Trypanosoma cruzi Infection in Pregnancies without Congenital Transmission Is Associated with Reduced Fetal Growth: A Cross-Sectional Study in Argentina, Honduras, and Mexico.

We aimed to measure the association between Trypanosoma cruzi infection in pregnancy and reduced fetal growth in the absence of T. cruzi congenital transmission. We conducted a cross-sectional study of secondary data of all singleton live births between 2011 and 2013 in five hospitals from Argentina, Honduras, and Mexico. We excluded newborns with T. cruzi infection. Noninfected pregnant people were those without any positive rapid tests. The main study outcomes were birth weight, head circumference, and length for gestational age and sex. Logistic regression models were adjusted for country, age, education level, and obstetric history. Of the 26,544 deliveries, 459 (1.7%) pregnant people were found by rapid tests to be positive for T. cruzi. Of these, 320 were positive by enzyme-linked immunosorbent assay and 231 had a positive polymerase chain reaction (PCR) test. Uninfected newborns from T. cruzi-infected pregnant people were more likely to have birth weights below the 5th and 10th percentiles and head circumferences below the 3rd and 10th percentiles. Among T. cruzi-infected pregnant people diagnosed by PCR, the odds ratios were 1.58 for birth weight below the 10th percentile (95% CI, 1.12-2.23) and 1.57 for birth weight below the 5th percentile (95% CI, 1.02-2.42). Higher T. cruzi parasitic loads in pregnancy had a stronger association with reduced fetal growth (both in birth weight and head circumference), with an odds ratio of 2.31 (95% CI, 1.36-3.91) for a birth weight below the 5th percentile. The association shows, irrespective of causality, that newborns of pregnancies with T. cruzi have an increased risk of reduced fetal growth. We recommend further studies to assess other potential confounders and the causality of these associations.

Humidity and temperature preference in two Neotropical species of sand flies.

BACKGROUND: Arthropods vector a multitude of human disease-causing organisms, and their geographic ranges are shifting rapidly in response to changing climatic conditions. This is, in turn, altering the landscape of disease risk for human populations that are brought into novel contact with the vectors and the diseases they carry. Sand flies in the genera Lutzomyia and Pintomyia are vectors of serious disease-causing agents such as Leishmania (the etiological agent of leishmaniasis) and may be expanding their range in the face of climate change. Understanding the climatic conditions that vector species both tolerate physiologically and prefer behaviorally is critical to predicting the direction and magnitude of range expansions and the resulting impacts on human health. Temperature and humidity are key factors that determine the geographic extent of many arthropods, including vector species. METHODS: We characterized the habitat of two species of sand flies, Lutzomyia longipalpis and Pintomyia evansi. Additionally, we studied two behavioral factors of thermal fitness-thermal and humidity preference in two species of sand flies alongside a key aspect of physiological tolerance-desiccation resistance. RESULTS: We found that Lu. longipalpis is found at cooler and drier conditions than Pi. evansi. Our results also show significant interspecific differences in both behavioral traits, with Pi. evansi preferring warmer, more humid conditions than Lu. longipalpis. Finally, we found that Lu. longipalpis shows greater tolerance to extreme low humidity, and that this is especially pronounced in males of the species. CONCLUSIONS: Taken together, our results suggest that temperature and humidity conditions are key aspects of the climatic niche of Lutzomyia and Pintomyia sand flies and underscore the value of integrative studies of climatic tolerance and preference in vector biology.

Comparative analysis of Spodoptera frugiperda (J. E. Smith) (Lepidoptera, Noctuidae) corn and rice strains microbiota revealed minor changes across life cycle and strain endosymbiont association.

