Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 1 de 1
Filtrer
Plus de filtres











Base de données
Gamme d'année
1.
Trans R Soc Trop Med Hyg ; 104(5): 343-50, 2010 May.
Article de Anglais | MEDLINE | ID: mdl-20106494

RÉSUMÉ

We describe the epidemiology of malaria in a frontier agricultural settlement in Brazilian Amazonia. We analysed the incidence of slide-confirmed symptomatic infections diagnosed between 2001 and 2006 in a cohort of 531 individuals (2281.53 person-years of follow-up) and parasite prevalence data derived from four cross-sectional surveys. Overall, the incidence rates of Plasmodium vivax and P. falciparum were 20.6/100 and 6.8/100 person-years at risk, respectively, with a marked decline in the incidence of both species (81.4 and 56.8%, respectively) observed between 2001 and 2006. PCR revealed 5.4-fold more infections than conventional microscopy in population-wide cross-sectional surveys carried out between 2004 and 2006 (average prevalence, 11.3 vs. 2.0%). Only 27.2% of PCR-positive (but 73.3% of slide-positive) individuals had symptoms when enrolled, indicating that asymptomatic carriage of low-grade parasitaemias is a common phenomenon in frontier settlements. A circular cluster comprising 22.3% of the households, all situated in the area of most recent occupation, comprised 69.1% of all malaria infections diagnosed during the follow-up, with malaria incidence decreasing exponentially with distance from the cluster centre. By targeting one-quarter of the households, with selective indoor spraying or other house-protection measures, malaria incidence could be reduced by more than two-thirds in this community.


Sujet(s)
Paludisme à Plasmodium falciparum/épidémiologie , Paludisme à Plasmodium vivax/épidémiologie , Adolescent , Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Brésil/épidémiologie , Enfant , Enfant d'âge préscolaire , Méthodes épidémiologiques , Femelle , Humains , Nourrisson , Nouveau-né , Paludisme à Plasmodium falciparum/prévention et contrôle , Paludisme à Plasmodium vivax/prévention et contrôle , Mâle , Adulte d'âge moyen , Plasmodium falciparum/isolement et purification , Plasmodium vivax/isolement et purification , Réaction de polymérisation en chaîne , Santé en zone rurale , Jeune adulte
SÉLECTION CITATIONS
DÉTAIL DE RECHERCHE