Obsessive-compulsive symptoms in dementia: Systematic review with meta-analysis.

Dementia is a highly prevalent syndrome with various causes, characterized by cognitive deficit in one or more domains, with important impairment of functioning, which frequently presents with neuropsychiatric symptoms that may include obsessive-compulsive symptoms. OBJECTIVES: The main goal of this meta-analysis was to describe and determine the prevalence of obsessive-compulsive symptoms in dementia. MATERIALS AND METHODS: To accomplish that, MEDLINE, CENTRAL and Psycnet databases were searched from inception to March 2023. The Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data was applied. The principal summary measures were the mean of prevalence of obsessive-compulsive symptoms in patients with dementia and the number of each type of obsession or compulsion. RESULTS: Of the 643 articles screened, 92 were accepted for full-text assessment. Of these, 30 with information on prevalence of obsessive-compulsive symptoms in dementia or any description of those were included, yielding a total of 37 cohorts (5 studies with two cohorts and 1 study with three cohorts). According to our results, obsessive-compulsive symptoms have considerable prevalence in dementia (35.3%, 23.1-47.6%), namely in frontotemporal dementia (48.4%, 29.8-67.0%); obsessive-compulsive symptoms were less frequent in other dementia diagnosis (17.6%, 9.1-26.2%). The more frequent obsessive contents are symmetry (28.6%) and somatic (20.0%); and the more frequent compulsions are checking (27.4%); hoarding is also a relevant symptom (27.8%). DISCUSSION: There was considerable heterogeneity in the prevalence of obsessive-compulsive symptoms in frontotemporal dementia, that is, in part related with diagnostic criteria for dementia, as well as obsessive-compulsive symptom assessment. A careful distinction between compulsions and compulsive-like symptoms is fundamental. Hypervigilance for somatic symptoms and concerns about disease and mortality, as well as deficits in cognitive domains like attention and memory may explain why somatic obsessions and checking compulsions are more prevalent. CONCLUSIONS: The present results indicate that obsessive-compulsive symptoms may be prevalent in the clinical course of many patients with dementia, especially frontotemporal dementia. Better instruments are needed to describe obsessive-compulsive phenomena in a reliable and comparable way, particularly in a population such as dementia patients, whose subjectivity is difficult to access.

Natural Pigments Recovery from Food By-Products: Health Benefits towards the Food Industry.

Given the health risks associated with synthetic colorants, natural pigments have emerged as a promising alternative. These renewable choices not only provide health benefits but also offer valuable technical and sensory properties to food systems. The effective application of natural colorants, however, requires the optimization of processing conditions, exploration of new sources, and development of novel formulations to ensure stability and maintain their inherent qualities. Several natural pigment sources have been explored to achieve the broad color range desired by consumers. The purpose of this review is to explore the current advances in the obtention and utilization of natural pigments derived from by-products, which possess health-enhancing properties and are extracted through environmentally friendly methods. Moreover, this review provides new insights into the extraction processes, applications, and bioactivities of different types of pigments.

Obsessive-Compulsive Symptoms in Dementia: Scoping Review of Pathological Changes.

Objective: To review the literature on the neurobiological mechanisms of obsessive-compulsive symptoms (OCS) in people with dementia.Data Sources: MEDLINE/PubMed, CENTRAL, and PsycNet databases were searched from inception to March 2023.Study Selection: Original studies of any methodology with newly published data on the neurobiological underpinnings of OCS in patients with dementia, regardless of patient age or comorbidity and publication year, were included. The following search terms were used: (Obses* OR compul* OR OCD) AND (cognitive de* OR cognitive dysfunction OR cognitive disfunction OR dementia).Data Extraction: Individual study data were extracted onto a piloted extractions sheet.Results: Patients with dementia and OCS were reported to have atrophy and hypoperfusion of frontal, temporal, striatal, and limbic structures. Serotonergic agents may be efficacious in reducing OCS. One randomized controlled trial of paroxetine in behavioral symptoms of dementia did not show efficacy. Evidence of dopaminergic dysfunction is too sparse to draw conclusions. Microglia dysfunction mediates obsessive-compulsive-like symptoms. Mutations of microtubule-associated protein τ may increase the risk of OCS. Cognitive self-consciousness and obsessive-compulsive-related cognitions may mediate OCS in old age. Dysfunction of the processing of one class of stimuli may increase the salience of other classes of stimuli, leading to OCS.Conclusions: Frontal lobe hypometabolism and temporal lobe atrophy and hypometabolism are unexpected given previous research in obsessive compulsive disorder. Serotonergic agents have encouraging efficacy in case reports but require more specific research.Prim Care Companion CNS Disord 2024;26(3):23r03689. Author affiliations are listed at the end of this article.

