Vertical distraction osteogenesis of frontal segment and platelet-rich plasma in the edentulous mandible.

In patients with atrophy of the alveolar ridge of classes V and VI according to Cawood and Howell, the distraction osteogenesis (DO) is the only possibility of reconstruction connected with subsequent dental implants. This method was introduced by Ilizarov (1989), a Russian doctor. In the past few years, the distraction devices have undergone several changes and technical improvements. The usage of platelet-rich plasma (PRP) and autologous bone-platelet gel (ABPG) serving as the source of growth factors is considered a significant progress. The increase in the level of growth factors leads to new bone formation and in soft tissues enhances the healing around the bone and bone wound, lowers the risk of postoperative complications such as pain, swelling and bleeding as well as enables fast placement of implants (Ref. 19).

Sjögren´s syndrome in present.

Sjögren´s syndrome is a systemic autoimmune disease characterized by a reduced function of exocrine glands, mainly salivary and lacrimal glands based on chronic plasmocellular infiltration. Syndrome includes affection of glands in gastrointestinal system, respiratory apparatus, skin, and vaginal mucosa. I tis described separately as a primary Sjögren´s syndrome or together with other inflammatory rheumatic diseases as a secondary Sjögren´s syndrome. Advanced diagnostic is based mainly on serologic examinations. Treatment of patients reflects the form of Sjögren´s syndrome. Despite recent knowledge the treatment is rather symptomatic than causal (Ref. 12).

Use of thrombocyte concentrates in treatment of bone defects.

The use of plasma enriched with thrombocytes is a trend in surgical treatment of bone defects (Platelet-rich plasma, thrombocyte concentrate, hereinafter PRP). It contains a set of identified as well as unknown growth factors. It is nontoxic, has no immunity reaction, accelerates and improves the healing of wounds. The increased level of growth factors leads to improved formation of new bone matter, and at the same time speeds up healing of soft tissues surrounding the bones. In addition, the presence of various factors mutually modulates and influences their functions. These functions are specific and differentiate the growth factors from recombinant growth factors, which are simple and focus just on one regenerating operation. PRP and ABPG (autologous bone-platelet gel) are used for augmentations in implantology, alveolar injuries with loss, treatment of parodontopathies, cleavages, and for osteodistraction of atrophic mandibles (Ref. 24).