Nanobubbles in Ultrapure Water Can Self-Propel.

Nanobubbles are sub- micron-sized gas entities that find applications in a wide  range of scientific fields. Typically, they are thought to  diffuse according to Brownian motion. We report the  existence of self-propelled motion of oxygen bulk  nanobubbles in ultrapure water at body temperature.  Their motion, to a large extent, is self-affine; there are  different scaling exponents along the x- and y-axes as  well as for the lateral displacement. We use fractal  analysis, and we calculate the structure function, the  normalised velocity autocorrelation function, the  skewness, and the kurtosis. All descriptors attest the  existence of a quasi-Gaussian stochastic process, which  is classified as fractional Brownian motion. More than 50 \% of the trajectories along the x-axis follow  superdiffusion, while this amount drops to 30 \% for  motion along the y-axis as a result of the asymmetry of  the field of view.

Assessing the adsorption of a diverse range of pharmaceuticals to virgin and aged poly (ethylene terephthalate) microplastics in different environmental matrices.

In this study, the adsorption of a mixture of high-consumed drugs onto virgin and aged PET microplastics has been studied for the time ever. The target mixture comprised two anti-inflammatory drugs, diclofenac and ketoprofen, one anti-hypertensive, valsartan, and four common antibiotics, indomethacin, trimethoprim, isoniazid, and metronidazole. Two types of PET MPs (virgin and UV-aged) were used in the experimental procedure. Kinetic studies were conducted, and adsorption isotherms were obtained revealing the possible interactions that take place between adsorbents and adsorbates. Among the studied pharmaceuticals, diclofenac presents the highest uptake due to its hydrophobic nature, while aging appears to induce the adsorption of the drugs in MPs. Factors like pH or the environmental matrix were also evaluated. The results revealed that sorption is pH-dependent, while more complicated matrices like wastewater or seawater exhibit lower uptake than distilled water due to the natural organic matter present or the increased salinity, respectively. Finally, desorption studies were also conducted in three different aqueous solutions examining the pH effect. The desorption of the compounds was higher for diclofenac, followed by valsartan, and ketoprofen. The desorption percentages of antibiotics were quite low.

Impact of aged and virgin polyethylene microplastics on multi end-points effects of freshwater fish tissues.

The buildup of plastic waste in aquatic environments presents serious threats to the environment, wildlife, and ultimately to humans. Specifically, microplastics (MPs) ingestion by aquatic animals leads to adverse physiological and toxicological effects. In addition, discarded MPs undergo aging and degradation processes which affect their morphological properties and chemical composition, enhancing the absorption of environmental pollutants. Under this prism, the present research was conducted to investigate and compare the impact of 'aged' versus pristine low-density polyethylene microplastics (PE-MPs) on various toxicity endpoints as biochemical and molecular parameters in the muscle tissue and liver of the freshwater fish species Perca fluviatilis. In parallel, the morphological, physicochemical, and structural changes occurred in "aged" PE-MPs, (after being exposed to UV radiation for 120 days) were studied, significantly illustrating signs of oxidation and crack propagation at the surface of the studied MPs. Fish were exposed to artificial diet reached with virgin and "aged" PE-MPs, sized 100-180 µm, at concentrations of 1 mg/g of dry food for a period of 15-days. Thereafter, liver and muscle tissues were analyzed in relation to multi oxidative parameters. Compared to the control group, the observed changes in the examined fish included increased activities of antioxidant enzymes, as superoxide dismutase, catalase and glutathione reductase, enhanced concentrations of malondialdehyde, protein carbonylation, HSP70 levels, elevated MAPK phosphorylation, induction of ubiquitin-proteins, as well as heightened levels of Bax/Bcl-2 proteins, caspases and differentiated levels of LC3 II/I, SQSTM1/p62. From the studied biomarkers, apoptosis, ubiquitin and hsp70 levels, showed a more sensitive response against the ingested MPs, followed by autophagy, p38MAPK levels, antioxidant enzymes, MDA and carbonylation levels. The effect of "aged" PE-MPs was more pronounced compared to that of the virgin ones. When evaluating the response of all oxidative stress biomarkers across the studied tissues, the liver demonstrates the highest response for the majority of the biomarkers against both virgin and "aged" PE-MPs. These findings strongly indicate that "aged" MPs activate the antioxidant defence mechanisms and impact the cellular well-being of the examined fish species.

