RÉSUMÉ
BACKGROUND/AIM: There are no studies assessing the long-term quality of life (QoL) following three-dimensional laparoscopy cholecystectomy (3D-LC) in patients with cholelithiasis (Chole). PATIENTS AND METHODS: A cohort of 200 patients with Chole were randomized into 3D-LC or minilaparotomy cholecystectomy (MC) groups. RAND-36 survey was performed before randomization, four weeks and five years postoperatively. RESULTS: Similar postoperative five years RAND-36 scores were reported in the 3D-LC and MC groups. The MC and 3D-LC groups combined analysis, social functioning (SF, p=0.007), mental health (MH, p=0.001), role physical (RP, p<0.001) and bodily pain (BP, p<0.001) domains increased significantly. In comparison to the Finnish reference RAND-36 (FRR) scores, the scores at five years increased significantly in the MH domain, while four RAND-36 domains; Physical functioning (PF), general health (GH), RP, BP remained significantly lower in comparison to the FRR scores. CONCLUSION: A relatively similar long-term outcome in the 3D-LC and MC patients is shown. Interestingly, five RAND-36 domains increased during five years follow-up, while four RAND-36 domains remained lower than FRR scores, which may indicate onset of possible new symptoms following cholecystectomy in long-term follow-up.
Sujet(s)
Calculs biliaires , Mesures des résultats rapportés par les patients , Qualité de vie , Humains , Femelle , Mâle , Adulte d'âge moyen , Calculs biliaires/chirurgie , Études prospectives , Adulte , Enquêtes de santé , Sujet âgé , Enquêtes et questionnaires , Résultat thérapeutique , Cholécystectomie laparoscopique/effets indésirables , CholécystectomieRÉSUMÉ
BACKGROUND/AIM: National healthcare organizers require feedback from patients to improve medical treatment methods. Three-dimensional laparoscopy cholecystectomy (3D-LC) is a modern technique in surgery. However, there are no studies with patient feedback from validated questionnaires assessing the postoperative treatment results in 3D-LC. PATIENTS AND METHODS: Initially 200 patients with symptomatic cholelithiasis were randomized into 3D-LC or mini-laparotomy cholecystectomy (MC) groups. RAND-36-Item Health Survey was performed preoperatively and 4 weeks following surgery relating the survey scores between the 3D-LC and MC groups. RESULTS: Similar postoperative RAND-36 scores were reported for both groups preoperatively and at 4 weeks following surgery, and no significant differences in RAND-36 domains were shown. When the patients in both study groups were combined, Mental Health (p<0.001), Bodily Pain (p=0.01) and General Health (p=0.016) domain scores were significantly higher, indicating a significantly positive change in quality of life 4 weeks postoperatively, while those for the Role-Physical domain were significantly lower, indicating reduced physical activity during the 4 weeks following surgery. In comparison to the Finnish reference RAND-36 scores, scores at 4 weeks were significantly higher for the Mental Health domain (MC group, p<0.001 and 3D-LC group, p=0.001) whilst scores were significantly lower in four other domains: Physical Functioning, Social Functioning, Bodily Pain and Role-Physical. CONCLUSION: This study shows, for the first time using the RAND-36-Item Health Survey, relatively similar short-term outcomes in patients 4 weeks following cholecystectomy by 3D-LC and MC. Although scores for three RAND-36 domains were significantly higher postoperatively, indicating a significantly positive change in quality of life, a longer follow-up after cholecystectomy is needed for final conclusions to be drawn.
Sujet(s)
Cholécystectomie laparoscopique , Laparoscopie , Humains , Qualité de vie , Études prospectives , Cholécystectomie laparoscopique/effets indésirables , Cholécystectomie laparoscopique/méthodes , Cholécystectomie/méthodes , Résultat thérapeutique , Enquêtes de santé , Douleur postopératoireRÉSUMÉ
BACKGROUND/AIM: Three-dimensional laparoscopy (3D-Lap) is a recent innovation in surgery. The 3D-Lap is rarely used in cholecystectomy (3D-LC) and there are no prospective studies assessing advantages and disadvantages of 3D-LC versus minilaparotomy (MC) in cholecystectomy. PATIENTS AND METHODS: This was a prospective clinical study conducted in the Kuopio University Hospital, including 200 patients with symptomatic cholelithiasis who were randomized into 3D-LC (n=112) or MC (n=88) groups. The numeric rating scale (NRS) pain score and number of analgesic doses (NAD) following surgery were documented. RESULTS: Similar low postoperative pain scores were reported in the 3D-LC and MC groups during the first hours following surgery, although the 3D-LC patients reported lower NRS pain score (p<0.05) one hour postoperatively. Interestingly, the 3D-LC patients showed significantly less pain 24 hours following surgery, the mean of NRS of 0-10 score at rest being 1.2 in the 3D-LC group versus 2.2 in the MC group (p<0.001), and the pain at the quick movement/coughing, the mean NRS being 2.9 in the 3D-LC group versus 3.6 in the MC group (p=0.05). CONCLUSION: The 3D-LC patients reported significantly lower pain scores 24 hours postoperatively than MC patients. However, the patient experience of pain depends on many factors and our results suggest that both 3D-LC and MC are safe and efficient techniques for cholecystectomy.