Background: Spodoptera frugiperda (FAW) is a pest that poses a significant threat to corn production worldwide, causing millions of dollars in losses. The species has evolved into two strains (corn and rice) that differ in their genetics, reproductive isolation, and resistance to insecticides and Bacillus thuringiensis endotoxins. The microbiota plays an important role in insects' physiology, nutrient acquisition, and response to chemical and biological controls. Several studies have been carried out on FAW microbiota from larvae guts using laboratory or field samples and a couple of studies have analyzed the corn strain microbiota across its life cycle. This investigation reveals the first comparison between corn strain (CS) and rice strain (RS) of FAW during different developmental insect stages and, more importantly, endosymbiont detection in both strains, highlighting the importance of studying both FAW populations and samples from different stages. Methods: The composition of microbiota during the life cycle of the FAW corn and rice strains was analyzed through high-throughput sequencing of the bacterial 16S rRNA gene using the MiSeq system. Additionally, culture-dependent techniques were used to isolate gut bacteria and the Transcribed Internal Spacer-ITS, 16S rRNA, and gyrB genes were examined to enhance bacterial identification. Results: Richness, diversity, and bacterial composition changed significantly across the life cycle of FAW. Most diversity was observed in eggs and males. Differences in gut microbiota diversity between CS and RS were minor. However, Leuconostoc, A2, Klebsiella, Lachnoclostridium, Spiroplasma, and Mucispirilum were mainly associated with RS and Colidextribacter, Pelomonas, Weissella, and Arsenophonus to CS, suggesting that FAW strains differ in several genera according to the host plant. Firmicutes and Proteobacteria were the dominant phyla during FAW metamorphosis. Illeobacterium, Ralstonia, and Burkholderia exhibited similar abundancies in both strains. Enterococcus was identified as a conserved taxon across the entire FAW life cycle. Microbiota core communities mainly consisted of Enterococcus and Illeobacterium. A positive correlation was found between Spiroplasma with RS (sampled from eggs, larvae, pupae, and adults) and Arsenophonus (sampled from eggs, larvae, and adults) with CS. Enterococcus mundtii was predominant in all developmental stages. Previous studies have suggested its importance in FAW response to B. thuringensis. Our results are relevant for the characterization of FAW corn and rice strains microbiota to develop new strategies for their control. Detection of Arsenophonus in CS and Spiroplasma in RS are promising for the improvement of this pest management, as these bacteria induce male killing and larvae fitness reduction in other Lepidoptera species.

Enhancing pectin extraction from orange peel through citric acid-assisted optimization based on a dual response.

Pectin is widely used in several products in the industry. Conventionally, strong and harmful acids are used for its extraction. This study optimized the extraction of orange peel's pectin using citric acid, considering yield and degree of esterification (DE) as response variables. Proximal analyses were performed, and the samples were subjected to a Box-Behnken design on three central points, considering as variables the temperature, time, and pH. The results of proximate analyses of the orange peels revealed 11.76 % moisture content, 87.26 % volatiles, 0.09 % ash, 50.45 % soluble carbohydrates, 70.60 % total carbohydrates, 0.89 % fixed carbon, 5.35 % lipids, and 36.75 mg GAE/g of phenolic compounds. The resulting second-order polynomial model described the relation of the input and output variables related to each other. The best performance to obtain a higher yield (18.18 %) of high methoxyl pectin (DE 50 %) was set at 100 °C/30 min/pH 2.48. Pectin showed antioxidant properties by ABTS and DPPH assays and similar thermal properties to the commercial polymer. Its equivalent weight was 1219.51 mol/g, and the methoxyl and anhydrouronic acid were 2.23 and 67.10 %, respectively. Hence, pectin extraction with citric acid results in a high-quality polymer and could be used as a gelling agent, stabilizer, or texturizer in food products.

Novel species of Triatoma (Hemiptera: Reduviidae) identified in a case of vectorial transmission of Chagas disease in northern Belize.

Chagas disease is a leading cause of non-ischemic cardiomyopathy in endemic regions of Central and South America. In Belize, Triatoma dimidiata sensu lato has been identified as the predominate taxon but vectorial transmission of Chagas disease is considered to be rare in the country. We recently identified an acute case of vector-borne Chagas disease in the northern region of Belize. Here we present a subsequent investigation of triatomines collected around the case-patient's home. We identified yet undescribed species, closely related to Triatoma huehuetenanguensis vector by molecular systematics methods occurring in the peridomestic environment. The identification of a T. cruzi-positive, novel species of Triatoma in Belize indicates an increased risk of transmission to humans in the region and warrants expanded surveillance and further investigation.

Genome-Wide Association Studies (GWAS) Approaches for the Detection of Genetic Variants Associated with Antibiotic Resistance: A Systematic Review.

Antibiotic resistance is a significant threat to public health worldwide. Genome-wide association studies (GWAS) have emerged as a powerful tool to identify genetic variants associated with this antibiotic resistance. By analyzing large datasets of bacterial genomes, GWAS can provide valuable insights into the resistance mechanisms and facilitate the discovery of new drug targets. The present study aimed to undertake a systematic review of different GWAS approaches used for detecting genetic variants associated with antibiotic resistance. We comprehensively searched the PubMed and Scopus databases to identify relevant studies published from 2013 to February 2023. A total of 40 studies met our inclusion criteria. These studies explored a wide range of bacterial species, antibiotics, and study designs. Notably, most of the studies were centered around human pathogens such as Mycobacterium tuberculosis, Escherichia coli, Neisseria gonorrhoeae, and Staphylococcus aureus. The review seeks to explore the several GWAS approaches utilized to investigate the genetic mechanisms associated with antibiotic resistance. Furthermore, it examines the contributions of GWAS approaches in identifying resistance-associated genetic variants through binary and continuous phenotypes. Overall, GWAS holds great potential to enhance our understanding of bacterial resistance and improve strategies to combat infectious diseases.

