Pierre Robin Sequence: An Updated Evidence-Based Treatment Proposal.

BACKGROUND: The Pierre Robin sequence (PRS) is characterized by the presence of micrognathia, glossoptosis, and respiratory obstruction during the neonatal period, its prompt recognition allows to mitigate the associated morbidity and mortality. A diagnosis and treatment algorithm was previously proposed based on data from the literature to guide therapeutic efforts; therefore, it was proposed to carry out a new search for relevant evidence to update or complement it. METHODS: A literature review of the subject was conducted in PubMed, Embase, and Cochrane databases, corresponding to the period between November 2016 and September 2021. Using the GRADE methodology, 38 articles from different clinical studies that discussed diagnostic tests or therapeutic approaches, directly or indirectly compared, were selected and evaluated. RESULTS: After evaluating and analyzing the selected articles, the new information was incorporated into an updated algorithm according to the most recent evidence found for the diagnosis and comprehensive management of patients with PRS. CONCLUSION: To date, there is no consensus in the literature on the treatment of patients with PRS nor are there multicenter studies comparing different management modalities. The indications to proceed with surgical strategies do not present changes with respect to the previous article. Nutritional monitoring is the main objective, and the study of oral feeding is essential in all scenarios.

Impact of social marginalization on oral health-related quality of life in older adults.

The aim of this study was to determine the association between oral health-related quality of life (OHRQoL) and social marginalization in people aged 60 years and older enrolled in social security in Mexico. A cross-sectional and analytical study was carried out in older adults. To assess the OHRQoL, the OHIP-14 instrument was applied, and the degree of social marginalization and sociodemographic characteristics were analyzed. Measures of central tendency and dispersion, simple frequencies and proportions were estimated. Student's t-test was used for comparison of means, and prevalence ratio (PR) and logistic regression were used to assess associations, all with a significance value of 0.05 and 95% confidence intervals. Perceived OHRQoL in the population measured through the OHIP-14 reached an average value of 9.84 ± 8.91, with the highest value in the dimension of physical pain (2.06 ± 1.91). Perceived treatment need was higher among people with social marginality (p = 0.011). The multivariate analysis shows that marginalized people have a lower OHRQoL. Socially marginalized older adults showed a low a better perception of OHRQoL, independent of demographic and clinical factors.

Inequalities in diabetes mortality in Mexico: 2010-2019.

BACKGROUND: The impact of diabetes mellitus has been shown to be differentially expressed between social groups. OBJECTIVE: To estimate inequality gaps in diabetes mellitus mortality through absolute and relative measures according to geographic distribution and social conditions. MATERIAL AND METHODS: Diabetes mellitus-related deaths recorded in Mexico between 2010 and 2019 were analyzed, and inequality measurements at the state level were calculated by gender. RESULTS: National age-adjusted diabetes mellitus mortality rate showed an increase during the study period. CONCLUSION: The inequalities present in diabetes mortality should be considered for the design of health strategies.

ANTECEDENTES: Se ha demostrado que el impacto de la diabetes mellitus se expresa de manera diferenciada entre los grupos sociales. OBJETIVO: Estimar las brechas en la desigualdad en la mortalidad por diabetes mellitus a través de medidas absolutas y relativas según distribución geográfica y condiciones sociales. MATERIAL Y MÉTODOS: Se analizaron las muertes registradas en México por diabetes mellitus entre 2010 y 2019 y se calcularon las mediciones de desigualdad a nivel estatal por sexo. RESULTADOS: La tasa de mortalidad nacional por diabetes mellitus ajustada por edad mostró un incremento durante el periodo estudiado. CONCLUSIÓN: Las desigualdades presentes en la mortalidad por diabetes deben considerarse para el diseño de estrategias de salud.

Desigualdades en la mortalidad por diabetes en México: 2010-2019 / Inequalities in diabetes mortality in Mexico: 2010-2019

Resumen Antecedentes: Se ha demostrado que el impacto de la diabetes mellitus se expresa de manera diferenciada entre los grupos sociales. Objetivo: Estimar las brechas en la desigualdad en la mortalidad por diabetes mellitus a través de medidas absolutas y relativas según distribución geográfica y condiciones sociales. Material y métodos: Se analizaron las muertes registradas en México por diabetes mellitus entre 2010 y 2019 y se calcularon las mediciones de desigualdad a nivel estatal por sexo. Resultados: La tasa de mortalidad nacional por diabetes mellitus ajustada por edad mostró un incremento durante el periodo estudiado. Conclusión: Las desigualdades presentes en la mortalidad por diabetes deben considerarse para el diseño de estrategias de salud.