Sujet(s)
Cholécystectomie laparoscopique , Laparoscopie , Humains , Laparotomie/méthodes , Cholécystectomie laparoscopique/effets indésirables , Cholécystectomie laparoscopique/méthodes , Cholécystectomie/méthodes , Douleur postopératoire/diagnostic , Douleur postopératoire/étiologieRÉSUMÉ
OBJECTIVES: Protein levels of the transcription factor nuclear factor erythroid-derived 2-like 2 (Nrf2) and its inhibitor Kelch-like ECH-associated protein 1 (Keap1) have been proposed as prognostic factors in pancreatic ductal adenocarcinomas (PDACs). These cellular redox-state-regulating enzymes are targeted by several microRNAs, including miR-93 and miR-200a. METHODS: We assessed mRNA levels of Nrf2 and Keap1 and tissue expression of miR-93 and miR-200a in 51 patients with surgically treated PDAC. Expression levels were separately measured in malignant cells and adjacent benign cells. RESULTS: Keap1 and Nrf2 mRNA expression levels in cancer cells were lower than in adjacent benign tissue (Wilcoxon's test; p = 0.0015 and p = 0.000032, respectively). Conversely, miR-93 expression was higher in cancer cells than in adjacent benign tissue (p = 0.00082). Low levels of miR-93 and miR-200a in cancer cells were associated with poorer differentiation (p = 0.004 and p = 0.002, respectively). In univariate survival analysis, benign-tissue levels of miR-200a above the median predicted better relapse-free survival (RFS) (p = 0.045). CONCLUSIONS: High miR-93 and miR-200a levels in cancer cells of PDAC were associated with better differentiation, and miR-200a expression in benign tissue with excellent RFS. Keap1 and Nrf2 mRNA levels showed prominent down-regulation in cancerous versus benign tissue, but they were not associated with disease aggressiveness or outcome.
Sujet(s)
Carcinome du canal pancréatique/génétique , microARN/biosynthèse , Tumeurs du pancréas/génétique , Carcinome du canal pancréatique/métabolisme , Carcinome du canal pancréatique/anatomopathologie , Différenciation cellulaire/génétique , Études de cohortes , Survie sans rechute , Humains , Protéine-1 de type kelch associée à ECH/génétique , microARN/génétique , Facteur-2 apparenté à NF-E2/génétique , Tumeurs du pancréas/métabolisme , Tumeurs du pancréas/anatomopathologie , ARN messager/génétique , ARN messager/métabolisme , Études rétrospectivesRÉSUMÉ
BACKGROUND/AIM: Oxidative stress biomarker superoxide dismutase (SOD1) plasma levels in operated gallstone patients versus cancer patients are unknown. In addition, the number of analgesic doses during the first 24 h postoperatively (NAD24) in gallstone patients operated with laparoscopic cholecystectomy (LC) or minicholecystectomy (MC) is unreported. The aim of the study was to determine a correlation between the plasma SOD1 levels in the LC and MC patients versus cancer patients. PATIENTS AND METHODS: Initially, 114 patients with symptomatic gallstone disease were randomized into LC (n=54) or MC (n=60) groups. The plasma levels of the SOD1 marker were measured just before, immediately after (POP1) and 6 h after the operation (POP2). RESULTS: The median plasma SOD1 levels preoperatively and following surgery in the LC and MC patients versus cancer patients were statistically insignificant (p=0.90, p=0.88, p=0.21, respectively). The median plasma levels of SOD1 increased immediately after operation (POP1) and the postoperative elevation between the preoperative (PRE) and the POP1 values in the SOD1 marker were statistically significant (p=0.027). Then the median plasma levels of SOD1 marker decreased 6 h postoperatively (POP2) and the decrease between the POP1 and POP2 values in the SOD1 marker were statistically highly significant (p<0.001). There is a highly significant inverse correlation between the individual values of the NAD24 and plasma SOD1 values postoperatively in LC and MC patients (r=-0.335, p=0.011). CONCLUSION: The plasma SOD1 levels preoperatively and following surgery in the LC and MC patients versus cancer patients were quite similar. Cholecystectomy patients with enhanced levels of SOD1 appeared to have significantly lower number of analgesic oxycodone doses during the first 24 h postoperatively (NAD24).
Sujet(s)
Marqueurs biologiques/sang , Calculs biliaires/chirurgie , Oxycodone/usage thérapeutique , Douleur postopératoire/traitement médicamenteux , Superoxide dismutase-1/sang , Adulte , Sujet âgé , Analgésiques morphiniques/usage thérapeutique , Cholécystectomie/effets indésirables , Cholécystectomie/méthodes , Cholécystectomie laparoscopique/effets indésirables , Cholécystectomie laparoscopique/méthodes , Relation dose-effet des médicaments , Femelle , Humains , Mâle , Adulte d'âge moyen , Stress oxydatif , Douleur postopératoire/étiologie , Études prospectives , Facteurs tempsRÉSUMÉ
BACKGROUND/AIM: The levels of the oxidative stress biomarker superoxide dismutase (SOD1) in plasma in relation to pain at rest 24 hours after (NRS24) midline laparotomy in patients with rectus sheath block (RSB) analgesia is unknown. PATIENTS AND METHODS: Initially, 56 patients (39 with cancer), each with an intravenous oxycodone pump as patient-controlled analgesia, were randomized to four groups: control group, no RSB (n=12), single-dose (n=16), repeated-dose (n=12) and continuous infusion (n=16) of RSB analgesia. The plasma levels of SOD1 were measured directly before, immediately after and 24 hours after surgery. Pain at rest was scored on an 11-point numeric rating scale 24 hours postoperatively (NRS24: 0=no pain to 10=worst pain). RESULTS: The median plasma level of SOD1 increased immediately after operation and this was statistically highly significant (p=0.007). The median plasma level of SOD1 then decreased 24 hours postoperatively and this postoperative decrease was also statistically highly significant (p<0.001). The median plasma levels of SOD1 did not differ significantly between patients with benign disease and those with cancer, preoperatively and after surgery. There was highly significant positive correlation between SOD1 and glutathione peroxidase (GPX1) values postoperatively (r=0.67, p<0.001) and a trend for an inverse correlation between the individual values of the NRS24 and plasma SOD1 values postoperatively in patients with benign disease and those with cancer (r=-0.30, p=0.09). CONCLUSION: Midline laparotomy significantly alters the level of oxidative stress marker SOD1 immediately after surgery, but the level normalizes 24 hours following surgery. Interestingly, patients with increased levels of SOD1 appeared to have diminished postoperative pain after midline laparotomy.