Unmoving and uninflamed: Characterizing neuroinflammatory dysfunction in the Wistar-Kyoto rat model of depression.

Reductionistic research on depressive disorders has been hampered by the limitations of animal models. Recently, it has been hypothesized that neuroinflammation is a key player in depressive disorders. The Wistar-Kyoto (WKY) rat is an often-used animal model of depression, but no information so far exists on its neuroinflammatory profile. As such, we compared male young adult WKY rats to Wistar (WS) controls, with regard to both behavioral performance and brain levels of key neuroinflammatory markers. We first assessed anxiety- and depression-like behaviors in a battery consisting of the Elevated Plus Maze (EPM), the Novelty Suppressed Feeding (NSFT), Open Field (OFT), Social Interaction (SIT), Forced Swim (FST), Sucrose Preference (SPT), and Splash tests (ST). We found that WKY rats displayed increased NSFT feeding latency, decreased OFT center zone permanence, decreased EPM open arm permanence, decreased SIT interaction time, and increased immobility in the FST. However, WKY rats also evidenced marked hypolocomotion, which is likely to confound performance in such tests. Interestingly, WKY rats performed similarly, or even above, to WS levels in the SPT and ST, in which altered locomotion is not a significant confound. In a separate cohort, we assessed prefrontal cortex (PFC), hippocampus and amygdala levels of markers of astrocytic (GFAP, S100A10) and microglial (Iba1, CD86, Ym1) activation status, as well as of three key proinflammatory cytokines (IL-1ß, IL-6, TNF-α). There were no significant differences between strains in any of these markers, in any of the regions assessed. Overall, results highlight that behavioral data obtained with WKY rats as a model of depression must be carefully interpreted, considering the marked locomotor activity deficits displayed. Furthermore, our data suggest that, despite WKY rats replicating many depression-associated neurobiological alterations, as shown by others, this is not the case for neuroinflammation-related alterations, thus representing a novel limitation of this model.

The sphingosine 1-phosphate analogue, FTY720, modulates the lipidomic signature of the mouse hippocampus.

The small-molecule drug, FTY720 (fingolimod), is a synthetic sphingosine 1-phosphate (S1P) analogue currently used to treat relapsing-remitting multiple sclerosis in both adults and children. FTY720 can cross the blood-brain barrier (BBB) and, over time, accumulate in lipid-rich areas of the central nervous system (CNS) by incorporating into phospholipid membranes. FTY720 has been shown to enhance cell membrane fluidity, which can modulate the functions of glial cells and neuronal populations involved in regulating behaviour. Moreover, direct modulation of S1P receptor-mediated lipid signalling by FTY720 can impact homeostatic CNS physiology, including neurotransmitter release probability, the biophysical properties of synaptic membranes, ion channel and transmembrane receptor kinetics, and synaptic plasticity mechanisms. The aim of this study was to investigate how chronic FTY720 treatment alters the lipid composition of CNS tissue in adolescent mice at a key stage of brain maturation. We focused on the hippocampus, a brain region known to be important for learning, memory, and the processing of sensory and emotional stimuli. Using mass spectrometry-based lipidomics, we discovered that FTY720 increases the fatty acid chain length of hydroxy-phosphatidylcholine (PCOH) lipids in the mouse hippocampus. It also decreases PCOH monounsaturated fatty acids (MUFAs) and increases PCOH polyunsaturated fatty acids (PUFAs). A total of 99 lipid species were up-regulated in the mouse hippocampus following 3 weeks of oral FTY720 exposure, whereas only 3 lipid species were down-regulated. FTY720 also modulated anxiety-like behaviours in young mice but did not affect spatial learning or memory formation. Our study presents a comprehensive overview of the lipid classes and lipid species that are altered in the hippocampus following chronic FTY720 exposure and provides novel insight into cellular and molecular mechanisms that may underlie the therapeutic or adverse effects of FTY720 in the central nervous system.

Age-related impact of social isolation in mice: Young vs middle-aged.