Abstract Background: The impact of diabetes mellitus has been shown to be differentially expressed between social groups. Objective: To estimate inequality gaps in diabetes mellitus mortality through absolute and relative measures according to geographic distribution and social conditions. Material and methods: Diabetes mellitus-related deaths recorded in Mexico between 2010 and 2019 were analyzed, and inequality measurements at the state level were calculated by gender. Results: National age-adjusted diabetes mellitus mortality rate showed an increase during the study period. Conclusion: The inequalities present in diabetes mortality should be considered for the design of health strategies.

[Inequalities in diabetes mortality in Mexico: 2010-2019]. / Desigualdades en la mortalidad por diabetes en México: 2010-2019.

Background: The impact of diabetes mellitus has been shown to be differentially expressed between social groups. Objective: To estimate inequality gaps in diabetes mellitus mortality through absolute and relative measures according to geographic distribution and social conditions. Material and methods: Diabetes mellitus-related deaths recorded in Mexico between 2010 and 2019 were analyzed, and inequality measurements at the state level were calculated by gender. Results: National age-adjusted diabetes mellitus mortality rate showed an increase during the study period. Conclusion: The inequalities present in diabetes mortality should be considered for the design of health strategies.

Antecedentes: Se ha demostrado que el impacto de la diabetes mellitus se expresa de manera diferenciada entre los grupos sociales. Objetivo: Estimar las brechas en la desigualdad en la mortalidad por diabetes mellitus a través de medidas absolutas y relativas según distribución geográfica y condiciones sociales. Material y métodos: Se analizaron las muertes registradas en México por diabetes mellitus entre 2010 y 2019 y se calcularon las mediciones de desigualdad a nivel estatal por sexo. Resultados: La tasa de mortalidad nacional por diabetes mellitus ajustada por edad mostró un incremento durante el periodo estudiado. Conclusión: Las desigualdades presentes en la mortalidad por diabetes deben considerarse para el diseño de estrategias de salud.

Impact of social marginalization on oral health-related quality of life in older adults

Abstract The aim of this study was to determine the association between oral health-related quality of life (OHRQoL) and social marginalization in people aged 60 years and older enrolled in social security in Mexico. A cross-sectional and analytical study was carried out in older adults. To assess the OHRQoL, the OHIP-14 instrument was applied, and the degree of social marginalization and sociodemographic characteristics were analyzed. Measures of central tendency and dispersion, simple frequencies and proportions were estimated. Student's t-test was used for comparison of means, and prevalence ratio (PR) and logistic regression were used to assess associations, all with a significance value of 0.05 and 95% confidence intervals. Perceived OHRQoL in the population measured through the OHIP-14 reached an average value of 9.84 ± 8.91, with the highest value in the dimension of physical pain (2.06 ± 1.91). Perceived treatment need was higher among people with social marginality (p = 0.011). The multivariate analysis shows that marginalized people have a lower OHRQoL. Socially marginalized older adults showed a low a better perception of OHRQoL, independent of demographic and clinical factors.

Vulnerability of access to health services for informal workers in Mexico in the face of the SARS-CoV-2 pandemic. / Vulnerabilidad al acceso a los servicios de salud de los trabajadores informales en México ante la pandemia por SARS-CoV-2.

This critical-reflective essay problematizes the labor dynamics in the framework of informality considered as a determinant for access to the health system in Mexico and discusses the vulnerability of workers to the pandemic caused by the SARS-CoV-2 virus. This analysis aims to contribute to the construction of proposals aimed at improving the lives of male and female workers by guaranteeing their right to health.

El presente ensayo critico-reflexivo problematiza las dinámicas laborales en el marco de la informalidad considerado como un determinante para acceso al sistema de salud en México y discute la vulnerabilidad de los trabajadores ante la pandemia por el virus SARS-CoV-2. El presente trabajo pretende contribuir en la visibilización del problema para motivar la construcción en propuestas que contribuyan a mejorar la vida de trabajadores y trabajadoras garantizando su derecho a la salud.