Sujet(s)
Marqueurs biologiques/métabolisme , Laparotomie/effets indésirables , Stress oxydatif , Mesure de la douleur/méthodes , Douleur postopératoire/diagnostic , Superoxide dismutase-1/métabolisme , Études cas-témoins , Femelle , Études de suivi , Humains , Mâle , Adulte d'âge moyen , Gestion de la douleur , Douleur postopératoire/étiologie , Douleur postopératoire/métabolisme , Pronostic , Études prospectivesRÉSUMÉ
BACKGROUND/AIM: The plasma glutathione peroxidase (GPX1) levels in gallstone patients operated with laparoscopic cholecystectomy (LC) or minicholecystectomy (MC) versus cancer patients is unknown. PATIENTS AND METHODS: Initially, 114 patients with symptomatic gallstone disease were randomized into LC (n=53) or MC (n=61) groups. Plasma levels of C-reactive protein (hs-CRP) and the oxidative stress marker GPX1 were measured at three time points; before (PRE), immediately after (POP1) and 6 hours after operation (POP2). The end-point of our study was to determine a correlation between the plasma hs-CRP and GPX1 levels in the LC and MC patients versus cancer patients. RESULTS: The plasma GPX1 levels preoperatively and following surgery in the LC and MC patients versus cancer patients were quite similar (p=0.509, p=0.578, p=0.882, respectively). The patients with inflammation of the gallbladder wall (IGW) versus no-IGW had significantly higher plasma GPX median (interquartile range) levels preoperatively (11.5; 6.2-17.4 vs. 8.0; 5.6-14.5, p=0.033) and the GPX values following surgery (POP1, 11.4; 7.8-14.7 versus 7.3; 4.4-11.0, p=0.019 and POP2, 11.5; 7.1-16.2 versus 9.4; 4.2-13.1, p=0.027). The IGW in patients with LC and MC groups combined, correlated significantly to the plasma CRP levels preoperatively (r=0.280, p=0.005) and the CRP values following surgery (POP1, r=0.295, p=0.003 and POP2, r=0.338, p=0.001) and the GPX1 values postoperatively (POP1, r=0.319, p=0.001 and POP2, r=0.243, p=0.026) and to the length of the skin incision (r=0.248, p=0.009). CONCLUSION: The plasma GPX1 levels preoperatively and following surgery in the LC and MC patients versus cancer patients were quite similar. However, the inflammation of the gallbladder wall (IGW) correlated significantly with plasma GPX1 and hs-CRP values suggesting that inflammation and oxidative stress are related.
Sujet(s)
Protéine C-réactive/métabolisme , Calculs biliaires/sang , Calculs biliaires/chirurgie , Glutathione peroxidase/sang , Stress oxydatif , Adulte , Cholécystectomie/méthodes , Cholécystectomie laparoscopique/méthodes , Femelle , Calculs biliaires/anatomopathologie , Humains , Inflammation/sang , Inflammation/anatomopathologie , Mâle , Adulte d'âge moyen , Période postopératoire , Période préopératoire , Études prospectives , Résultat thérapeutique , Glutathione Peroxydase GPX1RÉSUMÉ
AIM: To evaluate whether the overall satisfaction, as measured by numeric rating scale (NRS), regarding rectus sheath block (RSB) analgesia is associated with the plasma glutathione peroxidase (GPX1) level. The second end-point of the study was to evaluate the differences in GPX1 levels in patients with and without RSB analgesia, with special emphasis on benign or malign disease status. PATIENTS AND METHODS: Initially, 56 patients were randomized to the placebo group (n=12) and to one of three active RSB analgesia groups: single-dose (n=16), repeated-dose (n=12) and continuous infusion (n=16) groups. The plasma level of GPX1 was measured at three time points: just before, immediately after and 24 h after surgery. The overall satisfaction and an opinion on the success of the analgesic procedure were surveyed using an 11-point numeric rating scale 24 h postoperatively (NRS from 0, completely dissatisfied, to 10, fully satisfied). RESULTS: The placebo group and the three active groups were similar in terms of their perioperative data. The plasma level of GPX1 decreased postoperatively in all four groups. No differences were detected in the GPX1 values between the placebo and the three active groups combined preoperatively and immediately after operation. However, the patients in the single-dose group had a significantly lower median GPX1 values 24 h after surgery compared to the three other groups separately (p=0.032). The median (interquartile range) plasma level of GPX1 differed significantly between patients with benign disease and those with cancer preoperatively (18.0, 12.5-22.0 versus 10.0, 6.3-18.8 pg/ml, p=0.006) and cancer diagnosis was correlated with lower individual plasma GPX1 values (r=-0.42, p=0.004). CONCLUSION: The placement of RSB analgesia does not significantly affect the level of oxidative stress biomarker GPX1 in patients with benign disease or cancer. A new finding with possible clinical relevance is that patients with cancer appeared to have a trend for lower plasma GPX1 values.
