RÉSUMÉ
BACKGROUND: We determined the prognostic impact of lymphovascular invasion (LVI) in a large, national, multicenter, retrospective cohort of patients with early breast cancer (BC) according to numerous factors. PATIENTS AND METHODS: We collected data on 17 322 early BC patients treated in 13 French cancer centers from 1991 to 2013. Survival functions were calculated using the Kaplan-Meier method and multivariate survival analyses were carried out using the Cox proportional hazards regression model adjusted for significant variables associated with LVI or not. Two propensity score-based matching approaches were used to balance differences in known prognostic variables associated with LVI status and to assess the impact of adjuvant chemotherapy (AC) in LVI-positive luminal A-like patients. RESULTS: LVI was present in 24.3% (4205) of patients. LVI was significantly and independently associated with all clinical and pathological characteristics analyzed in the entire population and according to endocrine receptor (ER) status except for the time period in binary logistic regression. According to multivariate analyses including ER status, AC, grade, and tumor subtypes, the presence of LVI was significantly associated with a negative prognostic impact on overall (OS), disease-free (DFS), and metastasis-free survival (MFS) in all patients [hazard ratio (HR) = 1.345, HR = 1.312, and HR = 1.415, respectively; P < 0.0001], which was also observed in the propensity score-based analysis in addition to the association of AC with a significant increase in both OS and DFS in LVI-positive luminal A-like patients. LVI did not have a significant impact in either patients with ER-positive grade 3 tumors or those with AC-treated luminal A-like tumors. CONCLUSION: The presence of LVI has an independent negative prognostic impact on OS, DFS, and MFS in early BC patients, except in ER-positive grade 3 tumors and in those with luminal A-like tumors treated with AC. Therefore, LVI may indicate the existence of a subset of luminal A-like patients who may still benefit from adjuvant therapy.
Sujet(s)
Tumeurs du sein , Tumeurs du sein/traitement médicamenteux , Traitement médicamenteux adjuvant , Survie sans rechute , Femelle , Humains , Pronostic , Études rétrospectivesRÉSUMÉ
BACKGROUND: Prognostic impact of lymph node micro-metastases (pN1mi) has been discordantly reported in the literature. The need to clarify this point for decision-making regarding adjuvant therapy, particularly for patients with endocrine receptor (ER)-positive status and HER2-negative tumors, is further reinforced by the generalization of gene expression signatures using pN status in their recommendation algorithm. PATIENTS AND METHODS: We retrospectively analyzed 13 773 patients treated for ER-positive breast cancer in 13 French cancer centers from 1999 to 2014. Five categories of axillary lymph node (LN) status were defined: negative LN (pN0i-), isolated tumor cells [pN0(i+)], pN1mi, and pN1 divided into single (pN1 = 1) and multiple (pN1 > 1) macro-metastases (>2 mm). The effect of LN micro-metastases on outcomes was investigated both in the entire cohort of patients and in clinically relevant subgroups according to tumor subtypes. Propensity-score-based matching was used to balance differences in known prognostic variables associated with pN status. RESULTS: As determined by sentinel LN biopsy, 9427 patients were pN0 (68.4%), 546 pN0(i+) (4.0%), 1446 pN1mi (10.5%) and 2354 pN1 with macro-metastases (17.1%). With a median follow-up of 61.25 months, pN1 status, but not pN1mi, significantly impacted overall survival (OS), disease-free survival (DFS), metastasis-free survival (MFS), and breast-cancer-specific survival. In the subgroup of patients with known tumor subtype, pN1 = 1, as pN1 > 1, but not pN1mi, had a significant prognostic impact on OS. DFS and MFS were only impacted by pN1 > 1. Similar results were observed in the subgroup of patients with luminal A-like tumors (n = 7101). In the matched population analysis, pN1macro, but not pN1mi, had a statistically significant negative impact on MFS and OS. CONCLUSION: LN micro-metastases have no detectable prognostic impact and should not be considered as a determining factor in indicating adjuvant chemotherapy. The evaluation of the risk of recurrence using second-generation signatures should be calculated considering micro-metastases as pN0.
