Sujet(s)
Incontinence anale , Complications du travail obstétrical , Femelle , Grossesse , Animaux , Humains , Cloaque/chirurgie , Vagin/chirurgie , Gros intestin , Accouchement (procédure) , Canal anal/chirurgie , Périnée/chirurgie , Incontinence anale/chirurgie , Complications du travail obstétrical/chirurgieRÉSUMÉ
BACKGROUND: The aim of the present study was to evaluate the long-term efficacy of percutaneous tibial nerve stimulation (PTNS) for patients with faecal incontinence (FI) refractory to conservative treatment. Secondary aims were to identify predictors of response and validate new treatment pathways for partial responders. METHODS: A prospective, interventional study was carried out in a specialist defecatory disorder unit from a university hospital between January 2010 and June 2017 on patients > 18 years old with FI refractory to conservative treatment. Thirty-minute PTNS sessions were performed in three phases (weekly, biweekly and monthly) up to a year, with clinical reassessment at 3, 6, 12 and 36 months. Patients were classified as optimal responders when their pretreatment Wexner score decreased > 50%; partial responders when it decreased 25-50%; and insufficient responders if it decreased < 25%. Only optimal and partial responders progressed into successive phases. RESULTS: Between 2010 and 2017, 139 patients (110 women, median age 63 years [range 22-82 years]) were recruited. After the first phase, 4 patients were optimal responders, 93 were partial responders and 36 were insufficient responders. At 6 and 12 months, 66 and 89 patients respectively were optimal responders, with an optimal response rate of 64% at the end of treatment. A total of 93.3% patients with a partial response initially finally became optimal responders. Furthermore, at 36 months, 71.9% of patients were still optimal responders without supplementary treatment, although their quality of life did not improve significantly. Baseline Wexner scores ≤ 10 and symptom duration < 1 year were identified as predictive factors for positive responses to PTNS. CONCLUSIONS: Patients undergoing PTNS for 1 year following this protocol had optimal long-term responses. PTNS sessions for up to 1 year in patients who were partial responders prevents a high percentage of them from needing more invasive treatments, and maintains long-term continence in patients who were optimal responders.
Sujet(s)
Incontinence anale , Humains , Femelle , Jeune adulte , Adulte , Adulte d'âge moyen , Sujet âgé , Sujet âgé de 80 ans ou plus , Adolescent , Incontinence anale/thérapie , Études prospectives , Qualité de vie , Traitement conservateur , Nerf tibialRÉSUMÉ
Fecal incontinence (FI) is a complex often multifactorial functional disorder which is associated with a significant impact on patients' quality of life. There is a broad spectrum of symptoms, and degrees of severity and diverse patient backgrounds. Several treatment algorithms from different professional societies and experts are available in the literature. However, no consensus has been reached on several aspects of FI management. We performed a critical review of the most recently published guidelines on FI, emphasising the lack of consensus, highlighting specific topics mentioned in each of the guidelines that are not covered in the others and defining the treatment proposed in different clinical scenarios.
Sujet(s)
Incontinence anale , Adulte , Incontinence anale/thérapie , Humains , Qualité de vieRÉSUMÉ
Clinical decision-making in the treatment of patients with obstructed defaecation remains controversial and no international guidelines have been provided so far. This study reports a consensus among European opinion leaders on the management of obstructed defaecation in different possible clinical scenarios.
Sujet(s)
Prise de décision clinique , Constipation/diagnostic , Constipation/chirurgie , Défécation , Occlusion intestinale/diagnostic , Occlusion intestinale/chirurgie , Algorithmes , Constipation/physiopathologie , Humains , Occlusion intestinale/physiopathologie , SyndromeSujet(s)
Maladies intestinales , Tumeurs du rectum , Humains , Complications postopératoires , Rectum , SyndromeRÉSUMÉ
BACKGROUND: The aim of the present study was to evaluate the effectiveness of sacral neuromodulation (SNM) as a treatment for congenital faecal incontinence (FI). METHODS: A retrospective study was conducted on patients with congenital FI who had SNM surgery at our institution between October 2005 and June 2013. An initial percutaneous nerve evaluation was performed, and patients with an improvement of more than 50% in their symptoms had permanently implants for SNM treatment. RESULTS: There were 4 patients who received a permanent implant. Mean duration of follow-up was 67.5 months (range 45-135 months). At last follow-up, 2 patients maintained significant improvement with SNM, 1 was explanted after 4 years of treatment due to infection but remained asymptomatic and SNM failed in the remaining patient who went on to graciloplasty. CONCLUSIONS: SNM may be of value for treating FI in patients with anorectal malformations.