Sujet(s)
Analgésie/méthodes , Marqueurs biologiques/sang , Glutathione peroxidase/sang , Bloc nerveux/méthodes , Stress oxydatif , Muscle droit de l'abdomen/innervation , Sujet âgé , Anesthésiques locaux/administration et posologie , Anesthésiques locaux/usage thérapeutique , Bupivacaïne/administration et posologie , Bupivacaïne/analogues et dérivés , Bupivacaïne/usage thérapeutique , Maladie , Femelle , Humains , Lévobupivacaïne , Mâle , Adulte d'âge moyen , Tumeurs/sang , Tumeurs/traitement médicamenteux , Tumeurs/chirurgie , Douleur postopératoire/prévention et contrôle , Muscle droit de l'abdomen/effets des médicaments et des substances chimiques , Résultat thérapeutique , Glutathione Peroxydase GPX1RÉSUMÉ
OBJECTIVES: To evaluate the impact of patient age on hospital resource use and treatment costs of acute abdominal pain (AAP). MATERIALS AND METHODS: A total of 300 adult patients with AAP were randomised to either computed tomography (CT, n=150) or selective imaging practice (SIP, n=150) groups. Final analysis included 254 patients, 143 (42 patients ≥65years) in the CT and 111 (32 patients ≥65years) in the SIP group. All CT group patients underwent abdominal CT whereas in the SIP group, imaging was based on the clinical assessment. For each patient, the hospital length of stay (LOS), the numbers and costs of diagnostic and treatment procedures arising from AAP were calculated and registered. The incremental cost-effectiveness ratio (ICER) and bootstrapped cost-effectiveness acceptability curve (CEAC) were estimated for routine CT. RESULTS: Treatment costs, imaging costs and LOS increased in conjunction with aging in both study groups, and were generally higher in the CT group compared to the SIP group. In the SIP group, CT was undertaken in 34% (27/79) of the <65year olds but in 59% (19/32) of the older patients (≥65years) (p=0.02). The proportion of patients with non-specific abdominal pain was significantly lower in patients ≥65years than in their younger counterparts (p=0.04). In the routine CT group, the ICER of obtaining a specific diagnosis was 1682 for patients <65years and 1055 for patients ≥65years. According to CEAC estimation, routine CT for every patient with AAP has a 95% probability of being cost-effective if society is willing to pay 14087 for an additional specific diagnosis for patients <65 years but only 4204 in those ≥65years. CONCLUSION: Treatment costs of AAP increase in parallel with aging, and the costs are generally higher with routine CT compared to selective imaging. The probability of obtaining a specific diagnosis of AAP increases with aging. If obtaining a specific diagnosis is deemed crucial, then routine CT is more cost-effective in patients over 65 years compared to younger patients. Considering the diagnostic challenges of AAP in the elderly, liberal CT use can be advocated in this patient group.
Sujet(s)
Abdomen aigu/imagerie diagnostique , Abdomen aigu/économie , Coûts des soins de santé/statistiques et données numériques , Ressources en santé/statistiques et données numériques , Tomodensitométrie/économie , Tomodensitométrie/méthodes , Abdomen/imagerie diagnostique , Adolescent , Adulte , Facteurs âges , Sujet âgé , Sujet âgé de 80 ans ou plus , Analyse coût-bénéfice/économie , Analyse coût-bénéfice/statistiques et données numériques , Imagerie diagnostique/économie , Imagerie diagnostique/méthodes , Femelle , Humains , Durée du séjour/économie , Durée du séjour/statistiques et données numériques , Mâle , Adulte d'âge moyen , Études prospectives , Jeune adulteRÉSUMÉ
PURPOSE: The assessment of the quality of life (QoL) in minilaparotomy cholecystectomy (MC) versus laparoscopic cholecystectomy (LC) with the ultrasonic dissection in both groups has not been addressed earlier. METHODS: Initially, 109 patients with non-complicated symptomatic gallstone disease were randomized to undergo either MC (n = 59) or LC (n = 50). RAND-36 survey was conducted preoperatively and at 4 weeks and 6 months postoperatively. The end point of our study was to determine differences in health status in MC versus LC groups. RESULTS: QoL improved significantly in both groups, and the recovery was similar in the two groups, except from the higher score in 'health change' subscale at 4 weeks in MC group [MC score 75.0 (25.0) vs. LC score 56.5 (23.2), p = 0.008]. The MC and LC groups combined, RAND-36 scores increased significantly in 'physical functioning' [combined mean (SD) preoperative score 80.5 (23.9) vs. 6-month postoperative score 86.5 (21.7), p = 0.015], 'vitality' [64.5 (19.2) vs. 73.5 (18.3), p = 0.001], 'health change' [43.0 (21.6) vs. 74.6 (25.4), p = 0.0001] and 'bodily pain' scores [57.7 (26.3) vs. 75.5 (25.5), p = 0.001], respectively. Four RAND-36 domains indicated statistically significant health status differences in comparing the preoperative and postoperative RAND-36 scores in LC and MC groups combined. CONCLUSIONS: Four RAND-36 domains indicated a significant positive change in QoL after cholecystectomy.