Sujet(s)
Tumeurs du sein , Tumeurs du sein/génétique , Femelle , Humains , Récidive tumorale locale , Pronostic , Études rétrospectives , Biopsie de noeud lymphatique sentinelleRÉSUMÉ
Breast cancer is the most commonly diagnosed type of cancer among women. For the last fifteen years, treatments that are less invasive than lumpectomy, such as high-intensity focused ultrasound (HIFU) therapy, have been developed, with encouraging results. In this study, a toroidal HIFU transducer was used to create lesions of at least 2 cm in diameter within less than one minute of treatment. The toroidal HIFU transducer created two focal zones that led to large, fast and homogeneous ablations (10.5 cc/min). The experiments were conducted in 30 human samples of normal breast tissues recovered from mastectomies to measure acoustic attenuation (N = 30), and then, HIFU lesions were created (N = 15). Eight HIFU ablations were performed to evaluate the reproducibility of the lesions. HIFU lesions were created in 45 s with a toroidal HIFU transducer working at 2.5 MHz. The longest and shortest axes of the HIFU lesions were 21.7 ± 3.1 mm and 23.5 ± 3.3 mm respectively, corresponding to an average volume of 7.3 ± 1.4 cm3. These HIFU lesions were performed at an average depth of 19.0 ± 1.5 mm, while the integrity of the skin was preserved. The HIFU-treated breast tissues had a higher level of attenuation (0.57 ± 0.11 Np.cm-1.MHz-1) when compared to the untreated tissues (0.21 ± 0.04 Np.cm-1.MHz-1). This study shows the feasibility of a fast and fully noninvasive treatment using a toroidal transducer for breast tumors measuring up to 15 mm in diameter.
Sujet(s)
Adénocarcinome/chirurgie , Tumeurs du sein/chirurgie , Ablation par ultrasons focalisés de haute intensité/méthodes , Transducteurs , Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Femelle , Humains , Techniques in vitro , Adulte d'âge moyenRÉSUMÉ
OBJECTIVE: The French national rare gynecological tumor network has been established to improve the quality of care through offering expertise in double reading histological diagnosis, reviewing cases and guiding management of these tumors through specialized multidisciplinary tumor boards and online clinical guidelines (www.ovaire-rare.com). The aim of this study is to evaluate the impact of the development and implementation of this network by assessing the conformity of medical practice with the guidelines concerning the granulosa cell tumors (GCTs). METHODS: This is a French nationwide study, including 463 patients (out of the 639 identified patients) with a definitive diagnosis of GCT between 2011 and 2016. Surgical practices were analyzed for conformity with the current guidelines (www.ovaire-rare.org). Medical records, surgical and pathological reports were systematically analyzed. Total conformity was defined by a conservative (unilateral salpingo-oophorectomy) or radical surgery (hysterectomy and bilateral salpingo-oophorectomy) including surgical staging (omentectomy, peritoneal biopsies and peritoneal cytology) according to the FIGO stage. Partial conformity referred to a conservative or radical surgery without surgical staging and non-conformity was defined as a non-optimal surgery as recommended by the guidelines. RESULTS: Median age at diagnosis was 49 years old (range 10-89). The median size of tumor was 94 mm (range 5-400). Radical surgery was performed in 240 patients (52%); while a fertility-sparing surgery was performed in 98 cases (21%). A surgical staging was performed in 76 cases (16%) and an evaluation of the endometrium in 289 cases (62%). Surgery was fully compliant with the guidelines in 65 patients (14%), partially compliant in 213 patients (46%), non-compliant in 137 patients (30%) and not assessable in 48 cases (10%). A statistically significant difference for compliance was observed in restaging surgery (p < 0,001), radical surgery (p = 0,017) and the period (before or after) of the implementation of the network (p < 0,001). Survival analyses did not allow us to demonstrate a significant difference in overall survival nor in PFS although there was a trend in favor of optimal surgery compared to incomplete/non optimal surgery. CONCLUSION: Surgical management's conformity to the guidelines increases over time from 2011 to 2016. According to this study, the implementation of a national network dedicated to rare gynecologic tumors seems to significantly improve the surgical management of the patients with ovarian granulosa cell tumors.
