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1.
Phys Rev Lett ; 110(3): 032501, 2013 Jan 18.
Article de Anglais | MEDLINE | ID: mdl-23373914

RÉSUMÉ

The decay of (19)O(ß(-)) and (19)Ne(ß(+)) implanted in niobium in its superconducting and metallic phases was measured using purified radioactive beams produced by the SPIRAL GANIL facility. Half-lives and branching ratios measured in the two phases are consistent within a 1σ error bar. This measurement casts strong doubts on the predicted strong electron screening in a superconductor, the so-called superscreening. The measured difference in screening potential energy is 110(90) eV for (19)Ne and 400(320) eV for (19)O. Precise determinations of the half-lives were obtained for (19)O, 26.476(9) s, and for (19)Ne, 17.254(5) s.

2.
Phys Rev Lett ; 109(9): 092503, 2012 Aug 31.
Article de Anglais | MEDLINE | ID: mdl-23002828

RÉSUMÉ

The 02(+) state in 34Si has been populated at the GANIL-LISE3 facility through the ß decay of a newly discovered 1(+) isomer in 34Al of 26(1) ms half-life. The simultaneous detection of e(+)e(-) pairs allowed the determination of the excitation energy E(02(+))=2719(3) keV and the half-life T(1/2)=19.4(7) ns, from which an electric monopole strength of ρ(2)(E0)=13.0(0.9)×10(-3) was deduced. The 2(1)(+) state is observed to decay both to the 0(1)(+) ground state and to the newly observed 0(2)(+) state [via a 607(2) keV transition] with a ratio R(2(1)(+)→0(1)(+)/2(1)(+)→0(2)(+))=1380(717). Gathering all information, a weak mixing with the 0(1)(+) and a large deformation parameter of ß=0.29(4) are found for the 0(2)(+) state, in good agreement with shell model calculations using a new SDPF-U-MIX interaction allowing np-nh excitations across the N=20 shell gap.

3.
Fiziol Zh (1994) ; 57(6): 31-7, 2011.
Article de Ukrainien | MEDLINE | ID: mdl-22420156

RÉSUMÉ

Ischemic stroke is one of the most severe brain pathologies that is extremely difficult to treat. Recently it has been found that acidosis accompanying cerebral ischemia induces activation of acid-sensing ion channel ASIC1a which results in its turn in the neuronal death. Here we present novel derivatives of 3-carboxamidinocoumarines that effectively inhibit ASIC1a and ASIC3 channels in concentration-dependent manner. The most active compound inhibits ASIC1a and ASIC3 channels with corresponding IC50 of 7.3 and 13.2 microM. Our data suggest that 3-carboxamidinocoumarines can be used as a scaffold for novel type of highly efficient anti-ischemic drugs.


Sujet(s)
Benzoates/synthèse chimique , Benzopyranes/synthèse chimique , Conception de médicament , Guanidines/synthèse chimique , Protéines de tissu nerveux/antagonistes et inhibiteurs , Canaux ioniques sensibles à l'acidité , Potentiels d'action/effets des médicaments et des substances chimiques , Animaux , Benzoates/composition chimique , Benzoates/pharmacologie , Benzopyranes/composition chimique , Benzopyranes/pharmacologie , Relation dose-effet des médicaments , Ganglions sensitifs des nerfs spinaux/cytologie , Guanidines/composition chimique , Guanidines/pharmacologie , Cellules HEK293 , Humains , Structure moléculaire , Neurones/effets des médicaments et des substances chimiques , Neurones/métabolisme , Rats , Canaux sodiques
4.
Phys Rev Lett ; 105(10): 102501, 2010 Sep 03.
Article de Anglais | MEDLINE | ID: mdl-20867514

RÉSUMÉ

The structure of 44S has been studied by using delayed γ and electron spectroscopy. The decay rates of the 02+ isomeric state to the 2(1)+ and 0(1)+ states, measured for the first time, lead to a reduced transition probability B(E2: 2(1)+→0(2)+)=8.4(26) e(2) fm4 and a monopole strength ρ2(E0: 0(2)+→0(1)+)=8.7(7)×10(-3). Comparisons to shell model calculations point towards prolate-spherical shape coexistence, and a two-level mixing model is used to extract a weak mixing between the two configurations.

5.
Phys Rev Lett ; 102(16): 162503, 2009 Apr 24.
Article de Anglais | MEDLINE | ID: mdl-19518704

RÉSUMÉ

Six proton-emitting states in 19Ne were studied through the inelastic scattering reaction H(19Ne,p);{19}Ne; (p)18F. Their energies and widths were derived from the protons detected at zero degree, while proton-proton angular correlations between the detector at zero degree and a segmented annular detector were used to determine their spin value. In addition to the known states, a new broad J=1/2 resonance has been evidenced at E_{x} approximately 7.9 MeV, approximately 1.45 MeV above the proton emission threshold. By introducing this resonance, the 18F(p,alpha)15O destruction rate in novae is significantly enhanced. This reduces the chance to observe the cosmic gamma-ray emission of 18F from novae in space telescopes.

6.
Phys Rev Lett ; 99(2): 022503, 2007 Jul 13.
Article de Anglais | MEDLINE | ID: mdl-17678217

RÉSUMÉ

The energies of the excited states in very neutron-rich (42)Si and (41,43)P have been measured using in-beam gamma-ray spectroscopy from the fragmentation of secondary beams of (42,44)S at 39A MeV. The low 2(+) energy of (42)Si, 770(19) keV, together with the level schemes of (41,43)P, provides evidence for the disappearance of the Z=14 and N=28 spherical shell closures, which is ascribed mainly to the action of proton-neutron tensor forces. New shell model calculations indicate that (42)Si is best described as a well-deformed oblate rotor.

7.
Phys Rev Lett ; 90(8): 082502, 2003 Feb 28.
Article de Anglais | MEDLINE | ID: mdl-12633421

RÉSUMÉ

A new isomeric 0(+) state was identified as the first excited state in the self-conjugate (N=Z) nucleus 72Kr. By combining for the first time conversion-electron and gamma-ray spectroscopy with the production of metastable states in high-energy fragmentation, the electric-monopole decay of the new isomer to the ground state was established. The new 0(+) state is understood as the band head of the known prolate rotational structure, which strongly supports the interpretation that 72Kr is one of the rare nuclei having an oblate-deformed ground state. This observation gives in fact the first evidence for a shape isomer in a N=Z nucleus.

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