Social isolation is a chronic mild stressor and a significant risk factor for mental health disorders. Herein we explored the impact of social isolation on depression- and anxiety-like behaviours, as well as spatial memory impairments, in middle-aged male mice compared to post-weaning mice. We aimed to quantify and correlate social isolation-induced behaviour discrepancies with changes in hippocampal glial cell reactivity and pro-inflammatory cytokine levels. Post-weaning and middle-aged C57BL7/J6 male mice were socially isolated for a 3-week period and behavioural tests were performed on the last five days of isolation. We found that 3 weeks of social isolation led to depressive-like behaviour in the forced swim test, anxiety-like behaviour in the open field test, and spatial memory impairment in the Morris water maze paradigm in middle-aged male mice. These behavioural alterations were not observed in male mice after post-weaning social isolation, indicating resilience to isolation-mediated stress. Increased Iba-1 expression and NLRP3 priming were both observed in the hippocampus of socially isolated middle-aged mice, suggesting a role for microglia and NLRP3 pathway in the detrimental effects of social isolation on cognition and behaviour. Young socially isolated mice also demonstrated elevated NLRP3 priming compared to controls, but no differences in Iba-1 levels and no significant changes in behaviour. Ageing-induced microglia activation and enhancement of IL-1ß, TNF-α and IL-6 proinflammatory cytokines, known signs of a chronic low-grade inflammatory state, were also detected. Altogether, data suggest that social isolation, in addition to inflammaging, contributes to stress-related cognitive impairment in middle-aged mice.

Functional Ingredients and Additives from Lemon by-Products and Their Applications in Food Preservation: A Review.

Citrus trees are among the most abundant fruit trees in the world, with an annual production of around 124 million tonnes. Lemons and limes are among the most significant contributors, producing nearly 16 million tonnes per year. The processing and consumption of citrus fruits generates a significant amount of waste, including peels, pulp, seeds, and pomace, which represents about 50% of the fresh fruit. Citrus limon (C. limon) by-products are composed of significant amounts of bioactive compounds, such as phenolic compounds, carotenoids, vitamins, essential oils, and fibres, which give them nutritional value and health benefits such as antimicrobial and antioxidant properties. These by-products, which are typically discarded as waste in the environment, can be explored to produce new functional ingredients, a desirable approach from a circular economy perspective. The present review systematically summarizes the potential high-biological-value components extracted from by-products to achieve a zero-waste goal, focusing on the recovery of three main fractions: essential oils, phenolic compounds, and dietary fibres, present in C. limon by-products, and their applications in food preservation.

Obsessive-compulsive symptoms in first episode psychosis and risk states: Systematic review with meta-analysis.

BACKGROUND AND HYPOTHESIS: Recent studies have reported high prevalences of obsessive-compulsive symptoms and obsessive-compulsive disorder in at risk and first-episode psychosis patients. This sparked an interest in the effect of these symptoms in the clinical characteristics and outcomes of patients. However these studies have never been formally meta-analyzed. STUDY DESIGN: Systematic review and meta-analysis of prevalence of obsessive-compulsive symptoms and obsessive-compulsive disorder in at risk and first-episode psychosis patients and comparison of clinical characteristics and outcomes in patients with and without obsessive-compulsive symptoms. STUDY RESULTS: Obsessive-compulsive disorder was present in 7.9 % (5.9 to 10.0 %) and 10.5 % (8.3 to 12.8 %) and obsessive-compulsive symptoms in 21.4 % (8.3 to 38.2 %) and 34.0 % (26.3 to 42.1 %) of at risk and first episode psychosis patients respectively. The prevalences of obsessive-compulsive symptoms had high heterogeneity due in part to different measurement methods and cut-off values. Similar ages of onset for OCS and psychosis symptoms were found (mean difference - 0.49 years, 95 % CI -1.74 to 0.77). Patients with obsessive-compulsive symptoms had statistically insignificant higher Positive and Negative Syndrome Scale (positive subscale) scores and marginally higher depression scores. There were no differences between both groups in age of onset, Positive and Negative Syndrome Scale (negative subscale) score, risk of conversion to psychosis, anxiety score, suicide rate, and functionality score. CONCLUSIONS: Obsessive-compulsive disorder and obsessive-compulsive symptoms are very prevalent in at risk and first-episode psychosis patients.

Innovative Processing Technologies to Develop a New Segment of Functional Citrus-Based Beverages: Current and Future Trends.

The food industries are interested in developing functional products due to their popularity within nutritional and healthy circles. Functional fruit-based beverages represent one of the fast-growing markets due to the high concentrations of bioactive compounds (BCs), which can be health promoters. Hence, functional beverages based on citrus fruits are a potential way to take advantage of their nutritional and bioactive properties that could attract the interest of consumers. In order to ensure microbial and quality stability, the beverages are subjected to preservation treatment; however, the application of high temperatures leads to the loss of thermolabile BCs. Nowadays, innovative processing technologies (IPT) such as pulsed electric field (PEF), high-pressure processing (HPP), ultrasound processing (US), ohmic heating (OH), and microwave (MW) are a promising alternative due to their efficiency and low impact on juice BCs. The available literature concerning the effects of these technologies in functional fruit-based beverages is scarce; thus, this review gathers the most relevant information about the main positive and negative aspects of the IPT in functional properties, safety, and consumer acceptance of functional citrus-based beverages, as well as the use of citrus by-products to promote the circular economy in citrus processing.

