RÉSUMÉ
Per- and polyfluoroalkyl substances (PFAS) are rampant, toxic contaminants from anthropogenic sources, called forever chemicals for their recalcitrance. Although banned in several parts of the world for public health implications, including liver, kidney, and testicular diseases, PFAS are abundant in water sources due to easy dispersion. With chemical properties resulting from strong hydrophobic bonds, they defile many physicochemical removal methods. Though adsorption processes such as granular activated carbon (GAC) are widely used, they are marred by several limitations, including cost and secondary contamination. Thus, eco-friendly methods involving a synergy of the removal principles have been preferred for ease of use, cost-effectiveness, and near-zero effect on the environment. We present novel eco-friendly methods as the solution to PFAS remediation towards environmental sustainability. Current eco-friendly methods of PFAS removal from water sources, including electrocoagulation, membrane/filtration, adsorption, and phytoremediation methods, were highlighted, although with limitations. Novel eco-friendly methods such as microbial fuel cells, photoelectrical cells, and plasma treatment offer solutions to PFAS remediation and are quite efficient in terms of cost, result, and environmental sustainability. Overall, the successful integration of eco-friendly techniques in a seamless manner ensures the desired result. We also present a balanced position on the ecosystem impact of these ecofriendly methods, noting the successes towards environmental sustainability while exposing the gaps for further research.
RÉSUMÉ
Protein engineering mechanisms can be an efficient approach to enhance the biochemical properties of various biocatalysts. Immobilization of biocatalysts and the introduction of new-to-nature chemical reactivities are also possible through the same mechanism. Discovering new protocols that enhance the catalytic active protein that possesses novelty in terms of being stable, active, and, stereoselectivity with functions could be identified as essential areas in terms of concurrent bioorganic chemistry (synergistic relationship between organic chemistry and biochemistry in the context of enzyme engineering). However, with our current level of knowledge about protein folding and its correlation with protein conformation and activities, it is almost impossible to design proteins with specific biological and physical properties. Hence, contemporary protein engineering typically involves reprogramming existing enzymes by mutagenesis to generate new phenotypes with desired properties. These processes ensure that limitations of naturally occurring enzymes are not encountered. For example, researchers have engineered cellulases and hemicellulases to withstand harsh conditions encountered during biomass pretreatment, such as high temperatures and acidic environments. By enhancing the activity and robustness of these enzymes, biofuel production becomes more economically viable and environmentally sustainable. Recent trends in enzyme engineering have enabled the development of tailored biocatalysts for pharmaceutical applications. For instance, researchers have engineered enzymes such as cytochrome P450s and amine oxidases to catalyze challenging reactions involved in drug synthesis. In addition to conventional methods, there has been an increasing application of machine learning techniques to identify patterns in data. These patterns are then used to predict protein structures, enhance enzyme solubility, stability, and function, forecast substrate specificity, and assist in rational protein design. In this review, we discussed recent trends in enzyme engineering to optimize the biochemical properties of various biocatalysts. Using examples relevant to biotechnology in engineering enzymes, we try to expatiate the significance of enzyme engineering with how these methods could be applied to optimize the biochemical properties of a naturally occurring enzyme.
RÉSUMÉ
Polybrominated diphenyl ethers (PBDEs) are persistent contaminants used as flame retardants in electronic products. PBDEs are contaminants of concern due to leaching and recalcitrance conferred by the stable and hydrophobic bromide residues. The near absence of legislatures and conscious initiatives to tackle the challenges of PBDEs in Africa has allowed for the indiscriminate use and consequent environmental degradation. Presently, the incidence, ecotoxicity, and remediation of PBDEs in Africa are poorly elucidated. Here, we present a position on the level of contamination, ecotoxicity, and management strategies for PBDEs with regard to Africa. Our review shows that Africa is inundated with PBDEs from the proliferation of e-waste due to factors like the increasing growth in the IT sector worsened by the procurement of second-hand gadgets. An evaluation of the fate of PBDEs in the African environment reveals that the environment is adequately contaminated, although reported in only a few countries like Nigeria and Ghana. Ultrasound-assisted extraction, microwave-assisted extraction, and Soxhlet extraction coupled with specific chromatographic techniques are used in the detection and quantification of PBDEs. Enormous exposure pathways in humans were highlighted with health implications. In terms of the removal of PBDEs, we found a gap in efforts in this direction, as not much success has been reported in Africa. However, we outline eco-friendly methods used elsewhere, including microbial degradation, zerovalent iron, supercritical fluid, and reduce, reuse, recycle, and recovery methods. The need for Africa to make and implement legislatures against PBDEs holds the key to reduced effect on the continent.