Machine learning and explainable artificial intelligence for the prevention of waterborne cryptosporidiosis and giardiosis.

Cryptosporidium and Giardia are important parasitic protozoa due to their zoonotic potential and impact on human health, and have often caused waterborne outbreaks of disease. Detection of (oo)cysts in water matrices is challenging and extremely costly, thus only few countries have legislated for regular monitoring of drinking water for their presence. Several attempts have been made trying to investigate the association between the presence of such (oo)cysts in waters with other biotic or abiotic factors, with inconclusive findings. In this regard, the aim of this study was the development of an holistic approach leveraging Machine Learning (ML) and eXplainable Artificial Intelligence (XAI) techniques, in order to provide empirical evidence related to the presence and prediction of Cryptosporidium oocysts and Giardia cysts in water samples. To meet this objective, we initially modelled the complex relationship between Cryptosporidium and Giardia (oo)cysts and a set of parasitological, microbiological, physicochemical and meteorological parameters via a model-agnostic meta-learner algorithm that provides flexibility regarding the selection of the ML model executing the fitting task. Based on this generic approach, a set of four well-known ML candidates were, empirically, evaluated in terms of their predictive capabilities. Then, the best-performed algorithms, were further examined through XAI techniques for gaining meaningful insights related to the explainability and interpretability of the derived solutions. The findings reveal that the Random Forest achieves the highest prediction performance when the objective is the prediction of both contamination and contamination intensity with Cryptosporidium oocysts in a given water sample, with meteorological/physicochemical and microbiological markers being informative, respectively. For the prediction of contamination with Giardia, the eXtreme Gradient Boosting with physicochemical parameters was the most efficient algorithm, while, the Support Vector Regression that takes into consideration both microbiological and meteorological markers was more efficient for evaluating the contamination intensity with cysts. The results of the study designate that the adoption of ML and XAI approaches can be considered as a valuable tool for unveiling the complicated correlation of the presence and contamination intensity with these zoonotic parasites that could constitute, in turn, a basis for the development of monitoring platforms and early warning systems for the prevention of waterborne disease outbreaks.

Fit-for-purpose WWTP unmanned aerial systems: A game changer towards an integrated and sustainable management strategy.

In the ongoing Anthropocene era, air quality monitoring constitutes a primary axis of European and international policies for all sectors, including Waste Water Treatment Plants (WWTPs). Unmanned Aerial Systems (UASs) with proper sensing equipment provide an edge technology for air quality and odor monitoring. In addition, Unmanned Aerial Vehicle (UAV) photogrammetry has been used in civil engineering, environmental (water) quality assessment and lately for industrial facilities monitoring. This study constitutes a systematic review of the late advances and limitations of germane equipment and implementations. Despite their unassailable flexibility and efficiency, the employment of the aforementioned technologies in WWTP remote monitoring is yet sparse, partial, and concerns only particular aspects. The main finding of the review was the lack of a tailored UAS for WWTP monitoring in the literature. Therefore, to fill in this gap, we propose a fit-for-purpose remote monitoring system consisting of a UAS with a platform that would integrate all the required sensors for air quality (i.e., emissions of H2S, NH3, NOx, SO2, CH4, CO, CO2, VOCs, and PM) and odor monitoring, multispectral and thermal cameras for photogrammetric structural health monitoring (SHM) and wastewater/effluent properties (e.g., color, temperature, etc.) of a WWTP. It constitutes a novel, supreme and integrated approach to improve the sustainable management of WWTPs. Specifically, the developments that a fit-for-purpose WWTP UAS would launch, are fostering the decision-making of managers, administrations, and policymakers, both in operational conditions and in case of failures, accidents or natural disasters. Furthermore, it would significantly reduce the operational expenditure of a WWTP, ensuring personnel and population health standards, and local area sustainability.