Vulnerabilidad al acceso a los servicios de salud de los trabajadores informales en México ante la pandemia por SARS-CoV-2 / Vulnerability of access to health services for informal workers in Mexico in the face of the SARS-CoV-2 pandemic

Resumen El presente ensayo critico-reflexivo problematiza las dinámicas laborales en el marco de la informalidad considerado como un determinante para acceso al sistema de salud en México y discute la vulnerabilidad de los trabajadores ante la pandemia por el virus SARS-CoV-2. El presente trabajo pretende contribuir en la visibilización del problema para motivar la construcción en propuestas que contribuyan a mejorar la vida de trabajadores y trabajadoras garantizando su derecho a la salud.

Abstract This critical-reflective essay problematizes the labor dynamics in the framework of informality considered as a determinant for access to the health system in Mexico and discusses the vulnerability of workers to the pandemic caused by the SARS-CoV-2 virus. This analysis aims to contribute to the construction of proposals aimed at improving the lives of male and female workers by guaranteeing their right to health.

Survival of Vascular Accesses in Chronic Hemodialysis Patients.

BACKGROUND/AIMS: Vascular access (VA) is the highest risk factor for blood infections, hospitalization, and mortality of patients undergoing hemodialysis (HD). The risk of mortality while using a catheter is greater than that while using grafts. The objective of this article is to know the survival rate in relation to the type of VA. METHODS: A retrospective cohort of HD patients was studied. The data gathered included age, gender, first VA at the surrogate site, days between the first and second access, number of accesses, and anatomical site of VA placement. Mean differences were estimated using χ2 or Student's t test. Survival was calculated using the Kaplan-Meier curves and included in tables. Statistical significance was established as p < 0.05. The statistical computer software package SPSSw v25 was used for the analysis. RESULTS: A total of 896 patients were included with a mean age of 47.88 years (SD ± 16.52), the duration of the first VA was 398.81 days (±565.79), the mean number of VAs used was 2.26 (±1.15), and the median time undergoing HD was 728.73 days. The duration of catheter placement was 330.42 days, and 728.60 days for fistula use (p = 0.001). The mean number of days of renal replacement was 611.59 days for catheter and 1,495.25 days for internal arteriovenous fistula (IAVF) patients (p = 0.001). CONCLUSIONS: The survival of the initial VA is greater for the IAVF, followed by the tunneled catheters and the lowest by the non-tunneled catheters, which continue to be frequently used in our setting.

Hypertension, Diabetes and Obesity, Major Risk Factors for Death in Patients with COVID-19 in Mexico.

BACKGROUND: Mexico has reported high death and case fatality rates due to COVID-19. Several comorbidities have been related to mortality in COVID-19, as hypertension, diabetes, coronary heart disease, chronic obstructive lung disease and chronic kidney disease. AIMS: To describe the main clinical characteristics of COVID-19 in the major social security institution in Mexico, as well as the contribution of chronic comorbidities and the population attributable fraction related to them. METHODS: Data for all patients with a positive test for SARS-CoV-2 in the institutional database was included for analysis. Demographic information, the presence of pneumonia and whether the patient was hospitalized or treated at home as an outpatient as well as comorbidities were analyzed. Case fatality rate was estimated for different groups. Odds ratios with 95% confidence intervals from a logistic regression model were estimated, as well as the population attributable fraction. RESULTS: By November 13, 2020, 323,671 subjects with COVID-19 infection have been identified. Case fatality rate is higher in males (20.2%), than in females (13.0%), and increases with age. Case fatality rate increased with the presence of obesity, hypertension and/or diabetes. Age and sex were major independent risk factors for mortality, as well as the presence of pneumonia, diabetes, hypertension, obesity, immunosuppression, and end-stage kidney disease. The population attributable fraction due to obesity in outpatients was 16.8%. CONCLUSIONS: Major cardiovascular risk factors and other comorbidities increase the risk of dying in patients with COVID-19. Identification of populations with high fatality in COVID-19, provides insight to deal with this pandemic by health services in Mexico.

Keystone flap: a safe coverage option in the handling of salvage for myelomeningocele.

