cardiaque/effets indésirables , Infections dues aux prothèses/mortalité , Adolescent , Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Marqueurs biologiques/sang , Protéine C-réactive/analyse , Loi du khi-deux , Créatinine/sang , Endocardite/sang , Endocardite/diagnostic , Femelle , État de santé , Implantation de valve prothétique cardiaque/instrumentation , Mortalité hospitalière , Humains , Modèles logistiques , Mâle , Adulte d'âge moyen , Analyse multifactorielle , Odds ratio , Pronostic , Infections dues aux prothèses/sang , Infections dues aux prothèses/diagnostic , Facteurs de risque , Accident vasculaire cérébral/mortalité , Facteurs temps , Turquie/épidémiologie , Jeune adulteRÉSUMÉ
The essential trace elements play important roles in the maintainance of the normal structure and physiology of cells. Several research groups have demonstrated that they also play important roles in states of cardiovascular diseases. Our aim is to investigate whether there is a relationship between trace elements (Zn and Cu) and the degree of atherosclerosis. The sample consisted of 67 patients with coronary artery disease and 26 clinically healthy individuals. Ninety-three subjects were separated into four groups according to their Gensini scores, the number of diseased vessels, the presence of acute coronary syndrome, and ejection fraction. Each group was divided into three subgroups, and serum zinc and copper levels were measured for each individual. The serum levels of zinc and copper were found to be significantly lower in patients with atherosclerosis than in the control group, but there were no significant differences in the serum levels of Cu and Zn between severe atherosclerosis and mild atherosclerosis. In Spearman's rank correlation, the zinc and copper levels were correlated with the Gensini score and the number of diseased vessels. The present study revealed a relationship between the serum levels of zinc and copper and atherosclerosis, but not between these levels and the severity of the disease.