RÉSUMÉ
HLA-B*15:679 and HLA-C*15:02:01:61 differ from HLA-B*15:12:01 and HLA-C*15:02:01:01 by a single nucleotides.
Sujet(s)
Allèles , Séquence nucléotidique , Antigènes HLA-C , Test d'histocompatibilité , Humains , Antigènes HLA-C/génétique , Inde , Exons , Analyse de séquence d'ADN/méthodes , Polymorphisme de nucléotide simple , Antigène HLA-B15/génétique , Antigène HLA-B15/immunologie , Alignement de séquences , CodonRÉSUMÉ
Allele variants HLA-C*01:02:01:74Q and -C*15:02:01:63 differ from -C*01:02:01:01 and -15:02:01:01 by a single nucleotide, respectively.
Sujet(s)
Allèles , Antigènes HLA-C , Test d'histocompatibilité , Humains , Antigènes HLA-C/génétique , Polymorphisme de nucléotide simple , Exons , Inde , Séquence nucléotidique , Analyse de séquence d'ADN/méthodesRÉSUMÉ
The novel HLA-B*15:665 and HLA-C*12:02:02:23 alleles were detected during the routine HLA typing process.
RÉSUMÉ
Novel HLA-C*06:02:01:94 and -C*15:02:01:58 alleles were detected during the routine HLA typing process.
RÉSUMÉ
Acute Myeloid Leukemia (AML) is a complex disease with rapid progression and poor/unsatisfactory outcomes. In the past few years, the focus has been on developing newer therapies for AML; however, relapse remains a significant problem. Natural Killer cells have strong anti-tumor potential against AML. This NK-mediated cytotoxicity is often restricted by cellular defects caused by disease-associated mechanisms, which can lead to disease progression. A stark feature of AML is the low/no expression of the cognate HLA ligands for the activating KIR receptors, due to which these tumor cells evade NK-mediated lysis. Recently, different Natural Killer cell therapies have been implicated in treating AML, such as the adoptive NK cell transfer, Chimeric antigen receptor-modified NK (CAR-NK) cell therapy, antibodies, cytokine, and drug treatment. However, the data available is scarce, and the outcomes vary between different transplant settings and different types of leukemia. Moreover, remission achieved by some of these therapies is only for a short time. In this mini-review, we will discuss the role of NK cell defects in AML progression, particularly the expression of different cell surface markers, the available NK cell therapies, and the results from various preclinical and clinical trials.
Sujet(s)
Leucémie aigüe myéloïde , Humains , Leucémie aigüe myéloïde/anatomopathologie , Cellules tueuses naturelles , Immunothérapie adoptive/méthodes , Récepteurs KIR/métabolisme , Cytokines/métabolismeRÉSUMÉ
The novel HLA-A*01:01:01:111 allele was detected during routine HLA typing.
Sujet(s)
Antigènes HLA-A , Séquençage nucléotidique à haut débit , Humains , Allèles , Inde , Test d'histocompatibilité , Antigènes HLA-A/génétiqueRÉSUMÉ
The novel HLA-B*40:01:02:59 and HLA-C*05:01:73 alleles were detected during the routine HLA typing process.
Sujet(s)
Gènes MHC de classe I , Antigènes HLA-B , Humains , Allèles , Analyse de séquence d'ADN , Antigènes HLA-B/génétique , Inde , Séquençage nucléotidique à haut débitRÉSUMÉ
Novel HLA-A*33:03:62, -B*52:01:01:25 alleles and confirmatory HLA-A*02:01:209 allele were detected during the HLA typing process.
Sujet(s)
Gènes MHC de classe I , Antigènes HLA-B , Humains , Allèles , Antigènes HLA-B/génétique , Test d'histocompatibilité , Antigènes HLA-A/génétique , Séquençage nucléotidique à haut débitRÉSUMÉ
The novel allele HLA-C*06:02:38:02 differs from HLA-C*06:02:38:01 by a nucleotide change at position; gDNA 168 T â A.
Sujet(s)
Gènes MHC de classe I , Antigènes HLA-C , Humains , Antigènes HLA-C/génétique , Allèles , Inde , NucléotidesRÉSUMÉ
The novel allele HLA-A*02:11:01:06 as compared with HLA-A*02:11:01:01 displays polymorphism at position; gDNA 1562 (C>A).
Sujet(s)
Antigènes HLA-A , Humains , Allèles , Antigènes HLA-A/génétiqueRÉSUMÉ
The novel allele HLA-C*03:599 as compared with HLA-C*03:04:01:02 displays polymorphism at position; gDNA 1618 (G>T).
Sujet(s)
Antigènes HLA-C , Humains , Antigènes HLA-C/génétique , AllèlesRÉSUMÉ
HLA-C*07:04:01:19 differs from C*07:04:01:01 by one nucleotide change in gDNA at position 2420 in intron 5.
Sujet(s)
Gènes MHC de classe I , Antigènes HLA-C , Humains , Antigènes HLA-C/génétique , Allèles , Inde , IntronsRÉSUMÉ
The novel HLA-C*12:02:47 allele was detected during routine HLA typing.
Sujet(s)
Antigènes HLA-C , Humains , Antigènes HLA-C/génétique , Allèles , IndeRÉSUMÉ
The novel allele HLA-A*24:02:01:136 as compared with HLA-A*24:02:01:01 displays a single nucleotide polymorphism at position; gDNA 2827 (C > A).
Sujet(s)
Séquençage nucléotidique à haut débit , Islam , Humains , Séquence nucléotidique , Allèles , Antigènes HLA-A/génétiqueRÉSUMÉ
The novel HLA-DQA1*01:01:01:10 allele differs from HLA-DQA1*01:01:01:07 by a single nucleotide change at gDNA 702 G T.
Sujet(s)
Séquençage nucléotidique à haut débit , Humains , Allèles , Analyse de séquence d'ADN , Chaines alpha des antigènes HLA-DQ/génétique , IndeRÉSUMÉ
The novel allele HLA-B*37:01:01:19 differs from B*37:01:01:01 by one nucleotide A->G in Intron 3 at gDNA1430.
Sujet(s)
Antigènes HLA-B , Séquençage nucléotidique à haut débit , Humains , Allèles , Introns , Inde , Antigènes HLA-B/génétiqueRÉSUMÉ
The novel allele, HLA-B*40:02:01:39 differs from the HLA-B*40:02:01:01 allele by a single nucleotide change at gDNA position 700.