Knowledge of COVID-19 among Brazilian health care professionals and associated factors.

ABSTRACT: Health care professional's knowledge is essential to contain epidemics. This research aimed to evaluate the knowledge of Brazilian health care professionals regarding COVID-19 to analyze whether there is a difference in knowledge between professionals in Primary Health Care and those in other levels of care or not; and to identify factors associated with knowledge. This is a cross-sectional study, including 716 participants who answered an online questionnaire between April and May 2020. Descriptive statistics, difference tests between groups, and logistic regression models were used to analyze the data. The average knowledge score was 12.42 points (out of a possible total of 15). There was no significant difference between professionals in Primary Health Care and those in other levels of care. Knowledge was associated with age, profession, perception regarding media's information quality, and hours exposed to information on COVID-19. Participants showed adequate knowledge, despite some specific gaps. Continuing education actions should prioritize younger nonmedical professionals.

Sistemas e serviços de saúde em âmbito mundial: organização da Atenção Primária à Saúde / Health systems and services worldwide: organization of primary health care / Sistemas y servicios de salud en nivel mundial: organización de la atención primaria de salud

Objetivo: Caracterizar, com base na literatura, sistemas e serviços de saúde em âmbito mundial. Método: Trata-se de uma Scoping Review, das bases de dados: Biblioteca Virtual de Saúde, Embase, ProQuest, National Library of Medicine National Institutes of Health e Scientific Electronic Library Online. Utilizou-se os descritores e suas combinações: Health Systems, Health Services, Structure of Services e Primary Health Care, entre 2009 e 2019, disponíveis em espanhol, francês, inglês, português. Foram analisados considerando objetivos dos estudos, tipo de proteção social, prestação de serviços, estrutura e organização da Atenção Primária à Saúde e financiamento. Resultados: Foram incluídos 12 estudos que se aquedaram à proposta da pesquisa. Os sistemas evidenciados estão relacionados aos países Iraque, Equador, Dinamarca, Argentina, Holanda, Canadá, Irlanda, Bélgica, França, Suécia, Reino Unido e Itália. Conclusões: Dentre os sistemas e serviços de saúde dos países analisados, alguns estão orientados pelo modelo de mercado, outros pela oferta pública da atenção à saúde e há aqueles que integram os dois modelos. Os sistemas de saúde devem ofertar serviços que alcancem toda a população, organizados a partir da Atenção Primária à Saúde. Os que adotam o modelo seguridade social são os que mais se aproximam deste cenário. (AU)

Objective: To map, from the literature, health systems and services worldwide, characterizing them as to the type of social protection, service provision, organizational structure of the PHC and origin of financing. Methods: This is a Scoping Review of databases: Virtual Health Library, Embase, ProQuest, National Library of Medicine, National Institutes of Health and Scientific Electronic Library Online. The descriptors and their combinations were used: Health Systems, Health Services, Structure of Services and Primary Health Care, between 2009 and 2019, available in Spanish, French, English, Portuguese. They were analyzed considering study objectives, type of social protection, service provision, structure and organization of Primary Health Care and financing. Results: Twelve studies that followed the research proposal were included. The systems shown are related to the countries: Iraq, Ecuador, Denmark, Argentina, Netherlands, Canada, Ireland, Belgium, France, Sweden, United Kingdom and Italy. Conclusion: Among the health systems and services of the analyzed countries, some are guided by the market model, others by the public offer of health care and there are those that integrate the two models. Health systems must offer services that reach the entire population, organized based on Primary Health Care. Those who adopt the social security model are the closest to this scenario. (AU)

Objetivo: Mapear, con base em la literatura, los sistemas y servicios de salud a nivel mundial, presentandolos em relación a su protección social, prestacion de los servicios de salud, estrutura organizacional y su fuente de financiamento. Caracterizar, con base en la literatura, los sistemas y servicios de salud a nivel mundial. Metodos: Esta es una revisión de alcance de las bases de datos: Biblioteca Virtual de Salud, Embase, ProQuest, Biblioteca Nacional de Medicina, Institutos Nacionales de Salud y Biblioteca Electrónica Científica en Línea. Se utilizaron los descriptores y sus combinaciones: Sistemas de Salud, Servicios de Salud, Estructura de Servicios y Atención Primaria de Salud, entre 2009 y 2019, disponibles en español, francés, inglés, portugués. Fueron analizados considerando: objetivos del estudio, tipo de protección social, prestación de servicios, estructura y organización de la Atención Primaria de Salud y financiamiento. Resultados: Se incluyeron doce estudios que se adhirieron a la propuesta de investigación. Los sistemas mostrados están relacionados con los países: Irak, Ecuador, Dinamarca, Argentina, Países Bajos, Canadá, Irlanda, Bélgica, Francia, Suecia, Reino Unido e Italia. Conclusion: Entre los sistemas y servicios de salud de los países analizados, algunos se guían por el modelo de mercado, otros por la oferta pública de atención en salud y existen los que integran los dos modelos. Los sistemas de salud deben ofrecer servicios que lleguen a toda la población, organizados en base a la Atención Primaria de Salud, quienes adoptan el modelo de seguridad social son los más cercanos a este escenario. (AU)

Hyperandrogenism, oligomenorrhea, and erythrocytosis caused by an ovarian Leydig cell tumor: A case report.