Estrés e Inteligencia Emocional en Adultos Mayores de Ciudad Chihuahua, Chihuahua, México / Stress and Emotional Intelligence in Older Adults in Chihuahua, Chihuahua, Mexico

Resumen Objetivo: Conocer la relación que existe entre la Inteligencia Emocional y los Eventos Estresantes de la Vida en los Adultos Mayores. Materiales y Métodos: Estudio descriptivo correlacional realizado en 95 participantes de Chihuahua, Chihuahua, México. Se aplicó una Cedula de Datos Personales, la Escala de Meta-Estado de Ánimo y el Inventario de Estrés en la Vida de Adultos Mayores. Resultados: El 64.2% de los participantes pertenecieron al sexo femenino, los eventos que más experimentaron los AM en el último año fueron la presencia de una lesión o enfermedad en el Adulto Mayor (67.4%), el no poder realizar actividades que disfrutaba mucho (65.3%) y la muerte de un miembro cercano a la familia (63.8%). No se encontró relación significativa entre la Inteligencia Emocional y los Eventos Estresantes de la Vida en los Adultos Mayores (rs = -.06, p = .56), sin embargo, se realizó en análisis con cada uno de los eventos y los resultados mostraron que la Inteligencia Emocional se relacionó de forma positiva con la muerte de un miembro cercano a la familia (rs = .65, p = .05), la alteración en la salud de algún miembro en la familia (rs = .54, p = .05), el no poder realizar actividades que disfrutaba (rs = .54, p = .05). Conclusiones: La experiencia repetida de los Eventos Estresantes de la Vida pueden impactar de forma negativa la salud del Adulto Mayor, se requiere de más estudios que permitan identificar como la IE puede ayudar al Adulto Mayor a enfrentar estos eventos.

Abstract Objective: To know the relationship that exists between Emotional Intelligence and Stressful Life Events in Older Adults. Materials and Methods: Correlational descriptive study, in 95 participants from Chihuahua, Chihuahua, Mexico. A Personal Data Record, the MetaMood Scale and the Stress Inventory in the Life of Older Adults were applied. Results: 64.2% of the participants were females, the events that the elderly experienced the most in the last year were the presence of an injury or illness in the Elderly (67.4%), not being able to carry out activities that they enjoyed a lot (65.3%) and the death of a close family member (63.8%). No significant relationship was found between Emotional Intelligence and Stressful Life Events in Older Adults (rs = -.06, p = .56), however, an analysis was carried out with each one of the events and the results showed that Emotional Intelligence was positively related to the death of a close family member (rs = .65, p = .05), the alteration in the health of a family member (rs = .54, p = .05), not being able to do activities they enjoyed (rs = .54, p = .05). Conclusions: The repeated experience of Stressful Life Events can negatively impact the health of the Elderly, more studies are required to identify how Emotional Intelligence can help the Elderly to face these events.

Magnetic and Viscoelastic Response of Magnetorheological Elastomers Based on a Combination of Iron Nano- and Microparticles.

In this paper, we discuss the creation of a hybrid magnetorheological elastomer that combines nano- and microparticles. The mixture contained 45 wt.% fillers, with combinations of either 0% nanoparticles and 100% microparticles or 25% nanoparticles and 75% microparticles. TGA and FTIR testing confirmed the materials' thermal and chemical stability, while an SEM analysis determined the particles' size and morphology. XRD results were used to determine the crystal size of both nano- and microparticles. The addition of reinforcing particles, particularly nanoparticles, enhanced the stiffness of the composite materials studied, but their overall strength was only minimally affected. The computed interaction parameter relative to the volume fraction was consistent with the previous literature. Furthermore, the study observed a magnetic response increment in composite materials reinforced with nanoparticles above 30 Hz. The isotropic material containing only microparticles had a lower storage modulus than the isotropic sample with nanoparticles without a magnetic field. However, when a magnetic field was applied, the material with only microparticles exhibited a higher storage modulus than the samples with nanoparticles.

Modeling the Ultrasonic Micro-Injection Molding Process Using the Buckingham Pi Theorem.