Sujet(s)
Lithiase vésiculaire/chirurgie , Qualité de vie , Cholécystectomie laparoscopique , Lithiase vésiculaire/psychologie , Femelle , Finlande , Humains , Mâle , Adulte d'âge moyen , Interventions chirurgicales mini-invasives , Complications postopératoires/psychologie , Études prospectives , Enquêtes et questionnaires , Résultat thérapeutiqueRÉSUMÉ
OBJECTIVE: The aim of the study was to evaluate the role of 8-OHdG (8-hydroxy-2'-deoxyguanosine) detecting oxidative stress response following cholecystectomy in a randomised multicentre study of patients with minilaparotomy cholecystectomy (MC) versus laparoscopic cholecystectomy (LC). METHODS: Initially, 106 patients with non-complicated symptomatic gallstone disease were randomised into MC (n = 56) or LC (n = 50) groups. Plasma levels of the oxidative stress marker 8-OHdG measured at three time points; before (PRE), immediately after (POP1) and 6 h after operation (POP2). RESULTS: The demographic variables and the surgical data were similar in the study groups. The plasma oxidative stress marker 8-OHdG concentrations following surgery in the MC versus LC patients were quite similar. There was no significant correlation between the individual values of the11-point numeric rating pain scale (NRS) versus the plasma 8-OHdG post-operatively in the MC and LC patients. However, there was a statistically significant correlation between the individual values of the plasma 8-OHdG (PRE) versus IL-10 (PRE) for the MC and LC patients (r = 0.214, p = 0.037). There was also a statistically significant correlation between the individual values of the plasma 8-OHdG (POP2) versus IL-1ß (POP2) for the MC and LC patients (r = 0.25, p = 0.01). CONCLUSION: Our results suggest that the oxidative stress marker 8-OHdG concentrations following surgery in MC versus LC patients were quite similar. A new finding with possible clinical relevance is a correlation between the individual plasma values of the 8-OHdG versus anti-inflammatory interleukin IL-10 and 8-OHdG versus IL-1ß (proinflammatory) in the MC and LC patients suggesting that inflammation and oxidative stress are related.
Sujet(s)
Cholécystectomie laparoscopique/méthodes , Lithiase biliaire/sang , Lithiase biliaire/chirurgie , Désoxyguanosine/analogues et dérivés , Stress oxydatif , 8-Hydroxy-2'-désoxyguanosine , Marqueurs biologiques/sang , Cholécystectomie laparoscopique/effets indésirables , Désoxyguanosine/sang , Femelle , Finlande , Humains , Interleukine-10/sang , Interleukine-1 bêta/sang , Mâle , Adulte d'âge moyen , Douleur postopératoire/étiologie , Jeune adulteRÉSUMÉ
AIM: To evaluate whether the post-surgery placement of the rectus sheath block analgesia (RSB) reduces the inflammatory response following surgery. The main hypothesis of our study was to find any correlation between patients' pain experience, numeric rating scale (NRS) postoperatively and concentrations of inflammatory response biomarkers, such as interleukin-1 receptor antagonist (IL-1ra), IL-6, IL-8, IL-10, IL-1ß, in patients with benign disease and cancer. PATIENTS AND METHODS: Initially, 46 patients with midline laparotomy were randomized to the placebo group (n=11) and to one of the three active groups; single-dose (n=12), repeated-dose (n=12) and continuous infusion (n=11) RSB analgesia groups. Plasma concentrations of high-sensitivity C-reactive protein (hs-CRP) and five interleukins (IL-1ra, IL-6, IL-8, IL-10, IL-1ß) were measured at three time points; just before, immediately after and 24 h after operation. The primary end-point was to compare plasma concentrations of the hs-CRP and five interleukins in the placebo group and in the three different RSB analgesia groups in patients with benign disease and cancer. RESULTS: The placebo group and three active groups were similar in terms of demographic variables and perioperative data. Of the anti-inflammatory cytokines, patients in the continuous infusion group had significantly higher IL-10 median values postoperatively than the three other study groups (p=0.029). In addition, patients in the three active groups combined had significantly higher IL-10 median values immediately after operation than the placebo group (p=0.028; in all patients with benign disease and cancer). There is a significant correlation between the individual values of NRS and IL-10 values postoperatively in the placebo group and the three active groups separately (r=0.40, p=0.03) and also a significant correlation between the individual values of the NRS scale and IL-1ß values postoperatively in the placebo group and the three active groups separately (r=0.38, p=0.04). CONCLUSION: Placement of RSB analgesia does not significantly reduce the inflammatory response biomarkers' concentrations in patients with benign disease or cancer patients. A new finding in the present work is a significant correlation in the NRS scale versus plasma concentrations of anti-inflammatory cytokine IL-10 and pro-inflammatory cytokine IL-1ß postoperatively suggesting that inflammation and pain are related.
Sujet(s)
Inflammation/prévention et contrôle , Tumeurs/composition chimique , Bloc nerveux/méthodes , Douleur postopératoire/prévention et contrôle , Adulte , Sujet âgé , Protéine C-réactive/analyse , Femelle , Humains , Antagoniste du récepteur à l'interleukine-1/sang , Interleukine-10/sang , Interleukine-18/sang , Interleukine-1 bêta/sang , Interleukine-6/sang , Interleukine-8/sang , Mâle , Adulte d'âge moyen , Tumeurs/chirurgieRÉSUMÉ
BACKGROUND: The aim of the study was to evaluate whether the post-surgery placement of the rectus sheath block (RSB) analgesia could alter the oxidative stress response. The main hypothesis of our study was to find some correlation between patients' pain experience, numeric rating scale (NRS) and the concentration of oxidative stress marker, 8-OHdG (8-hydroxy-2'-deoxyguanosine) in patients with benign disease and cancer. MATERIALS AND METHODS: Initially, 46 patients were randomized to the placebo group (n=11) and to one of the three active groups; single-dose (n=12), repeated-dose (n=12) and continuous infusion (n=11) RSB analgesia group. The plasma concentrations of the hs-C-reactive protein (CRP) and 8-OHdG were measured at three time points: just before, immediately after and 24 h after operation. The primary end-point was to compare plasma concentrations of the hs-CRP and 8-OHdG in the placebo group and in the three different RSB analgesia groups in patients with benign disease and cancer. RESULTS: The placebo group and three active groups were similar in terms of demographic variables and the perioperative data. The patients in the continuous infusion group had a trend for lower median 8-OHdG values post-operatively than the three other study groups (p=0.147; in all patients with benign disease and cancer). The patients in the cancer group showed a trend for higher median 8-OHdG values in the repeated-dose group than the patients in the benign group (p=0.241). There was a significant inverse correlation between the individual values of the plasma hs-CRP and 8-OHdG in patients with benign disease and cancer (r=-0.40, p=0.02). However, there was no significant correlation between the individual values of the NRS score and 8-OHdG post-surgery in patients with benign disease and cancer. CONCLUSION: The results suggest that the placement of RSB analgesia does not significantly alter the oxidative stress marker 8-OHdG concentrations in patients with benign disease or cancer patients. A new finding with possible clinical relevance is a significant inverse correlation between the individual plasma values of the hs-CRP and 8-OHdG in patients with benign disease and cancer.