Sujet(s)
Tumeur de la granulosa/diagnostic , Tumeur de la granulosa/chirurgie , Procédures de chirurgie gynécologique/normes , Tumeurs de l'ovaire/diagnostic , Tumeurs de l'ovaire/chirurgie , Adolescent , Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Enfant , Études de cohortes , Femelle , France/épidémiologie , Tumeur de la granulosa/mortalité , Adhésion aux directives , Procédures de chirurgie gynécologique/méthodes , Procédures de chirurgie gynécologique/statistiques et données numériques , Humains , Adulte d'âge moyen , Stadification tumorale , Tumeurs de l'ovaire/mortalité , Maladies rares/diagnostic , Maladies rares/chirurgie , Études rétrospectives , Jeune adulteRÉSUMÉ
Contraceptive options and menopause management are frequent clinical issues among women previously treated for a borderline ovarian tumour (BOT). OBJECTIVES: To synthesize knowledge on BOT and risk related to hormonal contraception and to menopausal hormone therapy (MHT), and to propose recommendations on contraception and MHT after BOT treatment. METHODS: Systematic review of the literature about hormonal contraception and BOT and on MHT and BOT was conducted on PubMed/Medline and the Cochrane Library. RESULTS: There are no data concerning hormonal contraception after BOT. Current or previous oral contraception is associated with a trend towards decreased risk of serous BOT. Mucinous BOT risk is not or slightly decreased by oral contraception. Hormonal contraception is thus not contraindicated in women previously treated for a BOT (grade C). MHT is associated with a trend towards increased risk of serous BOT. No relation was found between MHT and risk of mucinous BOT. Serous BOTs with high-risk histological criteria (micropapillary pattern, stromal microinvasion or peritoneal implants) are at high-risk of invasive potentially hormone-sensitive recurrence. Hence, caution is needed in the decisions of using MHT after serous BOT with one of these high-risk histological criteria, and MHT should be discussed on a case to case basis. MHT can be prescribed without restriction in women previously treated for mucinous and serous BOT without high-risk histological criteria (grade C). CONCLUSION: Hormonal contraception can be used after BOT. The histological characteristics of the tumour must be taken into account when deciding on the use of HRT/THM.
Sujet(s)
Carcinome épithélial de l'ovaire , Contraception hormonale , Hormonothérapie substitutive , Tumeurs de l'ovaire , Adulte , Sujet âgé , Carcinome épithélial de l'ovaire/anatomopathologie , Carcinome épithélial de l'ovaire/thérapie , Traitement conservateur , Femelle , France , Contraception hormonale/effets indésirables , Hormonothérapie substitutive/effets indésirables , Humains , Ménopause , Adulte d'âge moyen , Récidive tumorale locale , Tumeurs de l'ovaire/anatomopathologie , Tumeurs de l'ovaire/thérapie , Facteurs de risqueRÉSUMÉ
BACKGROUND: Pelvic exenteration remains one of the most mutilating procedures, with important postoperative morbidity, an altered body image, and long-term physical and psychosocial concerns. This study aimed to assess quality of life (QOL) during the first year after pelvic exenteration for gynecologic malignancy performed with curative intent. METHODS: A French multicentric prospective study was performed by including patients who underwent pelvic exenteration. Quality of life by measurement of functional and symptom scales was assessed using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 (version 3.0) and the EORTC QLQ-OV28 questionnaires before surgery, at baseline, and 1, 3, 6, and 12 months after the procedure. RESULTS: The study enrolled 97 patients. Quality of life including physical, personal, fatigue, and anorexia reported in the QLQ-C30 was significantly reduced 1 month postoperatively and improved at least to baseline level 1 year after the procedure. Body image also was significantly reduced 1 month postoperatively. Global health, emotional, dyspnea, and anorexia items were significantly improved 1 year after surgery compared with baseline values. Unlike younger patients, elderly patients did not regain physical and social activities after pelvic exenteration. CONCLUSIONS: Therapeutic decision on performing a pelvic exenteration can have a severe and permanent impact on all aspects of patients' QOL. Deterioration of QOL was most significant during the first 3 months after surgery. Elderly patients were the only group of patients with permanent decreased physical and social function. Preoperative evaluation and postoperative follow-up evaluation should include health-related QOL instruments, counseling by a multidisciplinary team to cover all aspects concerning stoma care, sexual function, and long-term concerns after surgery.