Dimensional analysis through the Buckingham Pi theorem was confirmed as an efficient mathematical tool to model the otherwise non-linear high order ultrasonic micro-injection molding process (UMIM). Several combinations of processing conditions were evaluated to obtain experimental measurements and validate the derived equations. UMIM processing parameters, output variable energy consumption, and final specimen's Young modulus were arranged in dimensionless groups and formulated as functional relationships, which lead to dimensionless equations that predict output variables as a function of the user-specified processing parameters and known material properties.

Microbiome analysis of Spodoptera frugiperda (Lepidoptera, Noctuidae) larvae exposed to Bacillus thuringiensis (Bt) endotoxins.

Background: Spodoptera frugiperda (or fall armyworm, FAW) is a polyphagous pest native to Western Hemisphere and recently discovered in the Eastern Hemisphere. In Colombia, S. frugiperda is recognized as a pest of economic importance in corn. The species has genetically differentiated into two host populations named "corn" and "rice" strains. In 2012, a study made in central Colombia demonstrated that the corn strain is less susceptible to Bacillus thuringiensis (Bt) endotoxins (Cry1Ac and Cry 1Ab) than the rice strain. In this country, Bt transgenic corn has been extensively produced over the last 15 years. Since gut microbiota plays a role in the physiology and immunity of insects, and has been implicated in promoting the insecticidal activity of Bt, in this study an analysis of the interaction between Bt endotoxins and FAW gut microbiota was made. Also, the detection of endosymbionts was performed here, as they might have important implications in the biological control of a pest. Methods: The composition and diversity of microbiomes associated with larval specimens of S. frugiperda(corn strain) was investigated in a bioassay based on six treatments in the presence/absence of Bt toxins and antibiotics (Ab) through bacterial isolate analyses and by high throughput sequencing of the bacterial 16S rRNA gene. Additionally, species specific primers were used, to detect endosymbionts from gonads in S. frugiperda corn strain. Results: Firmicutes, Proteobacteria and Bacteroidota were the most dominant bacterial phyla found in S. frugiperda corn strain. No significant differences in bacteria species diversity and richness among the six treatments were found. Two species of Enterococcus spp., E. mundtii and E. casseliflavus were detected in treatments with Bt and antibiotics, suggesting that they are less susceptible to both of them. Additionally, the endosymbiont Arsenophonus was also identified on treatments in presence of Bt and antibiotics. The results obtained here are important since little knowledge exists about the gut microbiota on this pest and its interaction with Bt endotoxins. Previous studies made in Lepidoptera suggest that alteration of gut microbiota can be used to improve the management of pest populations, demonstrating the relevance of the results obtained in this work.

Percepción de riesgo y religiosidad en el consumo de marihuana en adolescentes de zonas marginales / Perception of risk and religiosity in the consumption of marijuana in adolescents from marginal áreas

Resumen Objetivo: Describir el efecto de la percepción de riesgo y la religiosidad sobre el consumo de marihuana en adolescentes de zonas marginales del Estado de Chihuahua, Chihuahua. Materiales y métodos: Estudio descriptivo correlacional. El muestreo fue probabilístico aleatorio simple. La muestra final fue de 248 adolescentes de 12 a 17 años de zonas marginales de Chihuahua. Se utilizó una cédula de datos personales, inventario de religiosidad y la escala de percepción de riesgo. Resultados: El 59.3% de los adolescentes entrevistados fueron hombres, 59.7% católico y 23% cristiano. El 16.1% indicó consumo de marihuana alguna vez en la vida y 6.5% en el último año. El modelo de regresión logística de las variables de religiosidad y percepción de riesgo mostró una varianza explicada del 19% para el consumo de marihuana alguna vez en la vida, destacando que a mayor percepción de riesgo (β=-0.032, p<0.001) y mayor índice de religiosidad (β=-0.023, p<0.001) menor es la probabilidad del consumo de marihuana. Conclusiones: La percepción de riesgo y la religiosidad en adolescentes de zonas marginales muestran ser factores protectores para el consumo de marihuana. Estos resultados deben ser considerados en programas de prevención para el consumo de drogas en poblaciones marginales.

