RÉSUMÉ
The behavioral and neural responses to social exclusion were examined in women randomized to four conditions, varying in levels of attractiveness and friendliness. Informed by evolutionary theory, we predicted that being socially excluded by attractive unfriendly women would be more distressing than being excluded by unattractive women, irrespective of their friendliness level. Our results contradicted most of our predictions but provide important insights into women's responses to interpersonal conflict. Accounting for rejection sensitivity, P300 event-related potential amplitudes were largest when women were excluded by unattractive unfriendly women. This may be due to an expectancy violation or an annoyance with being excluded by women low on social desirability. An examination of anger rumination rates by condition suggests the latter. Only attractive women's attractiveness ratings were lowered in the unfriendly condition, indicating they were specifically punished for their exclusionary behavior. Women were more likely to select attractive women to compete against with one exception-they selected the Black attractive opponent less often than the White attractive opponent when presented as unfriendly. Finally, consistent with studies on retaliation in relation to social exclusion, women tended to rate competitors who rejected them as being more rude, more competitive, less attractive, less nice, and less happy than non-competitors. The ubiquity of social exclusion and its pointed emotional and physiological impact on women demands more research on this topic.
Sujet(s)
Beauté , Humains , Femelle , Jeune adulte , Adulte , Distance psychologique , Désirabilité sociale , Amis/psychologie , Potentiels évoqués cognitifs P300/physiologie , Adolescent , Face/physiologieRÉSUMÉ
Muscle wasting can be caused by nutrition deficiency and inefficient metabolism of amino acids, including Branched Chain Amino Acids (BCAAs). Branched Chain Amino Acids are a major contributor to the metabolic needs of healthy muscle and account for over a tenth of lean muscle mass. Branched chain alpha-ketoacid dehydrogenase (BCKD) is the rate limiting enzyme of BCAA metabolism. Inhibition of BCKD is achieved through a reversible phosphorylation event by Branched Chain a-ketoacid dehydrogenase kinase (BCKDK). Our study set out to determine the importance of BCKDK in the maintenance of skeletal muscle. We used the Gene Expression Omnibus Database to understand the role of BCKDK in skeletal muscle pathogenesis, including aging, muscular disease, and interrupted muscle metabolism. We found BCKDK expression levels were consistently decreased in pathologic conditions. These results were most consistent when exploring muscular disease followed by aging. Based on our findings, we hypothesize that decreased BCKDK expression alters BCAA catabolism and impacts loss of normal muscle integrity and function. Further research could offer valuable insights into potential therapeutic strategies for addressing muscle-related disorders.
Sujet(s)
Acides aminés à chaine ramifiée , Muscles squelettiques , Muscles squelettiques/métabolisme , Muscles squelettiques/anatomopathologie , Humains , Acides aminés à chaine ramifiée/métabolisme , Animaux , Vieillissement/métabolisme , Vieillissement/génétique , Maladies musculaires/métabolisme , Maladies musculaires/anatomopathologie , Maladies musculaires/génétique , 3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)/métabolisme , 3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)/génétique , Protein kinasesRÉSUMÉ
OBJECTIVES: Myeloproliferative neoplasm, unclassifiable (MPN-U, revised to MPN, not otherwise specified in the fifth edition of the World Health Organization classification) is a heterogeneous category of primary marrow disorders with clinical, morphologic, and/or molecular features that preclude classification as a more specific MPN subtype due to stage at diagnosis, overlapping features between MPN subtypes, or the presence of coexisting disorders. Compared with other MPN subtypes, the contribution of the mutational landscape in MPN-U in conjunction with other clinical and morphologic biomarkers to prognosis has been less well investigated. METHODS: We performed a multicenter, retrospective study of MPN-U (94 cases) to better define the clinicopathologic features, genetic landscape, and clinical outcomes, including subgroups of early-stage, advanced-stage, and coexisting disorders. The Dynamic International Prognostic Scoring System (DIPSS) plus scoring system was applied to assess its relevance to MPN-U prognosis. RESULTS: Multivariate analysis demonstrated bone marrow blast count and DIPSS plus score as statistically significant in predicting overall survival. Univariate analysis identified additional potential poor prognostic markers, including abnormal karyotype and absence of JAK2 mutation. Secondary mutations were frequent in the subset analyzed by next-generation sequencing (26/37 cases, 70.3%) with a borderline association between high molecular risk mutations and overall survival. CONCLUSIONS: This study, as one of the largest of MPN-U studies incorporating both clinicopathologic and molecular data, moves toward identification of biomarkers that better predict prognosis in this heterogeneous category.
