1.
J Antimicrob Chemother
; 40(6): 903-6, 1997 Dec.
Article
de Anglais
| MEDLINE
| ID: mdl-9462447
RÉSUMÉ
Serum cefuroxime concentrations were measured over a 12 h period in ten healthy adults following three iv dosing regimens: 750 mg cefuroxime, 1.5 g cefuroxime, and 750 mg cefuroxime with 1 g of probenecid given orally 3 h before the cefuroxime infusion. Probenecid prolonged the serum cefuroxime half-life by 63% (P < 0.05) with a significant increase in the mean time for which serum cefuroxime concentrations exceeded the MIC90 for common respiratory pathogens (2 mg/L) compared with either 750 mg cefuroxime (2.2 h, P < 0.05) or 1.5 g of cefuroxime (0.9 h, P < 0.05) without probenecid. The cost of the 750 mg cefuroxime dose plus probenecid is approximately half that of a 1.5 g cefuroxime dose.
Sujet(s)
Céfuroxime/pharmacocinétique , Céphalosporines/pharmacocinétique , Probénécide/pharmacologie , Agents rénaux/pharmacologie , Adolescent , Adulte , Aire sous la courbe , Biodisponibilité , Interactions médicamenteuses , Femelle , Période , Humains , Mâle , Taux de clairance métabolique , Adulte d'âge moyen , Probénécide/administration et posologie
2.
Ann Pharmacother
; 28(9): 1109, 1994 Sep.
Article
de Anglais
| MEDLINE
| ID: mdl-7803891