[Physiologic nutrition studies in swine with ileorectal anastomoses. 2. The effect of nourseothricin on nutrient digestibility, amino acid absorption, protein utilization and mineral balance of a rye diet]. / Ernährungsphysiologische Untersuchungen an Schweinen mit Ileo-Rektal-Anastomosen. 2. Mitteilung.

The supplement of nourseothricin (NT) to a rye diet did not have an influence on the precaecal and total apparent digestibility of the crude nutrients or the total digestibility of the amino acids (AA). NT produced significantly higher absorption of some AA in pigs with ileo-rectal anastomoses (IRA) which were orally supplied with electrolyte solution (ES). In general, IRA pigs showed the same results with regard to precaecal apparent AA absorption influenced by the AA pattern of endogenous protein as pigs with ileal cannulae. Functions in the large intestine seem to be important for the effect of NT supplements, as NT supplements to the diet of intact animals tendentially had a positive effect on N, Ca and P balances, IRA animals, however, showed a contrary effect. In comparison with the intracaecal infusion of ES, the oral supply of the IRA pigs resulted in higher N, Ca and P balances. The level of N utilization (N balance in % of the digested N) of the IRA pigs supplied orally was equally high as that of the intact animals (both groups without NT). As derives from literature and the available N, Ca and P balances--significantly influenced by ES supplements--an additional supplement of rations poor in crude fibres of 1 g Na/animal and day seems sufficient for covering the requirement of IRA pigs of a weight of 30...40 kg. After 18 days a P supply below the requirement resulted in a significantly reduced P level (inorganic) in the serum in both animal groups, with the level of the IRA pigs being significantly below that of the INT animals. For this reason, the P requirement of fattening pigs should be fully covered in experiments with IRA pigs. Although the IRA pigs supplied caecally with ES showed typical appearances of Na deficiency, their Na level in the serum did not differ from that of the other animals.

[Nutrition physiologic studies of swine with ileorectal anastomoses. 1. Surgical method, biochemical and morphologic findings]. / Ernährungsphysiologische Untersuchungen an Schweinen mit Ileo-Rektal-Anastomosen. 1. Mitteilung. Operationsmethodik, biochemische und morphologische Befunde.

For the purpose of studying nutrient digestion and absorption in the small intestine, pigs were provided with ileo-rectal anastomoses. The anaesthetic and operation method is described. X-ray examinations do not show a significant backflow of digesta into the from colon cranially open towards the anastomosis as well as a totally intact sphincter ani. With the help of additional doses of highly digestible, N-free nutrients rich in energy (starch + saccharose), the operated animals achieved a growth development corresponding to that of intact control animals. For the assessment of the physiologic state of the animals, the concentrations in the serum of the total protein, of albumin, urea, glucose, calcium, inorganic phosphorus and creatinine as well as the activities of aspartate amino transferase and alkaline phosphatase were determined. These showed for the respective criteria changes conditioned by age and dependent on feed intake. The fixing of the anastomoses did not result in disturbances of nutritional or organic damages. Histologic studies of the mucosa of stomach, duodenum and jejunum did not show pathologic changes. The weight of stomach, duodenum and jejunum, determined in 2 live weight ranges, is identical for operated and intact animals in relation to the weight of the empty body of the animals. The weight of ileum, caecum and colon of the operated animals is significantly lower, due to inactivity atrophy. The tissue amount available for the intake of a volume unit (weight-volume index) is nearly identical for operated and intact animals in the duodenum and the jejunum. The index functionally increasing for intact animals from the jejunum to the ileum (stenosis due to temporary digesta congestion in the ileum) remained the same with anastomosis animals for 29 or 26 weeks resp. after the operation. As a result of the biochemical and morphological studies it was shown that animals with an ileo-rectal anastomosis are suitable for the determination of nutrient digestibility at the end of the ileum.

[Behavior of copper and manganese in serum in hemodialysis]. / Das Verhalten des Kupfers und Mangans im Serum unter der Hämodialyse.

The extent to which chronic dialysis alters the serum copper and manganese content was examined. The copper content was not significantly altered, whereas the level of manganese in the blood rose highly significantly. This manganese originates from the dialysis fluid. The behaviour of the manganese level during dialysis treatment suggests that the element is deposited in the body. Its transport is clearly connected with protein, since the manganese is not found in the ultrafiltrate. The is no fear of manganese intoxication.

[Peripheral blood flow in patients with necrobiosis lipoidica (diabeticorum)]. / Untersuchungen zur peripheren Durchblutung bei Patienten mit Necrobiosis lipoidica (diabeticorum).

For the judgment of the peripheral blood supply 16 insulin-dependent diabetics with necrobiosis lipoidica at the lower extremities were compared with 15 insulin-dependent diabetics without necrobiosis lipoidica. The vascular changes in form of retinopathy, nephropathy, neuropathy, hypertension, the results of the radiologically provable vascular changes, oscillograms and impedance plethysmograms as well as the results of the muscle and skin clearance and angioscintigraphy were evaluated. The at last mentioned methods give an insight into the microangiopathy. The apparantly contradicting findings of the muscle clearance (smaller blood supply) and of the skin clearance (increased blood flow) find their explanation by the angioscintigraphically proved different regional parameters of blood flow in the necrobiotic regions. The angiopathic findings are characterized by the enrichment of activity in the marginal seam as a sign of hyperemia and decreased accumulation in the centre as an expression of necrobiosis. The changes of the connective tissue and their causes of development are discussed. Angiopathic and traumatic influences conditioned by metabolism, apart from local peculiarities are taken into consideration.