Genotoxicity and metabolic changes induced via ingestion of virgin and UV-aged polyethylene microplastics by the freshwater fish Perca fluviatilis.

The present study aims to compare and assess the toxicity induced by aged (irradiated with ultraviolet radiation for 120 days) polyethylene microplastics (PE-MPs) in comparison to virgin (non-irradiated) ones, after feeding the freshwater fish Perca fluviatilis. To this end, MPs mediated genotoxicity was assessed by the investigation of micronucleus nuclear abnormalities frequency in fish blood, and the degree of DNA damage in the liver and muscle tissues, while metabolic alterations were also recorded in both tissues. Results showed that both virgin and aged PE-MPs induced signaling pathways leading to DNA damage and nuclear abnormalities, as well as metabolites changes in all tissues studied. Metabolic changes revealed that the metabolism of nucleic acids, energy, amino acids, and neurotransmitters was more disrupted in the liver and by aged PE-MPs compared to muscles. Fish fed with aged PE-MPs exhibited greater DNA damage, while blood cells of fish fed with virgin PE-MPs seemed to be more vulnerable to nuclear abnormalities in relation to those fed with aged PE-MPs. Moreover, aged PE-MPs induced more acute overall effects on the metabolic profiles of fish tissues, and initiated stronger stress responses, inflammation, and cellular damages in fish tissues in relation to virgin ones. Characterization of both virgin and aged MPs revealed that the latter exhibited lower crystallinity and melting point, more irregular shapes and higher moiety of oxygen and carbonyl groups, which could be attributed for their observed higher toxicity. The research outcomes provide significant insights for advancing toxicological investigations in this field.

Understanding the adsorption of Reactive red 2 onto metal hydroxide sludge: analysis with physico-statistical steric and energetic perspectives.

This theoretical investigation delves into the analysis of Reactive red 2 (RR-2) adsorption isotherms on metal hydroxide employing a sophisticated double-layer model characterized by dual-energy levels within the realm of physical adsorption phenomena. An examination of five distinct statistical physics frameworks was undertaken to elucidate the modeling and interpretation of equilibrium data. Expression for the physico-chemical parameters involved in the adsorption phenomena was derived based on statistical physics treatment. Fitting experimental adsorption isotherms (308-333 K) to a DAMTBS has revealed the number of anchored molecules per site, occupied receptor site density, and the number of adsorbed layers. The steric parameter n varies between 0.92 and 1.05. More importantly, it is evidenced that the adhesion mechanism of (RR-2) onto metal hydroxide as determined by the estimated adsorption energies (< 40 kJ/mol) supports a spontaneous and exothermic physisorption process. Thermodynamic potential functions such as entropy, Gibbs free energy, and internal energy have been computed based on the most suitable model. This research advances our physical understanding of how metal hydroxide captures dye molecules RR-2 through adsorption reaction for water depollution treatment.

The Multifaceted Effects of Non-Steroidal and Non-Opioid Anti-Inflammatory and Analgesic Drugs on Platelets: Current Knowledge, Limitations, and Future Perspectives.