Abstract Objective: To describe the effect of the perception of risk and religiosity on the consumption of marijuana in adolescents from marginal areas of the State of Chihuahua, Chihuahua. Materials and methods: Study descriptive correlational design. The sampling was simple random probabilistic. The final sample consisted of 248 adolescents between the ages of 12 and 17 from marginal areas of Chihuahua. A personal data card, religiosity inventory and the risk perception scale were used. Results: 59.3% of the adolescents interviewed were men, of whom 59.7% said they were Catholic and 23% Christian. 16.1% indicated marijuana use at some time in their life, and 6.5% in the last year. The logistic regression model of the religiosity and risk perception variables showed an explained variance of 19% for marijuana use at some time in life, highlighting that the higher the risk perception (β=-0.032, p<.001) and a higher religiosity index (β=-0.023, p<0.001), the lower the probability of marijuana use. Conclusions: Risk perception and religiosity in adolescents from marginal areas show to be protective factors for marijuana use. These results should be analyzed in greater depth to be considered in prevention programs for drug use in marginal populations.

Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process.

In recent years, there has been a growing demand for biocompatible medical devices on the microscale. However, the manufacturing of certain microfeatures has posed a significant challenge. To address this limitation, a new process called ultrasonic injection molding or ultrasonic molding (USM) has emerged as a potential solution. In this study, we focused on the production of a specific microdevice known as Hem-O-Lok, which is designed for ligation and tissue repair during laparoscopic surgery. Utilizing USM technology, we successfully manufactured the microdevice using a nonabsorbable biopolymer that offers the necessary flexibility for easy handling and use. To ensure high-quality microdevices, we extensively investigated various processing parameters such as vibration amplitude, temperature, and injection velocity. Through careful experimentation, we determined that the microdevice achieved optimal quality when manufactured under conditions of maximum vibrational amplitude and temperatures of 50 and 60 °C. This conclusion was supported by measurements of critical microfeatures. Additionally, our materials characterization efforts revealed the presence of a carbonyl (C=O) group resulting from the thermo-oxidation of air in the plasticizing chamber. This finding contributes to the enhanced thermal stability of the microdevices within a temperature range of 429-437 °C.

Características de las lesiones retinianas en pacientes con diagnóstico de Toxoplasmosis ocular que acuden a un centro de referencia en oftalmología en Paraguay

Introducción: La toxoplasmosis es una enfermedad parasitaria, en América Latina la prevalencia es relativamente alta, se sabe que la enfermedad no solo es la causa más frecuente de uveítis posterior, sino también la causa principal de la uveítis en sí misma. En Paraguay no se dispone de datos epidemiológicos publicados sobre la misma. Objetivo: Determinar las características de las lesiones retinianas en pacientes con diagnóstico de Toxoplasmosis ocular. Metodología: El presente estudio es observacional, descriptivo, de corte transversal, temporalmente retrospectivo, con muestreo no probabilístico de casos consecutivos. Se enfocó en pacientes con diagnóstico de Toxoplasmosis que acudieron al servicio de Oftalmología del Hospital de Clínicas, durante el periodo de junio de 2020 a febrero 2022. Resultados: Se observó un 54,3 % de mujeres, una media de 30,62 +/- 12,96 años y un 62,8 % de procedencia urbana. El 88,3 % de los casos fueron unilaterales, la mitad de episodios primarios, el 93,6 % casos agudos, y el 97,9 % tuvo un mecanismo de trasmisión adquirido. La mayoría se presentó como Panuveítis, las localizaciones más frecuentes de las lesiones retinocoroideas fueron el Polo posterior (extramacular) y la periferia. El principal abordaje terapéutico fue el tratamiento con Trimetoprim Sulfametoxazol y corticoides sistémicos, la duración del tratamiento fue de 6,51 +/- 1,52 semanas, y las principales complicaciones fueron la Vitritis residual y la Hipertensión ocular. Discusión: La toxoplasmosis ocular es una causa importante de morbilidad visual. Se hace fundamental la prevención de la infección por este parásito mediante medidas higiénico-sanitarias, así como el diagnóstico y tratamiento precoz de los pacientes infectados, de tal manera a disminuir las complicaciones asociadas a esta patología.

Introduction: Toxoplasmosis is a parasitic disease, in Latin America the prevalence is relatively high, it is known that the disease is not only the most frequent cause of posterior uveitis, but also the main cause of uveitis itself. In Paraguay there are no published epidemiological data on it. Objective: To determine the characteristics of retinal lesions in patients diagnosed with ocular Toxoplasmosis. Methods: This study is observational, descriptive, cross-sectional, temporally retrospective, with non-probabilistic sampling of consecutive cases. It focused on patients diagnosed with Toxoplasmosis who attended the Ophthalmology service of the Hospital de Clínicas, during the period from June 2020 to February 2022. Results: 54.3% of women were observed, an average of 30.62 +/ - 12.96 years old and 62.8% of urban origin. 88.3% of the cases were unilateral, half were primary episodes, 93.6% acute cases, and 97.9% had an acquired transmission mechanism. Most presented as panuveitis, the most frequent locations of retinochoroidal lesions were the posterior pole (extramacular) and the periphery. The main therapeutic approach was treatment with trimethoprim sulfamethoxazole and systemic corticosteroids, the duration of treatment was 6.51 +/- 1.52 weeks, and the main complications were residual vitritis and ocular hypertension. Discussion: Ocular toxoplasmosis is an important cause of visual morbidity. It is essential to prevent infection by this parasite through hygienic-sanitary measures, as well as early diagnosis and treatment of infected patients, in order to reduce the complications associated with this pathology.

Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances "Take a Village".

Purpose of Review: Review international efforts to build a global public health initiative focused on toxoplasmosis with spillover benefits to save lives, sight, cognition and motor function benefiting maternal and child health. Recent Findings: Multiple countries' efforts to eliminate toxoplasmosis demonstrate progress and context for this review and new work. Summary: Problems with potential solutions proposed include accessibility of accurate, inexpensive diagnostic testing, pre-natal screening and facilitating tools, missed and delayed neonatal diagnosis, restricted access, high costs, delays in obtaining medicines emergently, delayed insurance pre-approvals and high medicare copays taking considerable physician time and effort, harmful shortcuts being taken in methods to prepare medicines in settings where access is restricted, reluctance to perform ventriculoperitoneal shunts promptly when needed without recognition of potential benefit, access to resources for care, especially for marginalized populations, and limited use of recent advances in management of neurologic and retinal disease which can lead to good outcomes. Supplementary Information: The online version contains supplementary material available at 10.1007/s40124-022-00268-x.

Malnutrición por exceso, alteraciones de salud mental y autoconcepto en población infanto-juvenil: revisión integrativa / Malnutrition due to excess, mental health disorders and self-concept in children and adolescents: an integrative review / Desnutrição por excesso, transtornos mentais e autoconceito em crianças e adolescentes: uma revisão integrativa

Introducción: Tanto la malnutrición por exceso como enfermedades de salud mental han afectado a los jóvenes y se ha buscado conocer cómo repercuten entre sí. El objetivo de esta revisión fue determinar si la malnutrición por exceso afecta la salud mental y/o el autoconcepto de la población infanto-juvenil. Material y método: Se realizó una revisión integrativa de la literatura en el período comprendido entre los años 2016 a 2021 a través de las bases de datos: PubMed, LILACS y EBSCO. Se identificaron 3.985 artículos de forma inicial, en donde sólo 9 cumplían criterios de inclusión y exclusión, dentro de los cuales destaca la disponibilidad del texto completo de forma gratuita o mediante las bases de datos de la Universidad Nacional Andrés Bello. Resultados: Los niños/adolescentes diagnosticados con problemas de malnutrición por exceso experimentan dificultades psicosociales por su autopercepción, dependiendo no sólo de su condición física, sino también de factores socioeconómicos, familiares y sociales, estableciéndose una relación directa bidireccional. Discusión: A partir de la primera infancia se adquieren ciertas pautas de comportamiento y aprendizajes que guían las conductas de cada individuo, dentro de estas pautas se encuentran los estereotipos de género, estándares de belleza implantados por la sociedad y medios de comunicación, estos se encuentran directamente relacionados con los problemas de autopercepción y autoestima presentes en la población infanto-juvenil, afectando en mayor porcentaje al género femenino. Conclusión: Los profesionales de Enfermería deben intervenir desde temprana edad en la promoción y prevención de la salud física y mental en la población infanto-juvenil.

Introduction: Both malnutrition due to excess and mental health diseases have affected young people and it has been sought to know how they affect each other. The objective of this review was to determine if malnutrition due to excess affects the mental health and/or self-concept of the child and adolescent population. Material and method: An integrative review of the literature was carried out in the period between 2016 and 2021 through the databases: PubMed, LILACS and EBSCO. Initially, 3,985 articles were identified, where only 9 met inclusion and exclusion criteria, among which the availability of the full text for free or through the databases of the Universidad Nacional Andrés Bello stands out. Results: Children/adolescents diagnosed with problems of malnutrition due to excess experience psychosocial difficulties due to their self-perception, depending not only on their physical condition, but also on socioeconomic, family and social factors, establishing a direct bidirectional relationship. Discussion: From early childhood certain patterns of behavior and learning are acquired that guide the behavior of each individual, within these guidelines are gender stereotypes, beauty standards implemented by society and the media, these are directly related to the problems of self-perception and self-esteem present in the child-juvenile population, affecting the female gender in a greater percentage. Conclusion: Nursing professionals should intervene from an early age in the promotion and prevention of physical and mental health in the child and adolescent population.

