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Objective: To analysis the medical expenses of six diseases and put forward the efficient methods to control their unreasonable rise. Methods: 22582 patients with six diseases in two largest hospitals in Xi'an were chosen and analyzed from 1/1/ 2003 to 10/1/2004. Results: Six diseases were the main reason of hospitalization and the malignancy was most important; drug expense of the uninsured patients, which was the key factor to induce the medical expenses rising, was higher than insured patients. Conclusion: The medical insurance program could control the drug expense efficiently; different control strategies to different diseases were important to distribute the medical resource and lighten the life burdens of the inpatients.
RÉSUMÉ
Objective To study the HLA-DRB1 genotype and their r elation with HBV infection among Han patients in shanxi area. Methods HLA-DRB1 genotyping was conducted in 54 patients HBV infection and 108 health controls, as well as 32 asymtomatic HBsAg carriers by using polymerase ch ain reaction/sequence specific primer (PCR-SSP) method. All the patients, asy mtomatic HBsAg carriers, and healthy subjects were inhabitants of Shan'xi area o f Han nationality. The association between HLA-DRB1 genotype and different repl ication of HBV were also studied. Results DRB1*04,DRB1*09,DRB 1*12, DRB1*15 were the most common genotypes in the Shan'xi Han inbabitants wit h the frequency of 16.2%,12.5%,11.6% and 13.4% respectively. Compared to 108 healthy controls, the allele frequency of HLA-DRB1*03 was 11.1% in HBV patien ts versus 3.7% in healthy controls, with odds ratio=3.57 and Pc=0.014 ( P
RÉSUMÉ
AIM: To study the HLA-DRB1 genotype and their relation with HBV infection in Shaanxi Han patients.METHODS: HLA-DRB1 genotyping was conducted in 108 case of chronic HBV infection and 108 health controls as well as 32 asymtomatic HBsAg carriers by using polymerase chain reaction-sequence specific primer method.All the patients,asymtomatic HBsAg carriers and health subjects were residents of Shaanxi district and belonged to Han nationality.The association between HLA-DRB1 genotype and different replication of HBV was also studied.RESULTS: DRB1~*04,DRB1~*09,DRB1~*12 and DRB1~*15 were the most common genotypes in Shaanxi Han residents with the frequency of 16.2%,12.5%,11.6% and 13.4%,respectively.Compared to 108 health controls,the allele frequency of HLA-DRB1~*03(10.6% of HBV patients versus 3.7% of health controls,odds ratio=3.10;P
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The results of detection for anti-HBc IgM in 6 acute hepatitis B cases and a group of individuals with subclinical infection in an epidemic of HB were reported in this paper. The authors had followed up 5 children with subclinical HB infection for 6-7 months and found that the anti-HBc IgM in their sera became negative or declined while anti-HBs became positive. The results showed that the marker of anti-HBc IgM could be used as an indicator of recent subclinical HB infection. This result is valuable in epide-miological survey of HB in general population. The geometric mean values (GMV) of S/N of anti-HBc IgM during the "window period" and the period of seroconversion to anti-HBs in subclinical infection were 3.9 and 1.9, respectively, and were lower than in clinical infection (6.9 and 7.4, respectively). Furthermore, the duration of that was shorter. The phenomenon is worthy of studying further. During the early convalescence, i. e., the period of seroconversion to anti-HBs in patients with acute hepatitis B, the GMV of S/N of anti-HBc IgM was high up to 7.4, which indicated that they might also be infectious.