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely utilized pharmaceuticals worldwide. Besides their recognized anti-inflammatory effects, these drugs exhibit various other pleiotropic effects in several cells, including platelets. Within this article, the multifaceted properties of NSAIDs on platelet functions, activation and viability, as well as their interaction(s) with established antiplatelet medications, by hindering several platelet agonists' pathways and receptors, are thoroughly reviewed. The efficacy and safety of NSAIDs as adjunctive therapies for conditions involving inflammation and platelet activation are also discussed. Emphasis is given to the antiplatelet potential of commonly administered NSAIDs medications, such as ibuprofen, diclofenac, naproxen and ketoprofen, alongside non-opioid analgesic and antipyretic medications like paracetamol. This article delves into their mechanisms of action against different pathways of platelet activation, aggregation and overall platelet functions, highlighting additional health-promoting properties of these anti-inflammatory and analgesic agents, without neglecting the induced by these drugs' side-effects on platelets' functionality and thrombocytopenia. Environmental issues emerging from the ever-increased subscription of these drugs are also discussed, along with the need for novel water treatment methodologies for their appropriate elimination from water and wastewater samples. Despite being efficiently eliminated during wastewater treatment processes on occasion, NSAIDs remain prevalent and are found at significant concentrations in water bodies that receive effluents from wastewater treatment plants (WWTPs), since there is no one-size-fits-all solution for removing all contaminants from wastewater, depending on the specific characteristics of the wastewater. Several novel methods have been studied, with adsorption being proposed as a cost-effective and environmentally friendly method for wastewater purification from such drugs. This article also presents limitations and future prospects regarding the observed antiplatelet effects of NSAIDs, as well as the potential of novel derivatives of these compounds, with benefits in other important platelet functions.

The effect of nanobubbles on Langmuir-Blodgett films.

Nanobubbles (NBs) are classified in two distinct categories: surface and bulk. Surface NBs are readily observed using atomic force microscopy (AFM), while the existence of bulk NBs has been a subject of debate, conflicting with the diffusion theory's predictions. Current methodologies for identifying bulk NBs yield inconclusive results. In this study, Langmuir Blodgett (LB) technique and AFM, are utilized to visualize NB imprints on anionic, cationic and zwitterionic lipid films deposited on glass-slide substrates. Our analysis of Langmuir monolayers compression isotherms reveals the impact of bulk NBs on lipid monolayer development. AFM scans of the deposited lipid films consistently show NB imprints. Notably, cationic and zwitterionic film depositions exhibit NB formations from the 1st layer, whereas in anionic films, these formations are observed only after the 3rd layer. These results suggest that the origin of these imprinted formations may be attributed to bulk NBs.

Terrestrial bioassays for assessing the biochemical and toxicological impact of biosolids application derived from wastewater treatment plants.

Wastewater treatment plants (WWTP) are facilities where municipal wastewater undergoes treatment so that its organic load and its pathogenic potential are minimized. Sewage sludge is a by-product of this process and when properly treated is preferentially called "biosolids". These treatments may include some or most of the following: thickening, dewatering, drying, digestion, composting, liming. Nowadays it is almost impossible to landfill biosolids, which however can well be used as crop fertilizers. Continuous or superfluous biosolids fertilization may negatively affect non-target organisms such as soil macro-organisms or even plants. These effects can be depicted through bioassays on terrestrial animals and plants. It has been shown that earthworms have been affected to various degrees on the following endpoints: pollutants' bioaccumulation, viability, reproduction, avoidance behavior, burrowing behavior. Collembola have been affected on viability, reproduction, avoidance behavior. Other terrestrial organisms such as nematodes and diplopods have also shown adverse health effects. Phytotoxicity have been caused by some biosolids regimes as measured through the following endpoints: seed germination, root length, shoot length, shoot biomass, root biomass, chlorophyll content, antioxidant enzyme activity. Very limited statistical correlations between pollutant concentrations and toxicity endpoints have been established such as between juvenile mortality (earthworms) and As or Ba concentration in the biosolids, between juvenile mortality (collembola) and Cd or S concentration in the biosolids, or between phytotoxicity and some extractable metals in leachates or aquatic extracts from the biosolids; more correlations between physicochemical characteristics and toxicity endpoints have been found such as between phytotoxicity and ammonium N in biosolids or their liquid extracts, or between phytotoxicity and salinity. An inverse correlation between earthworm/collembola mortality and stable organic matter has also been found. Basing the appropriateness of biosolids only on chemical analyses for pollutants is not cost-effective. To enable risk characterization and subsequent risk mitigation it is important to apply a battery of bioassays on soil macro-organisms and on plants, utilizing a combination of endpoints and established protocols. Through combined analytical quantification and toxicity testing, safe use of biosolids in agriculture can be achieved.