BACKGROUND: Myelomeningocele (MMC) is the most common and severe pathology of open spina bifida compatible with life. Its early closure is an urgent therapeutic objective to reduce the morbidity and mortality of neonates, being a surgical challenge with two major objectives: (1) achieve closure of the dural cerebrum-spinal fluid fistula and (2) ensure a stable and durable soft tissue coverage. The use of fasciocutaneous flaps in keystone design is shown as a safe and stable surgical option with excellent aesthetic results in patients with MMC and who presented failed primary closures. METHODS: Two clinical cases of fasciocutaneous flaps in keystone design were described as a coverage option in patients with lumbosacral MMC, in whom the primary closure was unsuccessful and required a safe coverage as a priority. RESULTS: Successful coverage of the lumbosacral defect was performed using keystone flaps in neonatal patients with MMC and previous manipulation of the soft tissues when attempting primary closure, but they have had dehiscence of the wound, with a large area of lumbosacral defect and sizeable defect/back ratio. CONCLUSIONS: The use of keystone flaps is a useful, accessible, and versatile technique as a management option for lumbosacral coverage defects in MMC, achieving a stable and safe covering of the meninges, without cerebrum-spinal fluid fistulas, which also allows the primary closure of the soft tissues in the donor area. The safety of this type of flap when used as salvage in lumbosacral defects with previously handled and raised tissues could infer that it is reliable enough to be considered as a first surgical option in the initial management of MMC.

Association of antepartum depression, generalized anxiety, and posttraumatic stress disorder with infant birth weight and gestational age at delivery.

BACKGROUND: Low- and middle-income countries bear a disproportionate burden of preterm birth (PTB) and low infant birth weight (LBW) complications where affective and anxiety disorders are more common in the antepartum period than in industrialized countries. OBJECTIVE: To evaluate the extent to which early pregnancy antepartum depression, generalized anxiety disorder, and posttraumatic stress disorder (PTSD) are associated with infant birth weight and gestational age at delivery among a cohort of pregnant women in Peru. METHODS: Our prospective cohort study consisted of 4408 pregnant women. Antepartum depression, generalized anxiety, and PTSD were assessed in early pregnancy using the Patient Health Questionnaire-9, Generalized Anxiety Disorder Scale-7 and PTSD Checklist - Civilian Version, respectively. Pregnancy outcome data were obtained from medical records. Multivariable linear and logistic regression procedures were used to estimate adjusted measures of association (ß coefficients and odds ratios) and 95% confidence intervals (CI). RESULTS: After adjusting for confounders, women with antepartum generalized anxiety (32.6% prevalence) had higher odds of LBW (adjusted odds ratio (OR)=1.47; 95%CI: 1.10-1.95) and were more likely to deliver small for gestational age (OR = 1.39; 95%CI: 1.01-1.92) infants compared to those without anxiety. Compared to those without PTSD, women with PTSD (34.5%) had higher odds of delivering preterm (OR = 1.28; 95%CI: 1.00-1.65) yet PTSD was not associated with LBW nor gestational age at delivery. Women with antepartum depression (26.2%) were at no increased risk of delivering a preterm, low-birth-weight or small-for-gestational-age infant. LIMITATIONS: Our ability to make casual inferences from this observational study is limited; however, these findings are consistent with prior studies. CONCLUSION: Generalized anxiety disorder during pregnancy appeared to increase odds of delivering a low-birth-weight or small-for-gestational-age infant, while PTSD was associated with increased odds of delivering preterm. Our findings, and those of others, suggest antenatal care should be tailored to screen for and provide additional mental health services to patients.