Sujet(s)
Analgésie/méthodes , Marqueurs biologiques , Désoxyguanosine/analogues et dérivés , Stress oxydatif , Douleur/traitement médicamenteux , Douleur/métabolisme , Complications postopératoires , 8-Hydroxy-2'-désoxyguanosine , Sujet âgé , Désoxyguanosine/sang , Désoxyguanosine/métabolisme , Femelle , Humains , Mâle , Adulte d'âge moyen , Gestion de la douleurRÉSUMÉ
OBJECTIVE: The aim of the study was to evaluate the inflammatory response to surgical trauma in minilaparotomy cholecystectomy (MC) compared to laparoscopic cholecystectomy (LC). Assessment of inflammatory response to surgical trauma in MC has not been addressed properly. Therefore, we investigated five interleukins (IL) and C-reactive protein (CRP) in MC versus LC group in a prospective randomised trial. METHODS: Initially, 106 patients with non-complicated symptomatic gallstone disease were randomised into MC (n = 56) or LC (n = 50) groups. Plasma levels of five interleukins (IL-1ß, IL-1ra, IL-6, IL-8, IL-10) and hs-CRP were measured at three time points; before operation (PRE), immediately after operation (POP1) and six hours after operation (POP2). The primary end-point of the study was to compare the plasma levels of five interleukins and CRP in LC versus MC group. RESULTS: The demographic variables and the surgical data were similar in the study groups. The patients in the MC group had higher elevation of the CRP mean values post-operatively (p = 0.01). However, the patients in the MC group had higher elevation of the IL-1ra mean values post-operatively, the mean pre-/post-operative IL-1ra values being 299/614 pg/ml in the MC group versus 379/439 pg/ml in the LC group (p = 0.003). There was no statistical significance in IL-6 mean values between the MC and LC groups pre- and post-operatively (POP1). However, the patients in the MC group had higher IL-6 mean values six hours post-operatively (POP2), the mean IL-6 values being 27.6 pg/ml in the MC group versus 14.8 pg/ml in the LC group (p = 0.037). In addition, the patients in the MC group had higher elevation of the IL-6 mean values post-operatively, the mean pre-/post-operative IL-6 values being 4.1/27.6 pg/ml in the MC group versus 3.8/14.8 pg/ml in the LC group (p = 0.04). There was no statistical significance in IL-8, IL-10, and IL-1ß mean values between the MC and LC groups pre- and post-operatively. CONCLUSION: Our results suggest that the inflammatory response in MC versus LC groups was similar based on the IL-8, IL-10, and IL-1ß values. A new finding with possible clinical relevance in the present work is higher relative elevation of the IL-1ra and IL-6 mean values post-operatively in the MC group.
Sujet(s)
Cholécystectomie laparoscopique , Calculs biliaires/chirurgie , Inflammation/étiologie , Laparotomie/méthodes , Complications postopératoires/étiologie , Adulte , Marqueurs biologiques/sang , Protéine C-réactive/métabolisme , Cholécystectomie/méthodes , Femelle , Humains , Inflammation/sang , Inflammation/diagnostic , Interleukines/sang , Mâle , Adulte d'âge moyen , Complications postopératoires/sang , Complications postopératoires/diagnostic , Études prospectives , Résultat thérapeutiqueRÉSUMÉ
OBJECTIVE: Ultrasonic dissection (UsD) has been used in laparoscopic cholecystectomy (LC), though it is not the golden standard technique. Applying UsD to cholecystectomy by minilaparotomy (MC) is less common and there are no prospective randomized trials comparing these two techniques. Therefore, we conducted the present study to investigate the use of the UsD in the MC versus the LC procedure. MATERIAL AND METHODS: Initially 104 patients with non-complicated symptomatic gallstone disease were randomized into MC (n = 53) or LC (n = 51) groups, both groups using UsD, over a period of 2 years (2013-2015). The study groups were similar in terms of age and American Society of Anesthesiologists (ASA) physical status score. RESULTS: The demographic variables and the surgical data were similar in the study groups. Similar low postoperative pain scores were reported in the two study groups during the first four hours after surgery. The incidence of nausea/vomiting was similar between the two study groups, 47% in the MC group versus 42% in the LC group. However, the patients in the MC group were treated more frequently with antiemetics, the incidence being 39% in the MC group versus 21% in the LC group (p = 0.02). The pain at rest at 24h after the surgery was similar in the two study groups, but the LC patients reported less pain at the normal activity, the mean of numerical rating scale (NRS) of 0-10 score being 3.9 in the MC group versus 2.9 in the LC group (p = 0.05), and the pain at the quick movement/coughing, the mean NRS being 4.9 in the MC group versus 3.2 in the LC group (p = 0.005). The length of sick leave was 17.4 days in the MC group and 14.4 days in the LC group (p = 0.05). CONCLUSION: Our results suggest that both MC and LC are feasible and safe options for mini-invasive cholecystectomy. A new finding with clinical relevance in the present work is a relatively similar short-term outcome in the MC and LC although the LC patients reported significantly lower pain score 24 hours postoperatively and a shorter convalescence.