Leydig cell tumors are rare ovarian neoplasms. Affected individuals typically present with amenorrhea/oligomenorrhea and rapidly progressive features of virilization. Erythrocytosis can also occur as a result of high testosterone levels.

Predictive Factors for Severe Maternal Morbidity in Brazil: A Case-Control Study.

The maternal mortality or "maternal near miss" ratio in Brazil reflects the socioeconomic indicators as well as the healthcare quality in some areas of this country, pointing out fragile points in the health services. The aim of this study was to estimate the association of diverse variables related to pregnancy and the occurrence of Near Miss in a population of women who were cared in public maternity wards in Brazil. A case-control study was performed. The association between variables and outcomes was verified through a chi-square test. A multiple analysis was carried out, producing odds ratio (OR) estimates with values of p≤0.25 in the univariate model. The results point to the following risk factors for Severe Maternal Morbidity: non-white (<0.001, OR 2.973), family income of up to two minimum wage salaries (<0.001; OR 2.159), not having a partner (<0.001, OR 2.694), obesity (<0.001, OR 20.852), not having received pre-natal care (<0.001, OR 2.843), going to less than six prenatal appointments (<0.001, OR 3.498), undergoing an inter-hospital transfer (<0.001, OR 24.655), and the absence of labor during admission (<0.001, OR 25.205). Although the results vary, the incidence of women with potential life-threatening complications is high in Brazil, which reinforces the need to universalize more complex interventions as well as coverage of primary care. The presence of precarious socio-economic indicators and unqualified obstetric care were risk factors for Severe Maternal Morbidity.

The use of ultra-high-pressure-liquid-chromatography tandem time-of-flight mass spectrometry as a confirmatory method in drug residue analysis: Application to the determination of antibiotics in piglet liver.

Consumption of food containing antibiotic residues can cause direct toxic effects, such as allergic reactions, or indirect effects, like the possibility to contribute to the development of antimicrobial resistance. It is essential for consumer food safety, as well as for public health, to monitor antibiotics in foods of animal origin intended for human consumption, particularly in piglets, a highly consumed meat in Portugal. Concerning the lack of regulations regarding the validation criteria for the ToF-MS (time-of-flight mass spectrometry) drug residues determination, this study presents an approach for the use of UHPLC (ultra-high-pressure-liquid-chromatography)-ToF-MS not only for screening but also for confirmatory purposes of 45 antibiotics from 7 different classes. Thus, a method was optimized and validated in accordance with Decision 2002/657/EC by evaluating CCα, CCß, specificity, selectivity, recovery, ruggedness, repeatability and reproducibility. For antibiotics with no MRL set, the lowest values achieved for CCα and CCß were, respectively, of 0.1 µg kg-1 and 0.2 µg kg-1 for cinoxacin. Regarding precision, the CV values obtained ranged from 5% to 21% for repeatability and from 6% to 22% for reproducibility. Recoveries were calculated falling between 82% and 120%. After validation, the method was used to analyse piglet liver samples. Antibiotic residues were determined in 47% of the 21 analysed samples. Nevertheless, all the antibiotics were detected at concentrations below the MRLs.

Long-Term Weight Loss and Metabolic Syndrome Remission after Bariatric Surgery: The Effect of Sex, Age, Metabolic Parameters and Surgical Technique - A 4-Year Follow-Up Study.

