Transcatheter aortic valve implantation-related infective endocarditis: experience from an Irish tertiary referral centre.

BACKGROUND: Transcatheter aortic valve implantation-related infective endocarditis (TAVI-IE) is a well-recognised and serious complication following TAVI. The purpose of this study was to describe the clinical characteristics, microorganism spectrum, and outcomes of TAVI-IE in an Irish context. METHODS: A prospective registry was used to assess the baseline demographics, procedural variables, and clinical outcomes of patients undergoing TAVI between 2009 and 2020 at two tertiary referral Irish Hospitals. RESULTS: A total of 733 patients underwent TAVI during the study period. During a follow-up duration of 1,949 person-years (median 28 months), TAVI-IE occurred in 17 (2.3%) patients. The overall incidence was 0.87 per 100 person-years and the median time from TAVI to presentation with IE was 7 months [IQR: 5-13 months]. In those who developed TAVI-IE, the mean age was 78.7 years, 70.5% were male, and there was a trend towards more permanent pacemaker implantations post-TAVI (17.6% vs. 5.86%; p = 0.08). The dominant culprit microorganisms were streptococci (41.1%) and four (23.5%) cases were attributed to dental seeding. Major complications of TAVI-IE included one (5.8%) stroke, one (5.8%) in-hospital death, and two (11.7%) urgent surgical aortic valve replacements. The Kaplan-Meier estimate of survival at 1-year was 82% (95% CI = 55-95). CONCLUSIONS: This Irish cohort of TAVI-IE exhibited a similar incidence and time to presentation compared to prior international registries; however, the 1-year mortality rate was comparatively lower. The need for rigorous dental clearance pre-TAVI and maintenance of dental health post-TAVI is underscored by the high prevalence of oral streptococcus species in this cohort.

Clinical experience with trans-catheter aortic valve implantation at a tertiary hospital in the Republic of Ireland.

INTRODUCTION: There is a paucity of published data on the clinical experience with trans-catheter aortic valve implantation (TAVI) in the Republic of Ireland. We sought to examine the clinical outcomes of patients with medium-term follow-up treated with TAVI at our institution. METHODS: A prospective TAVI registry was used to assess the baseline demographics, procedural variables and clinical outcomes of patients treated with TAVI between the inception of the programme in 2008 and November 2017. RESULTS: A total of 354 patients (mean age 80.9 ± 8.1 years, 58% male, mean STS score 6.1 ± 4.3%) were treated during the study period. Major in-hospital outcomes included in-lab death (n = 2, 0.6%), stroke (n = 8, 2.2%), device embolisation (n = 4, 1.2%), permanent pacemaker implantation (n = 22, 6.2%) and major vascular complication (n = 2, 0.6%). The median length of hospital stay was 4 days (IQR 2-8 days). The Kaplan-Meier estimate of freedom from death at 30 days and 1 year for the entire cohort was 97 ± 1% and 85.4 ± 2.3%, respectively. Trans-femoral access was associated with a significantly lower rate of death and/or stroke at 1 year compared to trans-apical access (84.9 ± 2.4% versus 60 ± 8.9%, p = 0.0005). There was no significant difference in freedom from death and/or stroke at 1 year between balloon-expandable and self-expanding valves (81.6 ± 2.6% versus 84.4 ± 7.4%, p = 0.63). CONCLUSION: This study documents low complication rates and favourable rates of survival following TAVI in a consecutive series of patients undergoing TAVI at a tertiary referral centre in the Republic of Ireland. These data support the application of this therapy in the Irish context.

Empowering the Girl Child, Improving Global Health.

The health and productivity of a global society is dependent upon the elimination of gender inequities that prevent girls from achieving their full potential. Although some progress has been made in reducing social, economic, and health disparities between men and women, gender equality continues to be an elusive goal. The Millennium Development Goals (2000-2015) and the Sustainable Development Goals (2015-2030) include intergovernmental aspirations to empower women and stress that change must begin with the girl child.

Cardiovascular disease in women: how nurses can promote awareness and prevention.

Cardiovascular disease (CVD) is the leading cause of death of women in the U.S. and Canada. Experts estimate that one in two U.S. women will die of heart disease or stroke compared with one in 25 women who will die of breast cancer. Risk factors for CVD include hypertension, high cholesterol, obesity and sedentary lifestyle.

Sustaining the vision for Millennium Development Goal 6, to halt and reverse the spread of HIV/AIDS and other infections.

The purpose of Millennium Development Goal 6 is to halt and reverse the spread of HIV/AIDS, malaria, and other diseases and provide universal access to treatment for HIV/AIDS. In this article we describe progress made in meeting the targets for HIV/AIDS set for 2015 and the President's Emergency Plan for AIDS Relief. This funding is geared toward developing sustainable solutions with which to combat diseases that threaten our global community.

The clinical content of preconception care: preconception care for special populations.

Women with disabilities, immigrant and refugee women, and cancer survivors may have medical, psychosocial, and/or cultural issues. Appropriate preconception guidance and management of reproductive planning and preconception issues is essential to ensure that women in these groups can make informed reproductive decisions and achieve optimal reproductive outcomes.

Implementing computerized physician order management at a community hospital.

BACKGROUND: In 2000, four community hospitals in the Cleveland Clinic Health System embarked on an electronic medical record (EMR) project to create an integrated information management environment and improve clinical decision making. METHODS: Executives and individuals from many departments and disciplines were organized into a project structure to launch the project, make decisions, and accomplish change management, which addressed communication, work-flow redesign, training, and support during transition to the new technology-enabled process. PROJECT: In 1999, a small group of regional information technology (IT) leaders for four community hospitals operated by the Cleveland Clinic Health System in the East Region developed a project for the implementation of computerized physician order management (CPOM). RESULTS: Huron Hospital, the first hospital selected for implementation, met its goals for a successful transition. After two pilots, implementation occurred on schedule and with a noticeable lack of major issues, both during rollout and thereafter. In addition, physician direct entry of orders reached the first-year goal of 40% physician entry in the first month and 75% within a year. CONCLUSIONS: Ensuring success required a systematic approach to the foundations of change management--work-flow redesign, communication, training, and support--during the transition.

The impact of diabetes mellitus on female sexual well-being.

For women, the risk for developing diabetes mellitus is reaching epidemic levels. As a result of the impact of diabetes on multiple body systems, women may suffer from medical and psychologic problems, including sexual dysfunction. It is difficult to separate sexual response from the many emotional and other contributing factors that may influence a relationship. Therefore, it is vital that clinicians address the issue of sexuality with their female diabetic patients. This article provides a brief review of the literature, followed by a discussion addressing the proper approach for sexual dysfunction screening. Finally, this article considers some of the current and future treatment modalities that can be used to enhance sexual functioning in female diabetics with impaired sexual function.

Uxoricide: a phenomenological study of adult survivors.

The effect on children of the murder of a parent by the other parent, uxoricide, is immediate and devastating. Usually in a single act, the child loses both parents, one to death and the other to the criminal justice system. This is a report on a qualitative study, with a sample of seven adults, designed to explore the experiences of these children as they grow to adulthood. The major themes developed in the data analysis include (1) a surprising lack of anger regarding the perpetrator, (2) intimate abuse in later personal relationships, and (3) a beginning description of paths to recovery.