Sujet(s)
Déchets électroniques , Éthers de polyhalogénophényle , Éthers de polyhalogénophényle/toxicité , Éthers de polyhalogénophényle/analyse , Afrique , Humains , Ignifuges/toxicité , Polluants environnementaux/toxicité , Animaux , Surveillance de l'environnement/méthodes , Écotoxicologie/méthodesRÉSUMÉ
Decabrominated diphenyl ether (BDE-209) is a typical persistent organic pollutant that can cross the placental barrier, increasing the exposure risk for offspring. Norepinephrine (NE) from nerve terminals and acetylcholine (Ach) can bind to specific receptors on immune cells, inhibit the immune function of the body then cause immunotoxicity. However, whether maternal exposure to BDE-209 could lead to immunotoxicity in the offspring by acting on the sympathetic and parasympathetic nervous systems remains unclear. In view of this, the pregnancy and lactation rat BDE-209 exposure model was established and the results demonstrated that pregnancy and lactation BDE-209 exposure could induce immunotoxicity to female offspring via affecting immunopathology (hematological and biochemical parameters, organ indices, and spleen histopathological), decreasing humoral immunity (serum hemolysin, immunoglobulins, and cytokine productions), damaging cellular immunity (splenic lymphocytes and spleen cytokine productions), and restraining nonspecific immunity. Moreover, a dramatically significant correlation was observed between spleen nerve indices and immunity indices. Additionally, the mechanism revealed that maternal BDE-209 exposure caused offspring immunotoxicity through (1) activating MHC/PKCθ/NF-κB pathway; (2) promoting sympathetic nervous pathway, by upregulating the expression of ß2AR protein, which in turn elevating cAMP, following activate PKA and phosphorylate CREB, ultimately leading to immunotoxicity;(3) activating parasympathetic nerve pathway by reducing the binding with Ach and α7nAchR, upregulating the expression of JAK2 and phosphorylating STAT3, induced immunotoxicity of female offspring.
Sujet(s)
Éthers de polyhalogénophényle , Exposition maternelle , Effets différés de l'exposition prénatale à des facteurs de risque , Animaux , Femelle , Grossesse , Éthers de polyhalogénophényle/toxicité , Exposition maternelle/effets indésirables , Effets différés de l'exposition prénatale à des facteurs de risque/immunologie , Effets différés de l'exposition prénatale à des facteurs de risque/induit chimiquement , Rats , Rate/effets des médicaments et des substances chimiques , Rate/immunologie , Système nerveux autonome/effets des médicaments et des substances chimiques , Rat Sprague-Dawley , Polluants environnementaux/toxicité , Mâle , Cytokines/métabolismeRÉSUMÉ
Per- and polyfluoroalkyl substances (PFAS) have been used in industrial and consumer applications for ages. The pervasive and persistent nature of PFAS in the environment is a universal concern due to public health risks. Experts acknowledge that exposure to high levels of certain PFAS have consequences, including reduced vaccine efficacy, elevated cholesterol, and increased risk of high blood pressure. While considerable research has been conducted to investigate the presence of PFAS in the environment, the pathways for human exposure through food and food packaging/contact materials (FCM) remain unclear. In this review, we present an exhaustive overview of dietary exposure pathways to PFAS. Also, the mechanism of PFAS migration from FCMs into food and the occurrence of PFAS in certain foods were considered. Further, we present the analytical techniques for PFAS in food and food matrices as well as exposure pathways and human health impacts. Further, recent regulatory actions working to set standards and guidelines for PFAS in food packaging materials were highlighted. Alternative materials being developed and evaluated for their safety and efficacy in food contact applications, offering promising alternatives to PFAS were also considered. Finally, we reported on general considerations and perspectives presently considered.
