Handgrip exercise induces sex-specific mean arterial pressure and oxygenation responses but similar performance fatigability.

Women exhibit an attenuated exercise pressor reflex (EPR) when compared to men. The influence of sex-specific mechanisms related to the EPR and performance fatigability remain to be fully elucidated. The purpose was to determine the impact of oxygenation and metabolic efficiency on sex-specific performance fatigability and increases in mean arterial pressure (MAP) resulting from a fatiguing isometric handgrip (IHG). Twenty-four adults volunteered to perform an IHG at 25% at maximal voluntary isometric contractions (MVICs). Pre- and posttest MVICs were conducted to quantify performance fatigability. MAP was collected at 3 timepoints. A near-infrared spectroscopy device was attached to the forearm to derive the following signals: oxy[haem], deoxy[haem], total[haem], and diff[haem]. These values were normalized and examined across time in 5% segments of time-to-task-failure. Metabolic efficiency was defined as the ratio force:deoxy[haem]. During the IHG, there was a decline in oxy[haem] for the men (b = -0.075), whereas the women demonstrated an increase (b = 0.117). For the men, the diff[haem] tracked the mean oxy[haem] response, but there was no change for the women. The men exhibited greater declines in metabolic efficiency, yet there were no sex differences in PF (46.6 ± 9.7% vs. 45.5 ± 14.2%). For relative MAP, the men (24.5 ± 15.1%) exhibited a greater (p = .03) increase than the women (11.0 ± 17.6%). These results indicated the EPR was more prominent for the men, perhaps due to differences in mechanical stimuli and a lack of ability to maintain metabolic efficiency. However, these physiological differences did not induce a sex difference in performance fatigability.

The Influence of Motor Unit Number and Muscle Activation on Early Phase Rate of Torque Development in Younger and Older Men.

This study examined the influence of muscle activation and motor unit number estimation (MUNE) on early phase voluntary rate of torque development (RTD) in younger (YM) and older (OM) men. Thirty-two YM (n = 17; Age = 22 yrs) and OM (n = 15; Age = 74 yrs) volunteered to participate in this study. Early phase RTD (first 50 ms of a rapid isometric contraction; RTD50) and normalized surface electromyography (first 50 ms of muscle excitation; nEMG50) were recorded from the right quadricep muscle group. MUNE was examined from the right vastus lateralis. Multiple linear regression analyses revealed that nEMG50 had a significant effect on RTD50 independent of age group (p ≤ 0.001). nEMG50 had a significant effect on RTD50 in the OM group (p = 0.037). MUNE had no effect on RTD50 independent of age. Older adults may depend more on muscle activation at contraction onset of early phase RTD compared to younger adults.