RÉSUMÉ
This study uses a spatial-temporal model to analyze the spatial spread of the AIDS epidemic (adult cases) in the municipality of Rio de Janeiro, Brazil, during three periods: 1988-1990, 1991-1993, and 1994-1996. City districts were used as the geographic units of analysis. A spatial analysis was also performed for pediatric AIDS cases due to vertical HIV transmission, according to period of birth, 1985-90 and 1991-96. For total adult AIDS cases, the initial period was characterized by a polygonal cluster located around the harbor area, which expanded from west to east. Among homosexual cases, in situ growth predominated, and a decrease in the intensity of the diffusion process was observed from the second to the final period. Among heterosexual cases, the epidemic displayed a relevant geographic spread, mainly from 1988-1990 to 1991-1993. Among female cases in the final time period, a cluster of high incidence rates was found towards the northwest, including very poor areas. Among pediatric cases in 1991-1996, a significant correlation was found between AIDS incidence rates and poverty levels in the respective municipal districts. The results suggest that a more complete understanding of AIDS spatial-temporal dynamics can make a major contribution to preventive measures.
Sujet(s)
Syndrome d'immunodéficience acquise/épidémiologie , Modèles statistiques , Agrégat spatio-temporel , Syndrome d'immunodéficience acquise/transmission , Adulte , Brésil/épidémiologie , Épidémies de maladies , Femelle , Humains , Incidence , Nouveau-né , Transmission verticale de maladie infectieuse , Mâle , GrossesseRÉSUMÉ
The HIV/AIDS epidemic is a dynamic unstable global phenomenon, constituting a veritable mosaic of regional sub-epidemics. As a consequence of the deep inequalities that exist in Brazilian society, the spread of HIV infection has revealed an epidemic of multiple dimensions undergoing extensive epidemiological transformations. Initially restricted to large urban centers and markedly masculine, the HIV/AIDS epidemic is currently characterized by heterosexualization, feminization, interiorization and pauperization. The evolution of the profile of AIDS in Brazil is above all due to the geographical diffusion of the disease from large urban centers towards medium and small municipalities in the interior, to the increase in heterosexual transmission and the persistent growth of cases among injecting drug users. The increase in transmission through heterosexual contact has resulted in substantial growth of cases among women, which has been pointed out as the most important characteristic of the epidemic's current dynamic in Brazil.
Sujet(s)
Syndrome d'immunodéficience acquise/épidémiologie , Infections à VIH/épidémiologie , Syndrome d'immunodéficience acquise/complications , Adolescent , Adulte , Sujet âgé , Brésil/épidémiologie , Enfant , Femelle , Infections à VIH/complications , Humains , Mâle , Adulte d'âge moyen , Facteurs socioéconomiquesRÉSUMÉ
A cross-sectional study was designed to assess safe sexual behaviour among heterosexual couples after the woman learned of her partner's infection with HIV. Female partners who had known their partners' serostatus for at least 4 weeks were eligible for participation. Couples were interviewed separately and independent predictors of safe sexual behaviour were identified using multiple logistic regression. Safe sexual behaviour was defined as no unprotected vaginal, oral, or anal intercourse. Of 328 women, 197 (60%) reported safe sexual behaviour since learning of their partners' infection. Significant independent predictors of safe sexual behaviour included older women (>30 years old) (odds ratio [OR]=1.89; 95% confidence intervals [CI]=1.01-3.51), current negative HIV serostatus (OR=2.72; 95% CI=1.50-4.94), advanced clinical stage of the index case (OR=1.96; 95% CI=1.07-3.59), longer duration of relationship (10+ years) (OR= 2.35; 95% CI=1.15-4.82), fewer sex contacts (<100) (OR=2.01; 95% CI=1.14-3.56), only one lifetime partner (OR=2.29; 95% CI=1.26-4.17), non-smoking (OR=2.67; 95% CI=1.43-4.99), not practising oral sex (OR=3.35; 95% CI=1.82-6.19) and previous HIV testing (OR=2.11; 95% CI=1.09-4.07). In addition, women who had known their partner's infection for longer were less likely to report safe sexual behaviour (P < 0.001). Our results indicate that among female partners of HIV-positive Brazilian men, learning of their partner's infection does not uniformly result in safe sexual behaviour. Counselling must emphasize disclosure of serostatus to female partners and target couples with short-term relationships, as well as those where the woman has known about her male partner's infection for a long time, because these are the least likely to maintain safe sexual behaviour.