Introdução: Tanto a desnutrição por excesso quanto as doenças de saúde mental têm afetado os jovens e tem-se procurado saber como elas afetam umas às outras. O objetivo desta revisão foi de-terminar se a desnutrição por excesso afeta a saúde mental e/ou autoconceito da população infantil e adolescente. Material e método: Foi realizada uma revisão integrativa da literatura no período entre 2016 e 2021 por meio das bases de dados: PubMed, LILACS e EBSCO. Inicialmente, foram identificados 3.985 artigos, onde apenas 9 atenderam aos critérios de inclusão e exclusão, dentre os quais se destaca a disponibilização do texto completo gratuitamente ou por meio das bases de dados da Universidade Nacional Andrés Bello. Resultados: As crianças/adolescentes diagnostica-das com problemas de desnutrição por excesso vivenciam dificuldades psicossociais devido à sua autopercepção, dependendo não apenas de sua condição física, mas também de fatores socioeconômicos, familiares e sociais, estabelecendo uma relação direta bidirecional. Discussão: Desde a primeira infância são adquiridos determinados padrões de comportamento e aprendizagem que orientam o comportamento de cada indivíduo, dentro dessas diretrizes estão os estereótipos de gênero, padrões de beleza implementados pela sociedade e pela mídia, estes estão diretamente relacionados aos problemas de autopercepção e autoconhecimento presente na população infanto-juvenil, afetando em maior percentual o gênero feminino. Conclusão: Os profissionais de enfermagem devem intervir desde cedo na promoção e prevenção da saúde física e mental da população infanto-juvenil.

Influence of Epoxy Resin Curing Kinetics on the Mechanical Properties of Carbon Fiber Composites.

In this study, the kinetic parameters belonging to the cross-linking process of a modified epoxy resin, Aerotuf 275-34™, were investigated. Resin curing kinetics are crucial to understanding the structure-property-processing relationship for manufacturing high-performance carbon-fiber-reinforced polymer composites (CFRPCs). The parameters were obtained using differential scanning calorimetry (DSC) measurements and the Flynn-Wall-Ozawa, Kissinger, Borchardt-Daniels, and Friedman approaches. The DSC thermograms show two exothermic peaks that were deconvoluted as two separate reactions that follow autocatalytic models. Furthermore, the mechanical properties of produced carbon fiber/Aerotuf 275-34™ laminates using thermosetting polymers such as epoxies, phenolics, and cyanate esters were evaluated as a function of the conversion degree, and a close correlation was found between the degree of curing and the ultimate tensile strength (UTS). We found that when the composite material is cured at 160 °C for 15 min, it reaches a conversion degree of 0.97 and a UTS value that accounts for 95% of the maximum value obtained at 200 °C (180 MPa). Thus, the application of such processing conditions could be enough to achieve good mechanical properties of the composite laminates. These results suggest the possibility for the development of strategies towards manufacturing high-performance materials based on the modified epoxy resin (Aerotuf 275-34™) through the curing process.

Building Programs to Eradicate Toxoplasmosis Part II: Education.

Purpose of Review: Review work to create and evaluate educational materials that could serve as a primary prevention strategy to help both providers and patients in Panama, Colombia, and the USA reduce disease burden of Toxoplasma infections. Recent Findings: Educational programs had not been evaluated for efficacy in Panama, USA, or Colombia. Summary: Educational programs for high school students, pregnant women, medical students and professionals, scientists, and lay personnel were created. In most settings, short-term effects were evaluated. In Panama, Colombia, and USA, all materials showed short-term utility in transmitting information to learners. These educational materials can serve as a component of larger public health programs to lower disease burden from congenital toxoplasmosis. Future priorities include conducting robust longitudinal studies of whether education correlates with reduced adverse disease outcomes, modifying educational materials as new information regarding region-specific risk factors is discovered, and ensuring materials are widely accessible.

Effect of Single-Walled Carbon Nanotubes on the Cross-Linking Process in Natural Rubber Vulcanization.

