Sujet(s)
Maladies de la paupière/traitement médicamenteux , Granulome/traitement médicamenteux , Probucol/administration et posologie , Xanthomatose/traitement médicamenteux , Maladies de la paupière/complications , Maladies de la paupière/anatomopathologie , Paupières , Femelle , Granulome/complications , Granulome/anatomopathologie , Humains , Adulte d'âge moyen , Cou , Peau/anatomopathologie , Résultat thérapeutique , Xanthomatose/complications , Xanthomatose/anatomopathologieRÉSUMÉ
Pigmented breast cancer in the skin caused by nonneoplastic melanocytes of epidermal origin is a rare condition of metastasis from breast cancer, but the pathogenesis of this phenomenon is almost unknown. In this report, we describe a case of breast cancer metastasis in the skin with prominent hyperkeratotic pigmentation caused by nonneoplastic melanocyte colonization. Immunohistochemical staining revealed that the metastatic tumor cells produced IL-23, which is reported not only to induce IL-17 but also to inhibit cell apoptosis in breast cancer cells, which affects tumor progression. In addition to IL-23, substantial numbers of IL-17-producing cells were detected at the peritumoral area, suggesting that IL-17 might induce not only melanogenesis but also keratinocyte proliferation and tumorigenesis. Our report suggests possible mechanisms of hyperkeratotic pigmentation of breast cancer metastasis in the skin.