Sujet(s)
Cholécystectomie laparoscopique/méthodes , Convalescence , Calculs biliaires/chirurgie , Procédures de chirurgie par ultrasons , Adulte , Sujet âgé , Antiémétiques/usage thérapeutique , Cholécystectomie laparoscopique/effets indésirables , Dissection/effets indésirables , Dissection/méthodes , Femelle , Humains , Laparotomie/effets indésirables , Laparotomie/méthodes , Mâle , Adulte d'âge moyen , Nausée/traitement médicamenteux , Nausée/étiologie , Mesure de la douleur , Douleur postopératoire/étiologie , Congé maladie/statistiques et données numériques , Procédures de chirurgie par ultrasons/effets indésirables , Vomissement/traitement médicamenteux , Vomissement/étiologieRÉSUMÉ
OBJECTIVE: Three different mesh fixation techniques were compared to find out how to perform a safe and cost-effective open inguinal hernioplasty in day-case setting with the best outcomes with regard to chronic pain. SUMMARY BACKGROUND DATA: Mesh fixation method may influence on the incidence of chronic pain after Lichtenstein hernioplasty. METHODS: Lichtenstein hernioplasty was performed under local anesthesia in 625 patients as day-case surgery in 8 Finnish hospitals. The patients were randomized to receive either a cyanoacrylate glue (Histoacryl, nâ=â216), self-gripping mesh (Parietex ProGrip, nâ=â202), or conventional nonabsorbable sutures (Prolene 2-0, nâ=â207) for mesh fixation. The incidence of wound complications, pain, recurrences, and patients discomfort was recorded on days 1, 7, 30, and 1 year after surgery. The primary endpoint was the sensation of pain measured by pain scores and the need of analgesics after 1 year of surgery. RESULTS: The type and size of inguinal hernias were similar in the 3 study groups. The duration of operation was 34â±â13, 32â±â9, and 38â±â9 minutes in the glue, self-gripping, and suture groups, respectively (Pâ<â0.001). There were no significant differences postoperatively in pain response or need for analgesics between the study groups. Two superficial infections (0.3%), 31 wound seromas (5.0%), and 4 recurrent hernias (0.6%) were recorded during a 1-year follow-up. Some 25 patients (4.2%) needed occasionally analgesics for chronic groin pain. A feeling of a foreign object and quality of life were similar in all study groups. CONCLUSIONS: This randomized trial failed to prove that mesh fixation without sutures causes less inguinodynia than suture fixation in Lichtenstein hernioplasty. Mesh fixation without sutures is feasible without compromising postoperative outcome.
Sujet(s)
Hernie inguinale/chirurgie , Herniorraphie/méthodes , Qualité de vie , Filet chirurgical , Techniques de suture/instrumentation , Matériaux de suture , Adhésifs tissulaires/usage thérapeutique , Femelle , Études de suivi , Humains , Mâle , Adulte d'âge moyen , Études prospectives , Lâchage de suture/prévention et contrôleRÉSUMÉ
BACKGROUND: The primary diagnosis of functional dyspepsia (FD) is made on the basis of typical symptoms and by excluding organic gastrointestinal diseases that cause dyspeptic symptoms. However, there is difficulty reaching a diagnosisin FD. OBJECTIVES: To assess the efficiency of the Usefulness Index (UI) test and history-taking in diagnosing FD. METHODS: A study on acute abdominal pain conducted by the World Organization of Gastroenterology Research Committee (OMGE) included 1333 patients presenting with acute abdominal pain. The clinical history-taking variables (n = 23) for each patient were recorded in detail using a preedefined structured data collection sheet, and the collected data were compared with the final diagnoses. RESULTS: The most significant clinical history-taking variables of FD in univariate analysis were risk ratio (RR): location of pain at diagnosis (RR = 5.7), location of initial pain (RR = 6.5), previous similar pain (RR = 4.0), duration of pain (RR = 2.9), previous abdominal surgery (RR = 4.1), previous abdominal diseases (RR = 4.0), and previous indigestion (RR = 3.1). The sensitivity of the physicians' initial decision in detecting FD was 0.44, specificity 0.99 and efficiency 0.98; UI was 0.19 and RR 195.3. In the stepwise multivariate logistic regression analysis, the independent predictors of FD were the physicians' initial decision (RR = 266.4), location of initial pain (RR = 3.4),duration of pain (RR = 3.1), previous abdominal surgery (RR = 3.7), previous indigestion (RR = 2.2) and vomiting (RR = 2.0). CONCLUSIONS: The patients with upper abdominal paininitially and a previous history of abdominal surgery and indigestion tended to be at risk for FD. In these patients the UI test could help the clinician differentiate FD from other diagnoses of acute abdominal pain.