RÉSUMÉ
The mating effort questionnaire (MEQ) is a multi-dimensional self-report instrument that captures factors reflecting individual effort in upgrading from a current partner, investment in a current partner, and mate seeking when not romantically paired. In the current studies, we sought to revise the MEQ so that it distinguishes among two facets of mate seeking-mate locating and mate attracting-to enable a more nuanced measurement and understanding of individual mating effort. Moreover, we developed additional items to better measure partner investment. In total, the number of items was increased from 12 to 26. In Study 1, exploratory factor analysis revealed that a four-factor solution, reflecting partner upgrading, mate locating, mate attracting, and partner investment, yielded the best fit. In Study 2, this structure was replicated using confirmatory factor analysis in an independent sample. Based on extant studies documenting the relationships between psychopathy, short-term mating effort, and sexual risk taking, a structural equation model (SEM) indicated that trait psychopathy positively predicted mate locating, mate attracting, and partner upgrading and negatively predicted partner investment. A separate SEM showed that partner upgrading positively predicted risky sexual behaviors, while partner upgrading and mate locating positively predicted acceptance of cosmetic surgery.
Sujet(s)
Comportement sexuel , Partenaire sexuel , Humains , Mâle , Enquêtes et questionnaires , Partenaire sexuel/psychologie , Comportement sexuel/psychologie , Femelle , Adulte , Jeune adulte , Adolescent , Analyse statistique factorielle , Reproductibilité des résultatsRÉSUMÉ
Winter cover crop performance metrics (i.e., vegetative biomass quantity and quality) affect ecosystem services provisions, but they vary widely due to differences in agronomic practices, soil properties, and climate. Cereal rye (Secale cereale) is the most common winter cover crop in the United States due to its winter hardiness, low seed cost, and high biomass production. We compiled data on cereal rye winter cover crop performance metrics, agronomic practices, and soil properties across the eastern half of the United States. The dataset includes a total of 5,695 cereal rye biomass observations across 208 site-years between 2001-2022 and encompasses a wide range of agronomic, soils, and climate conditions. Cereal rye biomass values had a mean of 3,428 kg ha-1, a median of 2,458 kg ha-1, and a standard deviation of 3,163 kg ha-1. The data can be used for empirical analyses, to calibrate, validate, and evaluate process-based models, and to develop decision support tools for management and policy decisions.
Sujet(s)
Grains comestibles , Secale , Agriculture , Écosystème , Grains comestibles/croissance et développement , Saisons , Secale/croissance et développement , Sol , États-UnisRÉSUMÉ
A new measure to assess friendship jealousy in the context of social media was developed. This one-factor, seven-item measure was psychometrically sound, showing evidence of validity and reliability in three samples of North American adults (Study 1, n = 491; Study 2, n = 494; Study 3, n = 415) and one-, two-, and three-year stability (Study 3). Women reported more social media friendship jealousy than men (Studies 2 and 3) and younger women had the highest levels of social media friendship jealousy (compared with younger men and older men and women; Study 2). Social media friendship jealousy was associated with lower friendship quality (Study 1) and higher social media use and trait jealousy (Study 2). The relation between social media friendship jealousy and internalizing symptoms indicated positive within time associations and longitudinal bidirectional relations (Study 3). Specifically, social media friendship jealousy predicted increases in internalizing problems, and internalizing problems predicted greater social media friendship jealousy accounting for gender and trait levels of social media friendship jealousy and internalizing problems. Anxious and depressed adults may be predisposed to monitor threats to their friendships via social media and experience negative consequences because of this behavior. Although social media interactions can be associated with positive well-being and social connectedness, our results highlight that they can also undermine friendships and mental health due to jealousy.
