[Risk-factors for development of suppurative-inflamatory infections in puerperas].

In this article there are shown data of epidemiolgycal analysis of parturition cases (analysis is performed with use of descriptive and evaluative method) for detection of potential risk factors for development of suppurative-inflamatory infections in puerperas. Study was performed in obstetric hospital of the " Imedis Clinica" within 2014 year. 3248 parturition cases were analysed, among them 2373 (73,06% cases of physiological birth and 875 (26,99%) caesarium operation cases. From all cases were detected only 296 (9,211%) cases complicated with basic forms of suppurative-inflamatory infections. Also was performed analysis of post-parturation complications, dependet on anamnesys of pregnants. As a result it was detected, that most significant risk factors for devolpment of suppurative-inflamatory infections in puerperas with physiological birth were genitourinay inflamatory diseases while pregnancy, prolonged (more than 6 hours) parturition period. In cases with caesarian operation, such factors, apart from operation itself, were genitourinary inflamatory diseases while pregnancy, prolonged (more than 5 hours) waterless period, tribal activities before operation, tribal activities more than 5 hours, operation duration longer than 30 minutes and huge haemorage while surgery.

[Antibiotic resistance of nosocomial strains of Staphylococcus spicies].

115 clinical strains of Staphylococcus spicies were isolated in 2005-2010 and investigated from patients with wound infections hospitalized in Tbilisi surgical clinics. Detection of sensitivity/resistance to several groups of antibiotics, was detected by serial dilution method on agar media. During the period of testing, was detected increase in 2-fold of meticillin-resistant St. aureus and in 3-fold of meticillin-resistant St. epidermidis strains. Important increase of resistant Staphylococcus strains was identified to aminoglycosides, macrolides, lincosamines, tetracyclines and ftorchuinolons. Investigated strains of staphylococci were characterized by 100% sensitivity to vancomycine and linezolid.

[Antibacterial nature of medicinal ointments, based on Georgian mineral waters in treatment of generalized periodontitis].

The goal of the work was to determine antibacterial nature of the medicinal ointments (N1 - "Achtala"; N2 - "Sairme", N3 - "Tschaltubo", N4 "Amagleba") based on Georgian mineral waters and containing bio-active extracts. The goal of the work was to determine antibacterial nature of the medicinal ointments (N1 - "Achtala"; N2 - "Sairme", N3 - "Tschaltubo", N4 "Amagleba") based on Georgian mineral waters and containing bio-active extracts. The investigation was done in purpose to determine microbial structure of oral cavity of the 80 patients with chronic generalized periodontitis, as a result was confirmed, that microbial structure of these patients was rather heterogeneous and is presented by different aerobe, microaerophil and anaerobe microbial flora. The sensitivity, resistance, of isolated microorganisms, was studied to modern groups of antibiotics. Results of investigations are: high antibacterial activities of ointments, prepared on mineral waters of Georgia. So, it can be recommended for usage in treatment schedule for patients with chronic generalized periodontitis.

[Comparative analyses of colonization degree of oral cavity by microbial flora during application of teeth prosthetic devices].

The degree of adhesion and colonization was studied among 27 patients with generalized paradontitis of moderate severity and in remission stage. All these patients had different material teeth prostheses. 12 patients had acrylic plastic "Ftorax" material prostheses and 15 of them polypropylenes prostheses. Prostheses prepared from acryl plastic were intensively colonized by stable microflora of oral cavity, as well as by paradontopathogens, whereas usage of polypropylenes prostheses is rather effective for patients with paradontitis, because it is followed by partial recovery of stable microflora and lack of secretion of parodontopathogenic types, such as actynomycetes, prevotellae, fusobacteria.

[Monitoring of level of antibiotic resistance of microbial strains, isolated in cases of surgical infections in period from 2003 to 2005 years].

Microbial structure of surgical infections and level of antibiotic resistance of microbial strains isolated in period from 2003 to 2005 years was investigated. As a result of performed investigation, 871 strains of different microbial species were isolated. It occurred that, in microbial structure of wound infections isolation of gram-positive microflora (509 strains) was 1,5 times higher than gram-negative (362 strains). Quantitative analisation has shown, that microorganisms were isolated in high amount, COU=10(5)-10(8). In 49% of cases microorganisms were isolated as microbial associations. In 37% of isolated microorganisms they had Nosocomial features. Investigation of sensitivity of microorganisms to antibiotics of all known group has shown tendency of rise of level of resistance even to modern antibiotics. It was found out Cephalosporins, Phtorhinolons and Karbapenems are showing good result. Basing on performed investigations could be recommended--strictening of strategy and control in use of antibiotics.

[Results of serotyping of strains isolated from patients with ulcerative colitis (colitis gravis), adaptive colitis and chronic catarrhal colitis].

Serotyping of 565 E.coli strains isolated from 273 patients with ulcerative colitis (70 patients); chronic catarrhal colitis (96 patients), adaptive colitis (107 patient) and of 72 E. coli strains isolated from 50 practically healthy persons (control group) was performed. Serotyping was performed in reaction of agglutination, on stage-glass, by use of commercial set consisting of O and H monovalent serum. As a result of performed investigation it was determined, that in patients with different intestinal inflammatory pathologies, there were found significant pathologic changes in intestinal microbiocenosis, in which main role are playing by strains of E. coli. Such violations of intestinal microbiocenosis often are leading to complications of basic disease. Serotyping of E. coli strains has shown, that in formation of pathologic microbiocenosis with more or less equal frequency are taking part enteropathogenic, enteroinvasive, enterotoxic strains of E. coli and also some definite serotypes of E. coli - representatives of normal intestinal microflora with ability of synthesis of thermolabile enterotoxin.