Sujet(s)
Électrothérapie/méthodes , Électrodes implantées , Incontinence anale/thérapie , Adolescent , Adulte , Sujet âgé , Canal anal/malformations , Canal anal/innervation , Canal anal/chirurgie , Incontinence anale/congénital , Femelle , Études de suivi , Humains , Plexus lombosacral/chirurgie , Mâle , Études rétrospectives , Sacrum/innervation , Sacrum/chirurgie , Résultat thérapeutique , Jeune adulteSujet(s)
Électrodes implantées , Fissure anale/thérapie , Neurostimulation électrique transcutanée/méthodes , Adulte , Maladie chronique , Défécation , Femelle , Fissure anale/physiopathologie , Humains , Mâle , Adulte d'âge moyen , Mesure de la douleur , Projets pilotes , Période postopératoire , Sacrum/innervation , Sacrum/chirurgie , Résultat thérapeutiqueSujet(s)
Incontinence anale/thérapie , Méningocèle/complications , Région sacrococcygienne/malformations , Sacrum/malformations , Neurostimulation électrique transcutanée/méthodes , Malformations multiples , Incontinence anale/étiologie , Femelle , Humains , Sacrum/innervation , Résultat thérapeutique , Jeune adulteRÉSUMÉ
BACKGROUND: Sacral nerve stimulation (SNS) has proven short- to medium-term effectiveness for the treatment of faecal incontinence (FI); fewer long-term outcomes have been presented and usually in small series. Here, the long-term effectiveness of SNS was evaluated in a large European cohort of patients with a minimum of 5 years' follow-up. METHODS: Prospectively registered data from patients with FI who had received SNS for at least 5 years from ten European centres were collated by survey. Daily stool diaries, and Cleveland Clinic and St Mark's incontinence scores were evaluated at baseline, after implantation and at the last follow-up. SNS was considered successful when at least 50 per cent symptom improvement was maintained at last follow-up. RESULTS: A total of 407 patients underwent temporary stimulation, of whom 272 (66·8 per cent) had an impulse generator implanted; 228 (56·0 per cent) were available for long-term follow-up at a median of 84 (i.q.r. 70-113) months. Significant reductions in the number of FI episodes per week (from median 7 to 0·25) and summative symptom scores (median Cleveland Clinic score from 16 to 7, St Mark's score from 19 to 6) were recorded after implantation (all P < 0·001) and maintained in long-term follow-up. In per-protocol analysis, long-term success was maintained in 71·3 per cent of patients and full continence was achieved in 50·0 per cent; respective values based on intention-to-treat analysis were 47·7 and 33·4 per cent. Predictive analyses determined no significant association between pretreatment variables and successful outcomes. Risk of long-term failure correlated with minor symptom score improvement during the temporary test phase. CONCLUSION: SNS remains an effective treatment for FI in the long term for approximately half of the patients starting therapy.