Sujet(s)
Amis , Médias sociaux , Mâle , Adulte , Humains , Femelle , Sujet âgé , Amis/psychologie , Jalousie , Relations interpersonnelles , Reproductibilité des résultatsRÉSUMÉ
Introduction: Previous research has highlighted the putative role of intrasexual competition (IC) in predicting women's body dissatisfaction, weight loss effort, and, at its extreme, eating disorders. However, extant research reporting on these links is limited by its exclusion of potential confounds, including psychopathologies such as depression. Moreover, it is presently unclear whether women higher in body mass index (BMI) may be more prone to the influence of IC in taking dieting risks. Methods: To address these gaps in the literature, 189 young adult women completed measures of IC, depressive symptoms, willingness to use a risky diet pill, and had their height and weight measured. Results: Results showed that IC interacted with BMI to predict willingness to use a risky diet pill, such that women high in both IC and BMI were most likely to take the risky diet pill. Further exploratory analyses considering potential directional links between BMI and depression supported mediating roles of depression (from BMI) and BMI (from depression) in predicting willingness to use a risky diet pill. Discussion: Results suggest that links between IC and dieting risks may be moderated by women's BMI, and that these links hold when considering depressive symptoms. Future longitudinal research would benefit from a better understanding of the potential directional links between BMI, depression, and diet pill use.
RÉSUMÉ
Objective: Extreme Risk Protection Orders (ERPO) allow a petitioner to file a civil order to temporarily restrict access to firearms among individuals ("respondents") deemed to be at extreme risk of harming themselves, others, or both. Although unable to file ERPOs for their clients in most states, health professionals may play a pivotal role in the ERPO process by recommending an eligible petitioner initiate the process. We describe the process of filing an ERPO when a healthcare, mental health, or social service professional contacted an ERPO petitioner. Method: Court documents of ERPOs involving health professionals in Washington State between December 8th, 2016 and May 10th, 2019 were qualitatively analyzed (n=24). We constructed pen portraits from the documents and analyzed them using an inductive qualitative thematic approach. Results: Themes included factors influencing the process by which each professional evaluated respondent behaviors, factors considered during assessment, factors influencing interpretation of respondent behaviors and subsequent provider response during a crisis. These influenced the outcome of the crisis event that led to ERPO filing. Conclusions: Each professional group differed in their approach to risk assessment of respondent behaviors. Strategies to better coordinate and align approaches may improve the ERPO process.
RÉSUMÉ
Young adults with first episode psychosis use cannabis at high rates. In light of progressively tolerant attitudes toward cannabis, decreased perceptions of risk, and limited implementation of substance use modules within coordinated specialty care (CSC) programs, this study sought to describe factors contributing to CSC providers' intentions to implement motivational enhancement therapy (MET) for cannabis reduction. Two focus groups were conducted with CSC providers (n = 14), with questions guided by theory of planned behavior. Content and thematic analyses were conducted to identify salient themes associated with the theory. Participants generally indicated intentions to implement MET; limiting factors included concerns about clients' willingness to discuss cannabis use, perception of support for abstinence-only goals, and concerns about intervention mechanics such as computerized assessments. To reduce barriers limiting provider intention to implement MET, authors recommend training on assessment protocols, the merits of harm-reduction, and strategies for lower-risk cannabis use.Please confirm if the author names are presented accurately and in the correct sequence. Author 1 Given name: [Ryan] Last name [Petros]. Author 2 Given name: [Denise D.] Last name [Walker]. Author 3 Given name: [Adam] Last name [Davis]. Author 4 Given name: [Maria] Last name [Monroe-DeVita]. Also, kindly confirm the details in the metadata are correct.Confirmed!
RÉSUMÉ
OBJECTIVES: IDH1 and IDH2 are among the most commonly mutated genes in myeloid neoplasms (MNs). It has been proposed that IDH2 R172 mutations (mR172) define a molecular subtype of acute myeloid leukemia (AML), but the clinicopathologic features of AML with mR172 have not been fully described. METHODS: We retrospectively identified and characterized all mR172 MNs with increased blasts in our archive for comparison to a similar number of MNs with IDH2 R140 (mR140) and IDH1 R132 (mR132) mutations (n = 39). RESULTS: mR172 cases had lower leukocyte counts and bone marrow cellularity than did non-mR172 cases. mR172 MNs often displayed blasts with highly invaginated, cleaved nuclei and typically expressed CD34, HLA-DR, CD117, and CD13 but often with diminished CD33. mR172 cases often had co-occurring mutations in myelodysplasia-associated genes and/or an adverse karyotype. Despite frequent adverse-risk genetic changes, in our cohort mR172 cases had significantly improved overall survival vs non-mR172 cases (P = .01), and we validated that mR172 was associated with improved survival in an independent large data set. CONCLUSIONS: We show that MNs with mR172 represent a morphologically and phenotypically distinct subtype, which in our cohort exhibited relatively favorable survival that is not captured in current AML risk assignment.
