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1.
Appl Radiat Isot ; 179: 110018, 2022 Jan.
Article de Anglais | MEDLINE | ID: mdl-34749092

RÉSUMÉ

Glioblastoma multiforme is the most common and aggressive brain tumor and it is difficult to treat with conventional surgery, chemotherapy, or radiation therapy. An alternative treatment is boron neutron capture therapy which requires an energy modulated beam of neutrons and a10B drug capable of adhering to the tumor. In this work, MCNP6 Monte Carlo code was used to evaluate the effect on the neutron spectrum by placing two filters along the radial beam tube of the TRIGA Mark III nuclear reactor of ININ in Mexico. Every filter was made with the same amount and type of materials: Steel and Graphite for filter 1 and Cadmium, Aluminum, and Cadmium (Cd + Al + Cd) for filter 2. Two cases were analyzed for each filter as follows: Case A for filter 1 was considering 30 cm of steel and 30 cm of graphite, while for case B, the dimensions of filter 1 were 15 cm of steel, 15 cm of graphite, 15 cm of steel and 15 cm of graphite. Cases A and B for filter 2 were analyzed considering the same dimensions and amount of materials. The work was in the aim to produce epithermal neutrons for boron neutron capture therapy. Neutron spectra were calculated at three sites along the beam tube and two sites outside the beam tube; here, the ambient dose equivalent, the personal dose equivalent, and the effective doses were also estimated. At a distance of 517 cm of core, in case B, results in an epithermal-to-thermal neutron fluence ratio of 30.39 was obtained being larger than the one recommended by the IAEA of 20.


Sujet(s)
Thérapie par capture de neutrons par le bore/méthodes , Tumeurs du cerveau/radiothérapie , Glioblastome/radiothérapie , Neutrons , Humains , Méthode de Monte Carlo , Réacteurs nucléaires
2.
Appl Radiat Isot ; 139: 46-52, 2018 Sep.
Article de Anglais | MEDLINE | ID: mdl-29704705

RÉSUMÉ

The characteristics of photons and neutrons produced during the interaction between a monoenergetic (12 and 18 MeV) electron beam and a tungsten scattering foil enclosed into a 10 cm-thick tungsten shell have been determined using Monte Carlo methods. This model was used aiming to represent a linac head working in electron-mode for cancer treatment. Photon and neutron spectra were determined around the scattering foil and to 50 and 100 cm below the electron source. Induced photons are mainly produced along the direction of the incoming electron beam. On the other hand, neutrons are produced in two sites, mainly in the inner surface of the linac head and in less extent in the scattering foil. The neutron spectra are evaporation neutrons which are emitted isotropically from the site where are produced leaking out from the linac head, reaching locations were the patient is allocated.

3.
Appl Radiat Isot ; 117: 27-31, 2016 Nov.
Article de Anglais | MEDLINE | ID: mdl-27102306

RÉSUMÉ

Regardless the motivation terrorism is the most important risk for the national security in many countries. Attacks with explosives are the most common method used by terrorists. Therefore several procedures to detect explosives are utilized; among these methods are the use of neutrons and photons. In this study the Monte Carlo method an explosive detection system using a 241AmBe neutron source was designed. In the design light water, paraffin, polyethylene, and graphite were used as moderators. In the work the explosive RDX was used and the induced gamma rays due to neutron capture in the explosive was estimated using NaI(Tl) and HPGe detectors. When light water is used as moderator and HPGe as the detector the system has the best performance allowing distinguishing between the explosive and urea. For the final design the Ambient dose equivalent for neutrons and photons were estimated along the radial and axial axis.


Sujet(s)
Américium/analyse , Explosifs/analyse , Explosifs/composition chimique , Méthode de Monte Carlo , Thérapie par capture de neutrons/instrumentation , Spectrométrie gamma/instrumentation , Américium/composition chimique , Simulation numérique , Conception assistée par ordinateur , Conception d'appareillage , Analyse de panne d'appareillage , Modèles statistiques , Thérapie par capture de neutrons/méthodes , Reproductibilité des résultats , Sensibilité et spécificité , Spectrométrie gamma/méthodes
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