INTRODUCTION: Bariatric surgery is an effective treatment for morbid obesity and its metabolic related comorbidities. However, the literature reports inconsistent results regarding weight loss (WL) and the resolution of comorbidities associated with obesity. OBJECTIVE: We aim to evaluate long-term differences in WL between different surgical techniques and the impact of each surgical technique on metabolic parameters (type 2 diabetes mellitus [T2DM], dyslipidemia,hypertension, and metabolic syndrome). We also aim to evaluate the effect of baseline clinical characteristics in WL and in the evolution of metabolic syndrome (MetS) components. Our hypothesis is that different types of surgery have different effects on WL and the prevalence of comorbidities over time. METHODS: We retrospectively evaluated WL and metabolic parameter remission (T2DM, dyslipidemia, hypertension, and MetS) during 4 years in 1,837 morbidly obese patients (females, 85%; age, 42.5 ± 10.6 years; BMI, 44.0 ± 5.8) who underwent bariatric surgery (Roux-en-Y gastric bypass [RYGB], laparoscopic sleeve gastrectomy [LSG], and laparoscopic adjustable gastric band [LAGB]). RESULTS: The mean percentage of WL for RYGB, LSG, and LAGB was, respectively, 32.9 ± 8.7, 29.8 ± 9.8, and 16.2 ± 9.6 at 12 months and 30.6 ± 9.1, 22.7 ± 10.0, and 15.8 ± 10.8 at 48 months (p < 0.001), even after adjustment for baseline weight, BMI, age, and sex (p < 0.001). Women had more WL during the first 36 months (p = 0.013 and 0.007 at 12 and 36 months, respectively) and older patients had less WL compared to younger ones (p <0.001), except at 48 months. Patients with T2DM had less WL than those without diabetes after adjustment (sex, age, and surgical technique) during the same period. Patients with hypertension had less WL at 12 months (p = 0.009) and MetS at 24 months (p = 0.020) compared to those without these comorbidities. There was no significant difference regarding the presence of dyslipidemia in WL. The RYGB group showed better results for MetS resolution. CONCLUSION: During the 4-year follow-up, RYGB was the surgical procedure that caused the highest WL and MetS resolution.

Formação de profissionais de saúde com ênfase na Atenção Primária à Saúde (APS) em diferentes países: semelhanças e diferenças / Training of health professionals with an emphasis on Primary Health Care (PHC) in different countries: similarities and differences / Capacitación de profesionales de la salud con énfasis en atención primaria de salud (APS) en diferentes países: similitudes y diferencias

Objetivo: Analisar modelos de formação de profissionais de saúde em diferentes países, com ênfase na Atenção Primária à Saúde, observando possíveis semelhanças e diferenças existentes; a partir de evidências cientificas no período de 2009 a2019. Material e métodos:Revisão bibliográfica (Scoping Review). Estudos identificados nas bases de dados PubMed; BVS; ProQuest e EMBASE. Como estratégia de busca adotou-se os descritores e suas combinações: Health Workforce, Aptitude, Professional Competence, Models Educational, Health Human Resource Training. Foram incluídos artigos publicados entre 2009 a 2019, sobre a formação em saúde, idiomas português, inglês, francês e espanhol; identificando-se 2.616 artigos. Excluindo artigos duplicados obteve-se 2.042. Mediante os demais critérios de exclusão: ausência de resumos, artigos não relacionados à formação no contexto da APS; teve-se o registro de 369 artigos. Após leitura dos títulos e resumos obteve-se 51 artigos. Através da leitura na integra, resultaram 28 artigos. Este estudo representa um recorte da revisão da literatura, onde selecionamos 10 artigos presentes no PubMed e BVS. Mediante análise de conteúdo na modalidade temática foram construídas categorias de análises discutidas neste estudo. Resultados: Identificou-se como tema "Formação de Profissionais para a Atenção Primária à Saúde e Saúde Comunitária", classificando-se, dois núcleos de sentidos: "Competências, atitudes, habilidades e conhecimentos na formação dos profissionais de saúde;" e "Educação e Aprendizagem Interprofissional em Saúde." Conclusão:Ênfase no desenvolvimento de competências e evidências da Educação Interprofissional na formação para atenção primária e saúde comunitária; valorizando as competências específicas; comuns e colaborativas, para o trabalho em equipe. (AU)

Objective: To analyze training models for health professionals in different countries, with an emphasis on Primary Health Care, observing possible similarities and differences; from scientific evidence from 2009 to 2019. Material and methods: Bibliographic review (Scoping Review). Studies identified in the PubMed databases; VHL; ProQuest and EMBASE. As search strategy, the descriptors and their combinations were adopted: Health Workforce, Aptitude, Professional Competence, Models Educational, Health Human Resource Training. Articles published between 2009 and 2019, on health education, Portuguese, English, French and Spanish were included; 2,616 articles were identified. Excluding duplicate articles, 2,042 were obtained. Through the other exclusion criteria: absence of abstracts, articles not related to training in the context of PHC; 369 articles were registered. After reading the titles and abstracts, 51 articles were obtained. Through full reading, 28 articles resulted. This study represents a section of the literature review, where we selected 10 articles present in PubMed and VHL. Through content analysis in the thematic modality, categories of analysis discussed in this study were constructed. Results: The theme "Training Professionals for Primary Health Care and Community Health" was identified, classifying two core meanings: "Skills, attitudes, skills and knowledge in the training of health professionals;" and "Interprofessional Health Education and Learning." Conclusion: Emphasis on the development of skills and evidence of Interprofessional Education in training for primary care and community health; valuing specific skills; common and collaborative, for teamwork. (AU)