Sujet(s)
Isocitrate dehydrogenases , Leucémie aigüe myéloïde , Syndromes myéloprolifératifs , Humains , Isocitrate dehydrogenases/génétique , Leucémie aigüe myéloïde/génétique , Mutation , Pronostic , Études rétrospectivesRÉSUMÉ
Mucosa-associated lymphoid tissue (MALT) lymphomas often express IgM and IRTA1 with only a minority demonstrating plasmacytic differentiation. However, like primary cutaneous marginal zone lymphoproliferative disorders (PCMZLPD), thyroid MALT lymphomas (T-MALT-L) frequently show plasmacytic differentiation and IgG positivity. Whether T-MALT-L share other features with PCMZLPD, including frequent IgG4 positivity and infrequent IRTA1 expression, and how IRTA1 staining compares to that in Hashimoto thyroiditis (HT) are unknown. Therefore, the clinicopathologic features of 18 T-MALT-L were assessed, and their IRTA1 expression compared with that in 5 HT cases. All T-MALT-L cases included a B-lymphoid component. Plasmacytic differentiation was present in 15 cases and was extensive in 12. Fourteen cases were IgG+ including 2 IgG4+ (12 κ+, 2 κ-/λ-). One case was IgAλ+. Plasmacytic cells were uniformly CD19+/CD56- but CD138- in 7/15 cases. IRTA1+ cells were present in 16/16 cases, ranging from scattered cells to >50%. They were often concentrated in "MALT ball"-type lymphoepithelial lesions, perifollicular regions, and sometimes in germinal centers. IRTA1 positivity was also present in all HT cases, although it was never very extensive and often had a perifollicular distribution, occasionally with sparse aggregates and positive cells within rare thyroid follicles. Thus, T-MALT-L share some features with PCMZLPD but are more similar to noncutaneous MALT lymphomas, with prominent lymphoepithelial lesions, ubiquitous although variable IRTA1 positivity, and infrequent IgG4 positivity. Plasmacytic differentiation is also common although CD138 loss is frequent and light chain staining may be absent. IRTA1 staining may help in the differential diagnosis with HT, although there is some overlap in staining patterns.
Sujet(s)
Lymphome B de la zone marginale , Syndromes lymphoprolifératifs , Tumeurs de la thyroïde , Humains , Lymphome B de la zone marginale/anatomopathologie , Plasmocytes/anatomopathologie , Tumeurs de la thyroïde/anatomopathologie , Immunoglobuline GRÉSUMÉ
Immunocompetence can influence an organism's reproductive fitness, and thus presumably their desirability as a mate (i.e., mate value). In humans, the link between immunocompetence and mate value has found circumstantial support by way of both expressed mate preferences for healthy partners, and via preferences for attractive phenotypes that are ostensibly linked to immune functioning. We examined whether a biological marker of immunocompetence, salivary immunoglobulin A (sIgA), along with self-reported frequency and severity of symptoms of poor health predicted individuals' reported mate value and mating behavior in a sample of 691 young adults. Our measures of immunocompetence (sIgA and symptoms of poor health) correlated significantly with one another, suggesting sIgA is a viable marker of general immune function in young adults. We then examined the independent contributions of these variables to mate value, controlling for age, sex, and body mass index (BMI). Results showed that sIgA (positively) and poor health (negatively) predicted mate value, but not lifetime number of sex partners or current romantic relationship status. These findings suggest that those with better health and immune function report being more desirable as mating partners but support past research showing null links to reported mating behavior. Together, these findings suggest that more comprehensive work on links between immunocompetence and mating is required.
