RÉSUMÉ
PURPOSE: Definitive or postoperative chemoradiation (CRT) is curative for human papillomavirus-associated (HPV+) oropharynx cancer (OPC) but induces significant toxicity. As a deintensification strategy, we studied primary transoral surgery (TOS) and reduced postoperative radiation therapy (RT) in intermediate-risk HPV+ OPC. METHODS: E3311 is a phase II randomized trial of reduced- or standard-dose postoperative RT for resected stage III-IVa (American Joint Committee on Cancer-seventh edition) HPV+ OPC, determined by pathologic parameters. Primary goals were feasibility of prospective multi-institutional study of TOS for HPV+ OPC, and oncologic efficacy (2-year progression-free survival) of TOS and adjuvant therapy in intermediate-risk patients after resection. TOS plus 50 Gy was considered promising if the lower limit of the exact 90% binomial confidence intervals exceeded 85%. Quality of life and swallowing were measured by functional assessment of cancer therapy-head and neck and MD Anderson Dysphagia Index. RESULTS: Credentialed surgeons performed TOS for 495 patients. Eligible and treated patients were assigned as follows: arm A (low risk, n = 38) enrolled 11%, intermediate risk arms B (50 Gy, n = 100) or C (60 Gy, n = 108) randomly allocated 58%, and arm D (high risk, n = 113) enrolled 31%. With a median 35.2-month follow-up for 359 evaluable (eligible and treated) patients, 2-year progression-free survival Kaplan-Meier estimate is 96.9% (90% CI, 91.9 to 100) for arm A (observation), 94.9% (90% CI, 91.3 to 98.6]) for arm B (50 Gy), 96.0% (90% CI, 92.8 to 99.3) for arm C (60 Gy), and 90.7% (90% CI, 86.2 to 95.4) for arm D (66 Gy plus weekly cisplatin). Treatment arm distribution and oncologic outcome for ineligible or step 2 untreated patients (n = 136) mirrored the 359 evaluable patients. Exploratory comparison of functional assessment of cancer therapy-head and neck total scores between arms B and C is presented. CONCLUSION: Primary TOS and reduced postoperative RT result in outstanding oncologic outcome and favorable functional outcomes in intermediate-risk HPV+ OPC.
Sujet(s)
Antinéoplasiques/usage thérapeutique , Marqueurs biologiques tumoraux/analyse , Cisplatine/usage thérapeutique , Inhibiteur p16 de kinase cycline-dépendante/analyse , Tumeurs de l'oropharynx/thérapie , Papillomaviridae/isolement et purification , Pharyngectomie , Radiothérapie conformationnelle avec modulation d'intensité , Carcinome épidermoïde de la tête et du cou/thérapie , Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Antinéoplasiques/effets indésirables , Chimioradiothérapie adjuvante , Cisplatine/effets indésirables , Études de faisabilité , Femelle , Humains , Mâle , Adulte d'âge moyen , Tumeurs de l'oropharynx/composition chimique , Tumeurs de l'oropharynx/anatomopathologie , Tumeurs de l'oropharynx/virologie , Pharyngectomie/effets indésirables , Survie sans progression , Études prospectives , Radiothérapie conformationnelle avec modulation d'intensité/effets indésirables , Carcinome épidermoïde de la tête et du cou/composition chimique , Carcinome épidermoïde de la tête et du cou/anatomopathologie , Carcinome épidermoïde de la tête et du cou/virologie , Facteurs tempsRÉSUMÉ
The free fibula flap is the preferred reconstructive method for oncologic defects of the mandible. Arterial inflow of the extremity is routinely evaluated with several modalities; however, venous screening is rarely performed. Patients with cancer are at elevated risk of occult deep venous thrombosis (DVT). An asymptomatic thrombus encountered during free fibula reconstruction is a serious concern. Although such cases have been reported, we suspect the incidence of DVT during fibula free flap harvest is underappreciated. This monograph uses a case example to review risk factors for occult DVT, present a strategy for preoperative assessment, and provide a reconstructive algorithm to for mandibular reconstruction in such instances.
Sujet(s)
Fibula/vascularisation , Lambeaux tissulaires libres/vascularisation , Complications peropératoires/diagnostic , Reconstruction mandibulaire/méthodes , Thrombose veineuse/diagnostic , Sujet âgé , Maladies asymptomatiques , Femelle , Fibula/transplantation , Lambeaux tissulaires libres/transplantation , Humains , Thrombose veineuse/étiologieRÉSUMÉ
Vocal cord paralysis after administration of the chemotherapeutic agent vincristine is a rare occurrence. Most occurrences are bilateral. Of the 24 cases referenced in this article, 19 are children. In all the reported cases, symptoms have occurred after multiple doses of vincristine have been administered. The authors report a case of a 39-year-old woman with unilateral vocal cord motion impairment occurring 3 days after the administration of the first dose of vincristine. This is the first case of vocal cord motion impairment reported after the administration of only 1 dose of this drug.