RÉSUMÉ
Despite the diverse research into the environmental impact of plastics, several stones have yet to be unraveled in terms of their ecotoxicological potential. Moreover, their detrimental impacts have become terrifying in recent years as the understanding of their tendency to associate and form cohorts with other emerging contaminants grew. Despite the hypothesis that microplastics may potentially adsorb organic pollutants, sequestering and making them not bioavailable for enhanced toxicity, evidence with pollutants such as Tetrabromobisphenol A (TBBPA) defers this assertion. TBBPA, one of the most widely used brominated flame retardants, has been enlisted as an emerging contaminant of serious environmental and human health concerns. Being also an additive to plasticware, it is not far to suspect that TBBPA could be found in association with micro/nanoplastics in our environment. Several pieces of evidence from recent studies have confirmed the micro/nanoplastics-TBBPA association and have exposed their compounded detrimental impacts on the environment and human health. This study, therefore, presents a comprehensive and up-to-date review of recent findings regarding their occurrence, factors that foster their association, including their sorption kinetics and isotherms, and their impacts on aquatic/agroecosystem and human health. The way forward and prospects for future studies were presented. This research is believed to be of significant interest to the readership due to its relevance to current environmental challenges posed by plastics and TBBPA. The study not only contributes valuable insights into the specific interaction between micro/nanoplastics and TBBPA but also suggests the way forward and prospects for future studies in this field.
Sujet(s)
Écotoxicologie , Polluants environnementaux , Microplastiques , Polybromobiphényles , Humains , Surveillance de l'environnement , IgnifugesRÉSUMÉ
Acrylamide (ACR) is an endogenous food contaminant, high levels of ACR have been detected in a large number of foods, causing widespread concern. Since different organism states respond differently to the toxic effects of pollutants, this study establishes an insulin-resistant BRL cell model to explore the differential susceptibility of BRL cells with/without insulin resistance in response to acrylamide-exposure (0.0002, 0.02, or 1â¯mM) toxicity effects and its mechanism. The results showed that ACR exposure decreased glucose uptake and increased intracellular lipid levels by promoting the expression of fatty acid synthesis, transport, and gluconeogenesis genes and inhibiting the expression of fatty acid metabolism genes, thereby further exacerbating disorders of gluconeogenesis and lipid metabolism in insulin-resistant BRL cells. Simultaneously, its exposure also exacerbated BRL cells with/without insulin-resistant damage. Meanwhile, insulin resistance significantly raised susceptibility to BRL cell response to ACR-induced toxicity. Furthermore, ACR exposure further activated the endoplasmic reticulum stress (ERS) signaling pathway (promoting phosphorylation of PERK, eIF-2α, and IRE-1α) and the apoptosis signaling pathway (activating Caspase-3 and increasing the Bax/Bcl-2 ratio) in BRL cells with insulin-resistant, which were also attenuated after ROS scavenging or ERS signaling pathway blockade. Overall results suggested that ACR evokes a severer toxicity effect on BRL cells with insulin resistance through the overactivation of the ERS signaling pathway.