Sujet(s)
Infections à VIH/prévention et contrôle , Rapports sexuels protégés/psychologie , Partenaire sexuel/psychologie , Adulte , Brésil , Études transversales , Femelle , Connaissances, attitudes et pratiques en santé , Humains , MâleRÉSUMÉ
The HIV/AIDS epidemic is a dynamic unstable global phenomenon, constituting a veritable mosaic of regional sub-epidemics. As a consequence of the deep inequalities that exist in Brazilian society, the spread of HIV infection has revealed an epidemic of multiple dimensions undergoing extensive epidemiological transformations. Initially restricted to large urban centers and markedly masculine, the HIV/AIDS epidemic is currently characterized by heterosexualization, feminization, interiorization and pauperization. The evolution of the profile of AIDS in Brazil is above all due to the geographical diffusion of the disease from large urban centers towards medium and small municipalities in the interior, to the increase in heterosexual transmission and the persistent growth of cases among injecting drug users. The increase in transmission through heterosexual contact has resulted in substantial growth of cases among women, which has been pointed out as the most important characteristic of the epidemic's current dynamic in Brazil.
A epidemia da infecção pelo HIV e da AIDS constitui fenômeno global, dinâmico e instável, traduzindo-se por verdadeiro mosaico de sub-epidemias regionais. Resultante das profundas desigualdades da sociedade brasileira, a propagação da infecção pelo HIV e da AIDS revela epidemia de múltiplas dimensões que vem sofrendo transformações epidemiológicas significativas. Inicialmente restrita aos grandes centros urbanos e marcadamente masculina, a atual epidemia do HIV e da AIDS caracteriza-se pelos processos de heterossexualização, feminização, interiorização e pauperização. As mudanças no perfil da AIDS no Brasil devem-se à difusão geográfica da doença a partir dos grandes centros urbanos em direção aos municípios de médio e pequeno porte, ao aumento da transmissão por via heterossexual e ao persistente crescimento dos casos entre usuários de drogas injetáveis. O aumento da transmissão por contato heterossexual implica no crescimento substancial de casos em mulheres, o qual tem sido apontado como uma das mais importantes características do atual quadro da epidemia no Brasil.
Sujet(s)
Adolescent , Adulte , Sujet âgé , Enfant , Femelle , Humains , Mâle , Adulte d'âge moyen , Infections à VIH/épidémiologie , Syndrome d'immunodéficience acquise/épidémiologie , Brésil/épidémiologie , Infections à VIH/complications , Facteurs socioéconomiques , Syndrome d'immunodéficience acquise/complicationsRÉSUMÉ
A study of HIV-related risk behavior was carried out in 1998 among Brazilian military conscripts aged 17-20 years. A sample of 30,318 subjects was selected in three strata, pertaining to counties from: 1) the North and Central-West (N/CW); 2) South (S); and the states of Rio de Janeiro and São Paulo. HIV prevalence rates were estimated in all strata. The objective of this paper was to analyze the results according to differences in socioeconomic status (SES). The statistical analysis used an index of sexual risk behavior and logistic regression models. The N/CW stratum showed the worst indicators for SES, sexual risk behavior, and sexually transmitted infections (STIs), as well as the highest HIV seroprevalence rate. The best indicators for all variables were found in the RJ/SP stratum. The South showed intermediate results. Level of schooling also played a relevant role. In all three strata the conscripts with an incomplete high school education displayed the worst sexual risk behavior index, shown to be a relevant predictor of STI-related problems, including HIV infection.
