Analysis of Socio Demographic Risk Factors of Cervical Intraepithelial Neoplasia at Colposcopic Clinic in Mymensingh Medical College Hospital.

Cervical intraepithelial neoplasia (CIN) is a pre-malignant lesion of the cervix of uterus. Several risk factors increased the risk of developing CIN. Purpose of this study was to evaluate the socio-demographic risk factors related to CIN at our setting. This Cross sectional observational study was performed at Colposcopic clinic of Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh from 9th November 2017 to 8th May 2018. Overall demographic features of 50 patients of precancerous cervical lesion show that, most of the patients belonged to the age group 30-39 years (46.0%), mean age was 32.7±10.3 years. Maximum numbers of respondents came from rural area (58.0%), followed by urban area (42.0%). Among them house wife- 46.0%, daily worker- 30.0% and illiterate 36.0%, primary level of education 32.6%. Among the patients the poor class 46.0% and 58.0% of the respondents were married at age ≤19 year. Among the respondents, (26.0%) were conceived their first child 1 month after their marriage and 54.0% of the women within 12 months of marriage. In this study multipara were (62.0%). Oral contraceptive pill was taken by (42.0%) of patients. The association of risk factors revealed that betel or tobacco chewing present in 28.0% cases; history of menstrual regulation (MR), dilatation, evacuation and curettage (DE&C), miscarriage were in 26.0% cases, family history of cancer were in 16.0% cases and multiple sexual exposure was in 10.0% cases. Women develop pre-malignant cervical lesions require early treatment. It is recommended that provision of proper health care support, early detection of CIN and proper management, can reduce the fatal outcome of the disease.

First Cardiac Magnetic Resonance Experience in Bangladesh: A Case of Arrhythmogenic Right Ventricular Dysplasia.

Arrhythmogenic right ventricular dysplasia (ARVD) is a progressive degeneration and replacement of the right ventricular (RV) myocardial tissue by fat and fibrosis and produce clinical condition. Desmosome gene mutations are only the causative state for ARVD hereditary disorder. The arrhythmogenic right ventricular cardiomyopathy incidence is about 1/1000-5000. Mostly young people and athletes are bearing the clinical presentations include presyncope, syncope, ventricular tachycardias or ventricular fibrillation leading to cardiac arrest. We report about the first case of Cardiac magnetic resonance (CMR) imaging to diagnose a case Arrhythmogenic right ventricular dysplasia (ARVD) of a 34-year-old male from Savar, Dhaka, Bangladesh who was referred to cardiac emergency for the evaluation recurrent dizzy spells.

A preliminary dual-energy X-ray absorptiometry-based finite element model for assessing osteoporotic hip fracture risk.

To more accurately assess osteoporotic hip fracture risk in a specific patient, a dual-energy X-ray absorptiometry (DXA)-based finite element model was constructed from the patient's femur DXA image. The outermost contour of the femur bone segmented from the DXA image was used to generate a finite element mesh. Bone mechanical properties, such as Young's modulus, are correlated with areal bone mineral density (BMD) captured in the DXA image. A quasi-static loading condition representing a sideway fall was applied to the finite element model. Three fracture risk indices were introduced and expressed as ratios of internal forces caused by impact forces occurring in sideway fall to bone ultimate cross-section strength at the three critical locations, i.e. the femoral neck, the intertrochanteric region, and the subtrochanteric region. The proposed finite element modelling procedure was validated against six representative clinical cases extracted from the Manitoba BMD database, where initial and follow-up DXA images have been taken to monitor longitudinal variation of areal BMD in individual patients. It was found from the clinical validation that variations in the proposed fracture risk indices have the same trends as those indicated by the conventional areal BMD and T-score. In addition, by the three proposed fracture risk indices it is possible to further identify the specific fracture location. It was also found that for the same subject, the variations in the three fracture risk indices have quite different magnitudes, with intertrochanteric region the largest and subtrochanteric region the smallest, which is probably owing to the different content of trabecular and cortical bones in the three regions. With further development, it is promising that the proposed DXA-based finite element model will be a useful tool for accurate assessment of osteoporosis development and for treatment monitoring.