Sujet(s)
Image du corps , Tumeurs de l'appareil génital féminin/chirurgie , Exentération pelvienne/psychologie , Exentération pelvienne/rééducation et réadaptation , Qualité de vie , Adulte , Sujet âgé , Femelle , Études de suivi , Tumeurs de l'appareil génital féminin/anatomopathologie , Tumeurs de l'appareil génital féminin/psychologie , Humains , Adulte d'âge moyen , Période postopératoire , Pronostic , Études prospectives , Enquêtes et questionnairesRÉSUMÉ
BACKGROUND: Breast cancer (BC) patients with comparable prognostic features have heterogeneous outcomes, party related to a possible radiotherapy resistance leading to local-regional recurrences (LRR). The objective of the present study was to identify predictive molecular biomarkers of LRR of BC. PATIENTS AND METHODS: Genetic profile of 146 BC patients' tumours included in the ProfiLER clinical trial (NC01774409) between 2013 and 2016 were analysed using next-generation-sequencing and comparative-genomic-hybridization tests. Patients and tumour characteristics were retrospectively collected and analysed for association with genomic rearrangements (mutations, amplification, deletions). Only gene alterations observed in >3% of the tumours were selected. RESULTS: A total of 193 genomic rearrangements were identified, and 16 were observed in >3% of tumours. One was statistically correlated to the risk of local relapse. A median loco-regional progression-free survival (LRPFS) of 23.6 years was reported for PIK3CA mutation carriers (n = 31, 21.2%) versus 9.9 years for PIK3CA wild-type patients (HR 0.27, 95% CI 0.12-0.65, P = 0.002 in univariate analysis). PIK3CA mutation was identified as an independent protective factor on LRR using multivariate analysis (HR 0.29, 95% CI 0.09-0.99, P = 0.047). All other mutations, amplifications or deletions were not found associated with LRPFS. CONCLUSION: PIK3CA mutation was associated with a lower risk of local relapse in this population of BCs. This is consistent with recent studies suggesting PIK3CA to be part of biological pathways impacting the radiosensitivity.
Sujet(s)
Marqueurs biologiques tumoraux/génétique , Tumeurs du sein/génétique , Carcinome canalaire du sein/génétique , Carcinome lobulaire/génétique , Réarrangement des gènes , Récidive tumorale locale/génétique , Radiotolérance/génétique , Adulte , Tumeurs du sein/anatomopathologie , Tumeurs du sein/radiothérapie , Carcinome canalaire du sein/radiothérapie , Carcinome canalaire du sein/secondaire , Carcinome lobulaire/radiothérapie , Carcinome lobulaire/secondaire , Phosphatidylinositol 3-kinases de classe I/génétique , Association thérapeutique , Femelle , Études de suivi , Génomique , Séquençage nucléotidique à haut débit , Humains , Métastase lymphatique , Adulte d'âge moyen , Mutation , Invasion tumorale , Récidive tumorale locale/anatomopathologie , Récidive tumorale locale/radiothérapie , Pronostic , Études prospectives , Études rétrospectives , Taux de survieRÉSUMÉ
OBJECTIVES: Isolated axillary lymph node metastases is an unusual clinical presentation of breast carcinoma. We studied its different issues. METHODS: This study is a follow-up study of 16patients, treated between 1996 and 2012, presenting with axillary metastases with an occult breast carcinoma, which could not be identified by physical examination nor by a conventional imaging or a breast MRI. Clinical characteristics, histological analysis, treatment, monitoring and five-year survival rate were studied. RESULTS: The incidence of this kind of breast cancer was 0.20%. A breast MRI was performed in 75% of the patients. The histology of these tumors showed a rate of hormono-sensibility of 50% and an HER2 overexpression of 44%. Sixty-nine percent of the patients had no breast surgery or radiotherapy; global five-year survival rate for these women was 77.4%±11.5. CONCLUSION: The survival rates of this study should lead the practitioner to choose a less aggressive breast therapy. Moreover, the histological characteristics explain the high metastatic potential of these tumors, and relate them to the HER2+ subclass of gene expression patterns of breast carcinomas.
Sujet(s)
Aisselle , Tumeurs du sein/diagnostic , Métastase lymphatique/anatomopathologie , Sujet âgé , Tumeurs du sein/anatomopathologie , Tumeurs du sein/thérapie , Femelle , Humains , Imagerie par résonance magnétique , Adulte d'âge moyen , Récepteur ErbB-2/analyse , Récepteurs aux stéroïdes/analyse , Taux de survieRÉSUMÉ
OBJECTIVES: We retrospectively reviewed all the cases of axillary lymph node dissection (ALND) performed within a year after an immediate breast reconstruction procedure by a pedicled Latissimus dorsi, which is transferred to the anterior thoracic wall through an axillary funnel. Operative technical steps are described taking account of the new anatomical relationship of the axilla. METHODS: We assessed postoperative immediate complications and late sequelaes. RESULTS: From 1999 to 2013, 21 ALND were performed. Immediate postoperative period was free of complication in 85% of cases when following the operative steps described in this work. Partial or total necrosis of the reconstructed breast did not occur. With a median follow-up of 64 months, 6 patients (28% of the whole population) presented at least one sequelae like a feeling of heavy arm (n=2, 9%) or a lymphedema (n=3, 14%), a chronic neuropathic pain (n=4, 19%) or a limitation in the arm range of motion (n=2, 9%). CONCLUSION: ALND after immediate breast reconstruction by a pedicled Latissimus dorsi is feasible and safe, without any additional postoperative complication in comparison with a classic ALND.