Sujet(s)
Infections à VIH , Personnel militaire , Prise de risque , Adolescent , Adulte , Niveau d'instruction , Infections à VIH/prévention et contrôle , Humains , Revenu , Mâle , Comportement sexuel , Facteurs socioéconomiques , Enquêtes et questionnairesRÉSUMÉ
This study proposes a procedure to estimate the number of orphans due to maternal AIDS. The procedure estimates the number of orphans by calendar year, multiplying the cumulative fertility rate by the number of AIDS deaths among women aged 15-49 years. Because the procedure refers to the number of children that are alive, the estimate is adjusted by contemplating the proportion of pediatric AIDS cases due to vertical transmission and the probability of survival in the 5-9-year age group. To estimate the number of AIDS orphans in Brazil from 1987 to 1999, the procedure was applied by stratifying according to geographical region, taking into account the differences in regional fertility rates, completeness of death reporting, and misclassification of AIDS-related deaths as due to other causes. The total number of cumulative AIDS orphans for 1987-99 was estimated at approximately 30,000.
Sujet(s)
Syndrome d'immunodéficience acquise/mortalité , Enfant de personnes handicapées/statistiques et données numériques , Mères/statistiques et données numériques , Syndrome d'immunodéficience acquise/transmission , Adolescent , Adulte , Brésil/épidémiologie , Enfant abandonné , Femelle , Humains , Transmission verticale de maladie infectieuse/statistiques et données numériques , Adulte d'âge moyen , Grossesse , Taux de grossesseRÉSUMÉ
This study estimates the number of HIV-infected individuals from 15 to 49 years of age in Brazil in 1998 based on sentinel population studies in pregnant women, with a selection bias in the sample. A principal components procedure was used to group 44 counties in homogeneous 13 clusters. Two indicators were constructed for each cluster: a) the logarithm of the accumulated AIDS incidence rate among women from 15 to 34 years of age (1996) and b) the logarithm of the growth ratio for the mean AIDS incidence rate for women from 15 to 34 years of age for the period from 1990-1992 to 1993-1996. Taking the log of the proportion of HIV-infected pregnant women as the dependent variable and the two above-mentioned indicators as the independent variables, a regression line was fitted to the aggregate data. Estimation of the model's parameters allowed us to calculate the proportion of infected individuals by macro-region, by age (15-34 and 35-49 years) and gender. The point estimate was 536 thousand HIV-infected adults with a 68% CI (470.689 - 603.305).
Sujet(s)
Infections à VIH/épidémiologie , Syndrome d'immunodéficience acquise/épidémiologie , Adolescent , Adulte , Brésil/épidémiologie , Femelle , Humains , Modèles linéaires , Mâle , Adulte d'âge moyen , Grossesse , PrévalenceRÉSUMÉ
In Brazil, implementation of the so-called "Provão", or National Medical Course Examination, has raised numerous levels of discussion. This article aims to identify patterns in some of the more controversial issues: whether the Exam is really an instrument for evaluation of medical courses themselves, or that of future physicians; adequacy of assumptions underlying the questions as formulated; and lack of precision in the questions.
Sujet(s)
Enseignement médical , Évaluation des acquis scolaires , Brésil , Études d'évaluation comme sujet , Humains , Écoles de médecineRÉSUMÉ
The present study addresses sociodemographic characteristics, knowledge and attitudes regarding HIV/AIDS, as well as risk behaviour and perception of vulnerability to HIV infection, in the first 295 homosexual and bisexual volunteers (excluding male commercial sex workers and transvestites) taking part in a cohort study in Rio de Janeiro. The sample has a higher socio-economic level than the remainder of the cohort, and than comparable strata of the general population, and a sound knowledge about how to protect themselves against HIV infection. In addition, an association between perception of vulnerability to infection and the practice of unprotected anal sex was observed. An association was also observed between higher levels of formal education and perception of vulnerability; however no association was found with markers for past and recent exposure to sexually transmitted infections (hepatitis B, HbsAG and syphilis). The results of the present study suggest that knowledge and awareness of risk do not easily translate into behaviour change, since significant proportions of the cohort continue to practise unprotected sex with both principal and casual partners, despite their awareness of HIV infection risks as well as preventive measures.
