Cobb Syndrome Associated with Spinal Cavernoma ­ Case Report / Síndrome de Cobb associada a cavernoma medular ­ Relato de caso

Cobb syndrome, or cutaneomeningospinal angiomatosis, is a rare condition that affects young adults, and its etiology has not been completely elucidated. It is characterized by a cutaneous sign, or stigma, associated with spinal or intracranial malformations. The symptoms are quite diverse, but, in most cases, the disease presents motor deficit and pain. The present study reports the case of a 48-year-old female patient, who initially sought dermatological medical care for a single skin lesion in the posterior cervical region. During the excision, it was noticed that the lesion had contiguous behavior to the deep anatomical planes, thus requiring the evaluation of the neurosurgical team. The purpose of this report is to describe this rare disease, covering more details about diagnosis and therapy.

Síndrome de Cobb, ou angiomatose cutâneo-meningo-espinhal, é uma condição rara que afeta adultos jovens, e sua etiologia não foi completamente elucidada. Caracterizase por um sinal cutâneo, ou estigma, associado a malformações espinhais ou intracranianas. Os sintomas são bastante diversos, mas, na maioria dos casos, a doença apresenta déficit motor e dor. O presente estudo relata o caso de uma paciente do sexo feminino de 48 anos, que inicialmente procurou atendimento médico dermatológico para uma única lesão cutânea na região cervical posterior. Durante a excisão, notou-se que a lesão apresentava comportamento contíguo aos planos anatômicos profundos, exigindo assim a avaliação da equipe neurocirúrgica. O objetivo deste relatório é descrever essa doença rara, abrangendo mais detalhes sobre diagnóstico e terapia.

Brain Tuberculoma as a Differential Diagnosis of Single Intracranial Lesion: Case Report

Tuberculosis (TB) of the central nervous system (CNS) is considered one of the most severe forms of presentation of the disease. Although only 1% of TB cases involve the CNS, these cases represent around between 5 and 15% of extrapulmonary forms.1,2 Tuberculous meningitis (TBM) is the most frequent form of CNS TB. The granulomas formed in the cerebral tuberculoma may cause hydrocephalus and other symptoms indicative of a CNS mass lesion. In the absence of active TB or TBM, the symptoms may be interpreted as indicative of tumors.3,4 The prognosis is directly related to the early diagnosis and proper treatment installation.5 We report the case of a patient with intracranial hypertension syndrome, expansive mass in the parieto-occipital region, accompanied by a lesion in the rib, initially thought to be a metastatic lesion, although posteriorly diagnosed as a cerebral tuberculoma.