Sujet(s)
Aisselle , Lymphadénectomie/effets indésirables , Lymphadénectomie/méthodes , Mammoplastie/méthodes , Adulte , Tumeurs du sein/anatomopathologie , Tumeurs du sein/chirurgie , Femelle , Humains , Adulte d'âge moyen , Complications postopératoires/épidémiologie , Études rétrospectives , Résultat thérapeutiqueRÉSUMÉ
OBJECTIVE: Complication and survival analysis of cytoreduction surgery with modified posterior pelvic exenteration in the surgical treatment of the ovarian malignant tumor. METHODS: A retrospective monocentric study between 2000 and 2013 in Rhone-Alpes cancer treatment center. One hundred and fifty-two patients with ovarian cancer and treated by surgery with modified posterior pelvic exenteration were included. Complication in the 30 days after surgery was analysed by the Clavien-Dindo classification. RESULTS: In our study, rate of global complication was 62.5% with a morbidity rate of grave complication of 7.9%. Our rate of complete resection was 82.2%. Three fistulas (2.2%) were found. On average, there was 6.6±1.8 (2-11) surgery gesture associated with Hudson resection during surgery. In univariate analysis, there was a statistic significant association between complication from the rank II of Clavien-Dindo classification and supraradical surgery, post-chemotherapy surgery, recurrent surgery, the resection of a diaphragmatic dome, and the partial gastric resection. This association was also observed with the number of surgical gesture associated with Hudson resection. CONCLUSIONS: The main prognostic surgical factor in ovarian cancer is to obtain a no macroscopic residual disease. The modified posterior pelvic exenteration allowed to obtain it. Our study demonstrates a low rate of grave complication further to this type of surgery.
Sujet(s)
Carcinomes/chirurgie , Tumeurs de l'ovaire/chirurgie , Exentération pelvienne/effets indésirables , Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Carcinomes/anatomopathologie , Femelle , Humains , Adulte d'âge moyen , Tumeurs de l'ovaire/anatomopathologie , Exentération pelvienne/méthodes , Complications postopératoires , Pronostic , Études rétrospectives , Jeune adulteRÉSUMÉ
OBJECTIVE: The objective of this study was to evaluate outpatient satisfaction for breast cancer surgery and compare with inpatient satisfaction. PATIENTS AND METHODS: Our observational prospective study included all patients who underwent breast cancer surgical procedure (breast-conserving surgery and sentinel node biopsy) between July and December 2013 in a cancer center. Patients were asked to answer a questionnaire at discharge and 30 days after surgery. RESULTS: One hundred and fifty-five patients (exclusively women) were included; the outpatient group comprised 102 patients and the inpatient group 53. The study showed no statistical difference in patients' satisfaction betweeen the two groups at discharge (P=0.20) and 30 days after surgery (P=0.30); 101 (99%) outpatients and 44 (95.7%) inpatients had very good or excellent level of satisfaction at discharge and 88 (92,7%) and 49 (98%), respectively 30 days after surgery. The overall mean satisfaction score was 9.1±1.2 [3-10] at discharge and 8.7±1.3 [3-10] 30 days after surgery. DISCUSSION AND CONCLUSION: Our study found high degree of satisfaction after breast surgery for cancer both for outpatients and inpatients. This suggests that ambulatory surgery is possible and valid for this type of oncologic breast surgery.
Sujet(s)
Procédures de chirurgie ambulatoire/méthodes , Tumeurs du sein/anatomopathologie , Tumeurs du sein/chirurgie , Mastectomie partielle/méthodes , Satisfaction des patients , Biopsie de noeud lymphatique sentinelle , Adulte , Sujet âgé , Femelle , Humains , Patients hospitalisés , Adulte d'âge moyen , Enquêtes et questionnairesRÉSUMÉ
BACKGROUND: Patients with schizophrenia display significant working memory and executive deficits. In patients with obsessive-compulsive disorder (OCD), several studies suggest that working memory dysfunction may be one of the causes of compulsive checking behaviors. Hence, this study aimed at assessing whether patients with schizophrenia were impaired on an image comparison task used to measure checking behaviors, and whether the origin and profile of impairment on this task was different between schizophrenia and OCD. METHODS: Eye movement recordings were used to assess the checking behavior of 24 patients with schizophrenia and 24 control participants who had to decide whether two images were different or identical. The verbal and visuo-spatial components of participants' working memory were measured using the reading span and backward location span tests. RESULTS: Compared to controls, patients with schizophrenia had reduced working memory spans and showed excessive checking behavior when comparing the two images. However, the intensity of their checking behavior was not significantly related to their working memory deficits. CONCLUSIONS: Several recent studies demonstrated that the excessive checking behaviors displayed by patients with OCD were related to working memory dysfunction. The absence of a relationship between the excessive checking behavior of patients with schizophrenia and their working memory deficits suggests that checking behaviors do not have the same origin in the two disorders.