Sujet(s)
Acrylamide , Stress du réticulum endoplasmique , Insulinorésistance , Transduction du signal , Animaux , Rats , Acrylamide/toxicité , Apoptose/effets des médicaments et des substances chimiques , Lignée cellulaire , Stress du réticulum endoplasmique/effets des médicaments et des substances chimiques , Glucose/métabolisme , Métabolisme lipidique/effets des médicaments et des substances chimiques , Espèces réactives de l'oxygène/métabolisme , Transduction du signal/effets des médicaments et des substances chimiquesRÉSUMÉ
Acrylamide (ACR) is a common industrial contaminant with endocrine-disrupting toxicity. Numerous studies have indicated that females and diabetics are more sensitive to environmental contaminants. However, it remains unknown whether female diabetics are susceptible to ACR-induced toxicity and its potential mechanisms. Thus, the female ACR-exposure diabetic Balb/c mice model was established to address these issues. Results showed that ACR could induce liver injury in normal mice and cause more serious inflammatory cell infiltration, hepatocyte volume increase, and fusion in diabetic mice liver. Meanwhile, ACR could lead to exacerbation of diabetic symptoms in diabetic mice by disturbing the glucose and lipid metabolism in the liver, which mainly manifests as the accumulation of liver glycogen and liver lipids, the reduction of the activity/content of glycolytic and metabolizing enzyme as well as pentose phosphatase, upregulation of the gene expression in fatty acid transporter and gluconeogenesis, and downregulation of the gene expression in fatty acid synthesis and metabolism. Moreover, ACR exposure could induce oxidative stress, inflammation, and endoplasmic reticulum stress in the liver by a decrease in hepatic antioxidant enzyme activity and antioxidant content, an increase in inflammatory factor levels, and a change in the related protein expression of endoplasmic reticulum stress (ERS) and apoptosis-related pathways in diabetic mice. Statistical analysis results revealed that ACR-induced liver injury was highly correlated with inflammation and oxidative stress, and ERS and diabetic mice had a higher risk of liver injury than normal mice. Overall results suggested that female diabetic mice easily suffer from ACR-induced toxicity, and the reason was that ACR could induce further damage to the liver by worsening the condition of inflammation, oxidative stress, and ERS in the liver.
Sujet(s)
Acrylamide , Diabète expérimental , Stress du réticulum endoplasmique , Souris de lignée BALB C , Animaux , Femelle , Acrylamide/toxicité , Stress du réticulum endoplasmique/effets des médicaments et des substances chimiques , Souris , Diabète expérimental/métabolisme , Diabète expérimental/induit chimiquement , Diabète expérimental/anatomopathologie , Foie/effets des médicaments et des substances chimiques , Foie/métabolisme , Foie/anatomopathologie , Lésions hépatiques dues aux substances/métabolisme , Lésions hépatiques dues aux substances/anatomopathologie , Stress oxydatif/effets des médicaments et des substances chimiquesRÉSUMÉ
Tetrabromobisphenol A bis (2- hydroxyethyl) ether (TBBPA-DHEE), as one of the main derivatives of Tetrabromobisphenol A, been attracted attention for its health risks. In this study, the neurotoxicity, mechanism, and susceptivity of TBBPA-DHEE exposure to sexually developing male rats were systematically studied. Neurobehavioral research showed that TBBPA-DHEE exposure could significantly affect the behavior, learning,and memory abilities of male-developing rats, and aggravate their depression. TBBPA-DHEE exposure could inhibit the secretion of neurotransmitters. Transcriptomics studies show that TBBPA-DHEE can significantly affect gene expression, and a total of 334 differentially expressed genes are enriched. GO function enrichment analysis shows that TBBPA-DHEE exposure can significantly affect the expression of genes related to synapses and cell components. KEGG function enrichment analysis shows that TBBPA-DHEE exposure can significantly affect the expression of signal pathways related to nerves, nerve development, and signal transduction. Susceptibility analysis showed that female rats were more susceptible to TBBPA-DHEE exposure than male rats. Therefore, TBBPA-DHEE exposure has neurodevelopmental toxicity to male developmental rats, and female developmental rats are more susceptible than male developmental rats. Its possible molecular mechanism is that TBBPA-DHEE may inhibit the secretion of neurotransmitters and affect signal pathways related to neurodevelopment and signal transduction.
