A "human knockout" model to investigate the influence of the α-actinin-3 protein on exercise-induced mitochondrial adaptations.

Research in α-actinin-3 knockout mice suggests a novel role for α-actinin-3 as a mediator of cell signalling. We took advantage of naturally-occurring human "knockouts" (lacking α-actinin-3 protein) to investigate the consequences of α-actinin-3 deficiency on exercise-induced changes in mitochondrial-related genes and proteins, as well as endurance training adaptations. At baseline, we observed a compensatory increase of α-actinin-2 protein in ACTN3 XX (α-actinin-3 deficient; n = 18) vs ACTN3 RR (expressing α-actinin-3; n = 19) participants but no differences between genotypes for markers of aerobic fitness or mitochondrial content and function. There was a main effect of genotype, without an interaction, for RCAN1-4 protein content (a marker of calcineurin activity). However, there was no effect of genotype on exercise-induced expression of genes associated with mitochondrial biogenesis, nor post-training physiological changes. In contrast to results in mice, loss of α-actinin-3 is not associated with higher baseline endurance-related phenotypes, or greater adaptations to endurance exercise training in humans.

Decision making, goal consensus, and effectiveness in university hospitals.

This article examines changes in the influence of several key actors (state and university officials, board members, and hospital and medical school administrators) in management and policy decisions for university hospitals (UHs). We propose that the decreasing influence of external actors in UH decision making and the increasing influence of UH and medical school actors as well as UH-medical school goal consensus will be related to higher levels of UH performance. Data are drawn from a national sample of 52 UHs that participated in a study of UH decision making in 1981 and 1985. Results indicate that state and university actors lost influence in UH policy decisions between 1981 and 1985, while actors internal to academic health centers (AHCs) gained influence in such decisions. The data indicate a similar trend, although not as strong, regarding influence in UH management decisions. Results from regression analyses indicate that decreasing levels of external influence on UH decision making are related to UH effectiveness, but increasing levels of AHC influence and goal consensus have weak or inconsistent relationships with UH effectiveness. Implications for improving the performance of UHs are discussed.

Structural change in academic health centers.

In response to opportunities and threats in their environments, academic health centers (AHCs) are making important changes in their structure. Several AHCs have legally separated their university hospital from the university. In contrast, other AHCs are linking the university hospital more closely to the medical school by concentrating authority for key decisions in the office of an AHC executive. This article draws from a national study of AHCs and examines the advantages and disadvantages of such changes in AHC structure. An important reason for these changes is maximizing revenues from patient care; an important consequence is the increased salience of patient care among the multiple purposes of AHCs.

Managing support services in publicly owned hospitals.

One of the most significant problem areas for publicly owned hospitals is the administration and control of support services. The location of the control of these services affects their responsiveness and efficiency.

Impact of environment on state university hospital performance. An explanatory model.

This article, by means of a path model, shows the impact of environment on state university hospital performance. The state environment is shown to affect systematically the intensity of local competition, the reputation of the medical school, the financial independence of the parent university, the allocation of indigent care dollars, the nature of governance and management, and the performance of the hospital. Results show that while certain environments are predictably more supportive of universities and university hospitals, these environments tend also to attract health care competition. Competition is shown to pressure hospitals into greater efficiency, but competition is shown also to hurt viability. But a hospital management that pays attention to the hospital environment is shown to help both efficiency and viability. The model explains respectively 37% and 46% of the variance in hospital efficiency and viability.

Defining nursing assignment patterns.

A new way of defining nursing assignment patterns, consistent with current work in studies of organizations, is presented. An instrument has been devised which allows direct measurement of the assignment pattern in use on a patient unit. Although current instrumentation requires continued refinement, the instrument has been used successfully on a dozen patients units to characterize the assignment pattern and appears to be both practical and superior to more conventional methods of characterizing assignment patterns which are now in use.

Service unit management and nurses' satisfaction.

Nurses' satisfaction was compared in 55 patient units, 32 with service unit management (SUM) and 23 without. Satisfaction of licensed practical nurses was unrelated to SUM, but intrinsic task satisfaction of registered nurses (and of head nurses, who were considered separately) was positively related to the presence of SUM. Transfer of nonprofessional tasks out of nursing and reduction of tension arising from reduced responsibility of nurses for coordinating activities with ancillary departments are possible explanations for the positive relation between the presence of SUM and professional nurses' satisfaction.