Sujet(s)
Attention/physiologie , Mouvements oculaires/physiologie , Mémoire à court terme/physiologie , Schizophrénie/physiopathologie , Adulte , Études cas-témoins , Femelle , Humains , Mâle , Troubles de la mémoire/physiopathologie , Adulte d'âge moyen , Stimulation lumineuseRÉSUMÉ
We report two cases of spontaneous regression of breast cancer occurred in our institution. It was about a 34- and an 82-year-old patient. The examination revealed a palpable nodule. In both cases, biopsy revealed a negative immunohistochemical staining for estrogen and progesterone receptors, and HER-2 negative. Histological analysis of the surgical specimen found fibrous tissue rearrangement without carcinoma. In the first case, a sarcoidosis was diagnosed at the same time, the mediastinal nodes mimicked a metastatic cancer. These cases illustrate a rare phenomenon. The main hypothesis is a carcinoma- directed immune response triggered by the biopsy.
Sujet(s)
Biopsie , Tumeurs du sein/anatomopathologie , Régression tumorale spontanée , Adulte , Sujet âgé de 80 ans ou plus , Tumeurs du sein/immunologie , Carcinome canalaire du sein/anatomopathologie , Femelle , Humains , Noeuds lymphatiques/anatomopathologie , Mammographie , Sarcoïdose/anatomopathologieRÉSUMÉ
The objective of the study is to determine whether surgery influences the outcome of stage IV ovarian cancer. The study design is as follows: From May 1995 to December 2000, 129 patients with FIGO stage IV ovarian cancer, recruited in 42 centers, were prospectively included in GINECO first-line randomized studies of platinum-based regimens with paclitaxel administered simultaneously or sequentially. In all, 109 were eligible for this study. Standard peritoneal cytoreductive surgery was defined as a procedure including at least total hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and peritoneal debulking. Surgery was considered optimal if residual lesions were smaller than 1 cm. The Kaplan-Meier method was used to compare survival. Initial abdominopelvic cytoreductive surgery was considered standard in 55 (54%) patients. Abdominopelvic surgery was optimal in 29 patients and nonoptimal in 26. Twenty-two (22%) patients had a simple biopsy, and 25 (24%) patients underwent substandard surgery. Twenty-two of these 47 patients without initial standard surgery underwent a second surgical procedure, and 17 of the 22 patients completed standard surgery. The median overall survival time in the entire population was 24.3 months (95% confidence interval [CI], 19.5-29.1 months). Patients treated without a cytoreductive surgical procedure had significantly worse median survival (15.1 months; 95% CI, 5.4-24.9 months) than patients who had optimal primary surgery (22.9 months; 95% CI, 15.6-30.1 months), nonoptimal primary surgery (27.1 months; 95% CI, 21.2-32.9 months), or neoadjuvant chemotherapy followed by surgery (45.5 months; 95% CI, 23.5-67.5 months) (P= .001). In conclusion, this study shows a significant benefit of debulking surgery in stage IV ovarian cancer patients who responded to neoadjuvant chemotherapy. Neoadjuvant chemotherapy can help to select patients for surgery.
Sujet(s)
Tumeurs de l'ovaire/traitement médicamenteux , Tumeurs de l'ovaire/chirurgie , Adulte , Sujet âgé , Évolution de la maladie , Survie sans rechute , Cellules épithéliales/anatomopathologie , Femelle , Humains , Adulte d'âge moyen , Traitement néoadjuvant , Stadification tumorale , Tumeurs de l'ovaire/anatomopathologie , Études rétrospectivesRÉSUMÉ
The biphasic waveform (BPW) is an abnormality of the optical transmission waveform obtained during measurement of the activated partial thromboplastin time on a specific photometric haemostasis autoanalyzer. This abnormality is related to calcium-dependent formation of complexes between C reactive protein and very low density lipoprotein. Biphasic waveform had a high sensitivity and negative predictive value for the identification of patients with severe sepsis and septic shock. On day 3, the time course of the biphasic waveform is a marker for the prognosis of sepsis-related mortality. The BPW is not a surrogate marker for C-reactive protein or procalcitonin and provides additional information. Further trials should be necessary using BPW for diagnostic and management procedures. Compared with other laboratory markers such as C reactive protein or procalcitonin, activated partial thromboplastin time waveform analysis is a tool that is rapid, inexpensive, effective and available 24 hours a day. When the analyzer is locally available, waveform analysis of this routine coagulation test provides information for the diagnosis of severe sepsis and the prognosis of septic patients.