Sujet(s)
Ignifuges , Polybromobiphényles , Femelle , Mâle , Rats , Animaux , Oxyde de diéthyle , Rat Sprague-Dawley , Éthers , Polybromobiphényles/toxicité , Polybromobiphényles/analyse , Éthers éthyliques , Agents neuromédiateurs , Ignifuges/toxicité , Ignifuges/analyseRÉSUMÉ
The increased use of antibiotics by humans for various purposes has left the environment polluted. Antibiotic pollution remediation is challenging because antibiotics exist in trace amounts and only highly sensitive detection techniques could be used to quantify them. Nevertheless, their trace quantity is not a hindrance to their transfer along the food chain, causing sensitization and the development of antibiotic resistance. Despite an increase in the literature on antibiotic pollution and the development and transfer of antibiotic-resistant genes (ARGs), little attention has been given to the behavior of antibiotics at the soil-solution interface and how this affects antibiotic adsorption-desorption interactions and subsequent uptake and transformation by plants. Thus, this review critically examines the interactions and possible degradation mechanisms of antibiotics in soil and the link between antibiotic soil-solution chemistry and uptake by plants. Also, different factors influencing antibiotic mobility in soil and the transfer of ARGs from one organism to another were considered. The mechanistic and critical analyses revealed that: (a) the charge characteristics of antibiotics at the soil-root interface determine whether they are adsorbed to soil or taken up by plants; (b) antibiotics that avoid soil colloids and reach soil pore water can be absorbed by plant roots, but their translocation to the stem and leaves depends on the ionic state of the molecule; (c) few studies have explored how plants adapt to antibiotic pollution and the transformation of antibiotics in plants; and (d) the persistence of antibiotics in cropland soils can be influenced by the content of soil organic matter, coexisting ions, and fertilization practices. Future research should focus on the soil/solution-antibiotic-plant interactions to reveal detailed mechanisms of antibiotic transformation by plants and whether plant-transformed antibiotics could be of environmental risk.
Sujet(s)
Antibactériens , Polluants du sol , Humains , Antibactériens/métabolisme , Sol , Polluants du sol/composition chimique , Plantes/métabolisme , Pollution de l'environnement/analyseRÉSUMÉ
Tetrabromobisphenol A bis(2-hydroxyethyl) ether (TBBPA-DHEE) is the major TBBPA derivative. It has been detected in different environmental samples. Previous studies show that TBBPA-DHEE caused neurotoxicity in rats. In this study, juvenile zebrafish were exposed to various concentrations of TBBPA-DHEE to ascertain the potential neurotoxicity of TBBPA-DHEE, the chemical, and its possible molecular mechanism of action. Behavioral analysis revealed that TBBPA-DHEE could significantly increase the swimming distance and speed in the 1.5 mg/L group compared to the control. In contrast, the swimming distance and speed were significantly reduced in the 0.05 and 0.3 mg/L groups, affecting learning, memory, and neurodevelopment. Similarly, TBBPA-DHEE exposure caused a concentration-dependent significant increase in the levels of excitatory neurotransmitters, namely, dopamine, norepinephrine, and epinephrine, which could be attributed to the change observed in zebrafish behavior. This demonstrates the neurotoxicity of TBBPA-DHEE on juvenile zebrafish. The concentration-dependent increase in the IBR value revealed by the IBR index reveals the noticeable neurotoxic effect of TBBPA-DHEE. Transcriptomic analysis shows that TBBPA-DHEE exposure activated the PPAR signaling pathways, resulting in a disturbance of fatty acid (FA) metabolism and changes in the transcript levels of genes involved in these pathways, which could lead to lipotoxicity and hepatotoxicity. Our findings demonstrate a distinct endocrine-disrupting response to TBBPA-DHEE exposure, possibly contributing to abnormal behavioral alterations. This study provides novel insights into underlying the mechanisms and effects of TBBPA-DHEE on aquatic organisms, which may be helpful forenvironmental/human health risk assessments of the emerging pollutant.