Sujet(s)
Abdomen aigu , Dyspepsie/diagnostic , Maladies gastro-intestinales/diagnostic , Recueil de l'anamnèse/méthodes , Abdomen aigu/diagnostic , Abdomen aigu/étiologie , Abdomen aigu/physiopathologie , Adolescent , Adulte , Dyspepsie/complications , Dyspepsie/physiopathologie , Femelle , Maladies gastro-intestinales/complications , Maladies gastro-intestinales/physiopathologie , Humains , Mâle , Adulte d'âge moyen , Mesure de la douleur/méthodes , Reproductibilité des résultats , Facteurs de risque , Indice de gravité de la maladie , Évaluation des symptômes/méthodesRÉSUMÉ
OBJECTIVE: The long-term outcome between laparoscopic cholecystectomy (LC) and minilaparotomy cholecystectomy (MC) with ultrasonic dissection (UsD) technique has not been compared in randomized trials. Therefore, we investigated the outcome after conventional LC and MC with UsD in 78 patients (ClinicalTrials.gov Identifier: NCT0172340). MATERIAL AND METHODS: Initially 88 patients with non-complicated symptomatic gallstone disease were randomized into MC (n = 44) or LC (n = 44) over a period of 2 years (2010-2012) and 78 of them (89%) were reached for a follow-up interview at 12 months after the surgery. RESULTS: Baseline parameters were similar in the two groups, and 1/44 MCs and 2/44 LCs were converted to open laparotomy. The prevalence of chronic post-surgical pain (CPSP) one year after the procedure was quite similar in the two groups: 3/36 (8%) in the MC group and 2/42 (5%) in the LC group (p = 0.502). Residual abdominal symptoms were common, but the proportion was similar in both groups (28% in MC and 33% in LC group, p = 0.665). Both groups were very satisfied with the cosmetic outcome (numeric rating scale, p = 0.470). The Quality of life (QoL) improved 34/36 (94%) in the MC group and 33/42 (79%) in the LC group (p = 0.046) and all patients in both groups were satisfied with the operation overall. CONCLUSION: Day-case MC and LC patients have a quite similar one-year outcome with no significant difference regarding residual abdominal symptoms, cosmetic satisfaction, QoL or CPSP.
Sujet(s)
Procédures de chirurgie ambulatoire/méthodes , Cholécystectomie laparoscopique/méthodes , Lithiase biliaire/chirurgie , Dissection/méthodes , Laparotomie/méthodes , Procédures de chirurgie par ultrasons/méthodes , Adulte , Sujet âgé , Femelle , Études de suivi , Humains , Mâle , Adulte d'âge moyen , Études prospectives , Qualité de vie , Résultat thérapeutique , Jeune adulteRÉSUMÉ
BACKGROUND: The impact of the age and sex adjusted body mass index (ISO-BMI) in the obese vs. non-obese children and adolescents with cholecystectomy for cholelithias is rarely reported. PATIENTS AND METHODS: The national database was searched for cholecystectomies performed in paediatric patients between 1997 and 2011, and the 59 paediatric and adolescent patients having cholecystectomy in the Kuopio University Hospital district were divided in two groups by age and sex adjusted BMI (ISO-BMI) using the cut-off point of overweight (ISO-BMI 25 kg/m(2)) based on the Finnish growth standards. RESULTS: Nationwide a total of 840 cholecystectomies were performed during the 15 years study period in Finland, most of which included females (77%), resulting in a mean of annual frequency of 4.8 (range: 3.9-6.1) procedures/100,000 population. In the study sample, most of the patients with the cholelithiasis were female (50/59, 85%). The gender distribution was equal among the younger patients, but among adolescents 6/52 (12%) of the patients with cholelithiasis were boys and 46/52 (88%) of the patients with cholelithiasis were girls. Obesity did not affect on operative parameters. The median operative time was 70 min (range, 30-155) and 66 min (44-130) in the high ISO-BMI-group. The recovery was similar in the two groups: the median length of hospital stay was 4 days in both groups. The patients in the low ISO-BMI-group vs. high ISO-BMI-group had a trend of higher serum bilirubin (p=0.16) and serum AFOS values (p=0.19). In the histological examination of the gallbladders 19/28 (68%) patients in the low ISO-BMI-group had inflammation vs. 26/31 (84%) patients in the high ISO-BMI-group (p=0.15). CONCLUSION: Our results between obese and non-obese children and adolescents with cholelithiasis are not statistically significant. The obese adolescents with female gender are in greater risk for cholelithiasis.
Sujet(s)
Indice de masse corporelle , Cholécystectomie , Lithiase biliaire/épidémiologie , Lithiase biliaire/chirurgie , Obésité/épidémiologie , Adolescent , Facteurs âges , Enfant , Enfant d'âge préscolaire , Lithiase biliaire/complications , Femelle , Finlande/épidémiologie , Calculs biliaires/épidémiologie , Calculs biliaires/chirurgie , Humains , Nourrisson , Nouveau-né , Mâle , Obésité/complications , Facteurs de risque , Facteurs sexuelsRÉSUMÉ
AIM: To assess the need for surgical treatment in patients with acute abdominal pain in a prospective randomized study. PATIENTS AND METHODS: Initially 203 patients with acute abdominal pain were randomized to the routine abdominal computed tomography CT (rCT, n=118), or selective abdominal CT group (sCT, n=85) over a period of 16 months. Ninety-three of the randomized patients (45.8%) underwent the study design and were reached for follow-up at three months. RESULTS: Diagnostic accuracy improved significantly in the rCT group (p<0.001). The surgeon's assessment of the need for surgery changed more often in the rCT group than in the sCT group (78.7% vs. 46.9%, p=0.002). The confidence to treat operatively increased significantly in the rCT vs. the sCT group (65.6% vs. 40.6%, p=0.028). The rCT was the only independent parameter for the change of the assessment of surgery. CONCLUSION: Routine CT allows for more confidence in decision making for the surgical treatment of patients with acute abdominal pain.