RÉSUMÉ
Purpose: The size and location of infarct and penumbra are key to decision-making for acute ischemic stroke (AIS) management. CT perfusion (CTP) software estimate infarct and penumbra volume using contralateral hemisphere relative thresholding. This approach is not robust and widely contested by the scientific community. In this study, we investigate the use of deep learning-based algorithms to efficiently locate infarct and penumbra tissue on CTP hemodynamic maps. Approach: CTP scans were retrospectively collected for 60 and 59 patients in the infarct only and infarct + penumbra substudies respectively. Commercial CTP software was used to generate cerebral blood flow, cerebral blood volume, mean transit time, time to peak, and delay time maps. U-Net-shaped architectures were trained to segment infarct or infarct + penumbra. Test-time-augmentation, ensembling, and watershed segmentation were used as postprocessing techniques. Segmentation performance was evaluated using Dice coefficients (DC) and mean absolute volume errors (MAVE). Results: The algorithm segmented infarct tissue resulted in DC of 0.64 ± 0.03 (0.63, 0.65), and MAVE of 4.91 ± 0.94 (4.5, 5.32) mL. In comparison, the commercial software predicted infarct with a DC of 0.31 ± 0.17 (0.26, 0.36) and MAVE of 9.77 ± 8.35 (7.12, 12.42) mL. The algorithm was able to segment infarct + penumbra with a DC of 0.61 ± 0.04 (0.6, 0.63), and MAVE of 6.51 ± 1.37 (5.91, 7.11) mL. In comparison, the commercial software predicted infarct + penumbra with a DC of 0.3 ± 0.19 (0.25, 0.35) and MAVE of 9.18 ± 7.55 (7.25, 11.11) mL. Conclusions: Use of deep learning algorithms to assess severity of AIS in terms of infarct and penumbra volume is precise and outperforms current relative thresholding methods. Such an algorithm would enhance the reliability of CTP in guiding treatment decisions.
RÉSUMÉ
As currently circumscribed, Acrogenospora (Acrogenosporaceae, Minutisphaerales, Dothideomycetes) is a genus of saprobic hyphomycetes with distinctive conidia. Although considered common and cosmopolitan, the genus is poorly represented by sequence data, and no neotropical representatives are present in public sequence databases. Consequently, Acrogenospora has been largely invisible to ecological studies that rely on sequence-based identification. As part of an effort to identify fungi collected during ecological studies, we identified strains of Acrogenospora isolated in culture from seeds in the soil seed bank of a lowland tropical forest in Panama. Here we describe Acrogenospora terricola sp. nov. based on morphological and phylogenetic analyses. We confirm that the genus has a pantropical distribution. The observation of Acrogenospora infecting seeds in a terrestrial environment contrasts with previously described species in the genus, most of which occur on decaying wood in freshwater environments. This work highlights the often hidden taxonomic value of collections derived from ecological studies of fungal communities and the ways in which rich sequence databases can shed light on the identity, distributions and diversity of cryptic microfungi.
Sujet(s)
Ascomycota , Banque de semences , Techniques de typage bactérien , Composition en bases nucléiques , ADN bactérien/génétique , Acides gras/composition chimique , Forêts , Phylogenèse , ARN ribosomique 16S/génétique , Graines/microbiologie , Analyse de séquence d'ADN , Sol , Climat tropical , PanamaRÉSUMÉ
OBJECTIVE: Young adults experiencing a first episode of psychosis (FEP) have high rates of cannabis use and cannabis use disorder (CUD). No evidence-based practice effectively treats CUD for people with FEP, and little is known about factors that influence intentions to reduce or stop using. A critical inquiry was conducted to identify salient factors contributing to intentions of young adults with FEP to reduce or discontinue cannabis use, guided by theory of planned behavior (TPB). METHOD: Online focus groups (n = 3) and individual interviews (n = 3) were conducted with 16 young adults with FEP (mean age of 23.7) and historical cannabis use (averaging 11.8 days of use in the previous 30). A content analysis was conducted to sort data into TPB constructs, and a thematic analysis was subsequently performed to identify the breadth of themes. RESULTS: Participants identified benefits of cannabis reduction and cessation for pursuing life goals, but most maintained regular use. Participants perceived cannabis as a facilitator of social interactions, enjoyable activities, and improved mental health (and reduced dysthymia). Many were concerned about reducing or discontinuing cannabis without replacement strategies to compensate for its benefits. CONCLUSIONS AND IMPLICATIONS FOR PRACTICE: In spite of life goals incompatible with cannabis use, cessation was not favored given the perceived benefits of cannabis and participants' lack of replacement strategies to facilitate social interactions, enjoyable activities, and euthymia. Interventions may be improved by addressing motivations for use and by teaching skills to build positive social support, schedule enjoyable activities, and ameliorate dysthymia. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
Sujet(s)
Cannabis , Abus de marijuana , Troubles psychotiques , Troubles liés à une substance , Humains , Jeune adulte , Adulte , Abus de marijuana/psychologie , Abus de marijuana/thérapie , Intention , Théorie du comportement planifié , Troubles psychotiques/psychologieRÉSUMÉ
The avian inner perivitelline layer (IPVL), containing the zona pellucida (ZP) family of proteins, surrounds the ovulated ovum. In mammalian species, ZP proteins serve as key component(s) in binding sperm and initiating the acrosome reaction. Sperm binding at the germinal disc (GD) region of the IPVL initiates fertilization in avian species, and the amount of sperm binding at the GD reflects female fertility. The current research determined whether reported differences in mRNA expression in two genetic lines of turkey hens (E, high fertility and F, low fertility) translated to the protein level. ZPB2 in the IPVL is greater in the GD region compared with the nongerminal disc (NGD) region, as indicated by both mRNA and protein expression. However, protein expressions of ZPB1 and ZPC in the IPVL of E- and F-line turkey hens was in contrast to previously reported mRNA expression. The results indicate that the mRNA expression of ZP proteins at their site of synthesis in E- and F-line hens often does not directly correlate with the IPVL abundance of these proteins. The greater protein concentration of ZPB2 in the GD region compared with the NGD regions suggests that this protein may be critical for sperm binding at the GD region.