Sujet(s)
Bisexualité/psychologie , Infections à VIH/psychologie , Homosexualité masculine/psychologie , Adolescent , Adulte , Brésil/épidémiologie , Études de cohortes , Femelle , Infections à VIH/épidémiologie , Humains , Mâle , Adulte d'âge moyen , Prise de risque , Maladies sexuellement transmissibles/épidémiologie , Maladies sexuellement transmissibles/étiologieRÉSUMÉ
Mortality caused by firearms has been increasing at an alarming rate in the state of Rio de Janeiro, Brazil. This study analyzes the gradual evolution of firearm mortality rates in this Brazilian state from 1979 to 1992, according to sex, age, and area of residence (capital city, metropolitan area, or the state's interior), and uses spatial statistical techniques to describe the propagation of this firearm mortality epidemic in time and space. During the period analyzed, mortality due to firearms showed the greatest increase among 15- to 19-year-old male adolescents, with yearly rates ranging from 13 to 16%, according to area of residence. For children 10 to 14 years of age, mortality caused by firearms increased by 10% annually in the same period. The highest annual increase occurred in the state's interior. At the beginning of the period studied, dissemination of firearm mortality was observed to follow a definite direction parallel to the federal road that runs along the east coast of the state. Between 1990 and 1992, however, the increase in deaths by firearms spread out in practically every direction. Empirical confirmation of a general expansion of firearm wound mortality contradicts the usual claim that violence is concentrated in areas of extreme poverty within Brazil's largest cities. Programs for prevention and control of this epidemic should focus on its various aspects and take into consideration both collective issues (such as proliferation of firearms among persons involved with international firearm smuggling, increases in criminal activity, expansion of drug trafficking, and exclusion from social opportunities) and personal issues (relationships and interaction of young people with their families, schools, and social environment).
Sujet(s)
Plaies par arme à feu/épidémiologie , Adolescent , Adulte , Facteurs âges , Brésil/épidémiologie , Enfant , Femelle , Humains , Mâle , Plaies par arme à feu/mortalitéRÉSUMÉ
HIV-1-positive individuals were recruited from January 1993 to December 1996 from several cohorts receiving follow-up in the city of Rio de Janeiro, Brazil, to evaluate HIV-1 genetic variability and the potential association with modes of transmission. HIV-1 subtyping was carried out using the heteroduplex mobility assay (HMA), and those samples corresponding to the typical Brazilian subtype B variant were further identified based on the Fok I restriction fragment length polymorphism (RFLP). DNA sequencing was performed to evaluate one case of subtype D infection. From the 131 HIV-1-positive individuals analyzed, 106 (80.9%) could be identified as infected by subtype B and 20 (15.3%) by subtype F. One of the samples (0.8%) was classified as subtype D. DNA samples from 4 patients (3.0%) did not yield polymerase chain reaction (PCR)-amplified products to be typed. Based on the Fok I RFLP, 39 of the 106 subtype B samples (37%) were identified as corresponding to the typical Brazilian subtype B variant containing the GWGR motif at the tip of the V3 loop. No statistically significant association could be detected between HIV-I subtypes and modes of transmission, exposure categories, or gender. This is the first reported case of HIV-1 subtype D infection in Brazil.
Sujet(s)
Infections à VIH/épidémiologie , VIH-1 (Virus de l'Immunodéficience Humaine de type 1)/classification , Séquence d'acides aminés , Brésil/épidémiologie , Études de cohortes , Séquence consensus , ADN viral/composition chimique , Femelle , Produits du gène env/composition chimique , Produits du gène env/génétique , Variation génétique , Infections à VIH/transmission , Infections à VIH/virologie , VIH-1 (Virus de l'Immunodéficience Humaine de type 1)/génétique , Humains , Mâle , Épidémiologie moléculaire , Données de séquences moléculaires , Hétéroduplexes d'acides nucléiques , Phylogenèse , Réaction de polymérisation en chaîne , Polymorphisme de restriction , Prévalence , Alignement de séquences , Répartition par sexe , Population urbaineRÉSUMÉ
BACKGROUND: Several risk factors for male-to-female human immunodeficiency virus (HIV) transmission are well established, but few studies have examined the role of postcoital vaginal bleeding. METHODS: Couples recruited from AIDS centers in Rio de Janeiro, Brazil, were interviewed for risk factors and had blood collected for examinations. Eligibility criteria included confirmed HIV positivity for the male partner, aged 18 years of older, heterosexual contact in the past year, and no other risk factor for female partners except sexual contact with the HIV-infected male partner. Logistic regression was used to assess the association between HIV serostatus and risk factors in the female partners. RESULTS: The prevalence of HIV infection was 47.6% among the 418 women available for analysis. The following factors were independently associated with HIV infection; anal sex (odds ratio [OR], 3.06), condom use during vaginal sex sometimes (OR, 1.42) and rarely to never (OR, 2.00) compared with always, frequency of sexual contacts (> 100 in the previous year) (OR, 1.71), HIV-infected male partners with symptoms of acquired immunodeficiency syndrome (OR, 1.70), and postcoital vaginal bleeding (OR, 1.89). The association of postcoital bleeding and HIV infection was more pronounced among women who did not engage in anal sex. CONCLUSIONS: The results support previous studies showing that advanced HIV infection in the male partner, anal sex, inconsistent condom use, and frequent sex are associated with HIV infection among the female partners of HIV-infected men. Postcoital vaginal bleeding was also identified as a risk factor for infection. In addition to other established preventive measures, a recommendation for seeking diagnosis and treatment of sexually transmitted diseases that are associated with postcoital bleeding and using water-soluble lubricants during sex to minimize trauma seems prudent.