A role for decorin in controlling proliferation, adhesion, and migration of murine embryonic fibroblasts.

The proteoglycan decorin putatively inhibits cell adhesion and cell migration on various extracellular matrix substrates through interactions with beta(1) integrins. This study, therefore, examined the adhesive, migration, and proliferative characteristics of decorin knockout (Dcn(-/-)) murine embryonic fibroblasts compared to wild-type controls on collagen-coated, fibronectin-coated, and uncoated tissue culture plates. The Dcn(-/-) cells showed significantly greater proliferation than wild-type controls on all substrates. The Dcn(-/-) cells also showed significantly greater adhesion to both collagen and fibronectin; both cell types showed greater adhesion to collagen. The addition of exogenous decorin had a differential effect on adhesion to collagen between cell types, but not on fibronectin. For collagen, blocking either alpha(2) or beta(1) integrin subunits significantly reduced adhesion for Dcn(-/-) cells; whereas for fibronectin, blocking either the alpha(5) or beta(1) integrin subunits reduced adhesion for both cell types. Decorin and the alpha(5)beta(1) integrin may have lesser roles in adhesion to fibronectin than previously presumed. Finally, compared to wild-type cells, Dcn(-/-) cells showed greater migration on both uncoated and collagen substrates. This study demonstrates that decorin affects the biology of various integrins that participate in cell proliferation, adhesion, and migration on various substrates.

Studies on the nutritional status of expectant mothers and newborn babies.

Heights, weights, haemoglobin, total proteins and albumin-globulin (A/G) ratio of 157 pregnant women in their last trimester of pregnancy are reported along with heights, weights, haemoglobin and albumin-globulin ratio of newborn babies. The results have been discussed.

PIP: To explore the relationshop between maternal health status and infant vitality, selected physical, nutritional, and biochemical parameters were measured in 157 pregnant women and 71 newborn infants at the Azimpur Maternity Center in India. The pregnant women had a mean height of 150 cm anda mean weight of 47.5 kg. The 3rd-trimester hemoglobin level averaged 10.53% for women in their 1st pregnancy, 9.84% for 2nd pregnancies, 10.04% for 3rd pregnancies, and 10.36% for 4th pregnancies. Both average total protein and packed cell volume remained relatively constant with increases in parity. The prevalence of combined moderate and severe anemia was 42.8% for women in their 1st pregnancy, 48% for 2nd pregnancies, 42.9% for 3rd pregnancies, 41.2% for 4th pregnancies, 47% for 5th pregnancies, and 43.3% for women with 6 or more pregnancies. Overall, 66% of the women had hemoglobin levels below 11 gm% and could be considered anemic. The concentration of the severe cases of anemia in the 1st 3 pregnancies may reflect the early age of childbearing in this series (average age at 1st pregnancy, 18.2 years), forcing the fetus and mother to compete for nutrients. The increased incidence of anemia with increasing parity is attributed to the gradual drain on maternal nutritional reseves. Unusually high globulin fractions were recorded in these women, perhaps due to the superimposed evironmental infective factors common in India. The mean birth length among infants in the study was 47.6 cm for males and (3.02 kg for males and 3.08 kg for females) was significantly lower than Western standards, reflectinbg the low weight of Indian women. Mean hemoglobin and total protein levels among the infants were within normal limits.

The causal role of hypoalbuminemia in human nephrotic hyperlipidemia.

Serum lipids and their lipoprotein fractions were measured in 16 nephrotic syndrome patients. All component of lipids and beta-lipoprotein fractions (LDL) showed an increase in all uncomplicated patients. The increase in serum lipids were inversely proportional to the albumen level in these patients. In 3 patients, lipids and beta-lipoprotein fractions returned to near normal after treatment, the proteinuria diminished and serum albumen became normal. Most of these patients did not need any treatment for hyperlipidemia.