New insights into the size-independent bioactive potential of pristine and UV-B aged polyethylene microplastics.

The present study investigates the morphological, physicochemical, and structural changes occurred by the UV-B aging process of low-density polyethylene microplastics (LDPE MPs), as well as the bioactive potential of both pristine and UVaged MPs towards healthy peripheral blood lymphocytes. Specifically, LDPE MPs (100-180 µm) prepared by mechanical milling of LDPE pellets, were UV-B irradiated for 120 days (wavelength 280 nm; temperature 25 °C; relative humidity 50 %) and further examined for alterations in their particle size and surface, their functional groups, thermal stability, and crystallinity (by means of SEM, FTIR spectroscopy, XRD patterns, and TGA measurements, respectively). In parallel, isolated human peripheral blood lymphocytes were treated with different concentrations (25-500 µg mL-1) of either pristine or aged MPs (UVfree and UV120d LDPE MPs) for assessing the cytogenotoxic (by means of trypan blue exclusion test and the cytokinesis-block micronucleus assay using cytochalasin-B) and oxidative effects (using the DCFH-DA staining) in both cases. According to the results, UVfree and UV120d-LDPE MPs, with a size ranging from 100 to 180 µm, can differentially promote cytogenotoxic and oxidative alterations in human lymphocytes. In fact, UVfree LDPE MPs not being able to be internalized by cells due to their size, could indirectly promote the onset of mild oxidative and cytogenotoxic damage in human peripheral lymphocytes, via a dose-dependent but size-independent manner. The latter is more profound in case of the irregular-shaped UV120d-LDPE MPs, bearing improved dispersibility and sharp edges (by means of cracks and holes), as well as oxygen-containing and carbonyl groups. To our knowledge, the present findings provide new data regarding the bioactive behavior of pristine and UV-B aged LDPE MPs, at least in the in vitro biological model tested, thus giving new evidence for their size-independent and/or indirect mode of action.

A critical review on the recent trends of photocatalytic, antibacterial, antioxidant and nanohybrid applications of anatase and rutile TiO2 nanoparticles.

Titanium dioxide nanoparticles (TiO2 NPs) have become a focal point of research due to their widespread daily use and diverse synthesis methods, including physical, chemical, and environmentally sustainable approaches. These nanoparticles possess unique attributes such as size, shape, and surface functionality, making them particularly intriguing for applications in the biomedical field. The continuous exploration of TiO2 NPs is driven by the quest to enhance their multifunctionality, aiming to create next-generation products with superior performance. Recent research efforts have specifically focused on understanding the anatase and rutile phases of TiO2 NPs and evaluating their potential in various domains, including photocatalytic processes, antibacterial properties, antioxidant effects, and nanohybrid applications. The hypothesis guiding this research is that by exploring different synthesis methods, particularly chemical and environmentally friendly approaches, and incorporating doping and co-doping techniques, the properties of TiO2 NPs can be significantly improved for diverse applications. The study employs a comprehensive approach, investigating the effects of nanoparticle size, shape, dose, and exposure time on performance. The synthesis methods considered encompass both conventional chemical processes and environmentally friendly alternatives, with a focus on how doping and co-doping can enhance the properties of TiO2 NPs. The research unveils valuable insights into the distinct phases of TiO2 NPs and their potential across various applications. It sheds light on the improved properties achieved through doping and co-doping, showcasing advancements in photocatalytic processes, antibacterial efficacy, antioxidant capabilities, and nanohybrid applications. The study concludes by emphasizing regulatory aspects and offering suggestions for product enhancement. It provides recommendations for the reliable application of TiO2 NPs, addressing a comprehensive spectrum of critical aspects in TiO2 NP research and application. Overall, this research contributes to the evolving landscape of TiO2 NP utilization, offering valuable insights for the development of innovative and high-performance products.