Sujet(s)
Coït , Infections à VIH/transmission , Hémorragie/complications , Comportement sexuel , Maladies du vagin/complications , Adulte , Brésil , Femelle , Humains , Mâle , Odds ratio , Prévalence , Facteurs de risque , SexualitéRÉSUMÉ
A procedure for the estimation of the infant mortality rate in Brazil, in the 1980's, based only on the age distribution of registered deaths, is here proposed. Using this technique, it is possible to estimate the probabilities of dying in the first year of life in a continuous way, year by year, for different regions of the country. The space-time distribution of the main causes of infant deaths is analysed and the relevance of using this coefficient to express the social and economic conditions of the Brazilian population from 1979 to 1989 is discussed.
Sujet(s)
Cause de décès , Mortalité infantile , Adolescent , Adulte , Facteurs âges , Sujet âgé , Brésil , Enfant , Enfant d'âge préscolaire , Certificats de décès , Femelle , Humains , Nourrisson , Nouveau-né , Mâle , Adulte d'âge moyen , Modèles statistiques , Analyse multifactorielle , Probabilité , Facteurs sexuels , Agrégat spatio-temporelRÉSUMÉ
A heterosexual partner study was carried out in Rio de Janeiro, Brazil, from August 1990 to December 1991. The main objectives were to determine the rate of male-to-female transmission of human immunodeficiency virus (HIV) and to determine risk factors. Male index cases were recruited according to the following criteria: 1) confirmed HIV positivity, 2) 18 years old or older; 3) heterosexual contact within the past year. Only female partners who reported not to have other risk factors but to have had sexual contact with the index case were invited to participate. Couples were interviewed for risk factors and had blood collected for laboratory studies. The overall prevalence of HIV infection was 45 percent among 204 female partners in the study. Using logistic regression, the authors found the following factors to be independently (p < 0.05) associated with HIV infection: 1) anal sex (odds ratio (OR) = 3.74, 95% confidence interval (CI) 1.87-7.45); 2) condom use during vaginal sex sometimes (OR = 1.45, 95% CI 1.07-1.96), rarely (OR = 2.10, 95% CI 1.15-3.83), or never (OR = 3.04, 95% CI 1.23-7.50) as compared with always; 3) frequency of sexual contacts in the year prior to interview (100+) (OR = 2.00, 95% CI 1.03-3.91); and 4) oral contraceptive use (OR = 2.04, 95% CI 0.97-4.29). In addition to a borderline significance of oral contraceptive use, there was a strong suggestion of an interaction with history of sexually transmitted diseases.
Sujet(s)
Infections à VIH/transmission , Séropositivité VIH/transmission , VIH-1 (Virus de l'Immunodéficience Humaine de type 1)/immunologie , Comportement sexuel , Partenaire sexuel , Adulte , Brésil/épidémiologie , Femelle , Infections à VIH/épidémiologie , Séropositivité VIH/épidémiologie , Humains , Mâle , Analyse multifactorielle , Prévalence , Facteurs de risque , Comportement sexuel/statistiques et données numériques , Enquêtes et questionnaires , Population urbaine/statistiques et données numériquesRÉSUMÉ
Viral DNA sequences were determined over the V3 region of env from 28 infected individuals living in the high HIV-1 prevalence Brazilian cities of Rio de Janeiro and São Paulo. Twenty-six belonged to envelope sequence subtype B, prevalent in North America and Europe, and one was classified as subtype F, found recently in Brazil and in Romania (one appeared to be a B/F recombinant). Octameric sequences at the tip of the subtype B V3 loops were variable and distinct from those prevalent in North America and Europe. The GPGR motif, prevalent in North American/European strains, was found in only 8 (28.5%) sequences, whereas GWGR was found in 12 (43%) and novel sequences in 8 (28.5%). Brazilian subtype B sequences also diverged from the consensus North American/European strains over the remainder of the V3 loop. These results suggest that Brazilian HIV-1 B strains may have important antigenic differences from prototype subtype B strains currently being evaluated for use in HIV vaccines. These results should be taken into account for future vaccine programs in Brazil.
