Lung Cancer Radiotherapy: Simulation and Analysis Based on a Multicomponent Mathematical Model.

BACKGROUND: Lung cancer has been one of the most deadly illnesses all over the world, and radiotherapy can be an effective approach for treating lung cancer. Now, mathematical model has been extended to many biomedical fields to give a hand for analysis, evaluation, prediction, and optimization. METHODS: In this paper, we propose a multicomponent mathematical model for simulating the lung cancer growth as well as radiotherapy treatment for lung cancer. The model is digitalized and coded for computer simulation, and the model parameters are fitted with many research and clinical data to provide accordant results along with the growth of lung cancer cells in vitro. RESULTS: Some typical radiotherapy plans such as stereotactic body radiotherapy, conventional fractional radiotherapy, and accelerated hypofractionated radiotherapy are simulated, analyzed, and discussed. The results show that our mathematical model can perform the basic work for analysis and evaluation of the radiotherapy plan. CONCLUSION: It will be expected that in the near future, mathematical model will be a valuable tool for optimization in personalized medical treatment.

Simulation analysis for tumor radiotherapy based on three-component mathematical models.

OBJECTIVE: To setup a three-component tumor growth mathematical model and discuss its basic application in tumor fractional radiotherapy with computer simulation. METHOD: First, our three-component tumor growth model extended from the classical Gompertz tumor model was formulated and applied to a fractional radiotherapy with a series of proper parameters. With the computer simulation of our model, the impact of some parameters such as fractional dose, amount of quiescent tumor cells, and α/ß value to the effect of radiotherapy was also analyzed, respectively. RESULTS: With several optimal technologies, the model could run stably and output a series of convergent results. The simulation results showed that the fractional radiotherapy dose could impact the effect of radiotherapy significantly, while the amount of quiescent tumor cells and α/ß value did that to a certain extent. CONCLUSIONS: Supported with some proper parameters, our model can simulate and analyze the tumor radiotherapy program as well as give some theoretical instruction to radiotherapy personalized optimization.

[Film dose analysis system and its application in radiotherapy verification].

OBJECTIVE: To propose a new computer software-based medical image processing technique with high resolution digital scanner for radiotherapy verification. METHODS: Under the platform of Windows 2000, the software, programmed with Visual C++.NET, was developed according to modular design. All data of the films and the treatment planning system could be processed as images or dose curves for a robust result. RESULTS: Many functions such as data acquisition, automatic analysis and computation and image processing were integrated in the system. Both geometric and dosimetric errors could be calculated at the same time to verify the radiotherapy accuracy. CONCLUSION: This system has good accuracy and stability for cost-effective radiotherapy verification.