Sujet(s)
Temps partiel de thromboplastine , Sepsie/sang , Sepsie/diagnostic , Marqueurs biologiques/sang , Protéine C-réactive/analyse , Calcitonine/sang , Peptide relié au gène de la calcitonine , Humains , Valeur prédictive des tests , Précurseurs de protéines/sang , Sensibilité et spécificitéRÉSUMÉ
The aim of the study was to determine Monarc (American Medical Systems) sling position after surgical treatment of stress urinary incontinence (SUI) through the transobturator approach. A total of 54 consecutive women with SUI were evaluated post-operatively with transvaginal ultrasound. A concomitant hysterectomy was performed in ten cases and a concomitant prolapse surgery in six cases. Ultrasound measurements include urethral length, the distance between the upper edge of the sling and the bladder neck (BN-S) and the BN-S/U ratio. The mean distance between the transobturator tape and the bladder neck was found to be 12.6 +/- 3.2 mm in the group of patients who underwent the transobturator procedure alone, 13 +/- 3.1 mm in the transobturator plus hysterectomy group and 12 +/- 2.8 mm in the transobturator plus prolapse group. The superior tape margin was at the mid-urethra in 81.5% of patients and always at a distance greater than 7 mm from the bladder neck. Eight patients did not have satisfactory results after the surgery. Only in one out of these eight patients was the transobturator sling not found to be at the mid-urethra. The superior tape margin of the Monarc sling remained at the level of mid-urethra in the majority of cases. It was never located too proximally beneath the bladder neck.
Sujet(s)
Bandelettes sous-urétrales , Urètre/imagerie diagnostique , Incontinence urinaire d'effort/imagerie diagnostique , Incontinence urinaire d'effort/chirurgie , Procédures de chirurgie urologique/méthodes , Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Femelle , Humains , Adulte d'âge moyen , Résultat thérapeutique , Échographie , Procédures de chirurgie urologique/instrumentationRÉSUMÉ
OBJECTIVE: The aim of the study was to evaluate the feasibility, morbidity and survival outcome of laparoscopy-assisted vaginal pelvic exenteration. PATIENTS AND METHODS: Since 2000, 7 en-bloc pelvic exenteration combining a vaginal or perineal approach and laparoscopic approach have been performed in our cancer center associated with complex laparoscopic reconstruction. All patients but one received previous irradiation. Two patients underwent a total pelvic exenteration; three patients an anterior and middle exenteration; two patients a middle and posterior exenteration. Urinary system was reconstructed with an ileal loop in one case, with a hand-assisted laparoscopic Miami pouch in four cases. Reconstruction of the vagina was performed with an omental cylinder in three cases, with a gluteal thigh flap in one case. A colorectal anastomosis was performed in three patients, one patient had an end colostomy. A mini-laparotomy conversion was necessary in one case because of a pelvic side involvement to perform an intraoperative irradiation. RESULTS: Mean time of the procedure was 6.5 hours with peroperative bleeding less than 500 cm3. Four patients presented minor complications. No revision of the Miami pouch was necessary. Mean length of hospital stay was 27 days. The four patients with a Miami pouch were able to self catheterize at the time of discharge. Mean follow-up was 14 months. Four patients died of the disease (three were metastatic). One patient presented a local recurrence. Two patients are free of disease. DISCUSSION AND CONCLUSION: Laparoscopic or laparoscopy-assisted vaginal pelvic exenteration followed by reconstruction is feasible with curative intent in selected patients.
