Psychosis related to methadone withdrawal.

We present two cases of typical psychosis related to methadone withdrawal. The two cases, appearing in the adult age, are not related to previous personal or familiar psychiatric illness and do not show the classical symptoms of methadone withdrawal. The appearance of this type of case is an experience repeated in different groups of researchers. In the line of previous investigators, we propose an alteration of neuromodulation in central opiate-dopamine system.