Sujet(s)
Ignifuges , Danio zébré , Humains , Rats , Animaux , Danio zébré/métabolisme , Éthers/analyse , Éthers/métabolisme , Analyse de séquence d'ARN , Ignifuges/toxicité , Ignifuges/analyse , Ignifuges/métabolismeRÉSUMÉ
The class of insecticides known as neonicotinoid insecticides has gained extensive application worldwide. Two characteristics of neonicotinoid pesticides are excellent insecticidal activity and a wide insecticidal spectrum for problematic insects. Neonicotinoid pesticides can also successfully manage pest insects that have developed resistance to other insecticide classes. Due to its powerful insecticidal properties and rapid plant absorption and translocation, dinotefuran, the most recent generation of neonicotinoid insecticides, has been widely used against biting and sucking insects. Dinotefuran has a wide range of potential applications and is often used globally. However, there is growing evidence that they negatively impact the biodiversity of organisms in agricultural settings as well as non-target organisms. The objective of this review is to present an updated summary of current understanding regarding the non-target effects of dinotefuran; we also enumerated nano- and bio-based mitigation and management strategies to reduce the impact of dinotefuran on non-target organisms and to pinpoint knowledge gaps. Finally, future study directions are suggested based on the limitations of the existing studies, with the goal of providing a scientific basis for risk assessment and the prudent use of these insecticides.
Sujet(s)
Guanidines , Insecticides , Animaux , Insecticides/toxicité , Écosystème , Néonicotinoïdes/toxicité , Composés nitrés/toxicité , InsectesRÉSUMÉ
In Africa, the effects of informal e-waste recycling on the environment are escalating. It is regularly transported from developed to developing nations, where it is disassembled informally in search of precious metals, thus increasing human exposure to harmful compounds. Africa has a serious problem with e-waste, as there are significant facilities in Ghana and Nigeria where imported e-waste is unsafely dismantled. however, because they are in high demand and less expensive than new ones, old electronic and electrical items are imported in large quantities, just like in many developing nations. After that, these objects are frequently scavenged to recover important metals through heating, burning, incubation in acids, and other techniques. Serious health hazards are associated with these activities for workers and individuals close to recycling plants. At e-waste sites in Africa, there have been documented instances of elevated concentrations of hazardous elements, persistent organic pollutants, and heavy metals in dust, soils, and vegetation, including plants consumed as food. Individuals who handle and dispose of e-waste are exposed to highly hazardous chemical substances. This paper examines heavy metal risks around e-waste sites and comparable municipal dumpsites in major African cities. Elevated concentrations of these heavy metals metal in downstream aquatic and marine habitats have resulted in additional environmental impacts. These effects have been associated with unfavourable outcomes in marine ecosystems, such as reduced fish stocks characterized by smaller sizes, increased susceptibility to illness, and decreased population densities. The evidence from the examined studies shows how much e-waste affects human health and the environment in Africa. Sub-Saharan African nations require a regulatory framework that includes specialized laws, facilities, and procedures for the safe recycling and disposal of e-waste.
Sujet(s)
Déchets électroniques , Métaux lourds , Humains , Animaux , Villes , Écosystème , Déchets électroniques/effets indésirables , Déchets électroniques/analyse , Métaux lourds/toxicité , Sol/composition chimique , Produits dangereux , Surveillance de l'environnementRÉSUMÉ
Plant-derived nanomaterials (PDNM) have gained significant attention recently due to their potential pharmacological applications against pathogenic microbes, antimicrobial resistance (AMR), and certain metabolic diseases. This review introduces the concept of PDNMs and their unique properties, including their small size, high surface area, and ability to penetrate biological barriers. Besides various methods for synthesizing PDNMs, such as green synthesis techniques that utilize plant extracts and natural compounds, the advantages of using plant-derived materials, such as their biocompatibility, biodegradability, and low toxicity, were elucidated. In addition, it examines the recent and emerging trends in nanomaterials derived from plant approaches to combat antimicrobial resistance and metabolic diseases. The sizes of nanomaterials and their surface areas are vital as they play essential roles in the interactions and relationships between these materials and the biological components or organization. We critically analyze the biomedical applications of nanoparticles which include antibacterial composites for implantable devices and nanosystems to combat antimicrobial resistance, enhance antibiotic delivery, and improve microbial diagnostic/detection systemsIn addition, plant extracts can potentially interfere with metabolic syndrome pathways; hence most nano-formulations can reduce chronic inflammation, insulin resistance, oxidative stress, lipid profile, and antimicrobial resistance. As a result, these innovative plant-based nanosystems may be a promising contender for various pharmacological applications.