Exploring patterns of antibiotics during and after COVID-19 pandemic in wastewaters of northern Greece: Potential adverse effects on aquatic environment.

Antibiotics, recognized as Emerging Contaminants (ECs), have raised concerns due to their pervasive presence in wastewater treatment plants (WWTPs) and subsequent release into aquatic environments, posing potential ecological risks and contributing to the development of antibiotic-resistant genes. The COVID-19 pandemic prompted an unprecedented surge in antibiotic consumption, necessitating a comprehensive assessment of its impact on antibiotic levels in wastewater. In this light, a four-year monitoring study (2020-2023) was conducted in a WWTP located in the Northern Greece (Thessaloniki), employing High-Resolution Mass Spectrometry (HRMS) technology to monitor twenty antibiotics, during distinct phases pre-, during, and post-COVID-19. Our findings revealed that macrolides and fluoroquinolones were among the most often detected categories during the sampling period. Among the compounds detected, azithromycin and clarithromycin showed the most significant increases during the pandemic, doubling their average concentrations. This establishes a clear correlation between the rise in their concentrations and the incidence of COVID-19 cases. A general downward trend after 2021 was attributed to the new restrictions posed in Greece during this year, regarding the liberal prescription of antibiotics. Seasonal variation revealed a minute augmentation of antibiotics' use during the months that infections are increased. Additionally, the study highlights the ecological risks associated with elevated antibiotic presence and emphasizes the need for continued monitoring and regulatory measures to mitigate potential ecological repercussions. These findings contribute to our understanding of the complex interplay between antibiotic consumption, environmental presence, and the COVID-19 pandemic's impact on antibiotic pollution in WWTPs.

Sustainable use of low-cost adsorbents prepared from waste fruit peels for the removal of selected reactive and basic dyes found in wastewaters.

Agricultural wastes are potential sustainable adsorbents since they are available in large quantities, are low-cost, and may require little or no treatment, in some cases. In this study, several fruit peels, such as banana, orange, and pomegranate, were collected from local markets and prepared by a simple and eco-friendly method and used as natural adsorbents for the removal of both anionic (Reactive Red 120 (RR120), Reactive Black 5 (RB5), Remazol Brilliant Blue R (RBBR)) and cationic Methylene Blue (MB) dyes found in wastewaters. Many industries, such as leather and textiles, can release huge amounts of synthetic dyes into the wastewater during dyeing processes. These are one of the most important pollutants of water pollution as they cause enormous damage to the water body and also affect the health of organisms due to their toxicity and carcinogenicity. The search for a sustainable and at the same time efficient material for the removal of a wide variety of dyes is the innovation of this work. These peels were prepared by washing, drying, grinding, and finally sieving, under natural sustainable conditions. Porosometry (BET analysis), FTIR, SEM/EDS, and XRD techniques were used to characterize the fruit peels before and after the adsorption process. Factors affecting the adsorption of dyes (adsorbent dosage, pH solution, initial concentration of dyes, contact time, and temperature) were investigated. According to the results, in terms of the effectiveness of fruit peels as (natural) adsorbent materials, for anionic dyes, 5.0-6.0 g/L of banana or orange dry peels was sufficient to remove near or even more than 90% anionic dyes at pH 2.0, and 4.0 g/L was sufficient to remove 98% of cationic MB dye at pH 9.0. Similar amount of pomegranate peels had lower efficiency for anionic dyes (50-70%), while cationic MB was still efficiently removed (98%) at pH 9.0. Moreover, the adsorption process in all cases was found to better fit to pseudo-second-order model, in comparison to pseudo-first-order model. According to isotherms, Freundlich model fitted better in some cases to the equilibrium data, while the Langmuir model in others. Finally, this study demonstrates the viability of reusing the banana, orange, and pomegranate peel adsorbents for eight, four, and five cycles, showing a gradual reduction of around 50% of their effectiveness.

