Sujet(s)
Anticonvulsivants/effets indésirables , Bromures/effets indésirables , Toxidermies/diagnostic , Épilepsie pharmacorésistante/traitement médicamenteux , Composés du potassium/effets indésirables , Anticonvulsivants/usage thérapeutique , Bromures/usage thérapeutique , Toxidermies/étiologie , Humains , Nourrisson , Mâle , Composés du potassium/usage thérapeutiqueSujet(s)
Infarctus cérébral/étiologie , Eczéma atopique/complications , Endocardite bactérienne/microbiologie , Infections à staphylocoques/microbiologie , Staphylococcus aureus/isolement et purification , Administration par voie cutanée , Adulte , Céfépime/usage thérapeutique , Infarctus cérébral/imagerie diagnostique , Eczéma atopique/traitement médicamenteux , Eczéma atopique/microbiologie , Échocardiographie , Endocardite bactérienne/sang , Endocardite bactérienne/imagerie diagnostique , Endocardite bactérienne/thérapie , Femelle , Glucocorticoïdes/administration et posologie , Implantation de valve prothétique cardiaque , Humains , Imagerie par résonance magnétique , Peau/microbiologie , Infections à staphylocoques/sang , Infections à staphylocoques/imagerie diagnostique , Infections à staphylocoques/thérapie , Résultat thérapeutiqueSujet(s)
Sarcome de Kaposi/diagnostic , Insuffisance veineuse/diagnostic , Sujet âgé , Antinéoplasiques d'origine végétale/usage thérapeutique , Biopsie , Maladie chronique , Diagnostic différentiel , Humains , Immunohistochimie , Japon , Membre inférieur , Mâle , Paclitaxel/usage thérapeutique , Sarcome de Kaposi/thérapieRÉSUMÉ
Mushrooms have garnered immense popularity for their nutritional as well as medicinal values. The therapeutic potential of mushrooms in Nepal, a country well known for its biodiversity and natural medicinal resources, remains largely unstudied. Therefore, this study attempts to unveil the antioxidative properties of Nepalese wild mushrooms. Sixty-two wild mushroom samples were collected from several forests in different parts of Nepal. Ethanol and water extracts of the dried samples were tested for their antioxidative activities using total phenolic content (TPC), oxygen radical absorbance capacity (ORAC) assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and reducing power (RP) assays. Ethanol extracts of samples belonging to the order Hymenochaetales showed significantly high activity in all the assays. Inonotus clemensiae had an exceptionally high TPC of 643.2 mg gallic acid equivalent (GAE)/g extract and also exhibited the lowest EC50 values in DPPH (0.081 mg/mL), ABTS (0.409 mg/mL), and EC0.5 value in reducing power (RP; 0.031 mg/mL) assays. High-performance liquid chromatography (HPLC) analysis of the top ten samples with the highest TPC was done to identify the phenolic compounds in the extracts, followed by liquid chromatography-mass spectrometry (LC-MS) analysis for some unknown compounds. These findings highlight the very strong antioxidative activity of Nepalese mushrooms, and paves the way for further research to explore their economic potential.