[Modification of suprapubic prostatectomy using a biological gluing technic]. / Modifikation der suprapubischen Prostatektomie unter Verwendung eines biologischen Klebeverfahrens.

Fibrinogen cryoprecipitate, thrombin solution and factor XIII concentrate were used for gluing in suprapubic transvesical prostatectomy. The fibrin glue was applied to an absorbable collagen velour placed in the prostatic bed. Postoperative blood loss was significantly smaller than in a control group. The gluing technique resulted in a sparing of the number of blood transfusions, a reduction in disturbances of wound healing and a shortening of postoperative hospital stay. Negative consequences of this gluing technique have not so far been observed.

[Polyamine levels in blood and plasma of patients with malignant melanoma]. / Polyaminspiegel im Blut und Plasma von Patienten mit malignem Melanom.

The polyamines putrescine, cadaverine, spermidine, spermine, and the amine histamine in whole blood and plasma of 42 patients with malignant melanoma were analysed after cold acid extraction and ion-exchange chromatography by fluorescence detection. Depending on the degree of tumor spreading the patients were grouped into 5 subpopulations; results were statistically compared with the values obtained from a normal population. The mean values of polyamine concentrations in the patient groups were generally not distinguishable from the mean values of the controls. Solely the mean of the spermidine values of postoperative patients with or without medical therapy and the spermine mean value for postoperative patients in tumor stage I and III were elevated. Cadaverine was never detected. The individual frequency of elevated polyamine levels in the plasma of single patients and variable, depending on patient subpopulation and polyamine under consideration. Spermidine was most frequently elevated (44%) in patients of tumor stage I under immunetherapy. We conclude that due to the low frequency of polyamine elevations to be found in plasma of melanoma patients by our method no diagnostic or prognostic significance and only limited importance for monitoring patients under therapy can be claimed for.