Risk factors of paclitaxel-induced peripheral neuropathy in patients with breast cancer: a prospective cohort study.

Objective: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and severe adverse reaction in taxane-based chemotherapy. This study aimed to analyze the risk factors of peripheral neuropathy in patients with breast cancer receiving paclitaxel chemotherapy to provide a reference for the early prevention of CIPN. Methods: We included 350 patients with breast cancer who received chemotherapy for the first time at the Tangshan People's Hospital between August 2022 and June 2023 and were followed for at least 3 months after the end of chemotherapy. The incidence of CIPN in patients with breast cancer was calculated, and risk factors for CIPN were analyzed using logistic regression analysis. Results: The incidence rate of CIPN was 79.1%. Multifactor logistic regression analysis indicated that age ≥45 years [odds ratio (OR)=5.119, 95% confidence interval (CI)=1.395-18.780] and ≥60 years (OR=9.366, 95% CI=1.228-71.421), history of hypertension (OR=3.475, 95% CI=1.073-11.250), cumulative dose of chemotherapy drugs >900 mg (OR=4.842, 95% CI=1.961-5.946), vitamin D deficiency (OR=6.214, 95% CI=2.308-16.729), abnormal alanine aminotransferase (OR=3.154, 95% CI=1.010-9.844), anemia before chemotherapy (OR=2.770, 95% CI=1.093-7.019), infusion duration of chemotherapy drugs >30 min (OR=3.673, 95% CI=1.414-9.539), body mass index ≥24 kg/m2 (OR=8.139, 95% CI=1.157-57.240), mild depression (OR=4.546, 95% CI=1.358-15.223), and major depression (OR=4.455, 95% CI=1.237-16.037) increased the risk of CIPN. Having a regular caregiver (OR=0.223, 95% CI=0.087-0.573), high levels of physical activity (OR=0.071, 95% CI=0.008-0.647), and strong social support (OR=0.048, 95% CI=0.003-0.682) were protective factors against CIPN. Conclusion: Clinical attention should be paid to patients with these risk factors, and active and effective preventive measures should be taken to reduce the occurrence of CIPN and improve the quality of life.

Relationship between college students’ perceived stress and their suicidal ideation: multiple mediating effect of resilience and depression / 西安交通大学学报(医学版)

【Objective】 To explore the relationship between perceived stress and suicidal ideation as well as the mediating effect of resilience and depression. 【Methods】 A sample of 875 college students was recruited for the study to complete a set of self-report measures of Chinese Perceived Stress Scale (CPSS), the Resiliency Scale of University Students, Suicidal Ideation Questionnaire, and Beck Depression Inventory (BDI). 【Results】 ①College students’ perceived stress and depression had significantly positive correlation with their suicidal ideation, while the students’ resilience had a significantly negative correlation with their perceived stress and depression. ②Perceived stress did not affect suicidal ideation of the college students directly, but indirectly affected their suicidal ideation through three significant mediating pathways: the separate mediating effects of (a) resilience and (b) depression, and the serial mediating effect of (c) resilience and depression. 【Conclusion】 Resilience and depression exert a chain mediating effect between perceived stress and suicidal ideation of college students.