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Nat Prod Res ; 34(4): 449-455, 2020 Feb.
Article de Anglais | MEDLINE | ID: mdl-31135192

RÉSUMÉ

The in vitro antifungal activity of extracts obtained from 14 medicinal plants of the mongolian flora were investigated by measuring their minimal inhibitory concentration (MIC) against fungi cause of cutaneous diseases such as Candida species, dermatophytes and Malassezia furfur. Among the species examined, Stellaria dichotoma L., Scutellaria scordifolia L. Aquilegia sibirica Fisch. Et Schrenk. and Hyoscyamus niger L. extracts demonstrated antifungal activity against all studied fungi. In particular, S. scordifolia L. methanol extract, obtained at room temperature, showed the best activity against Candida spp., Malassezia furfur and dermatophytes with GMMIC50 values of 22 µg/mL, 64 µg/mL and 32 µg/mL, respectively. The flavones, luteolin and apigenin, identified in S. scordifolia extracts, and rutin identified in S. dichotoma and Hyoscyamus niger L. extracts, could be responsible of the observed antifungal activity.


Sujet(s)
Antifongiques/isolement et purification , Extraits de plantes/pharmacologie , Plantes médicinales/composition chimique , Antifongiques/pharmacologie , Arthrodermataceae/effets des médicaments et des substances chimiques , Candida/effets des médicaments et des substances chimiques , Flavones/pharmacologie , Malassezia/effets des médicaments et des substances chimiques , Tests de sensibilité microbienne , Mongolie , Extraits de plantes/usage thérapeutique , Scutellaria/composition chimique , Infections de la peau/traitement médicamenteux , Infections de la peau/microbiologie
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