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NTX is FDA-approved for opiate and alcohol use disorders as anti-craving agent. It has been used successfully off-label in other psychiatric indications. Here, we shed some light on these while examining the extant evidence.
Sujet(s)
Naltrexone , Antagonistes narcotiques , Animaux , Humains , Alcoolisme/traitement médicamenteux , Besoin impérieux/effets des médicaments et des substances chimiques , Naltrexone/administration et posologie , Naltrexone/pharmacologie , Naltrexone/usage thérapeutique , Antagonistes narcotiques/administration et posologie , Antagonistes narcotiques/pharmacologie , Utilisation hors indication , Troubles liés aux opiacés/traitement médicamenteux , PsychopharmacologieRÉSUMÉ
Diagnostic confusion commonly arises when assessing for social communicative dysfunction. Clinicians are tasked to differentiate ASD, social pragmatic disorder and developmental language disorders, which can be difficult to contemplate on clinical grounds. Here, authors provide some helpful clinical tips to tease it out.
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Here, authors report on an interesting case of an adolescent with a diagnosis of schizo-affective disorder, maintained on LAI paliperidone palmitate that developed an unusual dystonic reaction in form of anismus that masquerade as constipation and faecal impaction. To our knowledge, this is one of the earliest reports of antipsychotic-induced anismus notably in adolescent population. Clinicians should be mindful of unusual forms of dyskinesias that might be associated with high-potency antipsychotic use.
Sujet(s)
Neuroleptiques , Palmitate de palipéridone , Humains , Palmitate de palipéridone/effets indésirables , Palmitate de palipéridone/administration et posologie , Neuroleptiques/effets indésirables , Neuroleptiques/administration et posologie , Adolescent , Troubles psychotiques/traitement médicamenteux , Mâle , Dyskinésie due aux médicaments , Femelle , Dystonie/induit chimiquementSujet(s)
Inbiteurs sélectifs de la recapture de la sérotonine , Troubles sexuels d'origine physiologique , Humains , Inbiteurs sélectifs de la recapture de la sérotonine/effets indésirables , Troubles sexuels d'origine physiologique/induit chimiquement , Troubles sexuels d'origine physiologique/traitement médicamenteux , Mâle , Femelle , Dysfonctionnements sexuels psychogènes/induit chimiquement , Dysfonctionnements sexuels psychogènes/traitement médicamenteux , Adulte , Adulte d'âge moyenSujet(s)
Trouble déficitaire de l'attention avec hyperactivité , Stimulants du système nerveux central , Méthylphénidate , Humains , Trouble déficitaire de l'attention avec hyperactivité/traitement médicamenteux , Méthylphénidate/usage thérapeutique , Méthylphénidate/administration et posologie , Méthylphénidate/effets indésirables , Stimulants du système nerveux central/usage thérapeutique , Stimulants du système nerveux central/administration et posologie , Enfant , MâleRÉSUMÉ
Clozapine, amongst antipsychotics, has a unique composite mode of action that might translate into an expanded therapeutic potential on clinical grounds. Sorely, clozapine remains underutilized.
Sujet(s)
Neuroleptiques , Clozapine , Dyskinésie due aux médicaments , Schizophrénie , Humains , Clozapine/effets indésirables , Schizophrénie/traitement médicamenteux , Dyskinésie due aux médicaments/traitement médicamenteux , Neuroleptiques/pharmacologieRÉSUMÉ
Here, authors report on an interesting case of early-onset of schizophrenia where adjunctive pregabalin alleviated risperidone-induced pseudoparkinsonism, helped with insomnia and agitation and boosted antipsychotic response with great tolerability. We wager that gabapentenoids can be a viable option in the niche of psychopharmacotherapy of schizophrenia in CAP population.
Sujet(s)
Neuroleptiques , Schizophrénie , Adolescent , Humains , Rispéridone/effets indésirables , Neuroleptiques/effets indésirables , Schizophrénie/traitement médicamenteux , Prégabaline/usage thérapeutiqueRÉSUMÉ
Introduction: Investigating the epidemiology of mental health disorders resulting from COVID-19 intervention measures, primary school closures, and social isolation in children and adolescents needs to be prioritized over adults at the post-pandemic stage. Most preliminary psychosocial studies conducted during the pandemic have demonstrated that younger age groups are the most vulnerable to such implications. Thus, this study aims to estimate the probable prevalence of specific anxiety disorders in children and quantify their relationships with relevant demographic risk factors. Methods: We used a cross-sectional study comprising 430 children aged between 8- and 18 years old living in Kuwait during the period of school closures as well as full and partial lockdowns. The survey included questions about participants' characteristics, children's anxiety using the Screen for Child Anxiety Related Emotional Disorders Questionnaire (SCARED) scale, and children's emotions and behaviours using the Strengths and Difficulties Questionnaire (SDQ). Univariate and multivariate logistic regression analyses were used to summarize the demographic and characteristics of the participants and their association with general, social, and generalized anxieties, as well as behavioural and emotional difficulties. Results: We inferred that 24.83% of our participants had at least one anxiety disorder, while 20.19% were classified as abnormal on the SDQ scale. Our multivariate analysis revealed that lockdown duration and sex of the child were consistently significant predictors (p-values < 0.05) of the broad spectrum of selected mental disorders. Additionally, we inferred notable increases in the likelihood of mental disorders associated with the increased duration of lockdowns. Conclusions: Our findings revealed preliminary insights into the vulnerability of young populations to the indirect negative impacts of strict public health measures during pandemic emergencies. Thus, authorities should consider such implications when planning and implementing similar interventions in future pandemics.
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Gepirone was recently launched and FDA-approved for MDD. It belongs to azapirones group of psychotropics that is in popular use in Japan and China. Here, author wraps up current knowledge on gepirone contrasted with the older and cheaper anxiolytic buspirone.