RÉSUMÉ
Intra-abdominal fibromatosis (IAF), usually located at the mesenteric level, is a locally invasive tumor of fibrous origin. Although lacking the ability to metastasize, it has the tendency to recur. The case described here is a case of mesenteric fibromatosis with involvement of the bowel wall, which had the appearance of a gastrointestinal stromal tumor (GIST), a tumor with malignant behavior. This report outlines the fact that certain non-typical cases of IAF with involvement of the bowel wall can be misdiagnosed as GIST. It is of outmost importance to make an early and correct diagnosis in such equivocal cases, so that the appropriate treatment can be closed.
Sujet(s)
Fibrome/diagnostic , Tumeurs gastro-intestinales/diagnostic , Tumeurs stromales gastro-intestinales/diagnostic , Tumeurs du jéjunum/diagnostic , Tumeurs du péritoine/diagnostic , Diagnostic différentiel , Fibrome/chirurgie , Tumeurs gastro-intestinales/anatomopathologie , Tumeurs stromales gastro-intestinales/anatomopathologie , Humains , Tumeurs du jéjunum/chirurgie , Mâle , Mésentère , Adulte d'âge moyen , Invasion tumorale , Tumeurs du péritoine/chirurgieRÉSUMÉ
PURPOSE: In this study we investigated the relationship between specific HLA antigens and sporadic pancreatic cancer in Greek population. METHODS: The allele frequencies of serologically and molecular defined class I and II HLA antigens were studied in 60 unrelated patients with pancreatic cancer histologically confirmed. The results obtained for HLA frequencies were compared with those of 105 healthy control subjects (control group). RESULTS: Increased frequencies of HLA-A30 (16.7 vs. 3.8%; P < 0.01; OR = 5.05), A31 (9.5 vs. 1.9%; P < 0.05; OR = 5.72), B18 (31.7 vs. 14.3%; P < 0.05; OR = 2.78) and Cw7 (53.3 vs. 21.9%; P < 0.01; OR = 4.07) were observed in patients with pancreatic cancer in comparison to the control subjects. CONCLUSIONS: This study demonstrates the association between specific HLA antigens and pancreatic cancer development in whites and suggests a genetic susceptibility factor for the disease.
Sujet(s)
Antigènes néoplasiques/analyse , Antigènes HLA/analyse , Tumeurs du pancréas/génétique , Sujet âgé , Sujet âgé de 80 ans ou plus , Alcoolisme/épidémiologie , Antigènes néoplasiques/génétique , Comorbidité , Diabète de type 2/épidémiologie , Femelle , Fréquence d'allèle , Gènes MHC de classe I , Gènes MHC de classe II , Marqueurs génétiques , Prédisposition génétique à une maladie , Génotype , Grèce/épidémiologie , Antigènes HLA/génétique , Antigènes HLA-A/analyse , Antigènes HLA-A/génétique , Antigènes HLA-B/analyse , Antigènes HLA-B/génétique , Antigène HLA-B18 , Antigènes HLA-C/analyse , Antigènes HLA-C/génétique , Test d'histocompatibilité , Humains , Mâle , Adulte d'âge moyen , Tumeurs du pancréas/épidémiologie , Tumeurs du pancréas/immunologie , /génétiqueRÉSUMÉ
The purpose of this article is to present the spectrum of vascular disease accompanying Behçet's disease. Four cases of the disease with various vascular manifestations are presented. In the first case superior vena cava syndrome due to thrombosis was the presenting symptom. In the second case foot ischemia with toe necrosis was prevalent. In the third case the patient developed recurrent aneurysmal disease in large and medium size arteries requiring successive vascular surgery, and in the fourth case the patient had SVC thrombosis and ruptured femoral aneurysm. All four patients were young males. Although vascular complications of Behçet disease are uncommon they may pose serious therapeutic problems.