RÉSUMÉ
BACKGROUND: Visfatin is a proinflammatory and insulin-mimetic adipokine contributing to whole body glucose and lipid metabolism. Studies to date are conflicting regarding the relationship between visfatin and non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the relationship of circulating visfatin with NAFLD. MATERIAL AND METHODS: The study included 114 NAFLD patients and 60 healthy non-diabetic controls. Plasma visfatin, adiponectin, tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) levels were measured by ELISA. High sensitive C-reactive protein (hsCRP) levels were measured by immunoturbidimetric fixed rate method. Insulin sensitivity determined by homeostasis model assessment (HOMA-IR) index. RESULTS: TNF-α, IL-6 and hsCRP levels were higher and, Adiponectin levels were lower in NAFLD group when compared to healthy controls (p < 0.001, for all). However, no difference was found regarding to visfatin levels between two groups. Different histologic subgroups of NAFLD had a significantly higher TNF-α, IL-6 and hsCRP, and lower adiponectin levels than those with controls (p < 0.001, for all). On the other hand, no statistically significant difference was found regarding to visfatin levels among different histologic groups. Visfatin was found to be negatively correlated with TNF-α (r = -0.236, p = 0.011) in NAFLD group. However, no association was found between visfatin and histological findings. CONCLUSION: Our findings show that plasma visfatin levels are not altered in the early stages of NAFLD. However, it is inversely associated with TNF-α. These findings suggest a role for visfatin in protection against liver injury in this widespread disease.
Sujet(s)
Cytokines/sang , Stéatose hépatique/sang , Hépatite/sang , Médiateurs de l'inflammation/sang , Inflammation/sang , Nicotinamide phosphoribosyltransferase/sang , Adiponectine/sang , Adulte , Analyse de variance , Marqueurs biologiques/sang , Biopsie , Protéine C-réactive/analyse , Études cas-témoins , Test ELISA , Stéatose hépatique/immunologie , Stéatose hépatique/anatomopathologie , Hépatite/immunologie , Hépatite/anatomopathologie , Humains , Inflammation/immunologie , Inflammation/anatomopathologie , Insuline/sang , Interleukine-6/sang , Foie/immunologie , Foie/anatomopathologie , Cirrhose du foie/sang , Cirrhose du foie/immunologie , Cirrhose du foie/anatomopathologie , Mâle , Adulte d'âge moyen , Néphélométrie et turbidimétrie , Stéatose hépatique non alcoolique , Facteur de nécrose tumorale alpha/sang , Jeune adulteRÉSUMÉ
Malignancies account for about 20% of incidentally diagnosed venous thromboembolism. Surgery- or chemotherapy-induced risk of thrombosis is also high in patients with cancer. We report on a young male with skeletal Ewing's sarcoma who presented with deep vein thrombosis in the affected limb, which is quite a rare clinical condition. Venous thrombosis of the lower extremities in young patients should prompt the clinician to search for underlying local malignancies.