Homicidios en jóvenes y desigualdades sociales en México, 2017

[RESUMEN]. Objetivo. Conocer la asociación entre las condiciones sociales y económicas y las tasas de homicidios en jóvenes de 10 a 24 años de edad en México en 2017. Métodos. En este estudio ecológico se estudiaron las desigualdades sociales asociadas con los homicidios en la población de 10 a 24 años en 2017 en México a través de fuentes secundarias de información, correspondientes a las defunciones por homicidio por entidad federativa en México. Las desigualdades sociales en salud se estudiaron mediante la medición absoluta y relativa de las brechas de desigualdad y se estimaron razones de prevalencias de mortalidad con modelos de regresión de Poisson. Resultados. En 2017 se produjeron 8 094 homicidios en la población joven, que fueron más frecuentes en hombres (86,7%). Las brechas de desigualdad entre los estados fueron importantes. La desocupación de la población de mayores de 12 años, los hogares conformados por personas que no son familiares, la baja asistencia escolar y el ingreso por debajo de la línea de bienestar se asociaron de manera significativa con las tasas de homicidios. Conclusiones. La asociación de los determinantes sociales con los homicidios en la población estudiada es fuerte. Deben implementarse políticas y acciones intersectoriales que puedan ayudar a reducir las brechas de desigualdad y lograr mejores condiciones de vida y niveles de bienestar y salud de las personas y sus comunidades.

[ABSTRACT]. Objective. Assess the association between social and economic conditions and homicide rates in young people between 10 and 24 years of age in Mexico in 2017. Methods. This ecological study looked at the social inequalities associated with homicides in the population 10-24-year-old population in 2017 in Mexico, using secondary data sources for deaths by homicide in each Mexican state. Social inequalities in health were studied by measuring absolute and relative inequality gaps. Mortality rates were estimated using Poisson regression models. Results. In 2017, there were 8,094 homicides in the target population, predominantly in men (86.7%). There was high variance in inequality between states. Unemployment in the population over 12 years of age, households composed of people who are not family members, low school attendance rates, and income below the poverty line showed significant association with homicide rates. Conclusions. There is a strong association between social determinants and homicides in the study population. Policies and intersectoral actions should be implemented to help bridge inequality gaps and achieve better living conditions and higher levels of well-being and health for people and their communities.

[RESUMO]. Objetivo. Descrever a associação entre as condições socioeconômicas e as taxas de homicídios em jovens entre 10 e 24 anos no México em 2017. Métodos. Neste estudo ecológico foram examinadas as desigualdades sociais associadas aos homicídios na população entre 10 e 24 anos no México em 2017 com base em dados obtidos de fontes de informação secundárias relativos a mortes por homicídio por entidade federativa. As desigualdades sociais em saúde foram avaliadas com a mensuração absoluta e relativa das lacunas de desigualdade. As razões de prevalências de mortalidade foram estimadas com modelos de regressão de Poisson. Resultados. Em 2017, houve 8.094 homicídios na população jovem, com predomínio no sexo masculino (86,7%). As lacunas de desigualdade entre os estados foram significativas. Ociosidade juvenil (em maiores de 12 anos), domicílios constituídos por pessoas sem laços de parentesco, baixa frequência escolar e renda abaixo da linha do bem-estar foram fatores que tiveram uma associação significativa com as taxas de homicídios. Conclusões. Observou-se uma forte associação entre os determinantes sociais e os homicídios na população estudada. Políticas e ações intersetoriais devem ser implementadas para ajudar a reduzir as lacunas de desigualdade e melhorar as condições de vida, o nível de bem-estar e a saúde das pessoas e suas comunidades.

[The informality of labor and the right to health in Mexico: a critical analysis]. / Informalidad laboral y derecho a la salud en México, un análisis crítico.

In light of the labor conditions defined within the framework of neoliberalism implemented in Mexico, labor dynamics are problematized, the main problems of access to the health and social security system are identified and the systematic violation of rights - especially the right to work, to social security and to health - are discussed. The objective of this article is to contribute with proposals for the construction of a comprehensive, inclusive, healthcare and social security system that contributes to the improvement of the lives of workers.

Frente a las condiciones de trabajo definidas en el marco del neoliberalismo implementado en México, se problematiza las dinámicas laborales, identifica los principales problemas de acceso al sistema de salud y de seguridad social y discute la vulneración sistemática de derechos, principalmente del derecho al trabajo, a la seguridad social y a la salud. Se propone contribuir con propuestas para la construcción de un sistema de salud y seguridad social integral, incluyente y solidario que coadyuve a mejorar la vida de trabajadores y trabajadoras.