RÉSUMÉ
Dominant theorizing and research surrounding the operation of intersexual selection in evolutionary psychology tends to be guided by an adaptationist framework and aligned with models of sexual selection involving direct benefits (e.g., parental care) and indirect "good gene" and condition-dependent benefits. In this way, evolutionary psychologists more often espouse Alfred Russel Wallaces' utilitarian viewpoint that traits become attractive because they honestly signal vigor and vitality, which gives priority to natural selection. In doing so, Darwin's esthetic perspective originally articulated in The Descent of Man and alternative models of sexual selection (e.g., Fisherian runaway), are given less consideration. This is despite some informative reviews on the topic in evolutionary psychology. In the current conceptual analysis, we discuss the potential of Prum's Lande-Kirkpatrick (LK) null model of sexual selection to help make sense of some of the mixed evidence regarding the links between attractive traits and purported markers of phenotypic and genetic condition. We then consider how the implications of the LK null model can help to shift theoretical assumptions and guide future work in evolutionary psychology on intersexual selection.
RÉSUMÉ
Despite recent empirical interest, the links between optimism and pessimism with pro-environmental behavior (PEB) remain equivocal. This research is characterized by a reliance on cross-sectional data, a focus on trait-level at the neglect of state-level optimism-pessimism, and assessments of retrospective self-reported ecological behavior that are subject to response bias. To attend to these gaps, 140 North American adults (M age = 34; SD = 11.60; 44% female) were experimentally primed with bogus optimistic or pessimistic environmental news articles, and then asked to report their levels of state optimism-pessimism, intentions to purchase green products, in vivo PEB (donating to WWF and providing contact information to join an environmental organization), and support for geoengineering technologies. Results confirmed that optimistic (versus pessimistic) environmental messaging enhanced the expression of state optimism, which then contributed to PEB and support for geoengineering. These results have important implications for the framing of environmental messaging intended to promote ecologically conscious behavior.
RÉSUMÉ
Many have examined the desirability and mate competition tactics of adults higher on psychopathy using cross-sectional data, but few have studied the longitudinal associations between the lower-order factors of psychopathy (e.g., primary and secondary psychopathy) with indices of mating behavior in adolescents. More work is also needed to unravel how psychopathic youth outcompete rivals for mates. Delinquency has long been associated with dating and sexual behavior in adolescents, which may help to explain the competitive success of youth higher in psychopathic traits in vying for mates. We used cross-lagged panel modeling with three waves of data from a randomly drawn sample of 514 Canadian adolescents who provided annual self-reports of primary and secondary psychopathy, delinquency, and dating involvement from Grades 10 to 12 (15-18 years of age). Constructs were temporally stable. Secondary psychopathy and delinquency had positive within-time correlations with current dating status in Grade 10. A cross-lagged pathway from delinquency to dating involvement was supported from Grade 10 to 11, which replicated from Grade 11 to 12. However, this effect was specific to boys and not girls. An indirect effect also emerged whereby secondary psychopathy in Grade 10 increased the likelihood of being in a dating relationship in Grade 12 via heightened delinquency in Grade 11.