Sujet(s)
Tumeurs de l'appareil génital féminin/chirurgie , Exentération pelvienne/méthodes , Adulte , Sujet âgé , Anastomose chirurgicale , Côlon/chirurgie , Femelle , Tumeurs de l'appareil génital féminin/mortalité , Humains , Laparoscopie , Durée du séjour , Adulte d'âge moyen , Métastase tumorale , Récidive tumorale locale , Exentération pelvienne/mortalité , Lambeaux chirurgicaux , Analyse de survie , Utérus/chirurgie , Vagin/chirurgieRÉSUMÉ
OBJECTIVE: To compare the accuracy of rectal endoscopic ultrasonography (REU) and magnetic resonance imaging (MRI) for predicting rectal wall involvement in patients presenting histologically proven deeply infiltrating endometriosis (DIE). METHODS: This was a retrospective study of a continuous series of 81 patients presenting histologically proven DIE who underwent preoperative investigations using both REU and MRI. The sonographer and the radiologist, who were unaware of the clinical findings and patient history, but knew that DIE was suspected, were asked whether there was involvement of the digestive wall. RESULTS: Rectal DIE was confirmed histologically in 34 of the 81 (42%) patients. For the diagnosis of rectal involvement, sensitivity, specificity and positive and negative predictive value for REU were 97.1%, 89.4%, 86.8% and 97.7% and for MRI they were 76.5%, 97.9%, 96.3% and 85.2%. CONCLUSION: The sensitivity and negative predictive value of REU were higher than those of MRI suggesting that REU performs better than MRI in the diagnosis of rectal involvement for patients presenting with DIE. Prospective studies with a large number of patients are needed in order to validate these preliminary results.
Sujet(s)
Endométriose/diagnostic , Endosonographie/méthodes , Maladies du rectum/diagnostic , Adulte , Anthropométrie , Endométriose/imagerie diagnostique , Endométriose/chirurgie , Femelle , Humains , Imagerie par résonance magnétique/méthodes , Valeur prédictive des tests , Soins préopératoires/méthodes , Maladies du rectum/imagerie diagnostique , Maladies du rectum/chirurgie , Études rétrospectives , Sensibilité et spécificitéRÉSUMÉ
OBJECTIVE: Verrucous carcinoma is a rare form of vulvar squamous carcinoma, with particular clinical presentation and histological description. We analyze the specificity of the treatment of this form. MATERIALS AND METHODS: We analyzed the records of 8 patients treated in our hospital between 1995 and 2001. In the absence of an associated lesion, the treatment was partial vulvectomy without lymph node dissection. A close follow-up was then organized. RESULTS: Mean age was 76 years (range 54 to 92). In 7 out of the 8 cases we found an associated lesion: invasive squamous carcinoma, VIN III or lichen. Two patients later developed a squamous carcinoma. Two others died because of intercurrent diseases. The last four patients are doing well. CONCLUSION: We confirm the efficacy of the treatment generally proposed: partial vulvectomy, without lymph node dissection and without complementary treatment but with a close follow-up. The coexistence of other vulvar lesions such as lichen is remarkable in our series.
Sujet(s)
Antinéoplasiques/usage thérapeutique , Carcinome verruqueux/chirurgie , Tumeurs de la vulve/chirurgie , Sujet âgé , Sujet âgé de 80 ans ou plus , Carcinome verruqueux/traitement médicamenteux , Carcinome verruqueux/anatomopathologie , Femelle , Humains , Adulte d'âge moyen , Pronostic , Études rétrospectives , Résultat thérapeutique , Vulve/chirurgie , Tumeurs de la vulve/traitement médicamenteux , Tumeurs de la vulve/anatomopathologieRÉSUMÉ
OBJECTIVE: To compare the risk of major complications during the set-up procedures for laparoscopy according to whether the classic technique (creation of the pneumoperitoneum followed by introduction of the optics trocar) or open laparoscopy is used. METHODS: Comparison was made of two retrospective series each carried out in a department promoting one of the two techniques. The setting was a university-affiliated hospital. Two groups of patients were compared: group A, classic laparoscopy, n = 8324; group B, open laparoscopy, n = 1562. We investigated the set-up procedures of operative laparoscopy according to the rules of classic or open laparoscopy. RESULTS: The risk of failure requiring conversion to laparotomy is significantly higher in the group of patients who underwent open laparoscopy [three cases (0.19%) vs. 0 case (0.0%); p = 0.004]. The risk of major complications is comparable in the two groups [group A, four cases (0.05%) vs. group B, three cases (0.19%); p = 0.08]. In the classic laparoscopy group there were four major complications: one injury to the aorta and three bowel injuries. In the open laparoscopy group there were three major complications: two bowel injuries and one postoperative occlusion. CONCLUSIONS: Open laparoscopy does not reduce the risk of major complications during the set-up procedures for laparoscopy. Randomized prospective trials are indispensable for comparing the risks involved with the classic technique and those of open laparoscopy.