Informalidad laboral y derecho a la salud en México, un análisis crítico / The informality of labor and the right to health in Mexico: a critical analysis

Resumen Frente a las condiciones de trabajo definidas en el marco del neoliberalismo implementado en México, se problematiza las dinámicas laborales, identifica los principales problemas de acceso al sistema de salud y de seguridad social y discute la vulneración sistemática de derechos, principalmente del derecho al trabajo, a la seguridad social y a la salud. Se propone contribuir con propuestas para la construcción de un sistema de salud y seguridad social integral, incluyente y solidario que coadyuve a mejorar la vida de trabajadores y trabajadoras.

Abstract In light of the labor conditions defined within the framework of neoliberalism implemented in Mexico, labor dynamics are problematized, the main problems of access to the health and social security system are identified and the systematic violation of rights - especially the right to work, to social security and to health - are discussed. The objective of this article is to contribute with proposals for the construction of a comprehensive, inclusive, healthcare and social security system that contributes to the improvement of the lives of workers.

Keystone Flap: Overcoming Paradigms.

BACKGROUND: The physiology and geometry of the keystone flap (KF) are the main factors that support its development. This study reports our experience using the KF and proposes the concept of pedicular area. METHODS: A prospective cohort study was conducted from October 2014 to December 2016, in which 112 KF procedures were performed with an average follow-up time of 10 months. The conclusions drawn from clinical observations were compared with the findings of a literature review. RESULTS: One hundred twelve flaps were performed in 89 patients (45 men and 44 women) with an average age of 64 years (range, 3-89 years). The flap survival rate was 100%. The term pedicular area (PA) was coined to describe a flap segment that remains attached to its bed without vascular detriment and whose location can be randomly selected. In this study, the PA could be reduced up to a 10%, which means that over 90% of each flap was dissected without any harm. CONCLUSIONS: The KF is a safe, cost-effective technique with better results when compared with other reconstructive procedures. Although research is still needed to better understand the physiological adaptations of KF, the clinical evidence supports its use in many reconstructive scenarios.

[Homicides in young people and social inequalities in Mexico, 2017Homicídios em jovens e desigualdades sociais no México, 2017]. / Homicidios en jóvenes y desigualdades sociales en México, 2017.

OBJECTIVE: Assess the association between social and economic conditions and homicide rates in young people between 10 and 24 years of age in Mexico in 2017. METHODS: This ecological study looked at the social inequalities associated with homicides in the population 10-24-year-old population in 2017 in Mexico, using secondary data sources for deaths by homicide in each Mexican state. Social inequalities in health were studied by measuring absolute and relative inequality gaps. Mortality rates were estimated using Poisson regression models. RESULTS: In 2017, there were 8,094 homicides in the target population, predominantly in men (86.7%). There was high variance in inequality between states. Unemployment in the population over 12 years of age, households composed of people who are not family members, low school attendance rates, and income below the poverty line showed significant association with homicide rates. CONCLUSIONS: There is a strong association between social determinants and homicides in the study population. Policies and intersectoral actions should be implemented to help bridge inequality gaps and achieve better living conditions and higher levels of well-being and health for people and their communities.

OBJETIVO: Descrever a associação entre as condições socioeconômicas e as taxas de homicídios em jovens entre 10 e 24 anos no México em 2017. MÉTODOS: Neste estudo ecológico foram examinadas as desigualdades sociais associadas aos homicídios na população entre 10 e 24 anos no México em 2017 com base em dados obtidos de fontes de informação secundárias relativos a mortes por homicídio por entidade federativa. As desigualdades sociais em saúde foram avaliadas com a mensuração absoluta e relativa das lacunas de desigualdade. As razões de prevalências de mortalidade foram estimadas com modelos de regressão de Poisson. RESULTADOS: Em 2017, houve 8.094 homicídios na população jovem, com predomínio no sexo masculino (86,7%). As lacunas de desigualdade entre os estados foram significativas. Ociosidade juvenil (em maiores de 12 anos), domicílios constituídos por pessoas sem laços de parentesco, baixa frequência escolar e renda abaixo da linha do bem-estar foram fatores que tiveram uma associação significativa com as taxas de homicídios. CONCLUSÕES: Observou-se uma forte associação entre os determinantes sociais e os homicídios na população estudada. Políticas e ações intersetoriais devem ser implementadas para ajudar a reduzir as lacunas de desigualdade e melhorar as condições de vida, o nível de bem-estar e a saúde das pessoas e suas comunidades.