In this study, the effect of single-walled carbon nanotubes (SWCNTs) on the cross-linking of natural rubber (NR) using organic peroxides was investigated. NR-SWCNTs nanocomposites were prepared in an open two-roller mill followed by vulcanization with the compression molding process. Three different organic peroxides, 1,1-bis(tert-butylperoxy)-3,3,5-trimethylcyclohexane (T29), dicumyl peroxide (DCP), and 2,5-bis(tert-butylperoxy)-2,5-dimethyl-3-hexyne (T145), were used as vulcanizing agents. SWCNTs promote a remarkable reduction in the vulcanization time and increase the degree of cross-linking of vulcanized rubber when compared with neat or natural rubber-carbon-black composites; the same tendency was obtained in the NR-SWCNTs vulcanized with sulfur. Additionally, the mechanical performance of the NR-SWCNTs composites was significantly improved up to 75, 83, 27, and 10% for tensile strength, moduli, tear strength, and hardness. Raman spectroscopy studies evidence the occurrence of reaction between nanotube walls and free radicals generated from using organic peroxides during the vulcanization process. These results demonstrate that the incorporation of SWCNTs in combination with the use of organic peroxides for the NR vulcanization represents a potential alternative for the improvement of the physicochemical properties of NR composites.

Building Programs to Eradicate Toxoplasmosis Part III: Epidemiology and Risk Factors.

Purpose of Review: Review comprehensive data on rates of toxoplasmosis in Panama and Colombia. Recent Findings: Samples and data sets from Panama and Colombia, that facilitated estimates regarding seroprevalence of antibodies to Toxoplasma and risk factors, were reviewed. Summary: Screening maps, seroprevalence maps, and risk factor mathematical models were devised based on these data. Studies in Ciudad de Panamá estimated seroprevalence at between 22 and 44%. Consistent relationships were found between higher prevalence rates and factors such as poverty and proximity to water sources. Prenatal screening rates for anti-Toxoplasma antibodies were variable, despite existence of a screening law. Heat maps showed a correlation between proximity to bodies of water and overall Toxoplasma seroprevalence. Spatial epidemiological maps and mathematical models identify specific regions that could most benefit from comprehensive, preventive healthcare campaigns related to congenital toxoplasmosis and Toxoplasma infection.

Molecular phylogeny of heritable symbionts and microbiota diversity analysis in phlebotominae sand flies and Culex nigripalpus from Colombia.

BACKGROUND: Secondary symbionts of insects include a range of bacteria and fungi that perform various functional roles on their hosts, such as fitness, tolerance to heat stress, susceptibility to insecticides and effects on reproduction. These endosymbionts could have the potential to shape microbial communites and high potential to develop strategies for mosquito-borne disease control. METHODOLOGY/PRINCIPAL FINDINGS: The relative frequency and molecular phylogeny of Wolbachia, Microsporidia and Cardinium were determined of phlebotomine sand flies and mosquitoes in two regions from Colombia. Illumina Miseq using the 16S rRNA gene as a biomarker was conducted to examine the microbiota. Different percentages of natural infection by Wolbachia, Cardinium, and Microsporidia in phlebotomines and mosquitoes were detected. Phylogenetic analysis of Wolbachia shows putative new strains of Lutzomyia gomezi (wLgom), Brumptomyia hamata (wBrham), and a putative new group associated with Culex nigripalpus (Cnig) from the Andean region, located in Supergroup A and Supergroup B, respectively. The sequences of Microsporidia were obtained of Pi. pia and Cx. nigripalpus, which are located on phylogeny in the IV clade (terrestrial origin). The Cardinium of Tr. triramula and Ps. shannoni were located in group C next to Culicoides sequences while Cardinium of Mi. cayennensis formed two putative new subgroups of Cardinium in group A. In total were obtained 550 bacterial amplicon sequence variants (ASVs) and 189 taxa to the genus level. The microbiota profiles of Sand flies and mosquitoes showed mainly at the phylum level to Proteobacteria (67.6%), Firmicutes (17.9%) and Actinobacteria (7.4%). High percentages of relative abundance for Wolbachia (30%-83%) in Lu. gomezi, Ev. dubitans, Mi. micropyga, Br. hamata, and Cx. nigripalpus were found. ASVs assigned as Microsporidia were found in greater abundance in Pi. pia (23%) and Cx. nigripalpus (11%). An important finding is the detection of Rickettsia in Pi. pia (58,8%) and Bartonella sp. in Cx. nigripalpus. CONCLUSIONS/SIGNIFICANCE: We found that Wolbachia infection significantly decreased the alpha diversity and negatively impacts the number of taxa on sand flies and Culex nigripalpus. The Principal Coordinate Analysis (PCoA) is consistent, which showed statistically significant differences (PERMANOVA, F = 2.4744; R2 = 0.18363; p-value = 0.007) between the microbiota of sand flies and mosquitoes depending on its origin, host and possibly for the abundance of some endosymbionts (Wolbachia, Rickettsia).