Objetivo: analizar modelos de capacitación para profesionales de la salud en diferentes países, con énfasis en Atención Primaria de Salud, observando posibles similitudes y diferencias; de evidencia científica de 2009 a 2019. Material y métodos: revisión bibliográfica (revisión de alcance). Estudios identificados en las bases de datos PubMed; BVS; ProQuest y EMBASE. Como estrategia de búsqueda, se adoptaron los descriptores y sus combinaciones: Health Workforce, Aptitude, Professional Competence, Models Educational, Health Human Resource Training. Se incluyeron artículos publicados entre 2009 y 2019 sobre educación para la salud, portugués, inglés, francés y español; Se identificaron 2.616 artículos. Excluyendo artículos duplicados, se obtuvieron 2,042. A través de los otros criterios de exclusión: ausencia de resúmenes, artículos no relacionados con la capacitación en el contexto de la APS; Se registraron 369 artículos. Después de leer los títulos y resúmenes, se obtuvieron 51 artículos. A través de la lectura completa, resultaron 28 artículos. Este estudio representa una sección de la revisión de la literatura, donde seleccionamos 10 artículos presentes en PubMed y VHL. A través del análisis de contenido en la modalidad temática, se construyeron las categorías de análisis discutidas en este estudio. Resultados: Se identificó el tema "Capacitación de profesionales para atención primaria de salud y salud comunitaria", clasificando dos significados centrales: "Habilidades, actitudes, habilidades y conocimientos en la capacitación de profesionales de la salud" y "Educación y aprendizaje sanitario interprofesional". Conclusión: Énfasis en el desarrollo de habilidades y evidencia de la Educación Interprofesional en capacitación para atención primaria y salud comunitaria; valorando habilidades específicas; común y colaborativo, para trabajo en equipo. (AU)

Long-term diabetes outcomes after bariatric surgery-managing medication withdrawl.

BACKGROUND/OBJECTIVES: Bariatric surgery leads to type 2 diabetes mellitus (T2DM) remission, but recurrence can ensue afterwards. However, literature provides heterogenous remission/recurrence criteria and there is no consensus on long-term T2DM management after surgery. We aim to assess T2DM remission/recurrence rates using standardized criteria and to identify relapse predictors. We also intend to analyze the management of residual T2DM and the impact of maintaining/withdrawing metformin in avoiding future relapse. SUBJECTS/METHODS: We investigated a cohort of 110 obese patients with T2DM who underwent bariatric surgery and were followed for 5 years (Y0-Y5). Patients who ever attained remission were accounted for cumulate remission, while prevalent remission was considered for individuals who were on remission in a specific visit. RESULTS: A complete prevalent remission of 47.3% was reached at Y1 and it remained stable till Y5 (46.4-48.2%). Complete cumulative rate was of 57.3% at Y5. Five-year T2DM recurrence rate was 15.9% and it was associated with higher pre-operative HbA1c levels (ß = 1.06; p < 0.05) and a milder excess body weight loss (EBWL) (ß = 0.49; p < 0.05). Glucose-lowering agents were fully stopped in 51.4% of the patients till Y1 and in 16.2% of them afterwards. Medication withdrawal was mainly attempted in patients with a lower baseline HbA1c (ß = 0.54; p < 0.01) and higher first-year EBWL (ß = 1.04; p < 0.01). Patients that kept metformin after reaching a HbA1c in the complete remission range (<6.0%) did not have greater odds of avoiding relapse in the next visit (OR = 0.33; p = 0.08). CONCLUSIONS: Baseline HbA1c and EBWL were the main variables driving both T2DM relapse after bariatric surgery and the attempt to withdrawal anti-diabetic medication. In our population keeping metformin once an HbA1c < 6.0% is achieved did not seem to diminish relapse but further studies on this matter are needed.

Preoperative thyroid function and weight loss after bariatric surgery.

Thyroid function has an important role on body weight regulation. However, the impact of thyroid function on weight loss after bariatric surgery is still largely unknown. We evaluated the association between preoperative thyroid function and the excess weight loss 1 year after surgery, in 641 patients with morbid obesity who underwent bariatric surgery. Patients with a history of thyroid disease, treatment with thyroid hormone or antithyroid drugs and those with preoperative evaluation consistent with overt hypothyroidism or hyperthyroidism were excluded. The preoperative levels of TSH and FT4 were not associated with weight loss after bariatric surgery. The variation of FT3 within the reference range was also not associated with weight loss. In contrast, the subgroup with FT3 above the reference range (12.3% of patients) had a significantly higher excess weight loss than patients with normal FT3. This difference remained significant after adjustment for age, sex, BMI, type of surgery, TSH and FT4. In conclusion, we observed an association between high FT3 and a greater weight loss after bariatric surgery, highlighting a group of patients with an increased benefit from this intervention. Our results also suggest a novel hypothesis: the pharmacological modulation of thyroid function may be a potential therapeutic target in patients undergoing bariatric surgery.