RÉSUMÉ
Due to their size, flexibility, biocompatibility, large surface area, and variable functionality nanoparticles have enormous industrial, agricultural, pharmaceutical and biotechnological applications. This has led to their widespread use in various fields. The advancement of knowledge in this field of research has altered our way of life from medicine to agriculture. One of the rungs of this revolution, which has somewhat reduced the harmful consequences, is nanotechnology. A helpful ingredient for plants, silicon (Si), is well-known for its preventive properties under adverse environmental conditions. Several studies have shown how biogenic silica helps plants recover from biotic and abiotic stressors. The majority of research have demonstrated the benefits of silicon-based nanoparticles (Si-NPs) for plant growth and development, particularly under stressful environments. In order to minimize the release of brine, heavy metals, and radioactive chemicals into water, remove metals, non-metals, and radioactive components, and purify water, silica has also been used in environmental remediation. Potentially toxic elements (PTEs) have become a huge threat to food security through their negative impact on agroecosystem. Si-NPs have the potentials to remove PTEs from agroecosystem and promote food security via the promotion of plant growth and development. In this review, we have outlined the various sources and ecotoxicological consequences of PTEs in agroecosystems. The potentials of Si-NPs in mitigating PTEs were extensively discussed and other applications of Si-NPs in agriculture to foster food security were also highlighted.
Sujet(s)
Métaux lourds , Nanoparticules , Silicium/pharmacologie , Métaux lourds/toxicité , Métaux lourds/métabolisme , Plantes/métabolisme , Nanoparticules/toxicité , SiliceRÉSUMÉ
The reduction in agricultural production due to the negative impact of insects and weeds, as well as the health and economic burden associated with vector-borne diseases, has promoted the wide use of chemicals that control these "enemies." However, the use of these synthetic chemicals has been recognized to elicit negative impacts on the environment as well as the health and wellbeing of man. In this study, we presented an overview of recent updates on the environmental and health impacts of synthetic pesticides against agro-pest and disease vectors while exhaustive reviewing the potentials of natural plant products from Zanthoxylum species (Rutaceae) as sustainable alternatives. This study is expected to spur further research on exploiting these plants and their chemicals as safe and effective pesticide entities to minimize the impact of their chemical and synthetic counterparts on health and the environment.
Sujet(s)
Produits biologiques , Insecticides , Pesticides , Zanthoxylum , Humains , Pesticides/toxicité , Insecticides/toxicité , Mauvaises herbesRÉSUMÉ
Chemicals used for storage majorly possess insecticidal activities - deterring destructive insect pests and microorganisms from stored agricultural produce. Despite the controversy about their safety, local farmers and agro-wholesalers still predominantly use these chemicals in developing countries, especially Africa, to ensure an all-year supply of agriproducts. These chemicals could have short- or long-term effects. Despite the state-of-the-art knowledge, factors such as poor education and awareness, limited agricultural subventions, quests for cheap chemicals, over-dosage, and many more are the possible reasons for these toxic chemicals' setback and persistent use in developing countries. This paper provides an up-to-date review of the environmental and ecological effects, as well as the health impacts arising from the indiscriminate use of toxic chemicals in agriproducts. Existing data link pesticides to endocrine disruption, genetic mutations, neurological dysfunction, and other metabolic disorders, apart from the myriad of acute effects. Finally, this study recommended several naturally sourced preservatives as viable alternatives to chemical counterparts and emphasized the invaluable role of education and awareness programs in mitigating the use in developing nations for a sustainable society.
RÉSUMÉ
In conjunction with global climate change, progressive ocean warming, and acclivity in pollution and anthropogenic eutrophication, the incidence of harmful algal blooms (HABs) and cyanobacterial harmful algal blooms (CHABs) continue to expand in distribution, frequency, and magnitude. Algal bloom-related toxins have been implicated in human health disorders and ecological dysfunction and are detrimental to the national and global economy. Biomonitoring programs based on traditional monitoring protocols were characterised by some limitations that can be efficiently overdone using the CRISPR/Cas technology. In the present review, the potential and challenges of exploiting the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas technology for early detection of HABs and CHABs-associated toxigenic species were analysed. Based on more than 30 scientific papers, the main results indicate the great potential of CRISPR/Cas technology for this issue, even if the high sensitivity detected for the Cas12 and Cas13 platforms represents a possible interference risk.
