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1.
J Electromyogr Kinesiol ; 55: 102479, 2020 Dec.
Article de Anglais | MEDLINE | ID: mdl-33075711

RÉSUMÉ

Abnormal muscle stiffness is a potential complication after injury and identifying interventions that modify muscle stiffness may be useful to promote recovery. The purpose of this study was to identify the short-term effects of dry needling (DN) on resting and contracted gastrocnemius muscle stiffness and strength of the triceps surae in individuals with latent myofascial trigger points (MTrPs). In this randomized controlled trial, 52 individuals received two DN treatment sessions to latent MTrPs and 50 individuals received two sham needling sessions. Resting and contracted muscle stiffness were assessed both at the treatment site and a standardized central site in the medial gastrocnemius head immediately post-treatment and one week after the last session. There were significant group by time interactions for resting muscle stiffness at the site of the MTrP (p = .03), but not at the central site (p = .29). Post-needling between group comparison indicated that the DN group had significantly lower resting muscle stiffness at the site of the MTrP than the sham group after adjusting for baseline differences. There were no significant between group differences in contracted muscle stiffness or muscle strength. Identifying strategies that can reduce aberrant muscle stiffness may help to guide management of individuals with neuromuscular pain-related conditions. Level of evidence: Therapy, level 2.


Sujet(s)
Puncture sèche/méthodes , Contraction musculaire/physiologie , Force musculaire/physiologie , Muscles squelettiques/physiologie , Points de déclenchement/physiologie , Adulte , Puncture sèche/tendances , Femelle , Humains , Mâle , Mesure de la douleur/méthodes , Mesure de la douleur/tendances , Études prospectives , Jeune adulte
2.
Eur Neuropsychopharmacol ; 24(6): 986-95, 2014 Jun.
Article de Anglais | MEDLINE | ID: mdl-24440552

RÉSUMÉ

Psychiatric diseases may often represent the consequence of exposure to adverse events early in life. Accordingly, exposure to stress during gestation in rats has a strong impact on development and can cause long-term abnormalities in adult behavior. Considering that neuronal plasticity has emerged as a major vulnerability element in psychiatric disorders, we investigated the postnatal developmental profile of Brain-Derived Neurotrophic Factor expression (BDNF), an important mediator for long-term functional deterioration associated to mental illness, in male and female rats following exposure to prenatal stress (PNS). Since we found that the majority of alterations became fully manifest at early adulthood, we tried to prevent these abnormalities with an early pharmacological intervention. To address this point, we treated rats during adolescence with the multi-receptor antipsychotic lurasidone, which was proven to be effective in animal models of schizophrenia. Interestingly, we show that lurasidone treatment was able to prevent the reduction of BDNF expression in adult rats that were exposed to PNS. Collectively, our results provide further support to the notion that exposure to early life stress has a negative impact on neuronal plasticity and that pharmacological intervention during critical time windows may prove effective in preventing neuroplastic dysfunction, leading to long-term beneficial effects on brain function.


Sujet(s)
Facteur neurotrophique dérivé du cerveau/métabolisme , Isoindoles/pharmacologie , Neuroprotecteurs/pharmacologie , Cortex préfrontal/effets des médicaments et des substances chimiques , Effets différés de l'exposition prénatale à des facteurs de risque/prévention et contrôle , Stress psychologique/complications , Thiazoles/pharmacologie , Animaux , Neuroleptiques/pharmacologie , Technique de Western , Femelle , Chlorhydrate de lurasidone , Mâle , Cortex préfrontal/physiopathologie , Grossesse , Effets différés de l'exposition prénatale à des facteurs de risque/physiopathologie , ARN messager/métabolisme , Répartition aléatoire , Rat Sprague-Dawley , Réaction de polymérisation en chaine en temps réel , Caractères sexuels , Stress psychologique/physiopathologie
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