Analyzing the Impact of Bariatric Surgery in Kidney Function: a 2-Year Observational Study.

BACKGROUND: Obesity is an independent risk factor for chronic kidney disease (CKD). Our aims were: (1) to evaluate the impact of bariatric surgery (BS) on kidney function, (2) clarify the factors determining postoperative evolution of glomerular filtration rate (ΔGFR) and urinary albumin-to-creatinine ratio (ΔUACR), and (3) access the occurrence of oxalate-mediated renal complications. METHODS: We investigated a cohort of 1448 obese patients who underwent BS. Those with baseline-estimated GFR (eGFR0) < 30 mL/min or without information about the 2-year post-surgical eGFR (eGFR2) were excluded. RESULTS: A total of 725 patients were included. At baseline, 38(5.2%) had hyperfiltration with eGFR0 ≥ 125 mL/min/1.73m2 (G0), 492 (67.9%) had eGFR0 90-124 mL/min/1.73m2 (G1), 178 (24.6%) had eGFR0 60-89 mL/min/1.73m2 (G2), and 17 (2.3%) had eGFR0 < 60 mL/min/1.73m2 (G3). ΔGFR significantly increased in 96.6% (ΔGFR = 23.8 (IQR 15.9-29.8)) and 82.4% (ΔGFR = 18.6 (IQR 3.6-44.0)) of the subjects with G2 and G3 CKD, respectively (p < 0.001). The variables independently associated with ΔGFR were baseline body mass index (BMI) (positively), high blood pressure (HBP) (negatively), and fasting plasma glucose (FPG) (negatively), as well as FPG variation (positively). An overall prevalence of high UACR (≥ 30 mg/g-1) of 17.9% was found, with 81.5% of these subjects presenting A2(30-300 mg/g-1) and 18.5% A3(> 300 mg/g-1) UACR. UACR significantly decreased after BS (p < 0.001). Significant predictors of ΔUACR were BMI, systolic blood pressure, and HbA1c. Urinary excretion of calcium oxalate crystals was found in 77(11.1%) patients, with only 1 presenting oxalate-mediated renal complications. CONCLUSIONS: ΔGFR seems to be influenced by the initial kidney function, as it decreases in subjects with hyperfiltration but tends to increase in those with kidney dysfunction. These results suggest that BS is associated with improvement of kidney outcomes, without a significant increase in renal complications.

Comparative Effectiveness of Different Bariatric Procedures in Super Morbid Obesity.

BACKGROUND: Super obesity (BMI ≥ 50 kg/m2) is associated with significant morbidity and mortality. The best procedure to treat super obesity is not completely established. Our aim was to compare the effectiveness of bariatric procedures (adjustable gastric band [AGB], Roux-en-Y gastric bypass [RYGB], sleeve gastrectomy [SG]) in super obesity. METHODS: Retrospective observational study of super obese patients who underwent bariatric surgery. Data was assessed preoperatively and in the 1st and 2nd years of follow-up. RESULTS: We evaluated 213 individuals, 77.9% female, age of 43.38 ± 11.49 years, and preoperative BMI of 54.53 ± 4.54 kg/m2; 19 submitted to AGB, 127 to RYGB, and 67 to SG. In the pre-surgical assessment, there were no significant differences in age, anthropometric parameters, blood pressure, glycemic profile, and lipid profile between the three surgical groups. The percentage of excess weight loss (%EWL) in the 1st year was 67.58% in RYGB, 58.74% in SG, and 38.71% in AGB (p < 0.001), and the percentage of total weight loss (%TWL) was 36.29%, 31.59%, and 21.07%, respectively (p < 0.001). Two years after surgery (n = 147; follow-up rate of 69%), the %EWL and %TWL were significantly higher in the RYGB group (p < 0.001). RYGB had a higher success rate (%EWL ≥ 50% and %TWL ≥ 20%) in both years of follow-up (p < 0.001). In multiple linear regression, after adjusting for other covariates, RYGB was the only strong predictive factor of %EWL and %TWL (p < 0.001). CONCLUSION: RYGB proved to be more effective in super obesity. The beneficial effects in weight loss were evident both 1 and 2 years after the procedure, regardless of pre-surgical anthropometric characteristics.