RÉSUMÉ
Optima from KONE Instruments Corporation is a new selective laboratory analyzer for turbidimetric, colorimetric and ion selective electrode measurements. Overall analytical performance of Optima and reagents provided by KONE was evaluated according to ECCLS guidelines, in a multicentre study involving four different laboratories, including substrates (cholesterol, high-density lipoprotein-cholesterol, creatinine), specific proteins (transferrin, IgG), enzyme activities (gamma-glutamyltransferase, alanine aminotransferase) and electrolytes (sodium, potassium, chloride). The results obtained attest good precision of the system for all the analytes tested: the range of within-run CV is 0.5 %-4.3 %, and range of between-day CV % is 0.8 %-7.9 % (median of four laboratories). Except for total cholesterol (5 % overestimation compared to the reference method) accuracy of measurement is adequate. Creatinine and uric acid assays were subjects of interference (defined as deviation > 10 % from target value) by bilirubin and haemoglobin respectively.
Sujet(s)
Analyse chimique du sang/méthodes , Analyse chimique du sang/instrumentation , Protéines du sang/analyse , Cholestérol/sang , Colorimétrie/méthodes , Créatinine/sang , Europe , Humains , Électrodes sélectives , Lipoprotéines/sang , Études multicentriques comme sujet , Néphélométrie et turbidimétrie/méthodes , Reproductibilité des résultats , Sensibilité et spécificité , Acide urique/sangRÉSUMÉ
The basic laboratory program module was developed using a summarized information model of a clinical laboratory's functionality. Then, information systems for laboratories of different specialties were quickly implemented by adaptation, addition, and tuning of this basic module. Integrating this system into an HIS considerably improved the interaction between clinical departments and laboratories.
