Sujet(s)
Animaux , Centres de rééducation et de réadaptation , Numération des oeufs de parasites , Diagnostic différentiel , Troubles fonctionnels du côlon/diagnostic , Troubles fonctionnels du côlon/épidémiologie , Troubles fonctionnels du côlon/étiologie , Douleur abdominale/étiologie , Infection à Entamoeba/complications , Infection à Entamoeba/diagnostic , Infection à Entamoeba/épidémiologie , Entamoeba histolytica , Fèces/parasitologie , Lèpre/rééducation et réadaptation , Pays en voie de développement , Études de suivi , Inde/épidémiologieSujet(s)
Adolescent , Anticorps antibactériens/sang , Lépromine/immunologie , Antigènes bactériens/immunologie , Prélèvement d'échantillon sanguin , Test ELISA , Glycolipides/immunologie , Lèpre/diagnostic , Lèpre/immunologie , Mycobacterium leprae/immunologie , Mycobacterium leprae/isolement et purification , Sérumalbumine bovine/immunologie , TempératureRÉSUMÉ
Bassic acid, an unsaturated triterpene acid isolated from an ethanol extract of Bumelia sartorum rootbark, elicited significant hypoglycemic activity in alloxan-diabetic rats and altered the pattern of glucose tolerance in these animals. In addition, bassic acid treatment increased significantly the glucose uptake process and glycogen synthesis in isolated rat diaphragm. Bassic acid treatment increased plasma insulin levels significantly in alloxan-diabetic rats. It is suggested that the hypoglycemia activity of bassic acid may be mediated through enhanced secretion of insulin from the pancreatic beta-cells.
Sujet(s)
Hypoglycémiants/pharmacologie , Plantes médicinales/composition chimique , Triterpènes/pharmacologie , Animaux , Glycémie/métabolisme , Brésil , Diabète expérimental/traitement médicamenteux , Épinéphrine/pharmacologie , Glucose/métabolisme , Hyperglycémie provoquée , Glycogène/biosynthèse , Techniques in vitro , Insuline/sang , Mâle , Rats , Lignées consanguines de rats , Muscles respiratoires/effets des médicaments et des substances chimiques , Muscles respiratoires/métabolismeRÉSUMÉ
Bumelia sartorum has been mentioned in Brazilian folklore for its reputed use in the treatment of diabetes mellitus and inflammatory disorders. An ethanol extract of root bark elicited a hypoglycemic effect in normal and alloxan-induced diabetic rats. In addition, the extract altered glucose tolerance in alloxan-induced diabetic rats, enhanced glucose uptake in skeletal muscle and significantly inhibited glycogenolysis in the liver. These results indicate that the hypoglycemic effect may be similar to chlorpropamide and possibly due to an enhanced secretion of insulin from the islets of Langerhans or an increased utilization of glucose by peripheral tissues. Besides hypoglycemic activity, the ethanol extract also elicited significant anti-inflammatory activity, but did not show any significant effects on blood pressure, respiration or on the various isolated tissue preparations studied. Basic acid has been isolated from the ethanol extract and this component may be responsible for the observed anti-inflammatory activity. However, it is yet to be established whether basic acid is responsible for the observed hypoglycemic activity of the ethanol extract.