Sujet(s)
Protéine d'enveloppe gp120 du VIH/génétique , Infections à VIH/microbiologie , VIH-1 (Virus de l'Immunodéficience Humaine de type 1)/génétique , VIH-1 (Virus de l'Immunodéficience Humaine de type 1)/isolement et purification , Fragments peptidiques/génétique , Polymorphisme génétique , Vaccins contre le SIDA/isolement et purification , Séquence d'acides aminés , Séquence nucléotidique , Brésil , Amorces ADN/génétique , ADN viral/génétique , Femelle , Gènes env , VIH-1 (Virus de l'Immunodéficience Humaine de type 1)/classification , Humains , Mâle , Données de séquences moléculaires , Phylogenèse , Réaction de polymérisation en chaîne , ARN/génétique , Similitude de séquences d'acides aminésRÉSUMÉ
We studied 567 patients with active pulmonary tuberculosis (APT) in Rio de Janeiro, Brazil, by using a standardized questionnaire and by testing blood for HIV antibodies. The rate of HIV infection was 3.9% in 1987, 4.8% in 1988, and 5.2% in 1989, and did not differ by sex. It was highest (7.4%) in the 15- to 39-year age group. There was no difference between patients infected and not infected by HIV with regard to education, income, housing, or employment. Among all patients with definite HIV risk behavior, the HIV infection rate was 23.3%, rising to 31.2% among homo/bisexual men and 36.4% among intravenous drug users, and the rate was 6.5% for blood-transfusion recipients. Among patients who denied risk behavior, the rate was 1.2%. Generalized lymphadenopathy and oral candidiasis occurred with greater frequency among HIV-infected patients (p < 0.0001). Applying the World Health Organization 1985 clinical criteria and revised case definition for AIDS, we found, respectively, sensitivities of 34% and 76.9% and specificities of 31% and 26.3%; in the Rio de Janeiro environment, these clinical criteria without HIV serology should not be adopted for tuberculosis patients. For chest radiographs, a significant association was found between HIV infection and the occurrence of atypical images (p = 0.0001), and hilar and/or mediastinal adenopathy (p = 0.0002) and absence of cavities (p = 0.0003). A PPD (purified protein derivative) skin test induration of < 5 mm was identified in 53% of the HIV-positive cases and in 31.3% of the HIV-negative cases. Only 11.5% of HIV-infected APT patients met the Centers for Disease Control 1987 AIDS criteria.
Sujet(s)
Infections à VIH/épidémiologie , Tuberculose pulmonaire/complications , Adolescent , Adulte , Facteurs âges , Sujet âgé , Transfusion sanguine , Brésil/épidémiologie , Candidose buccale/complications , Femelle , Anticorps anti-VIH/sang , Infections à VIH/complications , Comportement en matière de santé , Homosexualité , Humains , Poumon/imagerie diagnostique , Mâle , Adulte d'âge moyen , Prévalence , Radiographie , Facteurs de risque , Sensibilité et spécificité , Toxicomanie intraveineuse/complications , Enquêtes et questionnaires , Test tuberculinique , Tuberculose pulmonaire/imagerie diagnostiqueRÉSUMÉ
A trend analysis of the AIDS epidemics in Brazil is presented, emphasizing temporal changes among the population groups most affected. Regional comparisons as well as projections of the extension of HIV infection and AIDS cases are also reported. Amongst the most relevant conclusions the alarming increase of cases in heterosexual populations and intravenous drug users is emphasised, specially in the southeast region.