Sujet(s)
Surveillance biologique , Cyanobactéries , Humains , Systèmes CRISPR-Cas , Prolifération d'algues nuisibles , Cyanobactéries/génétique , Pollution de l'environnementRÉSUMÉ
Antibiotic pollution is an ever-growing concern that affects the growth of plants and the well-being of animals and humans. Research on antibiotics remediation from aqueous media has grown over the years and previous reviews have highlighted recent advances in antibiotics remediation technologies, perspectives on antibiotics ecotoxicity, and the development of antibiotic-resistant genes. Nevertheless, the relationship between antibiotics solution chemistry, remediation technology, and the interactions between antibiotics and adsorbents at the molecular level is still elusive. Thus, this review summarizes recent literature on antibiotics remediation from aqueous media and the adsorption perspective. The review discusses the principles, mechanisms, and solution chemistry of antibiotics and how they affect remediation and the type of adsorbents used for antibiotic adsorption processes. The literature analysis revealed that: (i) Although antibiotics extraction and detection techniques have evolved from single-substrate-oriented to multi-substrates-oriented detection technologies, antibiotics pollution remains a great danger to the environment due to its trace level; (ii) Some of the most effective antibiotic remediation technologies are still at the laboratory scale. Thus, upscaling these technologies to field level will require funding, which brings in more constraints and doubts patterning to whether the technology will achieve the same performance as in the laboratory; and (iii) Adsorption technologies remain the most affordable for antibiotic remediation. However, the recent trends show more focus on developing high-end adsorbents which are expensive and sometimes less efficient compared to existing adsorbents. Thus, more research needs to focus on developing cheaper and less complex adsorbents from readily available raw materials. This review will be beneficial to stakeholders, researchers, and public health professionals for the efficient management of antibiotics for a refined decision.
Sujet(s)
Assainissement et restauration de l'environnement , Polluants chimiques de l'eau , Animaux , Humains , Antibactériens/analyse , Polluants chimiques de l'eau/analyse , Eaux usées , Pollution de l'environnement/analyse , Adsorption , Eau/analyseRÉSUMÉ
Tetrabromobisphenol A-bis (2-hydroxyethyl) ether (TBBPA-DHEE) has been detected in various environmental media and organisms, and its ecological risks and health hazards have attracted great attention, but sufficient toxicological data have not proved the toxic effects of TBBPA-DHEE exposure on aquatic organism. In this study, the neurotoxicity and mechanism of zebrafish (3-month-old) exposed to TBBPA-DHEE (0.86 µg/L, 12.9 µg/L, 193.5 µg/L) were studied. Furthermore, the neurotoxicity susceptibility of different sexes of zebrafish was revealed. Behavioral studies revealed that TBBPA-DHEE exposure has significant differences in average speed, duration of mania, the distance between objects, and ATP content between male and female zebrafish. Slight damage in brain tissue of male zebrafish was found. The transcriptome analysis revealed that the molecular mechanism of neurotoxicity in mature female and male zebrafish is different. For mature female zebrafish, TBBPA-DHEE significantly affected the expression of genes related to behavior and development, and its mechanism may be that it can produce neurotoxicity by affecting related genes in the hormone, synapse, and Ca2+ signaling pathway. For mature male zebrafish, TBBPA-DHEE can significantly affect their behavior and expression of nerve-related genes. Results from the transcriptomic analysis suggests that the possible molecular mechanism may be through the inhibition of Ca2+ signal transmission and produce neurotoxicity by affecting the expression of related genes in neural synapses, Ca2+ signal, and MAPK signal in brain tissue of zebrafish. The results suggested that exposure to low-dose TBBPA-DHEE could induce neurotoxicity in zebrafish, and female and male zebrafish showed different toxic effects and molecular mechanisms.