Insight into microplastics in the aquatic ecosystem: Properties, sources, threats and mitigation strategies.

Globally recognized as emergent contaminants, microplastics (MPs) are prevalent in aquaculture habitats and subject to intense management. Aquaculture systems are at risk of microplastic contamination due to various channels, which worsens the worldwide microplastic pollution problem. Organic contaminants in the environment can be absorbed by and interact with microplastic, increasing their toxicity and making treatment more challenging. There are two primary sources of microplastics: (1) the direct release of primary microplastics and (2) the fragmentation of plastic materials resulting in secondary microplastics. Freshwater, atmospheric and marine environments are also responsible for the successful migration of microplastics. Until now, microplastic pollution and its effects on aquaculture habitats remain insufficient. This article aims to provide a comprehensive review of the impact of microplastics on aquatic ecosystems. It highlights the sources and distribution of microplastics, their physical and chemical properties, and the potential ecological consequences they pose to marine and freshwater environments. The paper also examines the current scientific knowledge on the mechanisms by which microplastics affect aquatic organisms and ecosystems. By synthesizing existing research, this review underscores the urgent need for effective mitigation strategies and further investigation to safeguard the health and sustainability of aquatic ecosystems.

Advancements and sustainable strategies for the treatment and management of wastewaters from metallurgical industries: an overview.

Metallurgy is pivotal for societal progress, yet it yields wastewater laden with hazardous compounds. Adhering to stringent environmental mandates, the scientific and industrial sectors are actively researching resilient treatment and disposal solutions for metallurgical effluents. The primary origins of organic pollutants within the metallurgical sector include processes such as coke quenching, steel rolling, solvent extraction, and electroplating. This article provides a detailed analysis of strategies for treating steel industry waste in wastewater treatment. Recent advancements in membrane technologies, adsorption, and various other processes for removing hazardous pollutants from steel industrial wastewater are comprehensively reviewed. The literature review reveals that advanced oxidation processes (AOPs) demonstrate superior effectiveness in eliminating persistent contaminants. However, the major challenges to their industrial-scale implementation are their cost and scalability. Additionally, it was discovered that employing a series of biological reactors instead of single-step biological processes enhances command over microbial communities and operating variables, thus boosting the efficacy of the treatment mechanism (e.g., achieving a chemical oxygen demand (COD) elimination rate of over 90%). This review seeks to conduct an in-depth examination of the current state of treating metallurgical wastewater, with a particular emphasis on strategies for pollutant removal. These pollutants exhibit distinct features influenced by the technologies and workflows unique to their respective processes, including factors such as their composition, physicochemical properties, and concentrations. Therefore, it is of utmost importance for customized treatment and disposal approaches, which are the central focus of this review. In this context, we will explore these methods, highlighting their advantages and characteristics.

Pyrethroids toxicity in vertebrates and invertebrates and amelioration by bioactive compounds: A review.