Sujet(s)
Électrothérapie/méthodes , Incontinence anale/thérapie , Plexus lombosacral , Sujet âgé , Électrodes implantées , Incontinence anale/étiologie , Femelle , Humains , Mâle , Adulte d'âge moyen , Études prospectives , Courbe ROC , Résultat thérapeutiqueRÉSUMÉ
BACKGROUND: Sacral nerve stimulation (SNS) has better results and safety than other surgical procedures for faecal incontinence. This prospective study assessed the clinical effectiveness and costs of SNS at a single centre. METHODS: Patients who had experienced one or more episodes of faecal incontinence were studied for up to 5 years by continence diary, anorectal manometry and quality of life questionnaires. Direct medical costs were calculated and the cost-effectiveness of the treatment was analysed. RESULTS: Fifty-seven percutaneous nerve evaluations were performed in 47 patients between June 1999 and February 2006; 29 patients underwent permanent implantation. After a median follow-up of 34.7 (range 2.3-81.2) months, 25 of the 29 patients had a significant reduction in incontinence episodes; 14 patients were in complete remission. At 3-year follow-up, the mean reduction in incontinence episodes was 89 per cent. No change was observed in anal manometric values. Patients reported a significant improvement in quality of life. The introduction of SNS has an incremental cost-effectiveness ratio, below the accepted Spanish threshold. CONCLUSION: The introduction of SNS to the management of faecal incontinence within the Spanish setting is both effective and efficient.
Sujet(s)
Incontinence anale/thérapie , Sacrum/innervation , Neurostimulation électrique transcutanée/normes , Adulte , Sujet âgé , Analyse coût-bénéfice , Incontinence anale/économie , Femelle , Études de suivi , Humains , Mâle , Adulte d'âge moyen , Études prospectives , Qualité de vie , Enquêtes et questionnaires , Neurostimulation électrique transcutanée/économie , Résultat thérapeutiqueRÉSUMÉ
Miction and defecation disturbances are very frequent in the general population and far more so among neurological patients. It is essential to know the physiopathology of these disorders in clinical practice. The neurological control of these functions is carried out by automatisms that are regulated in the nuclei of the brain stem through somatic and vegetative peripheral structures that act simultaneously. The cortical, hypothalamic and reticular levels play a part in the activation or inhibition of the pontine nuclei. Continence depends on the integrity of the anatomical structures and the sensory, pressure and mechanical systems that enable the automatisms to develop. Neurological examination must be combined with studies conducted by other specialists on patients in which no neurological illness is known, but who have this kind of dysfunction. Adding a neurophysiological examination allows us to complete the clinical study and to check objectively for the existence of external anal sphincter denervation or disorders involving the exteroceptive reflexes of the sacrum. The recent appearance of techniques for treating incontinence that make use of the repeated and continuous stimulation of the sacral roots has revolutionised the way these patients are treated and calls for greater involvement of neurologists in dealing with these problems.
Sujet(s)
Canal anal/physiopathologie , Incontinence anale/physiopathologie , Urètre/physiopathologie , Incontinence urinaire/physiopathologie , Canal anal/anatomie et histologie , Défécation/physiologie , Électromyographie , Incontinence anale/thérapie , Humains , Tests neuropsychologiques , Urètre/anatomie et histologie , Incontinence urinaire/thérapie , Miction/physiologieRÉSUMÉ
Las alteraciones funcionales de la micción y de la defecación son muy frecuentes en la población general, y mucho más entre los pacientes neurológicos. Es esencial para la práctica clínica conocerla fisiopatología de estos trastornos. El control neurológico de estas funciones se realiza a partir de automatismos regulados en los núcleos del tronco cerebral mediante estructuras periféricas somáticas y vegetativas que actúan simultáneamente. Los niveles corticales, hipotalámicos y reticulares influyen en la puesta en marcha o inhibición de los núcleos protuberanciales. La continencia depende de la integridad de las estructuras anatómicas y de los sistemas mecánicos, presivos y sensoriales que permiten el desarrollo de los automatismos. Debe incluirse el examen neurológico en los estudios que realizan otros especialistas en los pacientes con este tipo de disfunciones en los que no se conoce enfermedad neurológica. Añadir el examen neurofisiológico permite completar el estudio clínico y reconocer de forma objetiva la existencia de denervación del esfínter anal externo o de alteraciones en los reflejos exteroceptivos sacros. La aparición reciente de técnicas de tratamiento de la incontinencia que usan la estimulación repetitiva y continua de las raíces sacras ha revolucionado el enfoque terapéutico de estos pacientes, e incita a una mayor participación de los neurólogos en estos problemas (AU)