Cadinane sesquiterpenoids, strobilols L and M, from Strobilurus ohshimae.

Strobilols L and M, which are cadinane sesquiterpene derivatives, were isolated from the liquid culture of the edible mushroom Strobilurus ohshimae. Their structures have been established on the basis of spectral analyses. Strobilols A-M were examined for their growth inhibition activity against human cancer cell lines YMB and COLO 201.

Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246.

Pyrrospirones A and B have been isolated from unpolished rice cultures of the endophytic fungus Neonectria ramulariae Wollenw KS-246. Their absolute stereostructures (1 and 2) were elucidated through spectroscopic methods using 1D and 2D NMR techniques and chemical transformations, including the modified Mosher's method. The compounds exhibited cytotoxicity and induced apoptosis in human promyelocytic leukemia HL-60 cells.

Two cyathane-type diterpenoids from the liquid culture of Strobilurus tenacellus.

The structures of two new cyathane-type diterpenoids isolated from a liquid culture of Strobilurus tenacellus have been elucidated. The chemical structures of the new compounds 1 and 2 were identified as (12S)-11alpha,14alpha-epoxy-13alpha,14beta,15-trihydroxycyath-3-ene and (12R)-11alpha,14alpha-epoxy-13alpha,14beta,15-trihydroxycyath-3-ene, respectively, by spectral methods, including HR-EI-MS, and 1D- and 2D-NMR techniques. Compounds 1 and 2 show antimicrobial activity against Pseudomonas aeruginosa. In addition, both compounds were also tested for activity against human cancer cells, and 2 showed growth inhibitory activity against YMB and COLO 201 cells.

A new secolactarane-type sesquiterpene from Strobilurus tephanocystis.

A new sesquiterpenoid, strobiluric acid has isolated from the liquid culture extract of the fungus Strobilurus stephanocystis together with seven known sesquiterpenoids. Their structures were established based on spectroscopic data.

Strobilols A-D: four cadinane-type sesquiterpenes from the edible mushroom Strobilurus ohshimae.

Four sesquiterpenoids--strobilols A (1), B (2), C (3), and D (4)--were isolated from the organic extracts of fruiting bodies of the edible mushroom Strobilurus ohshimae. Their structures were determined by spectroscopic methods. Compound 1 exhibited moderate activity against the brine shrimp Artemia salina. This paper is the first report on isolation of cadinane-type sesquiterpenoids from S. ohshimae.

Isolation and structure elucidation of neofusapyrone from a marine-derived Fusarium species, and structural revision of fusapyrone and deoxyfusapyrone.

Three polyketides containing a pyrone ring, neofusapyrone, fusapyrone, and deoxyfusapyrone, were isolated from the marine-derived fungus Fusarium sp. FH-146. Their structures were determined by extensive ID- and 2D-NMR and MS spectral analyses. Fusapyrone and deoxyfusapyrone were originally reported as a-pyrone derivatives; however, the revised structures indicate that they are gamma-pyrone derivatives. These three compounds exhibited antimicrobial activities.