Generations of different synthetic pesticides have been launched over time to maintain balance between production and consumption of the agricultural yield, control various disease programmes, store grains, etc. Pyrethroids, which are supposed to be non-toxic, have been excessively implemented and have contaminated soil and water bodies. Thus, pyrethroids cause severe and dreadful pernicious effects on various life forms residing in soil, air, and water. Various obnoxious effects of pyrethroids have been analyzed in the vertebrate and invertebrate systems of the animal kingdom. Pyrethroids, namely, Cypermethrin, Deltamethrin, Beta-cyfluthrin, Esfenvalerate, Fenvalerate, and Bifenthrin, have set out various types of degenerative and toxic impacts that include oxidative stress, hepatotoxicity, immunotoxicity involving thymic and splenic toxicity, neurotoxicity, nephrotoxicity, foetal toxicity, alterations in serum calcium and phosphate levels, cerebral and bone marrow degeneration, degeneration of the reproductive system, histological alteration, and DNA damage. Bioactive compounds like Diosmin, Curcumin, Rutin, Spirulina platensis, sesame oil, Naringin, Allicin, Piperine, alpha-lipoic acid, alpha-tocopherol, Cyperus rotundus L. tuber extract, herbal syrup from chicory and artichoke leaves, green tea extract, Quercetin, Trans-ferulic acid, Ascorbic acid, Propolis, ethanolic extract of grape pomace, and Melatonin have been reported to sublime the toxic effects of these pesticides. The expanding harmfulness of pesticides is a real and demanding issue that needs to be overcome, and bioactive compounds have been shown to reduce the toxicity in vivo as well as in vitro.

Bibliometric research analysis of molecularly imprinted polymers (MIPs): evidence and research activity dynamics.

The escalating issue of water pollution has become a worldwide issue that has captured the attention of numerous scientists. Molecularly imprinted polymers (MIPs) have emerged as adaptable materials with exceptional attributes, including easy synthesis, low cost, remarkable durability, long life, and accessibility. These attributes have motivated researchers to develop novel materials based on MIPs to tackle hazardous contaminants in environmental matrices. The purpose of this paper was to conduct a bibliometric analysis on MIPs' publications, in order to shed light on the developments and focus points of the field. The selected publications were obtained from Scopus database and subjected to a filtering process, resulting in 11,131 relevant publications. The analysis revealed that the leading publication source (journal) is Biosensors and Bioelectronics; the mostly employed keywords are solid-phase extraction, electrochemical sensor, and molecular recognition; and the top contributing countries are China, Iran, and the USA. The Latent Dirichlet Allocation (LDA) algorithm was used for extracting thematic axes from the textual content of the publications. The results of the LDA model showcase that the topic of synthesis and performance of MIPs for environmental applications can be considered as the most dominant topic with a share value of 72.71%. From the analysis, it can be concluded that MIPs are a cross-disciplinary research field.

Batch adsorption study in liquid phase under agitation, rotation, and nanobubbles: comparisons in a multi-parametric study.

Concern for environmental protection has increased throughout the years from a global perspective. To date, the predominance of adsorption as treatment technique in environmental chemistry remains unchallenged. Moreover, the scientific attention for investigating nanobubbles due to their unique properties has turned the search for their application in environmental processes with special emphasis on water treatment. This study is aimed at investigating the effect of rotation on batch adsorption process using commercial activated carbon as adsorbent material, compared with the widely used method of agitation. As liquid medium, deionized water and deionized water enhanced with nanobubbles (of air) were used. The wastewater was simulated by dissolving a common dye as model pollutant, methylene blue, at concentration of 300 mg/L in the tested liquid. The results indicated that the utilization of nanobubbles resulted in an improvement on adsorption rate, compared to the corresponding values of deionized water solutions. These results may lead to promising applications in the future, since just 1 h of operation increases the water purification and thus provides a simply applied, cost-effective, and rapid alternative.

The Effect of Nanobubbles on Transdermal Applications.

In the present work, a new method for dermal delivery using nanobubbles (NBs) is investigated. Oxygen NBs are generated in deionized water and used to produce cosmetic formulations with hyaluronic acid as an active ingredient. Nanobubbles result in the improvement of the effect and penetration of the active ingredient through Strat-M, a synthetic membrane that resembles human skin. Experiments conducted with the Franz Cell device confirm the greater penetration of the active ingredient into Strat-M due to NBs, compared to cosmetic formulations that do not contain NBs. The effect of NBs was further examined by measuring UV-Vis and FTIR spectra. A possible mechanism was outlined, too. It was also found that NBs do not change the pH or the FTIR spectrum of the cosmetic serum indicating non-toxicity.